首页工具

登录

搜索结果

Search Results for " anti-fibrosis "

30

抑制剂 & 化合物

12

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T20626	Esomeprazole	Proton pump; Cysteine Protease	Membrane transporter/Ion channel; Proteases/Proteasome
	Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。
T9195	SHR0302 ARQ252	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SHR0302 (ARQ252) 是一种具有口服活性的 JAK 抑制剂。它对 JAK1的结合力是 JAK2的 10 倍以上，是 JAK3的 77 倍，是 Tyk2的 420 倍。它抑制JAK1-STAT3磷酸化并诱导肝星状细胞凋亡，具有抗增殖和抗炎作用。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T6540	Ibuprofen Lysine 布洛芬赖氨酸盐,Neoprofen	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。
T4503	Talniflumate Somalgen,他尼氟酯	Chloride channel; COX; N-Acetylglucosaminyltransferase; Anion Exchanger	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Talniflumate (Somalgen) 是一种钙激活氯离子通道 (hCLCA1/mCLCA3) 阻滞剂，可减少动物模型和细胞培养中的粘蛋白合成和释放。它通过抑制环氧合酶，并抑制 Cl-/HCO3- 交换活性，具有抗炎作用。它还增加了远端肠梗阻综合征囊性纤维化小鼠模型的存活率。
T2486	IOWH-032 IOWH032,IOWH 032	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂，可用于研究治疗霍乱、腹泻和分泌性腹泻，在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。
T2686L	Esomeprazole Sodium 埃索美拉唑钠,(S)-Omeprazole sodium	ATPase; Proton pump	Membrane transporter/Ion channel
	Esomeprazole Sodium ((S)-Omeprazole sodium) 是一种口服有效的活性质子泵抑制剂。Esomeprazole sodium 通过抑制胃壁细胞中的 H+, K+-ATPase 来降低酸分泌，在胃食管反流疾病中有研究价值。Esomeprazole 是一种外泌体抑制剂，通过抑制 V-H+-ATPases 来阻断外泌体的释放。
T83064	Anti-hepatic fibrosis agent 2
	Fibrosis agent 2为针对Ewing肉瘤断点区域1 (EWSR1) 的特定抗纤维化化合物。
T2663	GTS-21 dihydrochloride GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。
T10409	ATX inhibitor 5	PDE	Metabolism
	ATX inhibitor 5 是一种有效且具有口服活性的 autotaxin (ATX) 抑制剂（IC50 ： 15.3 nM），可降低 CCl4 诱导的肝纤维化水平，具有抗肝纤维化作用，。
T14076	A 839977 A839977,A-839977	P2X Receptor; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Neuroscience
	A 839977是一种选择性 P2X7 受体拮抗剂,具有抗炎和镇痛活性，可抑制 P2X7 受体的 BzATP 诱发的钙内流，可用于研究肾纤维化 .
T15647	Tipelukast MN 001,KCA 757	Leukotriene Receptor	GPCR/G Protein
	Tipelukast (KCA 757) 是一种新型可口服的白三烯受体 (leukotriene receptor) 拮抗剂，是具有抗炎活性，可减少纤维化，下调 TIMP-1、1 型胶原蛋白。Tipelukast 可用于研究哮喘疾病。
T11411	GLPG1205	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	GLPG1205是一种有效的、具有口服活性的 GPR84（G 蛋白偶联受体）拮抗剂，具有抗炎活性。GLPG1205显示出良好的PK/PD 特征，可用于研究肺纤维化。
T76956	Vixarelimab RG-6536,RO-7622888,KPL-716	Interleukin	Immunology/Inflammation
	Vixarelimab (KPL-716) 是一种人源的抗 oncostatin M (OSM)单克隆抗体，对 OSM 受体的β链有亲和力，对 IL-31 和 OSM 的信号传导有抑制作用。Vixarelimab 可用于研究重度结节性痒疹和特发性肺纤维化。
T25136	Aztreonam lysine Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate
	Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF).
T70622	Selonsertib HCl
	Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis ...
T74996	FXR agonist 3
	FXR agonist3 是一种抗 NASH 试剂，通过激活 FXR 起作用。FXR agonist3 抑制 COL1A1、TGF-β1、α-SMA 和 TIMP1的表达，具有抗纤维化活性。FXR agonist3 显著减轻肝脏脂肪变性和炎症，改善肝纤维化水平。
T78944	VDR agonist 2
	VDR agonist 2（化合物16i）作为VDR（vitamin D receptor）激动剂，能有效抑制TGF-β1诱导的肝星状细胞（HSC）活化，并在体外和体内展现出显著的抗肝纤维化效果。
T80526	L-K6L9
	L-K6L9 对于囊性纤维化患者的铜绿假单胞菌 (P. aeruginosa) 表现出显著的抗菌 (antimicrobial) 活性和抗生物膜 (anti-biofilm) 能力。该化合物的抗酶解性质保证了其在体内的稳定性，且不引发细菌的耐药性。
T61586	TGFβ-IN-2
	TGFβ-IN-2 (Compound 9d) effectively inhibits the accumulation of total collagen induced by TGF-β in NRK-49F cells, with an IC 50 value of 4.31 μM. It also suppresses the in vitro protein expression of COL1A1, α-SMA, and p-Smad3, which are induced by TGF-β. Additionally, TGFβ-IN-2 shows promise as a potential anti-fibrosis compound for in vivo applications through oral administration [1].
T64008	Thi-DPPY
	Thi-DPPY 是一种有效的、口服具有活力的 JAK3 抑制剂，能够作用于 BTK (IC50: 62.4 nM)、JAK (IC50: 1.38 nM)。Thi-DPPY 能够抗 HBE 细胞的增殖。Thi-DPPY 在体内具有抗炎作用。Thi-DPPY 对特发性肺纤维化（IPF）表现出研究潜力。
T62301	J-1063
	J-1063 是一种选择性、口服具有活力的、有效的 ALK5 抑制剂 (IC50: 0.039 μM)。 J-1063 能够抑制炎症浸润，胶原沉积，肝细胞坏死，表现出抗肝纤维化作用。J-1063 具有潜力进行肝纤维化的研究。
T73155	BMS-986339
	BMS-986339 是一种具有口服活性的FXR 激动剂。BMS-986339 可与 His298 和 ASN287 残基形成氢键。BMS-986339 可用于原发性胆汁性肝硬化 (PBC)、原发性硬化性胆管炎 (PSC)、非酒精性脂肪性肝炎 (NASH)，和抗纤维化研究。
T10964L	DB1976 dihydrochloride DB1976 hydrochloride,DB1976 2HCl	Apoptosis; NF-κB	Apoptosis; NF-κB
	DB1976 dihydrochloride (DB1976 2HCl) ，一种转录因子 PU.1 抑制剂，具有潜在抗炎活性，可在体内实验中减缓小鼠的炎症和纤维化，改善了葡萄糖稳态和血脂异常。DB1976 dihydrochloride 促进细胞凋亡，可用于研究代谢功能障碍和非酒精性脂肪性肝炎。
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T79731	MLKL-IN-6	Necroptosis	Apoptosis
	MLKL-IN-6（compound P28）是一种针对Mixed Lineage Kinase domain-like（MLKL）的混合谱系激酶抑制剂，具有抗纤维化的潜力。它能够抑制MLKL的磷酸化和寡聚化，从而抑制细胞坏死、免疫细胞死亡，并减少粘附因子的表达。MLKL-IN-6展现出低细胞毒性，并可抑制肝星状细胞的激活，从而降低肝纤维化标志物的水平。
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...
T36673	CC 401 dihydrochloride
	High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication. Uehara et al (2004) c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 78 324 PMID:15316358 \|Uehara et al (2005) JNK mediates hepatic ischemia reperfusion injury. J...
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...

化合物

Cat.No: T20626

Target: Proton pump, Cysteine Protease

Cat.No: T9195

Synonym: ARQ252

Target: Apoptosis, JAK

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

Ibuprofen Lysine

Cat.No: T6540

Synonym: 布洛芬赖氨酸盐,Neoprofen

Target: COX

Cat.No: T4503

Synonym: Somalgen,他尼氟酯

Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger

Cat.No: T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

Esomeprazole Sodium

Cat.No: T2686L

Synonym: 埃索美拉唑钠,(S)-Omeprazole sodium

Target: ATPase, Proton pump

Anti-hepatic fibrosis agent 2

Cat.No: T83064

GTS-21 dihydrochloride

Cat.No: T2663

Synonym: GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine

Target: 5-HT Receptor, AChR

ATX inhibitor 5

Cat.No: T10409

Target: PDE

Cat.No: T14076

Synonym: A839977,A-839977

Target: P2X Receptor, Calcium Channel

Cat.No: T15647

Synonym: MN 001,KCA 757

Target: Leukotriene Receptor

Cat.No: T11411

Target: GPR, Others

Cat.No: T76956

Synonym: RG-6536,RO-7622888,KPL-716

Target: Interleukin

Aztreonam lysine

Cat.No: T25136

Synonym: Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate

Selonsertib HCl

Cat.No: T70622

Cat.No: T74996

Cat.No: T78944

Cat.No: T80526

Cat.No: T61586

Cat.No: T64008

Cat.No: T62301

Cat.No: T73155

DB1976 dihydrochloride

Cat.No: T10964L

Synonym: DB1976 hydrochloride,DB1976 2HCl

Target: Apoptosis, NF-κB

Cat.No: T36408

Synonym: Rhein-13C4

Cat.No: T79731

Target: Necroptosis

Flufenamic Acid-d4

Cat.No: T71303

Cat.No: T37861

CC 401 dihydrochloride

Cat.No: T36673

Cat.No: T36618

Cat. No.	Product Name	Target	Signaling Pathways
T6569	Mimosine Leucenine,NSC 69188,含羞草素,Leucenol,L-Mimosine	Others	Others
	Mimosine (Leucenol) 是一种酪氨酸类似物，具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂，是一种 Fe(III) 螯合剂。它作用于人类白血病细胞，通过金属离子螯合、线粒体激活和诱导活性氧产生来诱导细胞凋亡。
T4S1102	Liensinine diperchlorate 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate	Mitophagy; Others; Autophagy	Autophagy; Others
	Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬，具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
TN1936	Mogroside III-E 罗汉果皂苷ⅢE	IL Receptor; TNF; TLR	Apoptosis; Immunology/Inflammation
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
T10554	Bixin	Others	Others
	Bixin is isolated from the seeds of Bixa orellana and possesses anti-tumor, anti-inflammatory, and antioxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation, and ROS generation.

天然产物

Cat.No: T6569

Synonym: Leucenine,NSC 69188,含羞草素,Leucenol,L-Mimosine

Target: Others

Liensinine diperchlorate

Cat.No: T4S1102

Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Mogroside III-E

Cat.No: TN1936

Synonym: 罗汉果皂苷ⅢE

Target: IL Receptor, TNF, TLR

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Cat.No: T6S1049

Target: ATPase

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: T10554

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼