Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Abeprazan hydrochloride (Fexuprazan hydrochloride) 是一种有效的、可逆的、具有口服活性的potassium-competitive acid 阻滞剂,通过竞争性的与钾离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan hydrochloride 是一种质子泵抑制剂(PPI),通过减少胃酸的产生而起作用,可用于治疗胃酸相关疾病,如胃食管反流病(GERD)和消化性溃疡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,580 | 现货 | ||
5 mg | ¥ 3,990 | 现货 | ||
10 mg | ¥ 5,680 | 现货 | ||
25 mg | ¥ 8,730 | 现货 | ||
50 mg | ¥ 11,700 | 现货 | ||
100 mg | ¥ 15,900 | 现货 | ||
500 mg | ¥ 31,800 | 现货 |
产品描述 | Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activation. Abeprazan hydrochloride is a proton pump inhibitor (PPI) that acts by reducing gastric acid production and is used to treat gastric acid-related disorders, such as gastroesophageal reflux disease (GERD) and peptic ulcers. |
体外活性 | The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1]. |
体内活性 | Abeprazan hydrochloride inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models, and heidenhain pouch dog models[1]. |
别名 | DWP14012 hydrochloride, Fexuprazan hydrochloride |
分子量 | 446.87 |
分子式 | C19H18ClF3N2O3S |
CAS No. | 1902954-87-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5mg/mL (50.4mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2378 mL | 11.1889 mL | 22.3779 mL | 55.9447 mL |
5 mM | 0.4476 mL | 2.2378 mL | 4.4756 mL | 11.1889 mL | |
10 mM | 0.2238 mL | 1.1189 mL | 2.2378 mL | 5.5945 mL | |
20 mM | 0.1119 mL | 0.5594 mL | 1.1189 mL | 2.7972 mL | |
50 mM | 0.0448 mL | 0.2238 mL | 0.4476 mL | 1.1189 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Abeprazan hydrochloride 1902954-87-3 Membrane transporter/Ion channel Proton pump Fexuprazan Hydrochloride Abeprazan Hydrochloride DWP-14012 Hydrochloride DWP 14012 Hydrochloride DWP14012 Hydrochloride DWP14012 hydrochloride Fexuprazan hydrochloride Inhibitor inhibitor inhibit