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425

抑制剂 & 化合物

69

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20365	Monopotassium glutamate L-谷氨酸钾盐,Potassium glutamate,Potassium L-glutamate	Others	Others
	Monopotassium glutamate (Potassium glutamate) 可在食品中用作增味剂。
T7658	Dimethyl DL-Glutamate (hydrochloride)	Others	Others
	Dimethyl DL-Glutamate (hydrochloride) 是一种细胞渗透性谷氨酸衍生物，可在孤立的胰岛和糖尿病动物模型中增强胰岛素释放以响应葡萄糖。
T20331	Sodium lauroyl glutamate Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11	Others	Others
	Sodium lauroyl glutamate (Acylglutamate LS-11) 是一种氨基酸去污剂，可增加长链没食子酸烷基酯(如没食子酸烷基酯)的溶解度。
T72460	Dimethyl L-glutamate Dimethyl glutamate
	Dimethyl L-glutamate (Dimethyl glutamate), 一种可透膜的谷氨酸类似物，可刺激葡萄糖诱导的胰岛素 (insulin) 释放。Dimethyl L-glutamate 抑制KATP 通道的活性。Dimethyl L-glutamate 抑制E. gracilis 生长并导致细胞异常分裂。Dimethyl L-glutamate 可用于糖尿病、葡萄糖转运、磷酸化和进一步代谢的研究。
T40973	MDNI-caged-L-glutamate MDNI-caged-L-glutamate,MDNI-glu
	MDNI-glu is a photosensitive derivative of L-glutamate, a major excitatory amino acid, that is biologically inert. It demonstrates improved utilization of incident light.
T34938	Triethanolamine linoleoyl glutamate TEA-linoleoyl glutamate
	Triethanolamine linoleoyl glutamate is a bioactive chemical.
T35369	L(+)-Monosodium glutamate monohydrate L(+)-Monosodium glutamate monohydrate,MSG monohydrate,L-Glutamic acid monosodium salt monohydrate,Monosodium L-glutamate monohydrate	Others	Others
	L(+)-Monosodium glutamate monohydrate (MSG monohydrate, L-Glutamic acid monosodium salt monohydrate, Monosodium L-glutamate monohydrate, Monosodium L-glutamate monohydrate)是一种广泛使用的营养添加剂和调味剂。L(+)-Monosodium glutamate monohydrate 可导致氧化应激介导的 DNA 损伤和细胞凋亡。
T34677	Sodium palmitoyl glutamate Sodium N-palmitoyl-L-glutamate,Monosodium N-palmitoyl-L-glutamate
	Sodium palmitoyl glutamate is a amino acid.
T23278	RuBi-Glutamate	Others	Others
	Ruthenium-bipyridine-trimethylphosphine caged glutamate
T31266	Deanol glutamate
	Deanol glutamate is a central stimulant.
T31941	Glutamate cobalt
	Glutamate cobalt is a bioactive chemical.
T33724	Norfloxacin glutamate
	Norfloxacin glutamate is a bioactive chemical.
T34937	Triethanolamine glutamate
	Triethanolamine glutamate is a bioactive chemical.
T24043	Erythromycin glutamate
	Erythromycin glutamate is a macrolide bacteriostatic antibiotic. This antibiotic is metabolized through the liver and inhibits cytochrome enzyme P450A 3A41.
T20266	Tetrasodium glutamate diacetate
	Tetrasodium glutamate diacetate is a multi-purpose chelating agent and preservative booster. Tetrasodium Glutamate Diacetate serves the same function in formulations as EDTA. Tetrasodium Glutamate Diacetate is made from plant material, readily biodegradab
T34675	Sodium linoleoyl glutamate
	Sodium linoleoyl glutamate is salt obtained from linoleoyl glutamate.
T33326	Methotrexate-alpha glutamate Meapa-glu-glu
	Methotrexate-alpha glutamate is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions.
T31518	Dipinacoline glutamate L-Glutamic acid dipinacoline ester,DiPG
	Dipinacoline glutamate is a bioactive chemical.
T33911	PENB-L-Glutamate
	PENB-L-Glutamate is a caged glutamate.
T31497	Dineopentyl glutamate L-Glutamic acid bis(2,2-dimethylpropyl) ester,DNPE
	Dineopentyl glutamate is a bioactive chemical.
T20362	Glutamyl-glutamic acid Glu-glu,Dipotassium glutamyl-glutamate,N-L-alpha-Glutamyl-L-glutamic acid	Amino Acids and Derivatives	Metabolism
	Glutamyl-glutamic acid (Glu-glu) 是一些微球菌和节杆菌属菌的胞壁中的肽桥。
T31709	Ethyl glutamate NSC-156977,NSC156977,Alpha-ethylglutamic acid,gamma-Ethylglutamate,NSC 156977
	Ethyl glutamate 可用于生命科学领域的相关研究。其产品编号为 T31709，CAS号为 1119-33-1。
TP2397	Ornithine glutamate dipeptide Orn-glu
	Ornithine glutamate dipeptide is a amino acid.
T21053	L-Lysine L-glutamate
	L-Lysine L-glutamate is a bioactive chemical.
T23013	MNI-caged-L-glutamate	Others	Others
	rapidly and efficiently releases glutamate
T34676	Sodium oleoyl glutamate N-Oleoyl-L-glutamic acid monosodium salt,Acylglutamate OS-11
	Sodium oleoyl glutamate is a sodium salt oleoyl glutamate.
T78350	Glutamate dehydrogenase
	Glutamate dehydrogenase为存在于原核生物与真核生物线粒体中的酶类，适用于氨、α-酮戊二酸、L-谷氨酸及脲酶的酶促反应检测。
T20264L	Alanine glutamate acetate(13187-90-1 Free base)

T2A2497L	Glutamic acid diethyl ester L-Glutamate diethylester,Diethyl glutamate,Glutamyl diethyl ester
	Glutamic acid diethyl ester is a glutamic acid antagonist.
T66113	1-Methyl L-Glutamate
	1-Methyl L-Glutamate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66113，CAS号为 6384-08-3。
T73616	Glutamate dehydrogenase (NAD(P))
	Glutamate dehydrogenase NAD(P) (GLDH)（谷氨酸脱氢酶 NAD(P)）是一种存在于肝细胞、肾组织、脑、肌肉和肠细胞的线粒体酶，主要应用于生化研究。作为尿素循环的一环，该酶催化谷氨酸的逆向氧化脱氨反应，生成α-酮戊二酸（α-KG）。
T60645	Glutamate-5-kinase-IN-2
	Glutamate-5-kinase-IN-2 (compound 54) 通过促进 L-谷氨酸结合位点的构象变化，从而抑制 G5K 活性，它是谷氨酸 5-激酶 (G5K)的有效抑制剂，MIC 为 4.2 μM。Glutamate-5-kinase-IN-2 具有用于抗结核药物研究的潜力。
T22641	CDPPB	GluR	Neuroscience
	CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂，在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。
T60693	Glutamate-5-kinase-IN-1
	Glutamate-5-kinase-IN-1 (compound 50) 是谷氨酸-5-激酶 (G5K)的有效抑制剂，它通过改变 ATP 结合位点构象发挥抑制作用，其抑制浓度为 4.1 μM。Glutamate-5-kinase-IN-1 具有研究抗结核的潜力
T21747	VU0483605	GluR	Neuroscience
	VU0483605 是一种有效的特异性 mGluR1 正变构调节剂，对人和大鼠的 EC50 分别为 390 和 356 nM。
T35319	Zy 15109 N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate
	Zy 15109 can be used as inhaled mast cell stabilizer.
T14971	CIQ	NMDAR	Neuroscience
	CIQ 是亚基选择性NMDA 受体增强剂，可作用于NR2C 或NR2D 亚基。
T3482	CFMTI	GluR	Neuroscience
	CFMTI 是选择性代谢型谷氨酸受体 1 变构拮抗剂，IC50为2.6 nM。它对 mGluR1 的选择性比 mGluR5 高 2000 倍。
T3483	FTIDC	GluR	Neuroscience
	FTIDC 是非竞争性和选择性的口服变构代谢型谷氨酸受体 1 拮抗剂，对人 mGluR1a 的IC50为 5.8 nM。
T6598	MPEP	GluR	Neuroscience
	MPEP 是一种选择性 mGlu5 受体拮抗剂，IC50 为 36 nM，有抗焦虑和抗抑郁活性。
T60112	H-Glu(OEt)-OEt.HCl Diethyl L-glutamate hydrochloride,(S)-Diethyl 2-aminopentanedioate hydrochloride,L-谷氨酸二乙酯盐酸盐,Diethyl glutamate hydrochloride	Amino Acids and Derivatives	Metabolism
	H-Glu(OEt)-OEt.HCl (Diethyl L-glutamate hydrochloride) 是一种谷氨酸衍生物。
T8779	HBT1	GluR	Neuroscience
	HBT1 是一种 AMPA 受体增强剂，可诱导脑源性神经营养因子 (BDNF) 的产生，并且在原代神经元中几乎没有激动作用。 HBT1 以谷氨酸依赖的方式与 AMPA-R 的配体结合结构域结合。
T12406	PEPA	iGluR	Membrane transporter/Ion channel; Neuroscience
	PEPA 是一种变构 AMPA 受体调节剂，可与 GluA2o 和 GluA3o LBD 结合，可用作 AMPA 受体异质性的指标。
T16402	Org-26576	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Org-26576 是 AMPA 受体的一种正变构调节剂。
T6022	LY404039 pomaglumetad	Glucocorticoid Receptor; GluR	Endocrinology/Hormones; Neuroscience
	LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂，有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM，比对其他受体/转运蛋白的抑制性高 100 倍以上。
T20264	Ala-Glu-OH L-Glutamic acid, N-L-alanyl-,Alanine glutamate,Alanylglutamic acid
	Alanine glutamate is an agent of the dipeptide.
T3477	E4CPG	GluR	Neuroscience
	E4CPG 是一种 I/II 组代谢型谷氨酸受体的拮抗剂，可抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。
T3464	PHCCC (-) PHCCC	GluR	Neuroscience
	PHCCC ((-) PHCCC) 是 I 组代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。它对 mGluR2 和 mGluR8 也有很强的拮抗作用，具有抗帕金森病作用。
T3565	VU0155041 UV0155041,VU-0155041	GluR	Neuroscience
	VU0155041 是一种选择性的mGluR4正变构调节剂，有用于帕金森病的研究潜力，对人和大鼠 mGluR4 的EC50值分别为 798 和 693 nM。
T9133	Caroverine hydrochloride Caroverine HCL	GluR; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Caroverine hydrochloride (Caroverine HCL) 是竞争性可逆的NMDA 和AMPA 谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。

化合物

Monopotassium glutamate

Cat.No: T20365

Synonym: L-谷氨酸钾盐,Potassium glutamate,Potassium L-glutamate

Target: Others

Dimethyl DL-Glutamate (hydrochloride)

Cat.No: T7658

Target: Others

Sodium lauroyl glutamate

Cat.No: T20331

Synonym: Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11

Target: Others

Dimethyl L-glutamate

Cat.No: T72460

Synonym: Dimethyl glutamate

MDNI-caged-L-glutamate

Cat.No: T40973

Synonym: MDNI-caged-L-glutamate,MDNI-glu

Triethanolamine linoleoyl glutamate

Cat.No: T34938

Synonym: TEA-linoleoyl glutamate

L(+)-Monosodium glutamate monohydrate

Cat.No: T35369

Synonym: L(+)-Monosodium glutamate monohydrate,MSG monohydrate,L-Glutamic acid monosodium salt monohydrate,Monosodium L-glutamate monohydrate

Target: Others

Sodium palmitoyl glutamate

Cat.No: T34677

Synonym: Sodium N-palmitoyl-L-glutamate,Monosodium N-palmitoyl-L-glutamate

RuBi-Glutamate

Cat.No: T23278

Target: Others

Deanol glutamate

Cat.No: T31266

Glutamate cobalt

Cat.No: T31941

Norfloxacin glutamate

Cat.No: T33724

Triethanolamine glutamate

Cat.No: T34937

Erythromycin glutamate

Cat.No: T24043

Tetrasodium glutamate diacetate

Cat.No: T20266

Sodium linoleoyl glutamate

Cat.No: T34675

Methotrexate-alpha glutamate

Cat.No: T33326

Synonym: Meapa-glu-glu

Dipinacoline glutamate

Cat.No: T31518

Synonym: L-Glutamic acid dipinacoline ester,DiPG

PENB-L-Glutamate

Cat.No: T33911

Dineopentyl glutamate

Cat.No: T31497

Synonym: L-Glutamic acid bis(2,2-dimethylpropyl) ester,DNPE

Glutamyl-glutamic acid

Cat.No: T20362

Synonym: Glu-glu,Dipotassium glutamyl-glutamate,N-L-alpha-Glutamyl-L-glutamic acid

Target: Amino Acids and Derivatives

Ethyl glutamate

Cat.No: T31709

Synonym: NSC-156977,NSC156977,Alpha-ethylglutamic acid,gamma-Ethylglutamate,NSC 156977

Ornithine glutamate dipeptide

Cat.No: TP2397

Synonym: Orn-glu

L-Lysine L-glutamate

Cat.No: T21053

MNI-caged-L-glutamate

Cat.No: T23013

Target: Others

Sodium oleoyl glutamate

Cat.No: T34676

Synonym: N-Oleoyl-L-glutamic acid monosodium salt,Acylglutamate OS-11

Glutamate dehydrogenase

Cat.No: T78350

Alanine glutamate acetate(13187-90-1 Free base)

Cat.No: T20264L

Glutamic acid diethyl ester

Cat.No: T2A2497L

Synonym: L-Glutamate diethylester,Diethyl glutamate,Glutamyl diethyl ester

1-Methyl L-Glutamate

Cat.No: T66113

Glutamate dehydrogenase (NAD(P))

Cat.No: T73616

Glutamate-5-kinase-IN-2

Cat.No: T60645

Cat.No: T22641

Target: GluR

Glutamate-5-kinase-IN-1

Cat.No: T60693

Cat.No: T21747

Target: GluR

Cat.No: T35319

Synonym: N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate

Cat.No: T14971

Target: NMDAR

Cat.No: T3482

Target: GluR

Cat.No: T3483

Target: GluR

Cat.No: T6598

Target: GluR

H-Glu(OEt)-OEt.HCl

Cat.No: T60112

Synonym: Diethyl L-glutamate hydrochloride,(S)-Diethyl 2-aminopentanedioate hydrochloride,L-谷氨酸二乙酯盐酸盐,Diethyl glutamate hydrochloride

Target: Amino Acids and Derivatives

Cat.No: T8779

Target: GluR

Cat.No: T12406

Target: iGluR

Cat.No: T16402

Target: GluR, iGluR

Cat.No: T6022

Synonym: pomaglumetad

Target: Glucocorticoid Receptor, GluR

Cat.No: T20264

Synonym: L-Glutamic acid, N-L-alanyl-,Alanine glutamate,Alanylglutamic acid

Cat.No: T3477

Target: GluR

Cat.No: T3464

Synonym: (-) PHCCC

Target: GluR

Cat.No: T3565

Synonym: UV0155041,VU-0155041

Target: GluR

Caroverine hydrochloride

Cat.No: T9133

Synonym: Caroverine HCL

Target: GluR, NMDAR, iGluR

Cat. No.	Product Name	Target	Signaling Pathways
T20262	Arginine glutamate Modumate,NSC-122009,NSC 122009,NSC122009,NCI-C02120,Argimate
	Arginine glutamate is an agent of ammonia Detoxicant.
T6871	L-Glutamic acid monosodium salt Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG	Apoptosis; Ferroptosis; GluR; iGluR	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	L-Glutamic acid monosodium salt (MSG) 作为兴奋性氨基酸神经递质，是谷氨酸盐受体所有亚型的激动剂，对多巴胺从神经末梢释放的过程有激动作用。
T3379	Decanoic Acid Decoic acid,CAPRIC ACID,Caprynic acid,癸酸	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Decanoic Acid (Caprynic acid) 是中链甘油三酯中的成分，是非竞争性和可透过血脑屏障的 AMPA 受体抑制剂，具有抗癫痫作用。
T1186	Ifenprodil Tartrate	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂，抑制 GIRK (Kir3)，通过基底 GIRK 活性减少内向电流，有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T8394	D-Serine (R)-Serine,D-丝氨酸	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸，是 NMDA 谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用，包括 NMDAR 介导的神经传递，神经毒性，突触可塑性和细胞迁移。
T20191	(-)-Camphoric acid (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-	GluR	Neuroscience
	(-)-Camphoric acid (L-Camphoric acid) 是一种活性较低的樟脑酸对映异构体，樟脑酸可诱导 GluR 表达。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T6608	NMDA N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸，作为 D-异构体，是谷氨酸受体的 NMDA 受体亚型的定义激动剂。
TQ0027	Transcrocetinate disodium Disodium trans-crocetinate,藏红花,藏红花酸二钠盐	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Transcrocetinate disodium (Disodium trans-crocetinate) 从藏红花中提取的一种天然产物，是高亲和力NMDA 受体拮抗剂。
T4096	Quinolinic acid 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂，由 L-色氨酸通过犬尿氨酸途径合成，具有调节 NMDA 神经元损伤和功能障碍的潜力。
T1589	D-Cycloserine RO-1-9213,D-环丝氨酸	Others; Antibacterial; Antibiotic; iGluR	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
T4S0171	Transcrocetin trans-Crocetin,藏红花酸,藏红花,8,8'-Diapocarotenedioic Acid,Crocetin	Others; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	Transcrocetin (8,8'-Diapocarotenedioic Acid) 是来源于藏红花 (Crocus sativus L.) 的活性化合物，是一种能够透过血脑屏障的，高亲和力的NMDA 受体拮抗剂。
T2O2728	glycine 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸	MT Receptor; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质，也是谷氨酸的联合激动剂，有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中，并在治疗上用作营养物质。
T3010	Xanthurenic Acid 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate	Apoptosis; Endogenous Metabolite; GluR	Apoptosis; Metabolism; Neuroscience
	Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子，可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中，它被认为是Group II 代谢型谷氨酸受体的激动剂。
T0326L	L-Glutamine L-Glutamic acid 5-amide,L-谷氨酰胺	Ferroptosis; Endogenous Metabolite; GluR	Apoptosis; Metabolism; Neuroscience
	L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在的一种非必需氨基酸，由谷氨酸和氨合成。它为某些细胞中的氧化提供了碳源。
T3026	(-)-Huperzine A HupA,石杉碱,Huperzine A,石杉碱甲	Apoptosis; AChR; AChE; iGluR	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱，具有神经保护活性。它是高特异性可逆的，具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂，其IC50值为 82 nM。它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂，可研究神经退行性疾病，如阿尔茨海默病。
T1324	O-Phospho-L-serine L-Serine O-phosphate,磷酸化丝氨酸,Phosphoserine,Dexfosfoserine,L-SOP	Amino Acids and Derivatives; Endogenous Metabolite; GluR; NMDAR	Metabolism; Neuroscience
	O-Phospho-L-serine (Phosphoserine) 是 L-serine 合成过程中的直接前体物质，是 mGluR 激动剂。
T2A2497	L-Glutamic acid 谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol	Apoptosis; Ferroptosis; Endogenous Metabolite; iGluR	Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Glutamic acid (Glutaminol) 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型的激动剂，对多巴胺从神经末梢释放的过程有激动作用。
T4885	(-)-Aspartic acid (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,D-天门冬氨酸,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid	Endogenous Metabolite; NMDAR; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Aspartic acid (L-Homoproline) 是一种存在于无脊椎动物和脊椎动物中的内源性氨基酸，是 NMDA 受体激动剂，可调节睾酮合成。
T0948L	Corticosterone 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇，有盐皮质激素和糖皮质激素的活性，具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。
T3377	L-Phenylalanine L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel; Endogenous Metabolite; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸，是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂，用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂，Ki 为 980 nM。
T12016	Methyl L-pyroglutamate L-Pyroglutamic acid methyl ester,L-焦谷氨酸甲酯,(S)-Methyl 5-oxopyrrolidine-2-carboxylate	Others	Others
	Methyl L-pyroglutamate (L-Pyroglutamic acid methyl ester) 分离自甘蓝中分离，显示出抗炎活性。
T4920	2-Ketoglutaric acid Sodium Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	2-Ketoglutaric acid Sodium (AKG) 是一种三羧酸循环的中间产物，它可以由谷氨酸通过谷氨酸脱氢酶氧化脱氨产生，也可以作为磷酸吡哆醛依赖的转氨化反应的产物(由支链氨基酸转氨酶介导)，其中谷氨酸是常见的氨基供体。
T4913	Maleic acid	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	Maleic Acid 是大肠杆菌和单核细胞增生李斯特菌的谷氨酸脱羧酶抑制剂。
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。
T65135	Kynurenic acid Fibrostop 2,Quinurenic acid	GPR; GluR; NMDAR	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物，是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂，也是 GPR35/CXCR8 激动剂，具有神经保护和抗惊厥特性，可用于研究神经分裂和与代谢相关的疾病。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T5267	N-Acetyl-L-glutamic acid Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸，是动物细胞培养基的组成成分，是一种酿酒酵母和人类的代谢物。
T4813	L-Citrulline	Endogenous Metabolite	Metabolism
	L-Citrulline 是一种氨基酸，源自于精氨酸-瓜氨酸途径获得的 l-精氨酸，或脯氨酸、谷氨酰胺和谷氨酸盐的分解代谢过程中产生的鸟氨酸。
TN1449	Brandioside 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside	Antioxidant	oxidation-reduction
	Brandioside (2'-Acetylpoliumoside) 是可从马鞭草科植物 Callicarpa dichotoma Raeuschel 提取得到的苯丙素类糖苷，具有抗氧化活性，可削弱谷氨酸诱导的神经毒性，可用于研究糖尿病。
T5692	Pyrroloquinoline quinone	Others; Endogenous Metabolite	Metabolism; Others
	Pyrroloquinoline quinone 是氧化还原辅助因子，一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素，对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的，也存在于哺乳动物的组织。
T1131	Ivermectin MK-933,伊维菌素	Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂，具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入，还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。
T5287	N-Acetyl-L-aspartic acid AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-aspartic acid (AC-ASP-OH) 是天冬氨酸的衍生物，是由氨基酸天冬氨酸和乙酰辅酶 A 在神经元中合成的。
T2596	N-Acetyl-β-Asp-Glu	Others	Others
	N-Acetyl-β-Asp-Glu 是一种肽类神经递质，是哺乳动物神经系统中第三常见的神经递质。 NAAG 由通过肽键偶联的 N-乙酰天冬氨酸 (NAA) 和谷氨酸组成。
TN1677	Gartanin 1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷	BCL; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Gartanin 是山竹果中的一种天然黄酮，具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬，抑制其迁移。
T6102	2'-acetylacteoside	Antioxidant; Reductase	Endocrinology/Hormones; Metabolism; oxidation-reduction
	2'-Acetylacteoside 是一种苯乙醇苷类化合物，分离自来江藤中，可抑制自由基诱导的红细胞溶血，具有清除自由基的作用。
TN1905	Magnolioside 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷	Antifection	Microbiology/Virology
	Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中，对谷氨酸诱导的毒性有显著的神经保护作用。它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性，对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。
T5083	L-Cysteic acid monohydrate L-磺基丙氨酸一水合物,3-Sulfo-L-alanine Monohydrate	Endogenous Metabolite; GluR	Metabolism; Neuroscience
	L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) 是内源性代谢产物的一种。
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T4705	Aminoadipic acid DL-2-Aminoadipic acid,DL-2-氨基己二酸	Others; Endogenous Metabolite	Metabolism; Others
	Aminoadipic acid (DL-2-Aminoadipic acid) 是赖氨酸主要生化途径中的代谢物。它是赖氨酸和糖碱代谢的中间体。它拮抗由谷氨酸受体 N-甲基-D-天冬氨酸调节的神经兴奋特性。
T5558	Chelidonic acid Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质，用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂，Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。
TN3808	Dehydroheliobuphthalmin	Others	Others
	Dehydroheliobuphthalmin has significant neuroprotective activities against glutamate- induced neurotoxicity.
T38054	Avenaciolide
	Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM).
TN1581	Dihydroguaiaretic acid 二氢愈创木酸	COX; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience
	Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
TN1361	(+)-Afzelechin 阿夫儿茶精,(+)-阿夫儿茶精	Others	Others
	(+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM
TN3473	Axillarin
	Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress.
TN5169	Traxillaside 香榧	Others	Others
	Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells .
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天然产物

Arginine glutamate

Cat.No: T20262

Synonym: Modumate,NSC-122009,NSC 122009,NSC122009,NCI-C02120,Argimate

L-Glutamic acid monosodium salt

Cat.No: T6871

Synonym: Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG

Target: Apoptosis, Ferroptosis, GluR, iGluR

Cat.No: T3379

Synonym: Decoic acid,CAPRIC ACID,Caprynic acid,癸酸

Target: GluR, iGluR

Ifenprodil Tartrate

Cat.No: T1186

Target: Potassium Channel, NMDAR, iGluR

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Cat.No: T8394

Synonym: (R)-Serine,D-丝氨酸

Target: Endogenous Metabolite, NMDAR, iGluR

(-)-Camphoric acid

Cat.No: T20191

Synonym: (-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)-

Target: GluR

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

Cat.No: T6608

Synonym: N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid

Target: Endogenous Metabolite, NMDAR, iGluR

Transcrocetinate disodium

Cat.No: TQ0027

Synonym: Disodium trans-crocetinate,藏红花,藏红花酸二钠盐

Target: NMDAR, iGluR

Quinolinic acid

Cat.No: T4096

Synonym: 喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

Cat.No: T1589

Synonym: RO-1-9213,D-环丝氨酸

Target: Others, Antibacterial, Antibiotic, iGluR

Cat.No: T4S0171

Synonym: trans-Crocetin,藏红花酸,藏红花,8,8'-Diapocarotenedioic Acid,Crocetin

Target: Others, Endogenous Metabolite, iGluR

Cat.No: T2O2728

Synonym: 2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸

Target: MT Receptor, Endogenous Metabolite, iGluR

Xanthurenic Acid

Cat.No: T3010

Synonym: 8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate

Target: Apoptosis, Endogenous Metabolite, GluR

Cat.No: T0326L

Synonym: L-Glutamic acid 5-amide,L-谷氨酰胺

Target: Ferroptosis, Endogenous Metabolite, GluR

(-)-Huperzine A

Cat.No: T3026

Synonym: HupA,石杉碱,Huperzine A,石杉碱甲

Target: Apoptosis, AChR, AChE, iGluR

O-Phospho-L-serine

Cat.No: T1324

Synonym: L-Serine O-phosphate,磷酸化丝氨酸,Phosphoserine,Dexfosfoserine,L-SOP

Target: Amino Acids and Derivatives, Endogenous Metabolite, GluR, NMDAR

L-Glutamic acid

Cat.No: T2A2497

Synonym: 谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol

Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR

(-)-Aspartic acid

Cat.No: T4885

Synonym: (R)-Aspartic acid,Asp,D-(-)-Aspartic acid,D-天门冬氨酸,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid

Target: Endogenous Metabolite, NMDAR, iGluR

Cat.No: T0948L

Synonym: 皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants)

Target: Glucocorticoid Receptor, Endogenous Metabolite

L-Phenylalanine

Cat.No: T3377

Synonym: L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

Methyl L-pyroglutamate

Cat.No: T12016

Synonym: L-Pyroglutamic acid methyl ester,L-焦谷氨酸甲酯,(S)-Methyl 5-oxopyrrolidine-2-carboxylate

Target: Others

2-Ketoglutaric acid Sodium

Cat.No: T4920

Synonym: Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt

Target: Tyrosinase, Endogenous Metabolite

Cat.No: T4913

Target: Endogenous Metabolite, Antibacterial

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

Cat.No: T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

N-Acetyl-L-glutamic acid

Cat.No: T5267

Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

Cat.No: T4813

Target: Endogenous Metabolite

Cat.No: TN1449

Synonym: 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside

Target: Antioxidant

Pyrroloquinoline quinone

Cat.No: T5692

Target: Others, Endogenous Metabolite

Cat.No: T1131

Synonym: MK-933,伊维菌素

Target: Mitophagy, GluCls, P2X Receptor, SARS-CoV, HIV Protease, Antibiotic, Parasite, Autophagy, HSV

N-Acetyl-L-aspartic acid

Cat.No: T5287

Synonym: AC-ASP-OH,N-Acetylaspartic acid,N-乙酰-L-天门冬氨酸

Target: Others, Endogenous Metabolite

N-Acetyl-β-Asp-Glu

Cat.No: T2596

Target: Others

Cat.No: TN1677

Synonym: 1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷

Target: BCL, Caspase, JNK

2'-acetylacteoside

Cat.No: T6102

Target: Antioxidant, Reductase

Cat.No: TN1905

Synonym: 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷

Target: Antifection

L-Cysteic acid monohydrate

Cat.No: T5083

Synonym: L-磺基丙氨酸一水合物,3-Sulfo-L-alanine Monohydrate

Target: Endogenous Metabolite, GluR

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Aminoadipic acid

Cat.No: T4705

Synonym: DL-2-Aminoadipic acid,DL-2-氨基己二酸

Target: Others, Endogenous Metabolite

Chelidonic acid

Cat.No: T5558

Synonym: Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

Dehydroheliobuphthalmin

Cat.No: TN3808

Target: Others

Cat.No: T38054

Dihydroguaiaretic acid

Cat.No: TN1581

Synonym: 二氢愈创木酸

Target: COX, DNA/RNA Synthesis

Cat.No: TN1361

Synonym: 阿夫儿茶精,(+)-阿夫儿茶精

Target: Others

Cat.No: TN3473

Cat.No: TN5169

Synonym: 香榧

Target: Others

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