24
14
70
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9141 |
ERK-IN-3
ASN007 free base |
ERK | MAPK |
ERK-IN-3 (ASN007 free base) 是一种有效的口服活性 ERK 抑制剂,以低 IC50 值抑制 ERK1/2,可用于研究由 RAS 突变驱动的癌症。 | |||
T39453 |
ERK-IN-3 benzenesulfonate
|
||
ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK . ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations. | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T6993 |
Tauroursodeoxycholate sodium
牛磺熊脱氧胆酸钠,Sodium tauroursodeoxycholate,Tauroursodeoxycholic acid sodium salt,TUDC,牛磺熊去氧胆酸钠,Sodium Tauroursodeoxycholate (TUDC) |
Apoptosis; ERK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
Tauroursodeoxycholate sodium (TUDC) 是一种内质网应激抑制剂。Tauroursodeoxycholate sodium (TUDC) 抑制ERK,显著降低凋亡分子表达,如caspase-3和caspase-12。 | |||
T27242 |
EF24
EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone |
ERK; MEK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物,口服生物利用度高,抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平,并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路,从而发挥抗肿瘤作用。 | |||
T20759 |
XRP44X
XRP-44-X,XRP 44X,XRP-44X,XRP 44 X |
Ras | GPCR/G Protein; MAPK |
XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂,IC50为 10 nM,通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。 | |||
T3636 |
(E)-SIS3
SIS3,SIS3 盐酸盐,SIS3 HCl |
TGF-beta/Smad | Stem Cells |
(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂,能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。 | |||
T9428 |
HM43239
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
HM43239 是一种具有口服活性和选择性 FLT3抑制剂,IC50值为 1.1 nM (FLT3 野生型)、1.8 nM (FLT3 ITD 突变型) 和 1.0 nM (FLT3 D835Y 突变型)。HM43239 作为可逆的 I 型抑制剂直接抑制 FLT3 的激酶活性,并调节 p-STAT5, p-ERK SYK, JAK1/2 和 TAK1。HM43239 抑制白血病细胞的增殖并诱导其凋亡 (apoptosis)。 | |||
T16998 |
Tauroursodeoxycholate dihydrate
牛磺熊去氧胆酸二水合物,Taurolite dihydrate,TUDCA dihydrate,UR 906 dihydrate |
ERK; Caspase | Apoptosis; MAPK; Proteases/Proteasome |
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decreases the expression of apoptosis molecules, such as caspase-3 and caspase-12. | |||
T73039 |
CYP1B1-IN-3
|
||
CYP1B1-IN-3为选择性CYP1B1抑制剂,其IC50值分别针对CYP1B1、CYP1A1、CYP1A2为6.6, 347.3, >10000 nM。该化合物能够抑制细胞迁移与侵袭,并作用于P-gp、AKT/ERK、FAK/SRC及EMT信号通路。 | |||
T36584 |
HNMPA-(AM)3
|
Tyrosine Kinases | Tyrosine Kinase/Adaptors |
HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外,HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM,在蚊子和哺乳动物中分别) 具有抑制作用。 | |||
T62981 |
KRAS inhibitor-17
|
||
KRAS inhibitor-17 (compound 3-9) 是一种 KRAS G12C 的有效抑制剂 (IC50: 3.37 μM)。KRAS inhibitor-17 具有 p-ERK 抑制作用,在 MIA PaCA-2 细胞的 IC50=9.25 μM,在 A549 细胞中的 IC50 >33.3 μM。KRAS inhibitor-17 具有潜力进行胰腺癌,结直肠癌和肺癌的研究。 | |||
T74373 |
ERK1/2 inhibitor 3
|
||
ERK1/2 inhibitor 3 是一种有效的 ERK1/2抑制剂。丝裂原活化蛋白激酶 (MAPK) 在信号转导通路中起着极其重要的作用,而细胞外信号调节激酶 (ERK) 是 MAPK 家族的成员。ERK1/2 inhibitor 3 具有研究或预防癌症、炎症或其他增殖性疾病的潜力。 | |||
T62737 |
KRAS inhibitor-15
|
||
KRAS inhibitor-15 (compound 3-19) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.954 μM)。KRAS inhibitor-15 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 2.03,>33.3 μM。KRAS inhibitor-15 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。 | |||
T62752 | KRAS inhibitor-16 | ||
KRAS inhibitor-16 (compound 3-11) 是一种 KRAS G12C 的有效抑制剂 (IC50: 0.457 μM)。KRAS inhibitor-16 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 3.06,11.1 μM。 KRAS inhibitor-16 具有潜力进行胰腺癌,结直肠癌和肺癌的研究。 | |||
T62784 |
KRAS inhibitor-18
|
||
KRAS inhibitor-18 (compound 3-10) 是一种 KRAS G12C 的有效抑制剂 (IC50: 4.74 μM)。KRAS inhibitor-18 在 MIA PaCA-2,A549 细胞中表现出 p-ERK 抑制作用,IC50s 分别为 66.4,11.1 μM。KRAS inhibitor-18 具有潜力进行胰腺癌、结直肠癌和肺癌的研究。 | |||
T63967 |
Multi-kinase-IN-2
|
||
Multi-kinase-IN-2 是口服具有活力的血管激酶 (angiokinase) 抑制剂。Multi-kinase-IN-2 能够显著抑制血管激酶的活性,如 VEGFR-1/2/3、PDGFRα/β、FGFR-1、LYN 和 c-KIT 激酶。Multi-kinase-IN-2 能够明显减弱 AKT 和 ERK 蛋白的磷酸化,并可诱导细胞凋亡 (apoptosis),具有抗癌作用。 | |||
T79808 |
KRAS G12C inhibitor 61
|
ERK | MAPK |
KRAS G12C inhibitor 61 (Example 3) 在 MIA PaCa-2 细胞中抑制 ERK1/2 磷酸化,其 IC50 为 9 nM。此化合物适用于胰腺癌、结直肠癌和肺癌的研究。 | |||
T76022 |
Chemerin-9 (149-157) (TFA)
|
||
Chemerin-9 (149-157) TFA 作为趋化因子样受体1 (CMKLR1) 的有效激动剂,展现出抗炎活性,并能促进Akt与ERK磷酸化及活性氧生成,进而改善Aβ1-42诱发的记忆障碍。此外,该化合物还参与调节免疫反应、脂肪细胞分化以及糖代谢。 | |||
T76536 |
Pinealon
|
||
Pinealon是一种由三个氨基酸构成的肽,展现出神经保护属性。该化合物能够抑制ROS(活性氧)的积累和ERK1/2活化,激发脑组织主要细胞成分的活跃性,减缓自发性细胞凋亡率。此外,Pinealon对于防护大鼠后代免遭产前高同型半胱氨酸血症的影响亦显著。 | |||
T78871 |
PLM-101
|
||
PLM-101是一种口服抗癌剂,针对FLT3和RET具有选择性抑制作用,有效抑制急性髓系白血病(AML)细胞。通过抑制RET,PLM-101促使FLT3的自噬降解,并且通过抑制PI3K和Ras/ERK信号通路来发挥其抗白血病的活性。在小鼠MV4-11侧翼异种移植模型中,PLM-101以口服剂量3及10 mg/kg显示出抗肿瘤效果,并且在同种异种移植小鼠模型中,剂量为40 mg/kg(口服)亦展现出明显的抗肿瘤功效。 | |||
T35940 |
Darinaparsin
Dimethylarsinic glutathione,Darinaparsin |
||
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,... | |||
T71328 |
Theobromine-d6
|
||
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium.... | |||
T36679 | Rp-cAMPS sodium salt | ||
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S0619 |
Pachymic acid
3-O-Acetyltumulosic acid,茯苓酸 |
ERK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Pachymic acid (3-O-Acetyltumulosic acid) 是来自茯苓的一种三萜,可抑制Akt 和ERK 信号传导途径。 | |||
TN2354 |
Methylnissolin
3-Hydroxy-9,10-dimethoxyptercarpan,黄芪紫檀烷,黄芪紫檀烷苷,3-羟基-9,10-二甲氧基紫檀烷 |
ERK; PDGFR | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) 是从黄芪中分离的一种天然产物,可抑制血小板衍生生长因子(PDGF)-BB 诱导的细胞增殖,IC50为 10 μM。。它通过抑制 ERK1/2MAP 激酶级联反应抑制 PDGF-BB 诱导的血管平滑肌细胞增殖。它还抑制 PDGF-BB 诱导的细胞外信号调节激酶 1/2 (ERIC1/2) 丝裂原活化蛋白 (MAP) 激酶的磷酸化,具有抗菌和抗癌作用。 | |||
T13265 |
Urolithin B
尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮 |
ERK; NF-κB; Akt; Endogenous Metabolite; JNK; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Urolithin B 是一种 ellagitannins 的肠道微生物代谢产物,具有抗炎和抗氧化作用。它也是骨骼肌质量的调节因子,通过减少 IκBα 的磷酸化和降解来抑制 NF-κB 活性,并抑制 JNK、ERK 和 Akt 的磷酸化,并增强 AMPK 的磷酸化。 | |||
T2532 |
Tauroursodeoxycholate
Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA |
Apoptosis; ERK; P450; Caspase; Endogenous Metabolite | Apoptosis; MAPK; Metabolism; Proteases/Proteasome |
Tauroursodeoxycholate (UR 906),又称 ursodoxicoltaurine,是一种高度亲水性的三级胆汁酸,在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式,而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病,如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。 | |||
T6S0923 |
Hypericin
Hypericine,金丝桃素,Cyclosan |
Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Hypericin (Cyclosan) 是贯叶连翘的提取物,有抗菌、抗病毒、抗肿瘤和抗抑郁作用。 | |||
TN1880 |
Lucidenic acid B
Lucidenicacid B |
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物,可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解,可通过线粒体介导诱导人白血病细胞凋亡 。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。 | |||
T5S0890 |
Oleandrin
Neriostene,Folinerin,Foliandrin,欧夹竹桃苷 |
Apoptosis; ATPase; Potassium Channel; Sodium Channel | Apoptosis; Membrane transporter/Ion channel |
Oleandrin (Folinerin) 是夹竹桃属中的一种类固醇,可抑制Na+/K+-ATPase 活性,IC50为 620 nM。 | |||
T6S1740 |
Nardosinone
苷松新酮,甘松新酮 |
Others | Others |
Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂,分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具,不仅可用于研究神经生长因子 (NGF) 的作用机理,而且可用于研究神经毒性物质的作用机理。 | |||
T3876 |
Loureirin B
龙血素B,龙血素 B |
PAI-1; ERK; Potassium Channel; JNK | MAPK; Membrane transporter/Ion channel; Metabolism |
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。 | |||
T3S2344 |
β,β-Dimethylacrylshikonin
β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin |
ERK; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; MAPK; Metabolism |
β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物,从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达,促进血管生成,具有抗肿瘤活性。 | |||
T6S0525 |
Farrerol
|
ERK; p38 MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。 | |||
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
T72152 |
Eicosapentaenoic Acid sodium
二十碳五烯酸钠盐,Timnodonic acid sodium,EPA sodium |
||
Eicosapentaenoic Acid (EPA) sodium 为口服活性 ω-3 长链多不饱和脂肪酸 (ω-3 LC-PUFAs)。其通过DNA去甲基化,促进肿瘤抑制基因CCAAT/增强子结合蛋白δ (C/EBPδ)的重新表达,并通过H-RAS内含子1 CpG岛的去甲基化,激活U937白血病细胞中RAS/ERK/C/EBPβ途径。此外,该化合物能够促进血管平滑肌细胞松弛和血管舒张。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04430 |
p38 gamma/MAPK12 Protein, Human, Recombinant
mitogen-activated protein kinase 12,SAPK-3,P3 |
Human | Baculovirus Insect Cells |
p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778. | |||
TMPY-04429 |
p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)
ERK3,SAPK3,PRKM12,ERK6,P... |
Human | Baculovirus Insect Cells |
p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778. | |||
TMPY-00784 |
EphB2 Protein, Human, Recombinant (His & hFc)
Tyro5,EPHT3,DRT,EK5,PCBC,ERK,EPH receptor ... |
Human | HEK293 Cells |
EphB2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 86 kDa and the accession number is P29323-2. | |||
TMPY-01067 |
EphB2 Protein, Human, Recombinant (His)
EPH receptor B2,DRT,EK5,PCBC,ERK,CAPB,EPHT3 |
Human | HEK293 Cells |
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P29323-2. | |||
TMPY-04386 |
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST)
PCBC,CAPB,Hek5,EK5,EPHT3,EPH receptor B2,Tyro5,DRT,... |
Human | Baculovirus Insect Cells |
EphB2 Protein, Human, Recombinant (aa 570-987, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.2 kDa and the accession number is P29323-3. | |||
TMPK-00563 |
EPHB2 Protein, Cynomolgus, Recombinant (His)
DRT,Nuk,Sek3,TYRO5,EPHT3,HEK5,EphB2,Qek2,P... |
Cynomolgus | HEK293 Cells |
EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia. | |||
TMPH-01609 |
LGI1 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. | |||
TMPY-04378 |
MAPKAPK3 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase-activated protein kinase |
Human | Baculovirus Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in hu... | |||
TMPH-03368 |
SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.2 kDa and the accessio... | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPY-06986 |
FGF-8b Protein, Human, Recombinant
NEWENTRY,fibroblast growth factor 8 (androgen-induced),FGF-8... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPY-00132 |
Mesothelin Protein, Human, Recombinant
MPF,SMRP,Mesothelin |
Human | HEK293 Cells |
Mesothelin Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is Q13421-3. | |||
TMPY-04935 |
CD47 Protein, Human, Recombinant (aa 1-139, His)
MER6,CD47 molecule,IAP,OA3 |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant (aa 1-139, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is Q08722-3. | |||
TMPY-03763 |
Neuropilin-2 Protein, Human, Recombinant (hFc)
Neuropilin-2,NPN2,neuropilin 2,PRO2714,VEGF165R2,NP2 |
Human | HEK293 Cells |
Neuropilin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 120.7 kDa and the accession number is O60462-3. | |||
TMPY-05191 |
CD47 Protein, Human, Recombinant, Biotinylated
CD47 molecule,MER6,OA3,IAP |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3. | |||
TMPY-04683 |
CD47 Protein, Human, Recombinant
MER6,CD47 molecule,OA3,IAP |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is Q08722-3. | |||
TMPY-00072 |
GITR/TNFRSF18 Protein, Human, Recombinant (His)
AITR,GITR-D,tumor necrosis factor receptor superfamily, memb... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-01897 |
PRSS3 Protein, Human, Recombinant (His)
PRSS4,TRY4,TRY3,RP11-176F3.3,T9,M... |
Human | HEK293 Cells |
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ... | |||
TMPY-01020 |
Periostin/OSF-2 Protein, Human, Recombinant (His)
PN,OSF-2,OSF2,periostin,periostin, osteoblast specific facto... |
Human | HEK293 Cells |
Periostin/OSF-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is Q15063-3. | |||
TMPY-00892 |
Neuropilin-2 Protein, Human, Recombinant (His)
NP2,PRO2714,VEGF165R2,neuropilin 2,NPN2,Neuropilin-2 |
Human | HEK293 Cells |
Neuropilin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is O60462-3. | |||
TMPY-01180 |
CD86 Protein, Human, Recombinant (His)
CD86 antigen,B70,B7.2,B7-2,CD28LG2,LAB72 |
Human | HEK293 Cells |
CD86 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.6 kDa and the accession number is P42081-3. | |||
TMPY-05748 |
CD45 Protein, Human, Recombinant (aa 26-577, His)
L-CA,T200,LCA,B220,protein tyrosine phosphatase, receptor ty... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3. | |||
TMPY-04142 |
RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
OPTB7,OFE,OSTS,LOH18CR1,FEO,TRANCER,tumor necrosis factor re... |
Human | HEK293 Cells |
RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3. | |||
TMPJ-01099 |
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece... |
Human | HEK293 Cells |
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... | |||
TMPY-04298 |
CDCP1 Protein, Human, Recombinant (His)
TRASK,CD318,CUB domain containing protein 1,SIMA1 |
Human | HEK293 Cells |
CDCP1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.4 kDa and the accession number is Q9H5V8-3. | |||
TMPY-00357 |
HNT/NTM Protein, Human, Recombinant (His)
HNT,NTRI,IGLON2,neurotrimin |
Human | HEK293 Cells |
HNT/NTM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q9P121-3. | |||
TMPY-00480 |
NCAM1 Protein, Human, Recombinant (His)
neural cell adhesion molecule 1,CD56,MSK39,NCAM |
Human | HEK293 Cells |
NCAM1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 66.1 kDa and the accession number is P13591-3. | |||
TMPY-04466 |
STK40 Protein, Human, Recombinant (His & GST)
SHIK,SgK495,serine/threonine kinase 40 |
Human | Baculovirus Insect Cells |
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES... | |||
TMPY-04467 |
NME1 Protein, Human, Recombinant (His)
NME/NM23 nucleoside diphosphate kinase 1,NB,NDPK-A,... |
Human | E. coli |
NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as ... | |||
TMPK-00447 |
CD45 Protein, Human, Recombinant (aa 26-577, hFc)
CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3.... |
Human | HEK293 Cells |
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577... | |||
TMPY-01268 |
SMYD3 Protein, Human, Recombinant (GST)
SET and MYND domain containing 3,ZMYND1,KMT3 |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg... | |||
TMPY-03621 |
EphB2 Protein, Mouse, Recombinant (hFc)
Tyro5,Erk,Qek5,ETECK,Hek5,Drt,EPH receptor B2,Nuk,P... |
Mouse | HEK293 Cells |
EphB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 84.6 kDa and the accession number is P54763-3. | |||
TMPJ-01288 |
KLF6 Protein, Human, Recombinant
CPBP,GC-Rich Sites-Binding Factor GBF,Suppressor of Tumorige... |
Human | E. coli |
Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. KLF6 expression is highest in the placenta followed by spleen, thymus, prostate, testis, small intestinem and colon. However, it is weakly expressed in the pancreas, lung, liver, heart, and skeletal muscle. KLF6 functions as a transcriptional activator and could play a role in B-cell growth and development. Defects in KLF6 will resul... | |||
TMPY-03149 |
CDCP1 Protein, Human, Recombinant (mFc)
TRASK,SIMA135,CD318,CUB domain containing ... |
Human | HEK293 Cells |
CDCP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 61.4 kDa and the accession number is Q9H5V8-3. | |||
TMPK-00401 |
FGFR2 alpha (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
ECT1,K-SAM,CD332,CEK3,FGFR2 α,CFD... |
Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1 - 4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs. | |||
TMPK-00398 |
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi)
Fibroblast growth factor receptor 2,CD332,... |
Human | HEK293 Cells |
FGFR2 beta (IIIb) Domain Protein, Human, Recombinant (Avi) is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 15.49 kDa and the accession number is P21802-3. | |||
TMPY-04015 |
COL9A1 Protein, Human, Recombinant (mFc)
DJ149L1.1.2,STL4,collagen, type IX, alpha 1,MED,EDM6,collage... |
Human | HEK293 Cells |
COL9A1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 59.2 kDa and the accession number is P20849-3. | |||
TMPJ-00391 |
FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc)
FGF R2b,KGFR,BFR-1,FGFR2 β,FGFR2b,FGFR2,FGFR2 beta,CD3 |
Human | HEK293 Cells |
FGFR2IIIb Protein, Human, Recombinant (aa 22-378, hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is P21802-3. | |||
TMPY-05514 |
RANK/TNFRSF11A Protein, Human, Recombinant (mFc)
OFE,RANK,OPTB7,FEO,tumor necrosis factor receptor superfamil... |
Human | HEK293 Cells |
RANK/TNFRSF11A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9Y6Q6-3. | |||
TMPY-00276 |
PLGF/PGF Protein, Human, Recombinant (mFc)
placental growth factor,D12S1900,PLGF,SHGC-10760,PGFL,PlGF-2 |
Human | HEK293 Cells |
PLGF/PGF Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.7 kDa and the accession number is P49763-3. | |||
TMPY-06411 |
GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated
CD357,GITR-D,tumor necrosis factor receptor superfa... |
Human | HEK293 Cells |
GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17.79 kDa and the accession number is Q9Y5U5-3. | |||
TMPY-03960 |
COL9A1 Protein, Human, Recombinant (His)
EDM6,collagen, type IX, α1,STL4,collagen, type IX, alpha 1,M... |
Human | HEK293 Cells |
COL9A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.2 kDa and the accession number is P20849-3. | |||
TMPY-00715 |
CD84 Protein, Human, Recombinant (His)
LY9B,mCD84,CD84 molecule,hCD84,SLAMF5 |
Human | HEK293 Cells |
CD84 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24 kDa and the accession number is Q9UIB8-3. | |||
TMPY-03969 |
SUSD4 Protein, Human, Recombinant (mFc)
sushi domain containing 4,PRO222 |
Human | HEK293 Cells |
SUSD4, also known as sushi domain-containing protein 4, is a hypothetical cell surface protein whose tissue distribution and function are completely unknown. SUSD4 is detectable in murine brains, eyes, spinal cords, and testis but not other tissues. In brains, SUSD4 is highly expressed in the white matter on oligodendrocytes/axons, and in eyes, it is exclusively expressed on the photoreceptor outer segments. In in vitro complement assays, SUSD4 augments the alternative but not the classical path... | |||
TMPY-04216 |
EphB2 Protein, Mouse, Recombinant (His)
Drt,Nuk,Qek5,Tyro5,Prkm5,Sek3,ETECK,Cek5,Hek5,EPH r... |
Mouse | HEK293 Cells |
EphB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is P54763-3. | |||
TMPJ-00465 |
PTP1C Protein, Human, Recombinant (His)
HCP,Hematopoietic Cell Protein-Tyrosine Phosphatase,SH-PTP1,... |
Human | E. coli |
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter... | |||
TMPY-02573 |
IL-17RC Protein, Human, Recombinant (aa 1-454, His)
IL17RL,interleukin 17 receptor C,IL17-RL,UNQ6118/PRO20040/PR... |
Human | Baculovirus Insect Cells |
IL-17RC Protein, Human, Recombinant (aa 1-454, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.6 kDa and the accession number is Q8NAC3-3. | |||
TMPY-03883 |
CD47 Protein, Human, Recombinant (hFc)
OA3,CD47 molecule,IAP,MER6 |
Human | HEK293 Cells |
CD47 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.7 kDa and the accession number is Q08722-3. | |||
TMPY-01656 |
VEGF183 Protein, Human, Recombinant
血管内皮生长因子,VEGF165,VPF,VEGF,vascular endothelial growth factor... |
Human | Baculovirus Insect Cells |
VEGF183 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 21 kDa and the accession number is P15692-3. | |||
TMPK-00400 |
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated
Fibroblast growth factor receptor 2,KGFR,FGFR-2,KSAM,CD3... |
Human | HEK293 Cells |
FGFR2 beta (IIIb) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 28.3 kDa and the accession number is P21802-3. | |||
------------------------ 更多 ------------------------ |