Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EMD57033是一种心脏肌钙蛋白C(cTnC)激活剂,是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,350 | 现货 | ||
5 mg | ¥ 5,630 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,200 | 现货 | ||
50 mg | ¥ 13,800 | 现货 | ||
100 mg | ¥ 17,500 | 现货 | ||
500 mg | ¥ 34,800 | 现货 |
产品描述 | EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction. |
体外活性 | EMD57033 (5.0 to 5.8 mumol/L) enhances contractility and prolongs relaxation. Its effects are modulated by heart rate, [Ca2+]o, and contraction mode, with positive inotropic effects being more prominent for ejecting beats.[4] |
体内活性 | EMD-57033 (0.4 mg. kg(-1). min(-1) for 20 minutes) selective Ca(2+) sensitization with minimal PDE3I in vivo is achieved, improving basal and rate-stimulated contractility and mechanoenergetics of HF without compromising diastolic function. Despite PDE3I activity at higher doses, energetic benefits persist.[5] |
别名 | EMD-57033, (+)-EMD 57033, EMD 57033 |
分子量 | 425.5 |
分子式 | C22H23N3O4S |
CAS No. | 147527-31-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (105.8 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3502 mL | 11.7509 mL | 23.5018 mL | 58.7544 mL |
5 mM | 0.47 mL | 2.3502 mL | 4.7004 mL | 11.7509 mL | |
10 mM | 0.235 mL | 1.1751 mL | 2.3502 mL | 5.8754 mL | |
20 mM | 0.1175 mL | 0.5875 mL | 1.1751 mL | 2.9377 mL | |
50 mM | 0.047 mL | 0.235 mL | 0.47 mL | 1.1751 mL | |
100 mM | 0.0235 mL | 0.1175 mL | 0.235 mL | 0.5875 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
EMD57033 147527-31-9 Membrane transporter/Ion channel Metabolism Calcium Channel Carbonic Anhydrase EMD-57033 (+)-EMD 57033 EMD 57033 Inhibitor inhibitor inhibit