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Search Results for " fatty liver "

58

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12580	PTUPB	COX; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Neuroscience
	PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。
T2601	Vidofludimus SC12267,4sc-101	Dehydrogenase; DNA/RNA Synthesis; Interleukin	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂，可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
T12883	Fezagepras PBI-4050,3-戊基苯乙酸,Setogepram	GPR	Endocrinology/Hormones; GPCR/G Protein
	Fezagepras (Setogepram) 是一种可口服的 GPR40激动剂和GPR84拮抗剂或反向激动剂。它减轻肾、肝和胰腺纤维化，具有抗纤维化、抗炎和抗增殖作用。
T6714	URB-597 KDS-4103,FAAH Inhibitor II	Mitophagy; FAAH; Autophagy	Autophagy; Metabolism; Neuroscience
	URB-597 (FAAH Inhibitor II) 是一种可口服的选择性FAAH 抑制剂。它抑制大鼠脑膜、体外大鼠神经元和人肝微粒体中的 FAAH 活性，IC50分别为 5、0.5和 3 nM。它具有抗抑郁样作用，可研究缓解疼痛。
T9010	IMM-H007	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	IMM-H007 是一种新型降脂剂，可增加 abca1 蛋白的表达。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T9209	PF-05221304 STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat	Acetyl-CoA Carboxylase	Metabolism
	PF-05221304 (NSC-170984) 是一种具有口服活性的肝脏靶向乙酰辅酶A 羧化酶 (ACC) 抑制剂，ACC 是脂肪酸合成的限速酶。
T37184	CX08005 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid	Phosphatase	Metabolism
	CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂，可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。
T63016	Nrf2 activator-4	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂（EC50: 0.63 μM），对小神经胶质细胞中活性氧的产生有抑制作用，用于治疗人类代谢功能障碍相关的脂肪肝病。
T12408	Perhexiline maleate	Others; Mitochondrial Metabolism	Metabolism; Others
	Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。
T26165	Rubratoxin B
	Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.
T68370	Sdz 51641
	Sdz 51641 is an inhibitor of fatty acid oxidation which is highly selective for the liver.
T40302	FXR/TGR5 agonist 1
	FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
T35801	ML-262
	ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit fatty acid uptake (up to 50 μM).
T78093	Cisd2 agonist 1	Others	Others
	Cisd2 agonist 1 (Compound 4q)为一种EC50值为34 nM的Cisd2激动剂，可增强Cisd2表达并改善非酒精性脂肪肝疾病（NAFLD）的病理改变，同时具备良好的代谢稳定性，适用于NAFLD研究。
T75150	GIP/GLP-1 dual receptor agonist-1
	GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病，包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。
T11448	GOAT-IN-1	Others	Others
	GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral infa
T74132	GLP-1 receptor agonist 8
	GLP-1 receptoragonist 8 是一种有效的GLP-1R 激动剂。GLP-1 receptoragonist 8 具有研究糖尿病、肥胖和非酒精性脂肪肝 (NAFLD) 的潜力。
T35620	Ethoxyquin Dimer
	Ethoxyquin dimer is an antioxidant and metabolite of ethoxyquin .1 It prevents oxidation of polyunsaturated fatty acids in fish meal and fish oil. Dietary administration of ethoxyquin dimer (0.1, 0.3, and 0.5% w/w) induces microvesicular steatosis and hepatocyte necrosis, as well as increases liver levels of oxidized glutathione and total lipids in mice.2
T83421	1-Palmitoyl-sn-glycerol 3-phosphate 1-P-GPA
	1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) 是内源性代谢物，常用于非酒精性脂肪性肝病的研究。
T62029	ML261
	ML261 是肝脂滴形成的抑制剂，IC50值为 69.7 nM。ML261 在非酒精性脂肪性肝病 (NAFLD) 和炎症中具有研究价值。
T21978	p-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T78313	Fazpilodemab BFKB8488A	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Fazpilodemab (BFKB8488A) 是靶向 FGFR1c 和 Klothoβ 的激动性人源化双特异性抗体，适用于T2DM或NAFLD的研究。
T35512	(±)16-HDHA
	(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T36607	(±)8-HDHA
	(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T37408	Bischloroanthrabenzoxocinone
	Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 μg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 μg/ml. BABX also displays binding to liver X receptors (LXRs)...
T35508	(±)13-HDHA
	(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T35504	(±)10-HDHA
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid. Reference：[1]. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate. J. Lipid Res. 25(5), 507-517 (1984).[2]. Reynaud, ...
T37652	5(S),6(R)-DiHETE
	5(S),6(R)-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A4 (LTA4). Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA4 to 5(S),6(R)-DiHETE. It is a weak LTD4 receptor agonist in guinea pig lung membranes. It induces guinea pig ileum contraction with an ED50 value of 1.3 μM.
T35634	Platensimycin
	Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ...
T36606	(±)7-HDHA
	(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T37405	Octanoyl Coenzyme A (sodium salt)
	Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase.
T35443	1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
	1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral loss MS. Increased serum levels of 1-palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol are a potential biomarker for non-alcoholic fatty liver disease (NAFLD).
T37229	(±)8,9-DiHETE
	(±)8,9-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid .[1] It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases. Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.[2]
T69622	Ritivixibat
	Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂，同时也是胆汁酸调节剂，主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。
T36602	(±)4-HDHA
	(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also produces 4-HDHA. However, the enzymatic product is most likely the S-isomer. (±)4-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T73762	11,12-DiHETrE
	11,12-DiHETrE，一种细胞色素P450 (P450) 类二十烷素内源性代谢产物，用于早产研究，并可作为区分NAFL(非酒精性脂肪肝)与NASH(非酒精性脂肪性肝炎)的生物标志物。
T62277	PPARδ agonist 8
	Pparδ agonist 8 是一种 Pparδ 的有效激动剂。其中过氧化物酶体增殖物激活受体 (PPAR) 属于核内受体转录因子超家族，在体内代谢稳态、炎症、细胞生长和分化的调节中具有关键作用。Pparδ agonist 8 具有潜力进行非酒精性脂肪肝 (NAFLD) 的研究。
T72889	FXR agonist 4
	FXR agonist4，一种法尼酯X受体(FXR)激动剂，具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症，因此可用于非酒精性脂肪性肝病(NAFLD)的研究。
T78095	Demethyleneberberine chloride	NF-κB	NF-κB
	Demethyleneberberine chloride是一种具有线粒体靶向性的天然抗氧化剂，能通过抑制NF-κB通路及调节Th细胞平衡来缓解小鼠结肠炎并抑制炎症。此外，作为一种AMPK激活剂，该化合物亦用于非酒精性脂肪性肝病（NAFLD）的研究。
T82719	Cisd2 agonist 2
	Cisd2 agonist 2（compound 6）是Cisd2激活剂，具有191 nM的EC50值，其中Cisd2水平与NAFLD相关。在Cisd2hKO-het小鼠（杂合子肝细胞特异性Cisd2敲除）中，Cisd2 agonist 2未显示出显著的体内毒性。
T35505	(±)11-HDHA
	(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelets and canine retina. In addition to 11(S)-HDHA, 14(S)-HDHA is also produced by platelets. 11(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 50, 4.7, and 7.5 μM, respe...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T80060	Pyruvate carboxylase	Endogenous Metabolite	Metabolism
	Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。
T37904	Gadoleic Acid
	Gadoleic acid is a monounsaturated fatty acid.1,2It inhibits the dsDNA binding activity of p53 when used at a concentration of 1.2 nM.1Hepatic levels of gadoleic acid are reduced in rats fed a high-fat or a high-fat high-cholesterol diet and increased in rats fed a high-cholesterol diet.2 1.Iijima, H., Kasai, N., Chiku, H., et al.The inhibitory action of long-chain fatty acids on the DNA binding activity of p53Lipids41(6)521-527(2006) 2.Serviddio, G., Bellanti, F., Villani, R., et al.Effects of ...
T70899	Vidofludimus hemicalcium 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
	Vidofludimus (4sc-101 ; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂，也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂，可用于研究自身免疫性疾病，如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向FXR 用于脂肪肝的研究。
T36601	(±)17-HDHA
	(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 μM, respectively. (±)17-HDHA is a potential marker of ox...
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) 可降低 HepG2 和 3T3-L1 细胞中的脂质含量并激活AMPK 通路。AMPK activator 6 对血清中甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白-C (LDL-C) 和其他生化指标的增加有显著的抑制作用。AMPK activator 6 在非酒精性脂肪肝（NAFLD）和代谢综合征中有研究价值。
T82254	GSK-LSD1	Histone Demethylase	Chromatin/Epigenetic
	GSK-LSD1是一种LSD1抑制剂，能够降低肥胖小鼠模型的摄食量和体重，同时提升胰岛素敏感性与血糖控制。此外，GSK-LSD1对NAFLD也有改善作用，并能抑制COVID-19患者PBMC中SARS-CoV-2诱导的细胞因子释放。GSK-LSD1对抑制癌症的生长与转移也显示出潜在效果。
T35509	(±)14-HDHA
	(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA. 14(S)-HDoHE is also produced by salmon gills upon stimulation with calcium ionophore. 14(S)-HDHA was shown to be an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3...

化合物

Cat.No: T12580

Target: COX, Epoxide Hydrolase

Cat.No: T2601

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Cat.No: T12883

Synonym: PBI-4050,3-戊基苯乙酸,Setogepram

Target: GPR

Cat.No: T6714

Synonym: KDS-4103,FAAH Inhibitor II

Target: Mitophagy, FAAH, Autophagy

Cat.No: T9010

Target: Others, AMPK

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

Cat.No: T9209

Synonym: STAT5 Inhibitor III,NSC 170984,R 6238,,Clesacostat

Target: Acetyl-CoA Carboxylase

Cat.No: T37184

Synonym: 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid

Target: Phosphatase

Nrf2 activator-4

Cat.No: T63016

Target: Reactive Oxygen Species, Nrf2

Perhexiline maleate

Cat.No: T12408

Target: Others, Mitochondrial Metabolism

Cat.No: T26165

Cat.No: T68370

FXR/TGR5 agonist 1

Cat.No: T40302

Cat.No: T35801

Cisd2 agonist 1

Cat.No: T78093

Target: Others

GIP/GLP-1 dual receptor agonist-1

Cat.No: T75150

Cat.No: T11448

Target: Others

GLP-1 receptor agonist 8

Cat.No: T74132

Ethoxyquin Dimer

Cat.No: T35620

1-Palmitoyl-sn-glycerol 3-phosphate

Cat.No: T83421

Synonym: 1-P-GPA

Cat.No: T62029

p-nitro-Pifithrin-α

Cat.No: T21978

Cat.No: T78313

Synonym: BFKB8488A

Target: FGFR

Cat.No: T35512

Cat.No: T36607

Bischloroanthrabenzoxocinone

Cat.No: T37408

Cat.No: T35508

Cat.No: T35504

5(S),6(R)-DiHETE

Cat.No: T37652

Cat.No: T35634

Cat.No: T36606

Octanoyl Coenzyme A (sodium salt)

Cat.No: T37405

1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol

Cat.No: T35443

Cat.No: T37229

Cat.No: T69622

Cat.No: T36602

Cat.No: T73762

PPARδ agonist 8

Cat.No: T62277

Cat.No: T72889

Demethyleneberberine chloride

Cat.No: T78095

Target: NF-κB

Cisd2 agonist 2

Cat.No: T82719

Cat.No: T35505

Cat.No: T35881

Pyruvate carboxylase

Cat.No: T80060

Target: Endogenous Metabolite

Cat.No: T37904

Vidofludimus hemicalcium

Cat.No: T70899

Synonym: 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium

Cat.No: T36601

AMPK activator 6

Cat.No: T62052

Cat.No: T82254

Target: Histone Demethylase

Cat.No: T35509

Cat. No.	Product Name	Target	Signaling Pathways
T7529	Yamogenin 山药	Others	Others
	Yamogenin 是一种薯蓣皂素的非对映异构体。它通过抑制 HepG2 肝细胞中脂肪酸合成的基因表达来抑制甘油三酸酯 (TG) 的积累。它在萤光素酶配体测定中拮抗肝脏 X 受体 (LXR) 的激活。
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
T4854	Acetoacetic acid lithium salt LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂	Others; Endogenous Metabolite	Metabolism; Others
	Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) 是内源性代谢产物的一种。
T0461L	Berberine sulfate AI3-61947,Berberin sulfate,Berberine sulphate,Berberal
	Berberine sulfate (Berberal) 是苄基异喹啉生物碱原小檗碱类的季铵盐，可用于研究2型糖尿病、腹部肥胖和代谢相关脂肪性肝病。
T3804	Neomangiferin Mangiferin 7-glucoside,新芒果苷	Phosphatase	Metabolism
	Neomangiferin (Mangiferin 7-glucoside) 是一种天然的 C-glucosyl xanthone，分离自干燥的Anemarrhena asphodeloides 的根茎中。它能够减轻大鼠高脂饮食诱导的非酒精性脂肪性肝病 (NAFLD)。
T3S1513	(20R)-Protopanaxadiol Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol	Others; Antibacterial	Microbiology/Virology; Others
	(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长，有抗肿瘤活性和细胞毒性。
T4867	Erucic acid Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid	PI3K; Endogenous Metabolite	Metabolism; PI3K/Akt/mTOR signaling
	Erucic acid (13(Z)-Docosenoic Acid) 是单不饱和脂肪酸，分离自萝卜的种子。Erucic acid 可以容易地穿过血脑屏障，使大脑中长链脂肪酸的积累正常化。Erucic acid 能够改善认知障碍并有效预防痴呆。
T4129	Arachidonic acid Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar	Others; Endogenous Metabolite	Metabolism; Others
	Arachidonic acid (Immunocytophyte) 是不饱和的必需脂肪酸。它存在于动物和人类脂肪以及肝脏、大脑和腺体器官中，是动物磷脂的成分。它由膳食亚油酸合成而成，是前列腺素、血栓素和白三烯生物合成的前体。
TJO2758	D-Glucuronic acid D-葡萄糖醛酸,Aldehydo-D-Glucuronic Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) 是一种从许多树胶中分离出的重要中间体。它对皮肤具有抗炎作用。它及其衍生物葡萄糖醛酸内酯作为预防人类健康的肝脏解毒剂。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
T7732	Carbenoxolone Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral	Dehydrogenase; Gap Junction Protein	Cytoskeletal Signaling; Metabolism
	Carbenoxolone (Carbenoxolona) 是 11β-HSD 和 gap junction connexin 通道的抑制剂。 Carbenoxolone 抑制巨噬细胞迁移到心房并防止脂肪肝的发展。
TN5431	Icariside E4	Antioxidant; AMPK; Liver X Receptor; Lipid; Fatty Acid Synthase	Chromatin/Epigenetic; Metabolism; oxidation-reduction; PI3K/Akt/mTOR signaling
	Icariside E4是一种从小叶榆中提取得到天然化合物，通过AMPK 磷酸化和抑制HepG1细胞中MID1IP2的低脂化作用。Icariside E4具有抗伤害，抗氧化，抗阿尔茨海默氏症和抗炎作用，抑制了SREBP-1c，肝脏X 受体-α（LXR）和FASN 在HepG2细胞中从头脂肪生成的表达。Icariside E4是治疗脂肪肝疾病的有效候选药物，在HepG1细胞中具有低脂化潜力。
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T7529

Synonym: 山药

Target: Others

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

Acetoacetic acid lithium salt

Cat.No: T4854

Synonym: LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂

Target: Others, Endogenous Metabolite

Berberine sulfate

Cat.No: T0461L

Synonym: AI3-61947,Berberin sulfate,Berberine sulphate,Berberal

Cat.No: T3804

Synonym: Mangiferin 7-glucoside,新芒果苷

Target: Phosphatase

(20R)-Protopanaxadiol

Cat.No: T3S1513

Synonym: Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol

Target: Others, Antibacterial

Cat.No: T4867

Synonym: Prifac 2990,芥酸,13(Z)-Docosenoic Acid,cis-13-docosenoic acid

Target: PI3K, Endogenous Metabolite

Arachidonic acid

Cat.No: T4129

Synonym: Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar

Target: Others, Endogenous Metabolite

D-Glucuronic acid

Cat.No: TJO2758

Synonym: D-葡萄糖醛酸,Aldehydo-D-Glucuronic Acid

Target: Others, Endogenous Metabolite

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Cat.No: T7732

Synonym: Biogastrone,甘珀酸,Carbenoxolona,Carbenoxolone,Bioral

Target: Dehydrogenase, Gap Junction Protein

Cat.No: TN5431

Target: Antioxidant, AMPK, Liver X Receptor, Lipid, Fatty Acid Synthase

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Cat.No: T35624

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