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128

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2176	2,3-Butanedione 2-Monoxime Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) 是一种肌球蛋白 ATP 酶(myosin ATPase) 抑制剂。它诱导肌质网 Ca2+释放，能够有效抑制骨骼肌和心肌收缩。
T34280	Regrelor disodium INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589	P2Y Receptor	GPCR/G Protein; Neuroscience
	Regrelor disodium (INS 50589) 是一种 p2y12 受体拮抗剂，可预防血栓形成，可有效抑制血管平滑肌细胞收缩，抑制细胞增殖，减少炎症。
T25719	Lidamidine Lidamidina,Lidamidinum,利达脒	Others	Others
	Lidamidine (Lidamidinum) 是一种临床有效的止泻化合物，可抑制肠道分泌，减少肠道转运，并抑制平滑肌收缩。
TP2419	V-9-M Cholecystokinin nonapeptide V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M	Beta Amyloid	Neuroscience
	V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) 是胆囊收缩素(CCK)的前体化合物。胆囊收缩素(CCK)是一种刺激胆囊收缩和胰腺外分泌的脑肠肽，可从狗和猫的小肠中提取的，可以引起胆囊收缩。
T4054	Dantrolene sodium hemiheptahydrate Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Dantrolene sodium hemiheptahydrate (Sodium dantrolene) 是一种钙通道蛋白抑制剂, 抑制钙离子从肌浆释放, 它是一种乙内酰脲衍生物和直接作用的骨骼肌松弛剂。
T25372	EMD57033 EMD-57033,(+)-EMD 57033,EMD 57033	Calcium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	EMD57033是一种心脏肌钙蛋白C（cTnC）激活剂，是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。
TP2036L	DPDPE TFA (88373-73-3 free base) DPDPE TFA	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DPDPE TFA 是选择性 δ-阿片受体激动剂肽，在体内具有镇痛作用。
T28164	Nexopamil LU49938,LU 49938,LU-49938	Calcium Channel; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nexopamil (LU-49938) 是一种钙通道拮抗剂，是一种5-羟色胺2A 受体拮抗剂。Nexopamil 可抑制5-HT 诱导的间质细胞收缩和增殖。
TP1883	[Lys5,MeLeu9,Nle10]-NKA(4-10)	Neurokinin receptor	GPCR/G Protein; Neuroscience
	[Lys5,MeLeu9,Nle10]-NKA(4-10) 是高选择性和强效 NK2 受体激动剂，IC50值为 6.1 nM，可诱导大鼠眼底和膀胱收缩，EC50 值分别为 117 和 10 nM。
T1215	Nicardipine hydrochloride 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride	Calcium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。
T6625	Ozagrel hydrochloride Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂，用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T10101	Calcium channel-modulator-1	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM)，具有阻塞主动脉收缩的专业化。
T6236	Ozagrel 奥扎格雷,OKY-046,Domenan	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂，可抑制哮喘。它也是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
TP1198	Sincalide ammonium SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium	cholecystokinin	GPCR/G Protein
	Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物，是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩，常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。
T4132	BPTU BMS-646786	P2Y Receptor	GPCR/G Protein; Neuroscience
	BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂，能够阻断位于胃肠道神经肌肉接头的 P2Y1受体，具有抗血栓活性。
TP2279L	Obestatin (rat) acetate	GHSR	GPCR/G Protein
	Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。它抑制食物摄入，抑制空肠收缩，并减少体重增加。
T5856	Barnidipine hydrochloride 盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Barnidipine hydrochloride (YM-09730-5 hydrochloride) 是一种二氢吡啶类钙通道阻滞剂，对 CaA 受体具有选择性作用。它是一种抗高血压药物，通过减少其血管扩张作用继发的外周血管阻力起作用。
T11918L	Lysipressin acetate(50-57-7(fb_acetate)) Lysine vasopressin acetate,[Lys8]-Vasopressin acetate	Others	Others
	Lysipressin acetate(50-57-7(fb_acetate)) ([Lys8]-Vasopressin acetate) 诱导兔膀胱平滑肌收缩，激活腺苷酸环化酶。 Lysipressin 是一种抗利尿激素，已在猪和一些有袋动物家族中发现。
T0077	Dantrolene sodium Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Dantrolene sodium (Lapatinib ditosylate monohydrate) salt 是一种骨骼肌松弛药，是一种钙通道蛋白抑制剂，可抑制钙离子从肌浆释放。
T2525	Alosetron hydrochloride Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alosetron hydrochloride (GR 68755) 是一种高选择性的 5-HT3 受体拮抗剂，可减轻清醒或麻醉犬直肠扩张的内脏伤害性效应，具有抗炎活性，用于肠易激综合征的研究。它阻断 5HT3 介导的豚鼠肌间和粘膜下神经元的快速去极化，IC50约为 55 nM。
T1613	Hydralazine hydrochloride Hydralazine HCl,Apresoline,盐酸肼屈嗪	MAO; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂，可抗高血压。
TP2106L	Urantide acetate(669089-53-6 free base)	Neurotensin Receptor	GPCR/G Protein
	Urantide acetate(669089-53-6 free base) 是一种选择性和竞争性的 urotensin-II (UT) 受体拮抗剂 (pKB = 8.3)。体外阻断 hU-II 诱导的胸主动脉收缩。对去甲肾上腺素或内皮素 1 诱导的收缩或乙酰胆碱诱导的松弛没有影响。在钙动员测定（在表达 hUT 受体的 CHO 细胞中）中表现为部分激动剂。
T72038	YM-58790 YM-58790 free base	AChR	Neuroscience
	YM-58790 free base 是一种高效的 mAChR 拮抗剂。YM-58790 free base 对 M1 mAChR、M2 mAChR 和 M3 mAChR具有抑制作用， Ki 值分别为 28 nM ，260 nM ，和 15 nM 。YM-58790 free base 通过抑制膀胱加压来抑制大鼠的反射性节律性膀胱收缩。
T1115	Doxylamine succinate 琥珀酸多西拉敏,Decapryn	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂，具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应，可防止组胺引起的皮肤和粘膜疼痛和瘙痒。
T1139	Salbutamol Albuterol,沙丁胺醇,AH-3365	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。
T16739	RG-12525 NID 525	Leukotriene Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism
	RG-12525（NID 525）是一种可口服且具有选择性和竞争性的白三烯 D （LTD）拮抗剂，对 LTC4，LTD4 和 LTE4 诱导的豚鼠薄壁带收缩有抑制作用，IC50 值分别为 2.6 nM，2.5 nM 和 7 nM。RG-12525 对 CYP3A4 有抑制作用， Ki 值为 0.5 µM。RG-12525 是一种新型高效的 PPAR-γ 激动剂（IC50 值约为 60 nM），具有物种特异性，可用于研究哮喘。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T21610	Bradykinin (acetate)	Bradykinin Receptor	GPCR/G Protein
	Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质，也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生，是一种强大的血管扩张剂，可引起平滑肌收缩，并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。
T1577	Midodrine hydrochloride Pro-Amatine,盐酸米多君	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差，因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式，是一种直接作用的前药和拟交感神经药，具有抗低血压特性。
T22232	Alfuzosin
	Alfuzosin 是选择性和竞争性的α1肾上腺素受体拮抗剂，可用于良性前列腺增生（BPH）的研究。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T27364	FR 75513 FR-75513,FR75513
	FR 75513 inhibits the contraction of guinea pig detrusor muscle .
T68882	Clodanolene sodium
	Clodanolene sodium is a skeletal muscle contraction antagonist.
T23739	Antho-riamide I
	Antho-Riamide I is an active peptide. It also inhibits the spontaneous contraction of sea anemone muscles.
T70917	NA 0362
	NA 0362 is a derivative of SF 2370 that inhibits smooth muscle contraction.
T71443	Amphidinolide D
	Amphidinolide D is a powerful activator of actomyosin ATPase enhances skeletal muscle contraction.
T26970	CD-349 CD 349,CD349
	CD-349 is a calcium channel antagonist. CD-349 inhibits the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium.
TP1098	Motilin, canine Motilin (canine)
	Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist.
T71579	GOE-5438
	GOE-5438 is a calcium antagonist that has been shown to inhibit the excitation and contraction of single cardiomyocytes.
T68698	VPC 23153
	VPC 23153 is a sphingosine 1-phosphate 4 receptor agonist. This hygroscopic phospholipid causes contraction of pulmonary artries in rats.
T27829	Lidamidine Hydrochloride WHR1142A,WHR-1142A,Lidaral,WHR 1142A
	Lidamidine Hydrochloride is an alpha2-adrenergic receptor agonist. Lidamidine Hydrochloride inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.
T34762	T-0201 T 0201,TA0201,TA-0201,TA 0201
	T-0201 (TA 0201) is a highly potent, long-acting, orally active, and selective ETA receptor antagonist. T-0201 also inhibited ET-1-induced pulmonary artery contraction in isolated rabbits.
T37493	11-trans Leukotriene D4 11-trans Leukotriene D4
	11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
T11629	Ifenprodil glucuronide	Others	Others
	Ifenprodil glucuronide, a derivative of Ifenprodil, is a vasodilator and an inhibitor of platelet aggregation. In contrast to Ifenprodil, Ifenprodil glucuronide does not affect platelet aggregation nor arterial contraction.
T40563	Sandaracopimaric acid
	Sandaracopimaric acid is an anti-inflammatory diterpenoid compound that effectively reduces the contraction of phenylephrine-induced pulmonary arteries. With an EC50 of 43.93 μM, it exhibits noteworthy anti-inflammatory properties.
T34458	Ryanodol
	Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T27164	DHP-218 PAK-9,PAK9,PAK 9,DHP218
	DHP-218 is a calcium channel antagonist. DHP-218 inhibits Calcium-induced contraction of the rat aorta in high K+ solution with the pA2 value of 9.11. The IC50 value for the inhibitory effects of DHP-218 in high K+-induced and phenylephrine-induced contra
T71021	Fendiline
	Fendiline is a coronary vasodilator that inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as an antiarrhythmic and antianginal agent.
T34958	TRK-380 TAC301,TAC 301,TAC-301,TRK 380,TRK380
	TRK-380 (TAC-301) is an effective and selective β3-adrenergic receptor agonist. TRK-380 improves formalin-induced frequent urination in rats and carbachol-induced bladder contraction in dogs (a decrease of 37.6%).
T78030	GRGESP
	GRGESP为胶原凝胶收缩抑制剂，能够抑制人成纤维细胞在胶原凝胶中的扩散，显著减少凝胶收缩，适用于结缔组织形态发生研究。

化合物

2,3-Butanedione 2-Monoxime

Cat.No: T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Regrelor disodium

Cat.No: T34280

Synonym: INS-50589,INS50589,Regrelor sodium,Regrelor,INS 50589

Target: P2Y Receptor

Cat.No: T25719

Synonym: Lidamidina,Lidamidinum,利达脒

Target: Others

V-9-M Cholecystokinin nonapeptide

Cat.No: TP2419

Synonym: V 9 M,Prepro CCK Fragment V-9-M,Val-pro-val-glu-ala-val-asp-pro-met,Cholecystokinin Precursor (24-32),V9M,V-9-M

Target: Beta Amyloid

Dantrolene sodium hemiheptahydrate

Cat.No: T4054

Synonym: Dantrolene sodium hydrate,Dantrolene sodium salt,Dantrium,丹曲林钠五水合物,Sodium dantrolene

Target: Calcium Channel, Autophagy

Cat.No: T25372

Synonym: EMD-57033,(+)-EMD 57033,EMD 57033

Target: Calcium Channel, Carbonic Anhydrase

DPDPE TFA (88373-73-3 free base)

Cat.No: TP2036L

Synonym: DPDPE TFA

Target: Opioid Receptor

Cat.No: T28164

Synonym: LU49938,LU 49938,LU-49938

Target: Calcium Channel, 5-HT Receptor

[Lys5,MeLeu9,Nle10]-NKA(4-10)

Cat.No: TP1883

Target: Neurokinin receptor

Nicardipine hydrochloride

Cat.No: T1215

Synonym: 盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride

Target: Calcium Channel, Adrenergic Receptor, AChR, Autophagy

Ozagrel hydrochloride

Cat.No: T6625

Synonym: Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Calcium channel-modulator-1

Cat.No: T10101

Target: Others, Calcium Channel

Cat.No: T6236

Synonym: 奥扎格雷,OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Sincalide ammonium

Cat.No: TP1198

Synonym: SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium

Target: cholecystokinin

Cat.No: T4132

Synonym: BMS-646786

Target: P2Y Receptor

Obestatin (rat) acetate

Cat.No: TP2279L

Target: GHSR

Barnidipine hydrochloride

Cat.No: T5856

Synonym: 盐酸巴尼地平,YM-09730-5 hydrochloride,Mepirodipine (hydrochloride)

Target: Calcium Channel

Lysipressin acetate(50-57-7(fb_acetate))

Cat.No: T11918L

Synonym: Lysine vasopressin acetate,[Lys8]-Vasopressin acetate

Target: Others

Dantrolene sodium

Cat.No: T0077

Synonym: Lapatinib ditosylate monohydrate,丹曲林钠,Dantrolene sodium salt

Target: Others, Calcium Channel

Alosetron hydrochloride

Cat.No: T2525

Synonym: Lotronex,盐酸阿洛司琼,GR 68755C,GR 68755,GR 68755X

Target: 5-HT Receptor

Hydralazine hydrochloride

Cat.No: T1613

Synonym: Hydralazine HCl,Apresoline,盐酸肼屈嗪

Target: MAO, HIF/HIF Prolyl-Hydroxylase

Urantide acetate(669089-53-6 free base)

Cat.No: TP2106L

Target: Neurotensin Receptor

Cat.No: T72038

Synonym: YM-58790 free base

Target: AChR

Doxylamine succinate

Cat.No: T1115

Synonym: 琥珀酸多西拉敏,Decapryn

Target: Histamine Receptor

Cat.No: T1139

Synonym: Albuterol,沙丁胺醇,AH-3365

Target: Adrenergic Receptor

Cat.No: T16739

Synonym: NID 525

Target: Leukotriene Receptor, PPAR

Cat.No: T68123

Target: Calcium Channel

Bradykinin (acetate)

Cat.No: T21610

Target: Bradykinin Receptor

Midodrine hydrochloride

Cat.No: T1577

Synonym: Pro-Amatine,盐酸米多君

Target: Adrenergic Receptor

Cat.No: T22232

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Cat.No: T27364

Synonym: FR-75513,FR75513

Clodanolene sodium

Cat.No: T68882

Antho-riamide I

Cat.No: T23739

Cat.No: T70917

Amphidinolide D

Cat.No: T71443

Cat.No: T26970

Synonym: CD 349,CD349

Motilin, canine

Cat.No: TP1098

Synonym: Motilin (canine)

Cat.No: T71579

Cat.No: T68698

Lidamidine Hydrochloride

Cat.No: T27829

Synonym: WHR1142A,WHR-1142A,Lidaral,WHR 1142A

Cat.No: T34762

Synonym: T 0201,TA0201,TA-0201,TA 0201

11-trans Leukotriene D4

Cat.No: T37493

Synonym: 11-trans Leukotriene D4

Ifenprodil glucuronide

Cat.No: T11629

Target: Others

Sandaracopimaric acid

Cat.No: T40563

Cat.No: T34458

Cat.No: T27164

Synonym: PAK-9,PAK9,PAK 9,DHP218

Cat.No: T71021

Cat.No: T34958

Synonym: TAC301,TAC 301,TAC-301,TRK 380,TRK380

Cat.No: T78030

Cat. No.	Product Name	Target	Signaling Pathways
T14865	Carboprost tromethamine	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Carboprost tromethamine 是合成的前列腺素 F2α的15-甲基类似物，能有效促进子宫的规律收缩，显着减少产中及产后出血量。
T3A2467	Allocryptopine Thalictrimine,Fagarine I,别隐品碱	Potassium Channel	Membrane transporter/Ion channel
	Allocryptopine (Thalictrimine) 是一种延胡索乙素的衍生物，提取自Corydalis decumbens。Allocryptopine 具有抗心律失常作用，能有效阻断hERG 电流。
T6S0109	Sipeimine Kashmirine,西贝母碱,Imperialine,西贝碱	Others	Others
	Sipeimine (Kashmirine) 是一种天然产物，从平贝母中分离得到。
T20604L	Litorin acetate(55749-97-8 Free base)	Bombesin Receptor	GPCR/G Protein
	Litorin acetate 是一种两栖类铃蟾肽衍生物，是一种铃蟾肽受体激动剂。它刺激平滑肌收缩，刺激胃泌素、胃酸和胰腺分泌，抑制体内营养。
T5014	Prostaglandin E2 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E2 (PGE2) 是一种天然激素，参与人体内的各种生理过程，包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。
T4739	Sodium creatine phosphate dibasic tetrahydrate 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate	Others; Endogenous Metabolite	Metabolism; Others
	Sodium creatine phosphate dibasic tetrahydrate (Creatine phosphate disodium salt tetrahydrate) 主要存在于脊椎动物的骨骼肌中，是测定肌酸激酶的底物，能够用于骨骼肌收缩过程中 ATP 的再生。
TN1528	Cotoin	AChE	Neuroscience
	Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性，可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。
T7995	α-Angelica lactone α-当归内酯,当归内酯,Alpha-Angelica Lactone	Others; GST	Others; oxidation-reduction
	α-Angelica lactone 是一种乙烯基亲核试剂，也是一种天然存在的抗癌剂。它可以得到手性的 δ-氨基 γ，γ-二取代丁烯醇内酯羰基衍生物，并在 γ-碳上表现出亲电子俘获。它通过选择性增强谷胱甘肽-S-硫转移酶 (GST) 和 UDP-葡糖苷转移酶 (UGT) 解毒酶发挥强大的化学保护作用。
T4S0998	Trifolirhizin 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷	TNF; Tyrosinase	Apoptosis; Proteases/Proteasome
	Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性，IC50=506 μM。它具有抗炎和抗癌的潜能。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
T20604	Litorin
	Litorin, an amphibian bombesin peptide derivative, is found to suppress the nutriment, to stimulate the contraction of smooth muscle, to stimulate gastrin, gastric acid, and pancreatic secretion.
T10913	Cyclobuxine D	Others	Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum.
TN4051	Fargesone B	cAMP; Calcium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Fargesone B inhibits the vascular smooth muscle contraction by suppressing the voltage- and receptor-activated calcium influxes in a nonselective manner.
TN4812	Pluviatolide	AChR	Neuroscience
	(-)-Pluviatolide can inhibit electrically-induced and acetylcholine-induced contraction in the isolated guinea-pig ileum.
TN4713	Onitisin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
TN4484	Macrophylline	Others	Others
	Macrophylline A shows weak inhibitory action on KCl-induced contraction.
T38609	Mycalolide B
	Mycalolide-B is a marine sponge-derived compound that functions as a selective inhibitor of actomyosin ATPase. It effectively hinders ATP-induced contraction and Mg2+-ATPase activity in the absence of Ca2+.
TN3483	Bakkenolide D	IL Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.
TN5330	Lacinilene C 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one
	Lacinilene C, lacinilene C 7-methyl ether, scopoletin, 2-hydroxy-7-methoxycadalene and 2,7-dihydroxycadalene are 5 induced phytoalexins in cotton leaves. Lacinilene C methyl ether elicits contraction of TSM by enhancing the movement of calcium through pot
T83454	13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride
	13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。
T75520	Aplyronine A
	Aplyronine A是具有特异性肌动蛋白解聚活性、抗肿瘤及促凋亡功能的化合物，适用于癌症、肌肉收缩、细胞运动和细胞分裂等研究领域。
TN5061	Stephanine	Adrenergic Receptor; Antifection	GPCR/G Protein; Microbiology/Virology; Neuroscience
	l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit...
TN1790	Isopteropodine Uncarine E	5-HT Receptor; Antibacterial; AChR	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Isopteropodine (Uncarine E) 是从 Hamelia patens micropropagated 分离得到的一种异育亨宾型辛吲哚生物碱.具有抗菌活性，可刺激机体免疫系统。Isopteropodine 是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂，是PXR激活剂，可诱导大鼠子宫肌层收缩。

天然产物

Carboprost tromethamine

Cat.No: T14865

Target: Prostaglandin Receptor

Cat.No: T3A2467

Synonym: Thalictrimine,Fagarine I,别隐品碱

Target: Potassium Channel

Cat.No: T6S0109

Synonym: Kashmirine,西贝母碱,Imperialine,西贝碱

Target: Others

Litorin acetate(55749-97-8 Free base)

Cat.No: T20604L

Target: Bombesin Receptor

Prostaglandin E2

Cat.No: T5014

Synonym: 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)

Target: Endogenous Metabolite, Prostaglandin Receptor

Sodium creatine phosphate dibasic tetrahydrate

Cat.No: T4739

Synonym: 磷酸肌酸二钠盐,Creatine phosphate disodium salt tetrahydrate

Target: Others, Endogenous Metabolite

Cat.No: TN1528

Target: AChE

α-Angelica lactone

Cat.No: T7995

Synonym: α-当归内酯,当归内酯,Alpha-Angelica Lactone

Target: Others, GST

Cat.No: T4S0998

Synonym: 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷

Target: TNF, Tyrosinase

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: T20604

Cat.No: T10913

Target: Others

Cat.No: TN4051

Target: cAMP, Calcium Channel

Cat.No: TN4812

Target: AChR

Cat.No: TN4713

Target: 5-HT Receptor

Cat.No: TN4484

Target: Others

Cat.No: T38609

Cat.No: TN3483

Target: IL Receptor, Histamine Receptor

Cat.No: TN5330

Synonym: 3,10-Dihydroxy-1,3,5,7-cadinatetraen-9-one

13-Hydroxylupanine hydrochloride

Cat.No: T83454

Synonym: Hydroxylupanine hydrochloride

Cat.No: T75520

Cat.No: TN5061

Target: Adrenergic Receptor, Antifection

Cat.No: TN1790

Synonym: Uncarine E

Target: 5-HT Receptor, Antibacterial, AChR

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