125
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8701 |
GRP-60367
|
Others | Others |
GRP-60367 是一种小分子狂犬病病毒进入抑制剂,对某些 RABV 株具有纳摩尔作用效果。 | |||
T9231 |
Mbx2329
|
Antiviral | Immunology/Inflammation |
MBX2329 是一种流感病毒抑制剂,能特异性地抑制血凝素介导的病毒进入,HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。 | |||
T8793 |
CBS1117
|
Influenza Virus | Microbiology/Virology |
CBS1117 是一种病毒进入抑制剂,对甲型流感病毒 A/Puerto Rico/8/34 的 IC50为 70 nM。它干扰血凝素介导的融合过程。 | |||
T9717 |
Chlorcyclizine
|
HCV Protease; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Chlorcyclizine 是一种有效的组胺 H1拮抗剂。 | |||
T35373L |
Bulevirtide (Myrcludex B) acetate
|
HBV | Microbiology/Virology |
Bulevirtide (Myrcludex B) acetate 是一种病毒粒子进入抑制剂,可阻断病毒粒子的肝细胞进入途径,即肝钠/牛磺胆酸盐协同转运多肽 (NTCP) 受体。它可用于 HBV 和 HDV 感染研究。 | |||
T6256 |
YYA-021
YYA 021 |
gp120/CD4; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
YYA-021具有高抗HIV 活性和低细胞毒性,是一种抑制HIV 进入的小分子CD4模拟物,。 | |||
T24141 |
HIV-1 Inhibitor 18A
HIV-1 Inhibitor-18A |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) 特异性抑制多种 HIV-1 分离株的进入。 | |||
T13047 |
Synta66
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Synta66 是一种钙池操纵钙离子通道 Orai 抑制剂,用于神经系统疾病的研究。 | |||
T16688 |
Pyr6
N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。 | |||
T24984 |
5J-4
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
5J-4 是一种有效的钙释放激活钙通道 (CRAC) 和钙池操纵性钙内流(SOCE) 阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。 | |||
T13684 |
Equilin
7-Dehydroestrone |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Equilin (7-Dehydroestrone) 是神经营养性雌激素类固醇,具有血管扩张活性,通过 NF-κB 信号传导增加单核细胞-内皮粘附。Equilin 通过阻断Ca(2+)进入平滑肌来同样放松肠系膜动脉的阻力。 | |||
T15641 |
K777
APC-3316 |
P450; Cysteine Protease; CCR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
K777 是有效的,具有口服活性的,不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂。K777是有效的 CYP3A4 抑制剂(IC50= 60 nM)。K777也是选择性的 CCR4 拮抗剂,显示出强的趋化性抑制作用。K777 对 Cruzain(克鲁斯锥虫的主要半胱氨酸蛋白酶)和组织蛋白酶 B 和 L 具有不可逆的抑制作用。K777 通过靶向组织蛋白酶介导的细胞进入,显示出广谱的抗病毒作用。K777 抑制 EBOV 和 SARS-CoV 病毒的进入,IC50 值分别为 0.87 nM 和 0.68 nM。 | |||
T3052 |
Sancycline
Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline |
Antibacterial | Microbiology/Virology |
Sancycline (Bonomycin) 是半合成四环素,通过可逆地结合 30S 核糖体亚基并通过阻断氨酰-tRNA 进入核糖体 A 位点来抑制蛋白质翻译。 | |||
T8502 |
N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide
|
Influenza Virus | Microbiology/Virology |
N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide 通过与表面糖蛋白结合抑制埃博拉病毒进入宿主细胞,该化合物抑制埃博拉病毒,EC50 为 3.9 μM。 | |||
T26357 |
Pitstop 2
|
Apoptosis | Apoptosis |
Pitstop2 是一种选择性的两性蛋白结合的网格蛋白末端结构域抑制剂,IC50 值为 12 μM。 Pitstop2 严重干扰受体介导的内吞作用、HIV 进入和突触小泡循环。 | |||
T6016 |
Maraviroc
Celsentri,马拉维若,UK-427857,Selzentry |
HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Maraviroc (Selzentry) 是一种 C-C 趋化因子受体 5 拮抗剂,具有抑制HIV 的活性。 | |||
T9807 |
CPDS
|
Others | Others |
CPDS 是一种非渗透性硫醇剂,可影响多种线粒体功能。在大鼠肝线粒体中,它仅抑制 Pi/OH- 载体。它和丙二酸正丁酯都是完全抑制 Pi 进入所必需的。 | |||
T60085 |
MM3122
GTPL11533,MM-3122,Ac-GQFR-kbt |
SARS-CoV | Microbiology/Virology |
MM3122 (MM-3122) 是一种选择性的 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂,IC50为 0.34 nM。MM3122 可以有效阻断 TMPRSS2,从而抑制 SARS-CoV-2 和 MERS-CoV 进入人类细胞。 | |||
TP1828 |
N-Acetyl-Ser-Asp-Lys-Pro
|
RAAS | Endocrinology/Hormones |
N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。 它抑制多能造血干细胞进入细胞周期的 S 期,并防止小鼠中的 Ara-C 致死性。 | |||
T76687 |
Ibalizumab
TNX-355,TMB-355 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ibalizumab(TMB-355) 是一种人源化 IgG4 单克隆抗体,可作为 CD4 受体抑制, 通过与 CD4 受体结合来阻止 HIV-1进入细胞。Ibalizumab 具有抗HIV-1感染活性,可用于维持机体正常免疫功能。 | |||
T0806 |
Flunarizine dihydrochloride
Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪 |
Calcium Channel; Dopamine Receptor; Sodium Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。 | |||
T11076 |
Dooku1
|
Others | Others |
Dooku1 是Yoda1 的类似物,是一种内源性Piezo1通道的选择性拮抗剂,能够抑制Yoda1 诱导的主动脉舒张。它在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50值分别为1.3 μM 和1.5 μM。 | |||
T1127 |
Beclometasone dipropionate
Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase |
Glucocorticoid Receptor | Endocrinology/Hormones |
Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。 | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T8501 |
3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide
|
Influenza Virus | Microbiology/Virology |
3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide 具有抗埃博拉病毒的抗病毒活性靶向表面暴露的糖蛋白并抑制病毒进入宿主细胞。 Vero 细胞的体外研究表明,该化合物抑制病毒复制,EC50 为 0.38 μM。 | |||
T0957 |
Isradipine
PN 200-110,伊拉地平 |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂,具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂,也是一种潜在可行的帕金森病神经保护剂。 | |||
T27407 |
GDC0575 monohydrochloride
ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575 |
Chk | Cell Cycle/Checkpoint |
GDC0575 monohydrochloride (ARRY575) 是一种有效的、选择性的细胞周期检查点激酶 1(Chk1) 抑制剂,IC50 为 1.2 nM。GDC0575 monohydrochloride (ARRY575) 特异性结合并抑制 Chk1;这可能导致肿瘤细胞在 S 期和 G2/M 期绕过 Chk1 依赖性细胞周期停滞,从而允许细胞在进入有丝分裂之前进行 DNA 修复。 | |||
T27625 |
IQP-0528
SJ-3991,SJ3991,IQP0528 |
Antiviral; HIV Protease; Reverse Transcriptase | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
IQP-0528是一种高效的非核苷类逆转录酶抑制剂(NNRTI),通过阻断病毒进入,有可能用于治疗HIV 感染,并且作为杀微生物凝胶显示出抗病毒活性。IQP-0528对HIV-1和HIV-2都显示出抑制作用,对HIV-1的EC50为0.2 nM,对HIV-2的EC50为100 nM。 | |||
T9864 |
Debio-0123
WEE1-IN-5 |
Wee1 | Cell Cycle/Checkpoint |
Debio-0123 (WEE1-IN-5) 是一种口服有效且高度特异性的WEE1抑制剂,IC50值在低纳摩尔范围内。Debio-0123 抑制磷酸化 CDC2。Debio-0123 可增强卡铂在体内的抗肿瘤活性,而这两种药物单独使用都没有活性。 | |||
T16686 |
Pyr10
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
T75342 |
MitoSOX Red
|
Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
MitoSOX Red 是一种具有特异性和细胞膜渗透性且靶向活细胞线粒体的新型荧光探针。MitoSOX Red 进入线粒体后会被超氧化物氧化,而不会被其他 ROS 或 RNS 生成系统氧化。MitoSOX Red 随后与线粒体内核酸结合,产生强红色荧光。MitoSOX Red 可以作为荧光指示剂,特异性检测超氧化物。超氧化物歧化酶 (Superoxide dismutase,SOD) 能够预防 MitoSOX Red 氧化。 | |||
T2170 |
SKF-96365 hydrochloride
1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365 |
Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism |
SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂,也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流,延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。 | |||
T24522 |
NBD-10007
NBD 10007 |
||
NBD-10007 is an inhibitor of HIV-1 entry. | |||
T24521 |
NBD-09027
NBD 09027 |
||
NBD-09027 is an inhibitor of HIV-1 entry. | |||
T23770 |
B07 hydrochloride
B 07 HCl,B-07 HCl,B-07 hydrochloride,B07 HCl,B 07 hydrochloride |
||
B07 hydrochloride is a CCR5 antagonist-based inhibitor of HIV-1 entry. | |||
T26120 |
Ronipamil
Ronipamilo |
||
Ronipamil is an analogue of verapamil that used as a calcium entry blocker. | |||
T71871 |
EI-1
|
||
EI-1 is an inhibitor of Hepatitis C virus entry. | |||
T27641 |
ITX-4520
ITX 4520 |
||
ITX-4520 novel highly potent, orally bioavailable inhibitor of hepatitis C virus (HCV) entry. | |||
T15733 |
Lemildipine
NB-818,NPK-1886 |
Others | Others |
Lemildipine is a new blocker of dihydropyridine calcium entry. | |||
T70517 | CB5660386 | ||
CB5660386 inhibitor of HIV-1 entry. | |||
T12947 |
SOCE inhibitor 1
|
Others | Others |
SOCE inhibitor 1 is a inhibitor of store-operated calcium entry (SOCE)(IC50 of 4.4 μM). | |||
T71712 | NPD8716 | ||
NPD8716 is a hepatitis B/D virus entry inhibitor, targeting sodium taurocholate cotransporting polypeptide (NTCP). | |||
T68501 |
Noremopamil
|
||
Noremopamil is a calcium entry blocker, also being used as the precursor for radiolabelling emopamil. | |||
T39300 |
BNM-III-170
|
||
BNM-III-170 is able to inhibit HIV-1 viral entry into target cells. | |||
T71996 | VU0621623 | ||
VU0621623 is an arenavirus multiplication inhibitor which blocks lymphocytic choriomeningitis virus (LCMV) cell entry. | |||
T26999 |
CGP64222
CGP-64222,CGP 64222 |
||
CGP64222, a peptoid Tat/transactivation response element inhibitor, inhibits human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry. | |||
T68454 | IAV inhibitor 4l | ||
IAV inhibitor 4l is an IAV inhibitor targeting hemagglutinin and mediates viral entry by preventing HA-membrane fusion. | |||
T71056 |
SJP-L-5
|
||
SJP-L-5 is a inhibitor of HIV-1 infection by blocking viral DNA nuclear entry. | |||
T26830 |
BK 129
BK-129,BK129 |
||
BK 129 is a local anesthetic with relaxant properties. BK 129 inhibits Ca2+ entry into the smooth muscle cell and Ca2+ release from sarcoplasmic reticulum. | |||
T27038 |
CL385319 HCl
CL-385319,CL385319 hydrochloride,CL 385319,CL385319 |
||
CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2S0731 |
Trilobatin
三叶苷,三叶甙,P-Phlorizin |
Amylase | Metabolism |
Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂,是一种HIV-1抑制剂,靶向 Gp41 包膜蛋白,具有神经保护作用。它还是SGLT1/2抑制剂,可选择性诱导人肝母细胞瘤细胞增殖。 | |||
T19719 |
TBMP
butylated hydroxyanisole |
Others | Others |
TBMP (butylated hydroxyanisole) 是病毒包膜蛋白血凝素 (HA) 介导的进入新型抑制剂。 | |||
T11287 |
Filipin complex
|
Antifungal | Microbiology/Virology |
Filipin complex 是一种 28 元环戊烯大环内酯类抗真菌抗生素,由 S. filipinensis、S. avermitilis 和 S. miharaensis 产生的混合物,抑制 PRRSV 病毒进入细胞,通过与膜固醇相互作用发挥作用。 | |||
T0846 |
L-Carnitine
L(-)-Carnitine,Levocarnitine,左旋肉碱 |
Endogenous Metabolite; Fatty Acid Synthase | Metabolism |
L-Carnitine (L(-)-Carnitine) 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T0884 |
1-Docosanol
Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol |
Antifection; HSV | Microbiology/Virology |
1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇,局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。 | |||
T2A2498 |
L-Lysine
Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸 |
Virus Protease; Endogenous Metabolite; Antifection | Metabolism; Microbiology/Virology |
L-Lysine (Aminutrin) 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。 | |||
TN6508 |
Trachelogenin
(-)-Trachelogenin |
Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum,是一种 HCV 进入抑制剂 具有抗增殖作用,其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关,且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性,在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
TN5234 |
Vindorosine
|
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. | |||
T20123 |
L-Carnitine hydrochloride
L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80 |
||
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en | |||
TN4605 | Myriceric acid B | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val | |||
T35415 | α-D-Glucose-1,6-bisphosphate (potassium salt hydrate) | ||
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol... |