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124

抑制剂 & 化合物

17

天然产物

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Cat. No. Product Name Target Signaling Pathways
T14057 6-CFDA

6-羧基荧光素二醋酸,6-Carboxyfluorescein diacetate

Others Others
6-CFDA (6-Carboxyfluorescein diacetate) 是可用于流式细胞术和荧光显微镜的荧光探针,也可以用于活体多光子显微镜研究动物肝胆代谢。
T18894 5(6)-CFDA

CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯

Others Others
5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) 是具有细胞渗透性的胺反应型绿色荧光探针(λex: 492 nm; λem: 517 nm),可用于细胞染色分析。
T21231 Almotriptan

阿莫曲坦,LAS 31416,阿莫曲普坦

5-HT Receptor GPCR/G Protein; Neuroscience
Almotriptan (LAS 31416) 是一种用于研究偏头痛的5-HT1B/1D 受体激动剂。
T5039 Aminohippurate sodium

Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt

Others Others
Aminohippurate sodium (Sodium p-aminohippurate) 是能够利用肾血浆流量测量肾脏医学测试的诊断剂。
T3616 Carbazochrome

AC-17,Adrenostazin,Cromadrenal,Adona,Adchnon,卡巴克络,Adedolon

Others; Phospholipase Metabolism; Others
Carbazochrome (Adchnon) 是毛细管稳定剂,是抗出血剂,用于研究出血。
T18896 5(6)-FITC

Fluorescein 5(6)-isothiocyanate,异硫氰酸荧光素,Fluorescein isothiocyanate

Others Others
5(6)-FITC (Fluorescein isothiocyanate), or Fluorescein 5(6)-isothiocyanate, is a versatile amine-reactive derivative of fluorescein dye. It serves as an effective label for antibodies and other probes, finding utility in fluorescence microscopy, flow cytometry, and immunofluorescence-based assays such as ELISA and Western blotting.
T9376 Nitroarginine

N'-硝基-L-精氨酸,N'-Nitro-L-arginine

NO Synthase Immunology/Inflammation
Nitroarginine (N'-Nitro-L-arginine) 是一氧化氮合酶的竞争性抑制剂,可选择性减少流向肿瘤细胞的血流。
T6273 Vadimezan

DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404

Influenza Virus; VDA; STING; IFNAR Angiogenesis; Immunology/Inflammation; Microbiology/Virology
Vadimezan (DMXAA) 是一种血管破坏剂,一种鼠 STING 激动剂,也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性,可以诱导肿瘤中的血流快速停止,但不影响正常组织中的血流。
T23535L Xanthine amine congener trihydrochloride

Xanthine amine congener trihydrochloride (96865-92-8 Free base)

Adenosine Receptor GPCR/G Protein; Neuroscience
Xanthine amine congener trihydrochloride 是一种有效的腺苷拮抗剂,可逆转由腺苷激动剂 N6-环己基腺苷产生的尿流量、钠排泄和心率的减少。
T11318 Dopexamine hydrochloride

盐酸多培沙明,FPL60278AR

Adrenergic Receptor GPCR/G Protein; Neuroscience
Dopexamine hydrochloride (FPL60278AR) 是β2肾上腺素能受体激动剂。
T77767L1 GLF16 HCl

Others Others
GLF16 HCl 是一种荧光团偶联的苏丹黑 B 类似物,可通过通过荧光显微镜和流式细胞术快速检测、分离和实时跟踪衰老细胞。
T21263 Amlodipine maleate

Amlodipine (+-)-form maleate,Amvaz

Calcium Channel Membrane transporter/Ion channel; Metabolism
Amlodipine maleate (Amvaz) 是一种具有口服活性的二氢吡啶类钙通道阻滞剂,通过阻滞电压依赖性 L 型钙通道,从而抑制钙离子内流。Amlodipine maleate 可用于研究高血压和癌症。
T14875 Indocyanine green

Cardiogreen,IC Green,Foxgreen,吲哚菁绿

Others Others
Indocyanine green (Cardiogreen) 是低毒性荧光剂,普遍用于医学诊断,包括确定心输出量,肝功能和肝血流量,以及用于眼科血管造影。
T22361 Mepivacaine

Carbocaine

Sodium Channel Membrane transporter/Ion channel
Mepivacaine (Carbocaine) 是一种可用于局部麻醉的酰胺类化合物,可使人或动物短暂的失去自知觉。Mepivacaine 通过与神经细胞膜上特定的电压门控钠离子通道结合,抑制钠离子内流和膜去极化来发挥作用。Mepivacaine 适用于神经阻滞和硬膜外麻醉。
T15609 JC-1

CBIC2

Others Others
JC-1 (CBIC2) 是一种荧光亲脂性羰花青染料,用于测量线粒体膜电位。线粒体膜电位较高时,它在基质中汇聚形成聚合物,可以产生红色荧光(λex=585 nm,λem=590 nm)。线粒体膜电位较低时,它不能聚集在线粒体基质中,以单体形式存在产生绿色荧光(λex=510 nm,λem=527 nm)。
T36958 BODIPY 505/515

BODIPY 505/515 是一种亲脂性荧光探针,可定位到细胞内的脂质体,已被用于标记脂滴。BODIPY 505/515 已被用于电子显微镜、外荧光显微镜、共聚焦显微镜以及各种藻类物种的流式细胞仪应用中。
T39518 PFB-FDGlu

Others Others
PFB-FDGlu 是一种溶酶体葡糖脑苷脂酶(GCase)底物,具有细胞渗透特异性,裂解后产生荧光素。PFB-FDGlu 通常与流式细胞仪结合使用,以单个细胞为基础测量活细胞中 GCase 的活性。
T78393 C12FDG

5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside

C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) 作为一种亲脂性用于检测β-半乳糖活性的绿色荧光底物,是一种衰老标志物,常与流式细胞仪连用。
T40194 MeAIB

α-(Methylamino)isobutyric acid

Others Others
MeAIB 是一种n -乙酰转移酶抑制剂,抑制SNAT2相关信号通路。MeAIB 是氨基酸转运系统a (ATA1)的特异性底物。氨基酸转运系统a (ATA1)以Na+流动调控短链中性氨基酸的摄取。
T2090 Lexibulin

CYT-997

Apoptosis; Reactive Oxygen Species; Microtubule Associated Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂,可诱导细胞凋亡,并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M,在体内外具有高细胞毒性和血管增生阻断作用。
T0957 Isradipine

PN 200-110,伊拉地平

Calcium Channel; Autophagy Autophagy; Membrane transporter/Ion channel; Metabolism
Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂,具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂,也是一种潜在可行的帕金森病神经保护剂。
T4433 6-CFDA N-succinimidyl ester

Carboxyfluorescein diacetate succinimidyl

Others Others
6-CFDA N-succinimidyl ester (Carboxyfluorescein diacetate succinimidyl) 能够自发且不可逆地与游离胺结合。在流式细胞术实验中用于追踪哺乳动物细胞和细菌的细胞分裂。与多种细胞透化剂结合使用,作为一种有效的、非破坏性的荧光染料,可快速检测细菌细胞。
T2535 Ivabradine hydrochloride

盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Adrenergic Receptor GPCR/G Protein; Neuroscience
Ivabradine hydrochloride (S 16257-2) 是一种可口服的,超极化激活的环核苷酸门控离子通道通道阻滞剂。
T31206 Darexaban

YM 150,Darexaban, Tanexaban,YM150

Factor Xa Metabolism
Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂,IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T2130 Propidium Iodide

PI,碘化丙啶,碘化丙啶(PI)

Others Others
Propidium Iodide (PI) 是一种可用于细胞染色的红色荧光染料,适用于荧光显微镜、共聚焦显微镜、流式细胞仪以及荧光计分析。在水溶液中,Propidium Iodide 的Ex/Em 为493/636 nm;与核酸结合后,PI-核酸的Ex/Em 变为535/617 nm,同时荧光信号增强20-30倍。
T2671 Regadenoson

CVT-3146,瑞加德松,Lexiscan

Adenosine Receptor GPCR/G Protein; Neuroscience
Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂,具有冠状动脉舒张活性,对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂,可增加啮齿动物血脑屏障的通透性。
T3536 AZD1283

P2Y Receptor GPCR/G Protein; Neuroscience
AZD1283是P2Y12受体拮抗剂,EC50为3.0 ug/kg/min,结合的IC50为11 nM。它剂量依赖性地诱导血流量增加和抑制 ADP 诱导的血小板聚集,抗血栓形成的 ED50 值分别为 3.0 和 10 μg/kg/min。
T0096 Vardenafil

伐地那非,Vivanza,Levitra,Vardenafil hydrochloride

PDE Metabolism
Vardenafil (Vivanza) 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂,IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解,从而提高 cGMP 水平。它对 PDE1 (180 nM),PDE6 (11 nM),PDE2,PDE3,PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。
T30907 Chromonar hydrochloride

Antiangor,chromonar HCl,Karbokromen

Chromonar Hydrochloride is a coronary vasodilator that increases transwall blood flow.
T32426 KT 1

KT-1,KT1

KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood flow, coronary blood flow, peak posit
T27015 Cicrotoic acid

Cicrotoic acid, a biochemical drug, acts on bile flow and liquid composition of human bile.
T14058 6-FITC

6-异硫氰酸荧光素,6-Fluorescein Isothiocyanate

Others Others
6-Fluorescein Isothiocyanate (6-FITC) is a fluorescein derivative widely employed in applications such as flow cytometry.
T34895 Tocamphyl

Tocanfil,Biliphorin,Gallogen

Tocamphyl is a cholagogic agent that stimulates pancreatic exocrine and bile flow when administered in the duodenum.
T27351 Fostedil

KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546

Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardial blood flow during partial corona
T30602 Bts 39542

Bts-39542,Bts39542

Bts 39542 is a diuretic that plays a major role in the Henle circulation and increases renal blood flow without affecting glomerular filtration rate.
T21185 CEP03

CEP 03,CEP-03

CEP03 enhances EC/EPC proliferation, tubelike formation, and wound-healing efficiency, leading to promote angiogenesis and significantly improve blood flow perfusion recovery in the ischemic hind limbs of mice.
T39027 PKH 26

PKH 26 is a lipophilic membrane dye and widely used to determine cell proliferation in heterogeneous cells by flow cytometry. It is a red‐fluorescent dye (Ex/Em=551/567nm).
T37317 Fluo-3 (sodium salt)

Fluo-3 is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry.
T29792 AK-135

AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.
T30444 Bicisate dihydrochloride

Bicisate HCl

Bicisate dihydrochloride is usually complex with technetium Tc99m to measure cerebral blood flow with single-photon emission computed tomography (SPECT).
T21391 Flecainide

Tambocor,Apocard,Flecainida,Flecainidum

Flecainide acetate is a class Ic antiarrhythmic agent, it is used to treat a variety of cardiac arrhythmias including paroxysmal atrial fibrillation, paroxysmal supraventricular tachycardia, and ventricular tachycardia. It works by regulating the flow of
T39795 Tricarbonyldichlororuthenium(II) dimer

CORM-2

Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response.
T40274 XVA143

XVA143

XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo. XVA143 is an antagonist of both mouse and human CR3, inhibits the ability of P. gingivalis to persist in the mouse host and cause periodontal bone loss.
T30444L Bicisate (Free base)

Bicisate

Bicisate is usually complex with technetium Tc99m for its usage as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT).
T41029 Streptokinase

Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary artery occlusion.
T37316 Fluo-3 (potassium salt)

Fluo-3 (potassium salt) is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry.
T18989 Fluo-3AM

Fluo-3-pentaacetoxymethyl ester

Others Others
Fluo-3AM is a calcium indicator that exhibits an increase in fluorescence upon binding Ca2+. It is used to image the spatial dynamics of Ca2+ signaling in flow cytometry experiments.
T71988 Moxaverine hydrochloride

Moxaverine hydrochloride is a derivative of papaverine, a phosphodiesterase inhibitor. Moxaverine has been studied in phase III of a clinical trial for the treatment of ocular blood flow in patients with age- related macular degeneration and primary open angle glaucoma.
T0112L Diltiazem

Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401

Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is used to treat hypertension, angina pec
T24690 Pyrromecaine HCl

Bumecaine hydrochloride,Pyrromecaine

Pyrromecaine is a local anesthetic used for surface anesthesia. Pyromecaine has a wide spectrum of antiarrhythmic action, exerts a favorable effect on the contractility of the left ventricle, and on the myocardial blood flow following the ligation of the

化合物

6-CFDA
Cat.No: T14057
Synonym: 6-羧基荧光素二醋酸,6-Carboxyfluorescein diacetate
Target: Others
5(6)-CFDA
Cat.No: T18894
Synonym: CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯
Target: Others
Almotriptan
Cat.No: T21231
Synonym: 阿莫曲坦,LAS 31416,阿莫曲普坦
Target: 5-HT Receptor
Aminohippurate sodium
Cat.No: T5039
Synonym: Sodium 4-aminohippurate Hydrate,Sodium p-aminohippurate,4-氨基马尿酸钠盐,p-Aminohippuric acid sodium salt
Target: Others
Carbazochrome
Cat.No: T3616
Synonym: AC-17,Adrenostazin,Cromadrenal,Adona,Adchnon,卡巴克络,Adedolon
Target: Others, Phospholipase
5(6)-FITC
Cat.No: T18896
Synonym: Fluorescein 5(6)-isothiocyanate,异硫氰酸荧光素,Fluorescein isothiocyanate
Target: Others
Nitroarginine
Cat.No: T9376
Synonym: N'-硝基-L-精氨酸,N'-Nitro-L-arginine
Target: NO Synthase
Vadimezan
Cat.No: T6273
Synonym: DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404
Target: Influenza Virus, VDA, STING, IFNAR
Xanthine amine congener trihydrochloride
Cat.No: T23535L
Synonym: Xanthine amine congener trihydrochloride (96865-92-8 Free base)
Target: Adenosine Receptor
Dopexamine hydrochloride
Cat.No: T11318
Synonym: 盐酸多培沙明,FPL60278AR
Target: Adrenergic Receptor
GLF16 HCl
Cat.No: T77767L1
Synonym:
Target: Others
Amlodipine maleate
Cat.No: T21263
Synonym: Amlodipine (+-)-form maleate,Amvaz
Target: Calcium Channel
Indocyanine green
Cat.No: T14875
Synonym: Cardiogreen,IC Green,Foxgreen,吲哚菁绿
Target: Others
Mepivacaine
Cat.No: T22361
Synonym: Carbocaine
Target: Sodium Channel
JC-1
Cat.No: T15609
Synonym: CBIC2
Target: Others
BODIPY 505/515
Cat.No: T36958
Synonym:
Target:
PFB-FDGlu
Cat.No: T39518
Synonym:
Target: Others
C12FDG
Cat.No: T78393
Synonym: 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside
Target:
MeAIB
Cat.No: T40194
Synonym: α-(Methylamino)isobutyric acid
Target: Others
Lexibulin
Cat.No: T2090
Synonym: CYT-997
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated
Isradipine
Cat.No: T0957
Synonym: PN 200-110,伊拉地平
Target: Calcium Channel, Autophagy
6-CFDA N-succinimidyl ester
Cat.No: T4433
Synonym: Carboxyfluorescein diacetate succinimidyl
Target: Others
Ivabradine hydrochloride
Cat.No: T2535
Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl
Target: Adrenergic Receptor
Darexaban
Cat.No: T31206
Synonym: YM 150,Darexaban, Tanexaban,YM150
Target: Factor Xa
Propidium Iodide
Cat.No: T2130
Synonym: PI,碘化丙啶,碘化丙啶(PI)
Target: Others
Regadenoson
Cat.No: T2671
Synonym: CVT-3146,瑞加德松,Lexiscan
Target: Adenosine Receptor
AZD1283
Cat.No: T3536
Synonym:
Target: P2Y Receptor
Vardenafil
Cat.No: T0096
Synonym: 伐地那非,Vivanza,Levitra,Vardenafil hydrochloride
Target: PDE
Chromonar hydrochloride
Cat.No: T30907
Synonym: Antiangor,chromonar HCl,Karbokromen
Target:
KT 1
Cat.No: T32426
Synonym: KT-1,KT1
Target:
Cicrotoic acid
Cat.No: T27015
Synonym:
Target:
6-FITC
Cat.No: T14058
Synonym: 6-异硫氰酸荧光素,6-Fluorescein Isothiocyanate
Target: Others
Tocamphyl
Cat.No: T34895
Synonym: Tocanfil,Biliphorin,Gallogen
Target:
Fostedil
Cat.No: T27351
Synonym: KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546
Target:
Bts 39542
Cat.No: T30602
Synonym: Bts-39542,Bts39542
Target:
CEP03
Cat.No: T21185
Synonym: CEP 03,CEP-03
Target:
PKH 26
Cat.No: T39027
Synonym:
Target:
Fluo-3 (sodium salt)
Cat.No: T37317
Synonym:
Target:
AK-135
Cat.No: T29792
Synonym:
Target:
Bicisate dihydrochloride
Cat.No: T30444
Synonym: Bicisate HCl
Target:
Flecainide
Cat.No: T21391
Synonym: Tambocor,Apocard,Flecainida,Flecainidum
Target:
Tricarbonyldichlororuthenium(II) dimer
Cat.No: T39795
Synonym: CORM-2
Target:
XVA143
Cat.No: T40274
Synonym: XVA143
Target:
Bicisate (Free base)
Cat.No: T30444L
Synonym: Bicisate
Target:
Streptokinase
Cat.No: T41029
Synonym:
Target:
Fluo-3 (potassium salt)
Cat.No: T37316
Synonym:
Target:
Fluo-3AM
Cat.No: T18989
Synonym: Fluo-3-pentaacetoxymethyl ester
Target: Others
Moxaverine hydrochloride
Cat.No: T71988
Synonym:
Target:
Diltiazem
Cat.No: T0112L
Synonym: Diltiazem free base,Dilticard,地尔硫卓,CRD-401,CRD401,Dilzen,CRD 401
Target:
Pyrromecaine HCl
Cat.No: T24690
Synonym: Bumecaine hydrochloride,Pyrromecaine
Target:
Cat. No. Product Name Target Signaling Pathways
T13302 Viquidil hydrochloride

Quinotoxine hydrochloride

Others Others
Viquidil hydrochloride (Quinotoxine hydrochloride) 是奎尼丁的同分异构体,是一种脑血管扩张剂,具有抗血栓作用。
T3S1534 Secoxyloganin

断氧化马钱苷,幼枝含断氧化马钱子甙,金银花

Anti-infection Microbiology/Virology
Secoxyloganin 是从Lonicera japonicaThunb 提取得到,能够抑制血流量减少,具有抗过敏活性。
TN1328 7-Amino-4-methylcoumarin-3-acetic acid

7-氨基-4-甲基-3-香豆素醋酸,7-Amino-4-methylcoumarin

Others Others
7-Amino-4-methylcoumarin-3-acetic acid (7-Amino-4-methylcoumarin) 是荧光蛋白质标记剂,能够被紫外光(350 nm) 激活,可在蓝色区域 (440-460 nm) 发光。
T6263 Safflower-yellow

Others Others
Safflower-yellow 是从植物红花(Carthamus tinctorius)的花中提取的,作为中药已广泛用于治疗心脑血管疾病。
T19056 Safflower yellow

Saffron powder,Carthamas yellow,红花黄

Others Others
Safflower yellow (Saffron powder) 是提取自植物红花的花中,可用于研究心脑血管疾病。
T1436 4-Aminohippuric Acid

p-Aminohippuric acid,对氨基马尿酸

Amino Acids and Derivatives; Endogenous Metabolite Metabolism
4-Aminohippuric Acid 是诊断剂,能够用于肾脏检测,在肾血浆流量的测定中使用。
T7975 Rhodamine B

罗丹明B,Rhodamine B,罗丹明 B,Tetraethylrhodamine,Brilliant Pink B,Basic Violet 1,Rhodamine O

Others Others
Rhodamine B (Brilliant Pink B) 是荧光染料,常用于染色纺织品、肥皂、纸张、皮革和药品。
T2S2335 Dehydroevodiamine

DHED,去氢吴茱萸碱

Others; NF-κB; COX; PGE Synthase; NO Synthase Immunology/Inflammation; Neuroscience; NF-κB; Others
Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱,可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达,对豚鼠心室肌细胞具有抗心律失常作用。
T0070 Pentoxifylline

Oxpentifylline,PTX,己酮可可碱,BL-191

HIV Protease; PDE; Adenosine Receptor; Autophagy Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂,具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
T38248 2-Ethylpyrazine

Endogenous Metabolite; NO Synthase Immunology/Inflammation; Metabolism
2-Ethylpyrazine 存在与烘焙后的咖啡豆中,是一种挥发性化合物 。2-Ethylpyrazine 通过内皮衍生的松弛因子的活动诱导血管舒张。2-Ethylpyrazine 通过内皮内皮NO 合酶的作用激活NO 合成。2-Ethylpyrazine 通过诱导NO 释放和增加外周血流量来诱导血管舒张。
T1626 Prostaglandin E1

前列地尔,PGE1,列腺素E1,Alprostadil

Endogenous Metabolite; Prostaglandin Receptor GPCR/G Protein; Immunology/Inflammation; Metabolism
Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体,对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集,可作为血管扩张剂用于外周血管疾病的研究。
TN2080 Pinoresinol

松脂酚,松脂素,(+)-Pinoresinol

Apoptosis; NF-κB; CDK; p53 Apoptosis; Cell Cycle/Checkpoint; NF-κB
Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素,具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调,抑制 NF-kappaB 和激活蛋白 1 。
TN1367 Alismol

泽泻醇

Potassium Channel; Calcium Channel; PI3K Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks.
TN4616 N-Methyltaxol C

Others Others
N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
TN4277 Isocupressic acid

cAMP; P450; PKA GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
T74193 (R)-IDHP

(R)-IDHP为IDHP异构体,属于丹参代谢物。该化合物能通过抑制血管平滑肌细胞电压依赖性钙通道与受体操作钙通道的Ca2+释放和Ca2+内流,发挥血管松弛作用,适用于心脑血管疾病研究。
T37770 Taurohyodeoxycholic acid

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.2Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.3THDCA also reduces myeloperoxidase activity, expressi...

天然产物

Viquidil hydrochloride
Cat.No: T13302
Synonym: Quinotoxine hydrochloride
Target: Others
Secoxyloganin
Cat.No: T3S1534
Synonym: 断氧化马钱苷,幼枝含断氧化马钱子甙,金银花
Target: Anti-infection
7-Amino-4-methylcoumarin-3-acetic acid
Cat.No: TN1328
Synonym: 7-氨基-4-甲基-3-香豆素醋酸,7-Amino-4-methylcoumarin
Target: Others
Safflower-yellow
Cat.No: T6263
Synonym:
Target: Others
Safflower yellow
Cat.No: T19056
Synonym: Saffron powder,Carthamas yellow,红花黄
Target: Others
4-Aminohippuric Acid
Cat.No: T1436
Synonym: p-Aminohippuric acid,对氨基马尿酸
Target: Amino Acids and Derivatives, Endogenous Metabolite
Rhodamine B
Cat.No: T7975
Synonym: 罗丹明B,Rhodamine B,罗丹明 B,Tetraethylrhodamine,Brilliant Pink B,Basic Violet 1,Rhodamine O
Target: Others
Dehydroevodiamine
Cat.No: T2S2335
Synonym: DHED,去氢吴茱萸碱
Target: Others, NF-κB, COX, PGE Synthase, NO Synthase
Pentoxifylline
Cat.No: T0070
Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191
Target: HIV Protease, PDE, Adenosine Receptor, Autophagy
2-Ethylpyrazine
Cat.No: T38248
Synonym:
Target: Endogenous Metabolite, NO Synthase
Prostaglandin E1
Cat.No: T1626
Synonym: 前列地尔,PGE1,列腺素E1,Alprostadil
Target: Endogenous Metabolite, Prostaglandin Receptor
Pinoresinol
Cat.No: TN2080
Synonym: 松脂酚,松脂素,(+)-Pinoresinol
Target: Apoptosis, NF-κB, CDK, p53
Alismol
Cat.No: TN1367
Synonym: 泽泻醇
Target: Potassium Channel, Calcium Channel, PI3K
N-Methyltaxol C
Cat.No: TN4616
Synonym:
Target: Others
Isocupressic acid
Cat.No: TN4277
Synonym:
Target: cAMP, P450, PKA
(R)-IDHP
Cat.No: T74193
Synonym:
Target:
Taurohyodeoxycholic acid
Cat.No: T37770
Synonym:
Target:
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