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Search Results for " k -atpase "

90

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0712	Suloctidil	ATPase; Platelet aggregation	Membrane transporter/Ion channel; Others
	Suloctidil 是一种外周血管扩张剂，作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性，可治疗痴呆和血栓形成病症。
T6443	Chloroprocaine hydrochloride 盐酸氯普鲁卡因,Chloroprocaine HCl	ATPase; Others	Membrane transporter/Ion channel; Others
	Chloroprocaine hydrochloride (Chloroprocaine HCl) 是一种 Na/K-ATPase 活性抑制剂，IC50为 13 mM，可阻断外周神经。
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T0490	Chlorpropamide Diabinese,氯磺丙脲	ATPase; ABC	Membrane transporter/Ion channel
	Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。
T6953	Prilocaine Citanest,丙胺卡因,Propitocaine,NSC 40027	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine (NSC-40027) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T2621	Rostafuroxin PST 2238	ATPase; RSV	Membrane transporter/Ion channel; Microbiology/Virology
	Rostafuroxin (PST 2238) 是洋地黄毒苷衍生物，是一种口服有效的 Na+,K+-ATPase 抑制剂，具有抗高血压和抗 RSV 活性，用于研究治疗原发性高血压的试验。
T2686L	Esomeprazole Sodium 埃索美拉唑钠,(S)-Omeprazole sodium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T2686	Esomeprazole Magnesium (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium (NEXIUM) 是一种口服有效的 H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病中具有研究价值。Esomeprazole magnesium 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T6928	Pantoprazole SKF96022,泮托拉唑,BY1023	Apoptosis; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole (BY1023) 是一种质子泵抑制剂，用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。
T8386	Esomeprazole Magnesium trihydrate 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate	Proton pump	Membrane transporter/Ion channel
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) 是一种口服有效的H+, K+-ATPase 抑制剂，在上消化道疾病和胃食管反流疾病的研究中具有价值。它是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T0161	Pantoprazole Sodium Hydrate SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis; Potassium Channel; Proton pump; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) 是一种具有口服活性的质子泵抑制剂。它是取代的苯并咪唑，是H+/K+-ATPase 抑制剂。它可改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T6929	Pantoprazole sodium Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc	Apoptosis; Others; Proton pump; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Others
	Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂，是一种取代的苯并咪唑，是H+/K+-ATPase 抑制剂，IC50为 6.8 μM。它可以改善 pH 值稳定性，具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
T27812	Leminoprazole	ATPase	Membrane transporter/Ion channel
	Leminoprazole 是一种可口服的 H+，K（+）-ATPase 抑制剂，可保护胃黏膜细胞免受各种细胞损伤，可用于治疗胃溃疡。
T17030	Tegoprazan	ATPase; Proton pump	Membrane transporter/Ion channel
	Tegoprazan 是一种口服有效的、高选择性胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，能够控制胃酸分泌和运动，在体外检测的对猪、犬、人的 H+/K+-ATP 酶的 IC50为0.29-0.52 μM。
T2404	Vonoprazan fumarate 富马酸沃诺拉赞,TAK-438	ATPase	Membrane transporter/Ion channel
	Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB（钾竞争性酸阻滞剂），可可逆地抑制 H+/K+、ATP 酶。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T16865	SCH28080	ATPase; Proton pump	Membrane transporter/Ion channel
	SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。
T2189	Sodium orthovanadate Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate	ATPase; Phosphatase	Membrane transporter/Ion channel; Metabolism
	Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP 酶的抑制剂，有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。
T10435	Linaprazan 利那拉生,AZD0865	Potassium Channel	Membrane transporter/Ion channel
	Linaprazan (AZD0865) 通过K+竞争抑制胃中的H+,K+ -ATPase. (IC 50: 1.0 ± 0.2 μM)。Linaprazan 对酸有很强的抑制作用。
T9553	8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid	Others	Others
	8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-car 是一种 H+/K+ ATPase 抑制剂，IC50=0.38μM。
T28136	NC-1300-B NC1300B,NC 1300 B	ATPase	Membrane transporter/Ion channel
	NC-1300-B 抑制 H（+）-K（+）-ATP 酶，可用于研究胃溃疡。
T27303	Farglitazar GI-262570,GI 262570,GI262570
	Farglitazar is a PPAR-γ agonist. GI262570 stimulates the ENaC and Na,K-ATPase system resulting in the increasing of water and sodium reabsorption in distal nephron.
T19826	Rabeprazole LY307640	Potassium Channel; STAT	JAK/STAT signaling; Membrane transporter/Ion channel; Stem Cells
	Rabeprazole (LY307640) 是一种 H+/K+-ATPase 抑制剂，通过靶向 STAT3 介导的糖酵解来抑制胃上皮细胞中的细胞增殖，可用于研究胃溃疡。
T1651	Rabeprazole sodium Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium	Apoptosis; Proton pump	Apoptosis; Membrane transporter/Ion channel
	Rabeprazole sodium (Habeprazole Sodium) 是一种质子泵抑制剂，不可逆地抑制胃 H+/K+-ATPase，可研究胃溃疡和胃食管反流。它诱导细胞凋亡，也抑制尿苷核苷核糖水解酶，IC50为 0.3 μM。
T20714	Levolansoprazole 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole	Proton pump	Membrane transporter/Ion channel
	Levolansoprazole ((S)-Lansoprazole) 是一种质子泵抑制剂，不可逆地抑制壁细胞中 H+/K+ 刺激的 ATPase 泵 (IC50: 5.2 µM)。它还抑制分离的犬壁细胞中的酸形成(IC50：82 µM)。 (R)-和 (S)-兰索拉唑均具有药理活性，具有相似的效力。
T14052	5-IAF 5-Iodoacetamidofluorescein
	5-IAF 是吲哚乙酰胺的一种荧光素衍生物，是一种荧光探针，可用来标记蛋白质和其他含有游离硫醇（半胱氨酸侧链）。5-IAF 可标记狗肾脏Na,K-ATP 酶的催化（α）亚单位。
TP1033L	Transdermal Peptide Disulfide Acetate TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)	ATPase	Membrane transporter/Ion channel
	Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) 是一种 11 个氨基酸的肽，与 Na+/K+-ATPase β 亚基 (ATP1B1) 结合，主要与 ATP1B1 的 C 端相互作用。透皮肽可以增强许多大分子的透皮传递。透皮肽 TD 1 酰胺是一种新型肽，旨在增强透皮药物传递。
T0674	Lansoprazole 兰索拉唑,A-65006,AG-1749	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole (A-65006) 是一种可抑制胃酸生成的质子泵抑制剂。它是中性鞘磷脂酶的外泌体抑制剂。
T10221	Abeprazan hydrochloride DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump	Membrane transporter/Ion channel
	Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂，通过竞争性的与钾离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI)，通过减少胃酸的产生而起作用，可用于治疗胃酸相关疾病，如胃食管反流病(GERD)和消化性溃疡。
T1756L	Ilaprazole IY81149,艾普拉唑,IY 81149,IY-81149	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole (IY-81149) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制H+/K+-ATPase，在兔壁细胞制剂中的IC50为 6 μM。它也是一种有效的T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T1756	Ilaprazole sodium IY-81149 sodium,艾普拉唑钠	Proton pump; TOPK	MAPK; Membrane transporter/Ion channel
	Ilaprazole sodium (IY-81149 sodium) 是一种具有口服活性质子泵抑制剂，以剂量依赖性方式不可逆地抑制 H+/K+-ATPase，在兔壁细胞制剂中的 IC50为 6 μM。它也是一种有效的 T 细胞起源蛋白激酶(TOPK)抑制剂，用于胃溃疡的研究。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T1734	Rabeprazole Sulfide 雷贝拉唑相关物质E,Rabeprazole Related Compound E	Proton pump; Antibacterial	Membrane transporter/Ion channel; Microbiology/Virology
	Rabeprazole Sulfide (Rabeprazole Related Compound E) 是 Rabeprazole 的活性代谢产物。Rabeprazole 是一种质子泵抑制剂类的抗溃疡药物，有效抑制幽门螺旋杆菌的活性，可通过与胃壁细胞中的(H+/K+)-ATPase 相互作用来抑制胃酸分泌，可研究各种消化系统疾病。
T2093	PF 03716556 PF-3716556	ATPase	Membrane transporter/Ion channel
	PF 03716556 (PF-3716556) 是一种有效且特异性的 P-CAB（钾竞争性酸阻滞剂），用于治疗胃食管反流病。
T15599	Istaroxime hydrochloride PST2744 hydrochloride	Others	Others
	Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
T15600	Istaroxime PST2744	Others	Others
	Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).
T12471	Picoprazole	Others	Others
	Picoprazole is a specific H+/K+-ATPase inhibitor (IC50 of 3.1±0.4 μM).
T12822	S3337	Others	Others
	S3337 is an inhibitor of H+, K+-ATPase
T16894	SKF96067	Others	Others
	SKF96067 is a reversible gastric H+/K+-ATPase inhibitor.
T35923	Caloxin 2A1 TFA
	Caloxin 2A1 TFA is a peptide inhibitor specifically targeting the extracellular plasma membrane Ca2+-ATPase (PMCA), without influencing the basal activities of Mg2+-ATPase or Na+-K+-ATPase[1].
T12977	Soraprazan BYK61359	Others	Others
	Soraprazan is a reversible, and fast-acting gastric H+/K+ ATPase inhibitor.
T76374	SPAI-1
	SPAI-1，特异性单价阳离子ATP酶抑制剂，源自猪十二指肠。能体外抑制Na+，K+-ATP酶和H+，K+-ATP酶，同时刺激Mg2+-ATP酶。
T23685	AHR-9294
	AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo.
T30250	AZD0865 AZD-0865,AZD 0865
	AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset.
T69801	AU-461
	AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent.
T36060	Digoxigenin Monodigitoxoside
	Digoxigenin monodigitoxoside是地高辛的一种Na+/K+ ATPase 抑制剂和强心苷代谢物。
T26450	A 80915A A80915A,A-80915A
	A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase, potassium slows the rate of inhibition by

化合物

Cat.No: T0712

Target: ATPase, Platelet aggregation

Chloroprocaine hydrochloride

Cat.No: T6443

Synonym: 盐酸氯普鲁卡因,Chloroprocaine HCl

Target: ATPase, Others

Cat.No: T20626

Target: Proton pump, Cysteine Protease

Cat.No: T0490

Synonym: Diabinese,氯磺丙脲

Target: ATPase, ABC

Cat.No: T6953

Synonym: Citanest,丙胺卡因,Propitocaine,NSC 40027

Target: ATPase, Sodium Channel

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Cat.No: T2621

Synonym: PST 2238

Target: ATPase, RSV

Esomeprazole Sodium

Cat.No: T2686L

Synonym: 埃索美拉唑钠,(S)-Omeprazole sodium

Target: ATPase, Proton pump

Esomeprazole Magnesium

Cat.No: T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,埃索美拉唑镁,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Cat.No: T6928

Synonym: SKF96022,泮托拉唑,BY1023

Target: Apoptosis, Proton pump, Autophagy

Esomeprazole Magnesium trihydrate

Cat.No: T8386

Synonym: 埃索美拉唑镁三水合物,埃索美拉唑镁(三水),(S)-Omeprazole magnesium trihydrate

Target: Proton pump

Pantoprazole Sodium Hydrate

Cat.No: T0161

Synonym: SKF96022 sodium hydrate,泮托拉唑钠水合物,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

Cat.No: T6929

Synonym: Pantecta,泮托拉唑钠盐,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),泮托拉唑钠,BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Cat.No: T27812

Target: ATPase

Cat.No: T17030

Target: ATPase, Proton pump

Vonoprazan fumarate

Cat.No: T2404

Synonym: 富马酸沃诺拉赞,TAK-438

Target: ATPase

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Cat.No: T16865

Target: ATPase, Proton pump

Sodium orthovanadate

Cat.No: T2189

Synonym: Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate

Target: ATPase, Phosphatase

Cat.No: T10435

Synonym: 利那拉生,AZD0865

Target: Potassium Channel

8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxylic acid

Cat.No: T9553

Target: Others

Cat.No: T28136

Synonym: NC1300B,NC 1300 B

Target: ATPase

Cat.No: T27303

Synonym: GI-262570,GI 262570,GI262570

Cat.No: T19826

Synonym: LY307640

Target: Potassium Channel, STAT

Rabeprazole sodium

Cat.No: T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,雷贝拉唑钠,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Levolansoprazole

Cat.No: T20714

Synonym: 左旋兰索拉唑,(S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Cat.No: T14052

Synonym: 5-Iodoacetamidofluorescein

Transdermal Peptide Disulfide Acetate

Cat.No: TP1033L

Synonym: TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)

Target: ATPase

Cat.No: T0674

Synonym: 兰索拉唑,A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Abeprazan hydrochloride

Cat.No: T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Cat.No: T1756L

Synonym: IY81149,艾普拉唑,IY 81149,IY-81149

Target: Proton pump, TOPK

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Ilaprazole sodium

Cat.No: T1756

Synonym: IY-81149 sodium,艾普拉唑钠

Target: Proton pump, TOPK

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Rabeprazole Sulfide

Cat.No: T1734

Synonym: 雷贝拉唑相关物质E,Rabeprazole Related Compound E

Target: Proton pump, Antibacterial

Cat.No: T2093

Synonym: PF-3716556

Target: ATPase

Istaroxime hydrochloride

Cat.No: T15599

Synonym: PST2744 hydrochloride

Target: Others

Cat.No: T15600

Synonym: PST2744

Target: Others

Cat.No: T12471

Target: Others

Cat.No: T12822

Target: Others

Cat.No: T16894

Target: Others

Caloxin 2A1 TFA

Cat.No: T35923

Cat.No: T12977

Synonym: BYK61359

Target: Others

Cat.No: T76374

Cat.No: T23685

Cat.No: T30250

Synonym: AZD-0865,AZD 0865

Cat.No: T69801

Digoxigenin Monodigitoxoside

Cat.No: T36060

Cat.No: T26450

Synonym: A80915A,A-80915A

Cat. No.	Product Name	Target	Signaling Pathways
T1719	Bufalin	ATPase	Membrane transporter/Ion channel
	Bufalin 是蟾酥中的一种成分，是Na+/K+-ATPase 抑制剂，具有抗肿瘤活性，可与其基 α1、α2 和 α3 结合，Kd 值分别为 42.5、45 和 40 nM。
TJP2872	Acevaltrate Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate	ATPase; Others	Membrane transporter/Ion channel; Others
	Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性，IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性，IC50分别为 22.8 和 42.3 μM。
T5S0890	Oleandrin Neriostene,Folinerin,Foliandrin,欧夹竹桃苷	Apoptosis; ATPase; Potassium Channel; Sodium Channel	Apoptosis; Membrane transporter/Ion channel
	Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇，可抑制Na+/K+-ATPase 活性，IC50为 620 nM。
TN5073	Strophanthidin 毒毛旋花子甙元,Strophanthidine,葡萄球菌素	ATPase; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇，可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性，1到100 μ mol/L 抑制Na+/K+-ATPase 活性，10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。
T0295	Digitoxin Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄	ATPase; Others	Membrane transporter/Ion channel; Others
	Digitoxin (Digitoxinum) 是Na+/K+-ATPase 有效抑制剂, EC50 值为0.78 μM。
T2922	Phlorizin Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin	ATPase; SGLT	GPCR/G Protein; Membrane transporter/Ion channel
	Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂，也是Na+/K+-ATPase 抑制剂，对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。
T8183	Deslanoside 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C	ATPase; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。
T2O2668	Oleic acid Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸	Apoptosis; ATPase; Others; Endogenous Metabolite	Apoptosis; Membrane transporter/Ion channel; Metabolism; Others
	Oleic acid (Glycon Wo) 属于天然产物，是一种常见的饱和脂肪酸，在存在于多种动物、植物的脂肪和油脂中。Palmitic acid 是一种 Na+/K+ATP 酶激活剂。
T2822	Ginsenoside Rb1 Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III	ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。
T3432	Cinobufagin 华蟾蜍精,华蟾酥毒基,Cinobufagine	Apoptosis; ATPase; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel
	Cinobufagin (Cinobufagine) 是一种具有抗肿瘤功效的天然产物。
TQ0184	Chebulinic acid	ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells
	Chebulinic acid 是从诃子果中提取的一种天然产物，结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。
T36390	Sodium oleate Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt	ATPase	Membrane transporter/Ion channel
	Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。
T13618	Citreoviridin	Others	Others
	Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na+/K+-ATPase whereas, in microsomes, both Na+/K+-ATPase and Mg2+-ATPase activities are significantly stimulated in a dose-dependent manner.
TN6631	Chamigrenol
	Chamigrenol is a promising candidate for the development of potent Na+/K+ ATPase inhibitors and antimicrobial agents. It inhibited the activities of Na+/K+-ATPase, with the IC50 value of 15.9 ± 0.54 μg/mL.
TN5141	Thevetin B	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Thevetin B 是一种强心苷，是Na+-, K+-依赖性腺苷三磷酸酶 (Na+,K+-ATPase) 的抑制剂，来自 Thevetia peruviana。
T10455	Bafilomycin B1 巴佛洛霉素 B1	Others	Others
	Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi.
TN4697	Odoroside H	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Odoroside H has anticancer activities, the cytotoxic effects are induced by the inhibition of the plasma membrane bound Na(+)/K(+)-ATPase.
TN2306	Wilfordine	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
TN5060	Stauntosaponin A	ATPase; Potassium Channel; Sodium Channel	Membrane transporter/Ion channel
	Stauntosaponin A and stauntosaponin B show moderate inhibitory activities against Na+/K+-ATPase with IC50 values of 21 and 29 uM, respectively.
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T1719

Target: ATPase

Cat.No: TJP2872

Synonym: Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate

Target: ATPase, Others

Cat.No: T5S0890

Synonym: Neriostene,Folinerin,Foliandrin,欧夹竹桃苷

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Cat.No: TN5073

Synonym: 毒毛旋花子甙元,Strophanthidine,葡萄球菌素

Target: ATPase, Calcium Channel

Cat.No: T0295

Synonym: Digitoxoside,洋地黄毒苷,Unidigin,洋地黄毒甙,Digitoxinum,洋地黄

Target: ATPase, Others

Cat.No: T2922

Synonym: Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin

Target: ATPase, SGLT

Cat.No: T8183

Synonym: 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Cat.No: T2O2668

Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid,油酸

Target: Apoptosis, ATPase, Others, Endogenous Metabolite

Ginsenoside Rb1

Cat.No: T2822

Synonym: Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

Cat.No: T3432

Synonym: 华蟾蜍精,华蟾酥毒基,Cinobufagine

Target: Apoptosis, ATPase, Autophagy

Chebulinic acid

Cat.No: TQ0184

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Cat.No: T36390

Synonym: Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt

Target: ATPase

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Cat.No: T6S1049

Target: ATPase

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Cat.No: T13618

Target: Others

Cat.No: TN6631

Cat.No: TN5141

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: T10455

Synonym: 巴佛洛霉素 B1

Target: Others

Cat.No: TN4697

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: TN2306

Target: ATPase, Potassium Channel, Sodium Channel

Stauntosaponin A

Cat.No: TN5060

Target: ATPase, Potassium Channel, Sodium Channel

Cat.No: T38069

Cat.No: T35779

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