116
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8873 |
Bractoppin
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
Bractoppin 是一种BRCA1 (t)BRCT domain 识别磷酸肽的选择性抑制剂,IC50为 74 nM。它优先抑制 BRCA1 -tBRCT 依赖的 DNA 损伤。它减少 BRCA1 对 DNA 断裂片段的招募,进而抑制损伤诱导的 G2 期阻滞和重组酶 RAD51 的组装。 | |||
T4189 |
4-Oxofenretinide
3-Keto fenretinide,4-氧代维甲酰酚胺 |
cell cycle arrest | Cell Cycle/Checkpoint |
4-Oxofenretinide (3-Keto fenretinide) 是一种最近发现的 fenretinide 代谢物,可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。 | |||
T3485 |
Probimane
AT-2153,MM-159 |
Others | Others |
Probimane (AT-2153) 具有抗增殖作用、细胞周期 G2/M 期阻滞和用 MST-16 阻断人类肿瘤细胞系中的染色体分离。 | |||
T5699 |
SSE15206
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
SSE15206 是一种克服多药耐药性的微管聚合抑制剂,其在 HCT116 细胞中的 GI50值为 197 nM。由于癌细胞中纺锤体形成不完整,导致 G2/M 停滞,有丝分裂异常。 | |||
T9595 |
LP-261
|
Microtubule Associated | Cytoskeletal Signaling |
LP-261 是一种新型的微管蛋白靶向抗癌剂,可与微管蛋白上的秋水仙碱位点结合,诱导 G2/M 期阻滞,其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长,可用于癌症研究。 | |||
T78701 |
Tubulin inhibitor 32
|
Apoptosis | Apoptosis |
Tubulin inhibitor 32是一种口服活性的新型微管抑制剂,具有抗增殖和抗肿瘤活性,可抑制微管聚合,可诱导细胞凋亡及在G2/M期引起细胞周期停滞。 | |||
T77647 |
Tubulin polymerization-IN-43
|
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用,通过靶向 Colchicine 位点破坏细胞微管网络,促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。 | |||
T64923 |
Sodium citrate
Citrosodine,Natrocitral,柠檬酸钠 |
Others | Others |
Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。 | |||
T60129 |
MT189
Antiproliferative agent-14 |
Microtubule Associated | Cytoskeletal Signaling |
MT189 (Antiproliferative agent-14)是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂,IC50 为 3.41 μM。MT189 具有优异的抗增殖活性。Antiproliferative agent-14 具有在细胞周期的 G2/M 期阻滞细胞的能力。 | |||
T67746 |
IMS2186
|
Others | Others |
IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂, 可以使癌细胞周期阻滞在 G2/M 期,由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量,并且无眼内毒性。 | |||
T23601 |
ABC1183
ABC 1183,ABC-1183 |
GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
ABC1183是一种抑制GSK3α, GSK3β和CDK9的新型二氨基噻唑。ABC1183通过诱导G2/M 阻滞和改变GSK3、糖原合成酶、β-catenin 磷酸化和MCL1表达降低细胞存活率来抑制多种癌细胞株的生长,并具有口服活性。 | |||
T28886 |
Suprafenacine
N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide |
Microtubule Associated | Cytoskeletal Signaling |
Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂,可在 G2/M 期诱导细胞周期停滞和细胞凋亡。 它 与微管结合并抑制秋水仙碱连接处的聚集。 它对癌细胞有选择性,包括耐药癌细胞。 | |||
T16750 |
Rigosertib
ON-01910,瑞格色替 |
Apoptosis; FLT; PLK; PI3K; Bcr-Abl; CDK; PDGFR; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂,通过抑制 PI3K/Akt 途径诱导细胞凋亡,促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。它是一种选择性的非 ATP 竞争性PLK1抑制剂,IC50值为 9 nM。 | |||
T3124 |
Carbendazim
Bavistin,Carbendazole,多菌灵,Mercarzole |
Antifungal | Microbiology/Virology |
Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物,可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂,可作为真菌疾病研究的杀虫剂。 | |||
T8756 |
KRAS inhibitor-9
DUN09716 |
Apoptosis; Ras | Apoptosis; GPCR/G Protein; MAPK |
KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂,阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合,选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。 | |||
T27407 |
GDC0575 monohydrochloride
ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575 |
Chk | Cell Cycle/Checkpoint |
GDC0575 monohydrochloride (ARRY575) 是一种有效的、选择性的细胞周期检查点激酶 1(Chk1) 抑制剂,IC50 为 1.2 nM。GDC0575 monohydrochloride (ARRY575) 特异性结合并抑制 Chk1;这可能导致肿瘤细胞在 S 期和 G2/M 期绕过 Chk1 依赖性细胞周期停滞,从而允许细胞在进入有丝分裂之前进行 DNA 修复。 | |||
T2090 |
Lexibulin
CYT-997 |
Apoptosis; Reactive Oxygen Species; Microtubule Associated | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB |
Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂,可诱导细胞凋亡,并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M,在体内外具有高细胞毒性和血管增生阻断作用。 | |||
T41163 |
ZNL 02-096
Pomalidomide-C3-adavosertib |
Apoptosis; Wee1 | Apoptosis; Cell Cycle/Checkpoint |
ZNL 02-096 (Pomalidomide-C3-adavosertib) 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。ZNL 02-096 可在亚摩尔浓度下选择性降解 Wee1,而不损伤 AZD 1775 的二级靶点 PLK1。在体外 MOLT-4 细胞中,ZNL 02-096 可诱导 Wee1 降解、DNA 损伤积累、细胞周期停滞在 G2/M 期和细胞凋亡。ZNL 02-096 在 300 种癌症细胞系中显示出抗增殖作用。 | |||
T19661 |
8-Chloroadenosine
NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂,可能用于治疗慢性淋巴细胞白血病。 它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性;在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。 | |||
T36674 |
DMU-212
|
Apoptosis; ERK | Apoptosis; MAPK |
DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物,表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。 | |||
T31004 |
Compound 8H
Compound-8H,Compound 8-H,Compound 343 |
||
Compound 8H is an inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines. | |||
T13901 |
SS28
|
Microtubule Associated | Cytoskeletal Signaling |
SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. | |||
T29449 |
5-AcTMF
5-ATMF,5-ATAN,5 ATMF |
||
5-AcTMF is an inducer of G2/M arrest, apoptosis and autophagy in cancer cells. | |||
TQ0016 |
NKP-1339
IT-139,KP-1339 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NKP-1339 (IT-139) induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. | |||
T13227 | Tubulin inhibitor 1 | Microtubule Associated | Cytoskeletal Signaling |
Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase. | |||
T23726 |
WB-308
WB308 |
||
WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis. | |||
T80132 |
CBP501 Affinity Peptide
|
||
CBP501 Affinity Peptide为Chk激酶抑制剂,具有消除DNA损伤剂诱导的G2停滞作用,主要应用于癌症研究领域。 | |||
T71231 |
VMY-1-101
|
||
VMY-1-101 is a synthesized fluorescent CDK inhibitor. VMY-1-101 demonstrates potent CDK inhibitory activity, enhanced induction of G2/M arrest and modest apoptosis as compared to purvalanol B. | |||
T72817 |
Colibactin 742
|
||
Colibactin 742 是一种稳定的大肠杆菌素衍生物,可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。 | |||
T61616 |
Antitumor agent-38
|
||
Antitumor agent-38 is a highly effective antitumor compound that exhibits antiproliferative activity towards cancer cells. It induces cell cycle arrest specifically at the late S and G2/M phase, while not impeding microtubule formation or altering cell morphology [1]. | |||
T71556 |
MK-1496
|
||
MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a n... | |||
T61401 |
3-(3-Phenoxybenzyl)amino-β-carboline
|
||
3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers. It induces cell cycle arrest and apoptosis in the G2/M phase. Additionally, 3-(3-Phenoxybenzyl)amino-β-carboline displays notable anticancer activity [1]. | |||
T36700 | CKD 602 | ||
Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo. | |||
T68570 | TPI-287 | ||
TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis. | |||
T81696 |
NBI-961
|
||
NBI-961为高效NEK2抑制剂,能阻断蛋白酶体降解作用。该化合物在弥漫性大B细胞淋巴瘤(DLBCL)细胞中诱导G2/有丝分裂停滞及细胞凋亡(apoptosis)。 | |||
T68671 |
Amsacrine Isothionate
|
||
Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. | |||
T61779 |
STAT3-IN-9
|
||
STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1]. | |||
T71034 |
Bizelesin
|
||
Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. | |||
T79429 |
Tubulin polymerization-IN-50
|
||
Tubulin polymerization-IN-50(compound 7n)是一种Tubulin polymerization抑制剂,其在SK-Mel-28细胞中的IC50值为5.05 μM,能够诱导(cell cycle)阻滞在G2/M期。 | |||
T60505 | Antitumor agent-43 | ||
Antitumor agent-43 (Compound 4B) 是一种有效的抗肿瘤剂,可诱导细胞周期阻滞在G2/M 期。Antitumor agent-43对 T-24 细胞的IC50值为0.5 μM。 | |||
T72205 |
Antiproliferative agent-19
|
||
Antiproliferative agent-19 (化合物 4a) 作为一种抗癌剂,通过诱导细胞凋亡和细胞周期在G2/M期的停滞来对肺癌细胞展现抗增殖活性。 | |||
T62693 |
Tubulin polymerization-IN-29
|
||
Tubulin polymerization-IN-29 是一种有效的微管蛋白聚合抑制剂,显示出有效的抗增殖效果。Tubulin polymerization-IN-29 能够诱导 HeLa 细胞的细胞周期阻滞在 G2/M 期。 | |||
T68673 | Amsacrine gluconate | ||
Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. | |||
T68672 | Amsacrine lactate | ||
Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. | |||
T61694 |
PARP1-IN-10
|
||
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while also significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1]. | |||
T78862 |
EGFR-IN-86
|
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR-IN-86(化合物4i)是一种高效的EGFR抑制剂,IC50为1.5 nM,对胶质母细胞瘤表现出强抗癌活性。该化合物能够诱导细胞凋亡并使U87细胞周期在G2/M期发生阻滞。 | |||
T72474 |
Anticancer agent 53
|
||
Anticancer agent 53 是一种强效抗癌剂。 Anticancer agent 53 显示出体外细胞毒性。Anticancer agent 53 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 S/G2/M 期。Anticancer agent 53 具有抗肿瘤活性且无明显毒性。 | |||
T61630 | HDAC-IN-42 | ||
HDAC-IN-42 (compound 14f) is a highly potent and selective inhibitor of histone deacetylase (HDAC) enzymes, with IC50 values of 0.19 μM for HDAC1 and 4.98 μM for HDAC6. It exhibits remarkable anticancer properties and inhibits cell proliferation. Additionally, HDAC-IN-42 induces apoptosis and causes cell cycle arrest specifically at the G2/M phase [1]. | |||
T60452 | PCAF-IN-2 | ||
PCAF-IN-2 (compound 17) 是一种有效的 PCAF 抑制剂(IC50 = 5.31 µM)。PCAF-IN-2 具有抗肿瘤活性。PCAF-IN-2 诱导细胞凋亡并且阻滞细胞周期在 G2/M 期。 | |||
T60781 |
Topoisomerase II inhibitor 8
|
||
Topoisomerase II inhibitor 8 (化合物 22) 显示出良好的抗增殖活性,并将细胞周期阻滞在 G2/M 期。Topoisomerase II inhibitor 8是拓扑异构酶 II 的有效抑制剂 (IC 50 = 0.52 μM)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0089 |
Juglanin
|
Apoptosis; JNK; Autophagy | Apoptosis; Autophagy; MAPK |
Juglanin 是来自金鸡脚的一种黄酮类天然产物,是一种 JNK 的激活剂,能诱导人乳腺癌细胞的凋亡和自噬,具有炎症和抗肿瘤活性。 | |||
T2764 |
(S)-10-Hydroxycamptothecin
10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡,可研究肝癌、胃癌、结肠癌和白血病。 | |||
T3981 |
Acacetin
4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin |
Apoptosis; IAP; COX; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience |
Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中,可导致癌细胞周期停滞,并诱导细胞凋亡和自噬。它有抗癌和抗炎活性,有潜力研究疼痛相关疾病。 | |||
T2220 |
2-Methoxyestradiol
2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2 |
Apoptosis; Reactive Oxygen Species; Microtubule Associated; Endogenous Metabolite; HIF; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB |
2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物,具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成,也可破坏微管的稳定。它可诱导半胱天冬酶活化,导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。 | |||
T3S0081 |
Oxypeucedanin
(+-)-Oxypeucedanin,氧化前胡素,Oxypeucadanin |
Potassium Channel | Membrane transporter/Ion channel |
Oxypeucedanin ((+-)-Oxypeucedanin) 是呋喃香豆素衍生物,分离自Angelica dahurica。它是选择性开放通道阻滞剂,可抑制hKv1.5通道电流,IC50值为 76 nM。它延长心脏动作电位持续时间,是潜在的抗心律失常试剂。它通过抑制癌细胞迁移来诱导细胞凋亡。 | |||
T2966 |
Beta-Sitosterol
Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis; Lipase; Endogenous Metabolite | Apoptosis; Metabolism |
Beta-Sitosterol (SKF 14463) 是一种植物甾醇,干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
TN4154 |
Gomisin L1
|
Others | Others |
(-)-Gomisin L1 induces G2/M arrest and apoptosis in human ovarian cancer cells. | |||
TN6547 |
Angustifoline
鲁冰花 |
||
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest. | |||
T72965 |
Inuviscolide
|
||
Inuviscolide,一种诱导细胞凋亡(apoptosis)的化合物,能够引起人黑素瘤细胞系在G2/M期的停滞,并展现出抗肿瘤和抗炎活性。 | |||
T75698 | Xylopine | ||
Xylopine 是一种具有细胞毒活性的阿朴啡生物碱,能诱导癌细胞氧化应激,从而引发 G2/M 细胞周期停滞及细胞凋亡(apoptosis)。 | |||
T75569 | Xerophilusin B | ||
Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂,对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用,可诱导 G2/M 细胞周期停滞,介导细胞凋亡 apoptosis。 | |||
TN1617 |
Ergosta-4,6,8(14),22-tetraen-3-one
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BCL; Caspase; p53 | Apoptosis; Proteases/Proteasome |
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful for the further utilization of man | |||
TN2344 |
Swainsonine
Tridolgosir |
Apoptosis; Others; Antibiotic | Apoptosis; Microbiology/Virology; Others |
Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱,是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性,可诱导细胞凋亡和细胞周期停滞在 G2/M 期。 | |||
T36961 |
Malformin C
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Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ... | |||
T75602 | Albanol B | ||
Albanol B 是一种芳基苯并呋喃衍生物,可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖,下调 CDK1表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期,诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2的磷酸化水平。 | |||
TN5639 |
Rocaglaol
Ferrugin,Aglaiastatin A |
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Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis |