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26

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8773	MID-1	Others; IGF-1R	Others; Tyrosine Kinase/Adaptors
	MID-1 是 MG53-IRS-1 相互作用的抑制剂，能够破坏 MG53 与 IRS-1 的分子缔合，并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解，升高 IRS-1 表达水平，增加胰岛素信号传导和葡萄糖摄取。
T77100	Nirsevimab MEDI8897	RSV	Microbiology/Virology
	Nirsevimab (MEDI8897) 是一种具有修饰 Fc 区的重组人呼吸道合胞病毒 (RSV) 单克隆抗体。Nirsevimab 高效靶向 RSV-B ，Kd 值为 1.5 nM。Nirsevimab 可用于预防 RSV 感染。
T6548	Irsogladine Dicloguamine,伊索拉定	PDE; AChR	Metabolism; Neuroscience
	Irsogladine (Dicloguamine) 是抗胃溃疡剂，通过 M1 毒蕈碱乙酰胆碱受体结合促进间隙连接细胞间通讯。
T50031	Virstatin	Others	Others
	Virstatin 是一种新型抗病毒药物，是一种有效的病毒复制抑制剂，已被证明对多种病毒有效，包括单纯疱疹病毒（HSV）、人类免疫缺陷病毒（HIV）和流感病毒等。
T7184	Firsocostat ND-630,NDI-010976,GS-0976	Acetyl-CoA Carboxylase	Metabolism
	Firsocostat (GS-0976) 是有效的乙酰辅酶A 羧化酶 (ACC) 抑制剂，抑制人类 ACC1 和 ACC2 的IC50分别为2.1和6.1 nM。
T75151	Aganirsen
	Aganirsen 是一种反义寡核苷酸（25个核苷酸），抑制胰岛素受体底物1 (IRS-1)。
T12200	Firsocostat S enantiomer ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer	Others	Others
	Firsocostat S enantiomer is the less active S enantiomer of Firsocostat.
T39068	Fomivirsen sodium
	Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein (required for viral replication), thus providing bioactive effects for CMV retinitis by inhibition of virus proliferation.
T38554	Eteplirsen 依特立生；依特普森,AVI 4658
	Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide utilized in research for Duchenne muscular dystrophy.
T74842	Trecovirsen
	Trecovirsen (GEM91) 是一种靶向 HIVgag 基因的反义寡核苷酸。
T38464	Miravirsen SPC-3649,Miravirsen
	Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122 . Miravirsen (SPC-3649) is used in the study for HCV infections.
T38860	Golodirsen Golodirsen,SRP-4053
	Golodirsen (SRP-4053) is a phosphorodiamidate morpholino oligomer (PMO) designed to selectively bind and target exon 53 of dystrophin pre-mRNA, with applications in the investigation of Duchenne muscular dystrophy (DMD).
T38899	Irsenontrine E2027,Irsenontrine
	Irsenontrine (E2027) is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9), primarily used for researching neurological diseases.
T38829	Lademirsen RG-012,SAR339375
	Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21 . Lademirsen has the potential for Alport nephropathy research.
T74436	Danvatirsen
	Danvantisen 是一种靶向 STAT3的反义寡核苷酸，具有潜在的抗肿瘤活性。Danvantisen 与 STAT3mRNA 结合，从而抑制转录本的翻译。抑制 STAT3的表达可诱导肿瘤细胞凋亡，抑制肿瘤细胞生长。
T73749	Fomivirsen
	Fomivirsen (ISIS-2922 free base)为一种21 mer磷酸硫寡核苷酸反义药物。作为抗巨细胞病毒视网膜炎(CMV)研究的重要试剂，通过结合并降解CMV immediate-early 2蛋白的mRNA，Fomivirsen有效抑制病毒复制。
T39517	Suvodirsen WVE-210201
	Suvodirsen (WVE-210201) is an oligonucleotide compound with potential applications in the study of Duchenne muscular dystrophy (DMD).
T75251	Firsocostat (S enantiomer)
	Firsocostat S enantiomer (ND-630 S enantiomer) 是 Firsocostat 的低活性的 S 型异构体。Firsocostat 是乙酰辅酶 A 羧化酶抑制剂。
T39108	Irsenontrine maleate E2027 maleate
	Irsenontrine (E2027) maleate is a selective and orally active inhibitor of phosphodiesterase 9 (PDE9). It can be utilized in the study of neurological diseases.
T74250	Custirsen
	Custirsen 是一种高度特异性的反义寡核苷酸，可抑制clusterin 的产生，clusterin 是一种抗凋亡蛋白，在化疗反应中上调表达，并导致耐药性。
T75157L	Cimdelirsen sodium
	Cimdelirsen (sodium) 为针对肝脏的反义寡核苷酸，通过减少生长激素受体(GHr)合成，抑制生长激素(GH)的过度分泌效应，进而降低肢端肥大症患者体内循环胰岛素样生长因子-1 (IGF-1)水平。
T73993	Fazirsiran
	Fazirsiran (ARO-AAT) 是第二代 RNA 干扰 (RNAi) 活性分子。Fazirsiran 由胆固醇偶联的 RNAi 触发器 (chol-RNAi) 组成，通过 RNAi 选择性降解 AAT mRNA，以及与 N-乙酰半乳糖胺 (NAG) 偶联的蜂毒肽衍生肽配制成赋形剂 EX1，促进肝细胞内 chol RNAi 的内体逃逸。
T61770	(R)-Irsenontrine
	(R)-Irsenontrine ((R)-E2027) 是Irsenontrine 的 R 型异构体，是一种有效的磷酸二酯酶 9 (PDE9) 抑制剂，抑制其IC50值为 0.041 μM。(R)-Irsenontrine 可用于神经系统疾病的研究。
T74569	Bepirovirsen
	Bepirovirsen 是一种反义寡核苷酸，靶向所有HBV 信使 RNAs。Bepirovirsen 导致HBV 来源的 RNAs、HBV DNA 和病毒蛋白的减少。Bepirovirsen 可用于慢性HBV 感染的研究。Bepirovirsen 结合位点序列 (GCACTTCGCTTCACCTCTGC)。
T75157	Cimdelirsen
	Cimdelirsen为针对肝脏的反义寡核苷酸，通过降低生长激素受体(GHr)的合成量，来减少生长激素(GH)过量分泌所导致的不良影响，进而在肢端肥大症患者中降低循环胰岛素样生长因子-1(IGF-1)的水平。
T4605	NT157	IGF-1R; STAT	JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	NT157 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。

化合物

Cat.No: T8773

Target: Others, IGF-1R

Cat.No: T77100

Synonym: MEDI8897

Target: RSV

Cat.No: T6548

Synonym: Dicloguamine,伊索拉定

Target: PDE, AChR

Cat.No: T50031

Target: Others

Cat.No: T7184

Synonym: ND-630,NDI-010976,GS-0976

Target: Acetyl-CoA Carboxylase

Cat.No: T75151

Firsocostat S enantiomer

Cat.No: T12200

Synonym: ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer

Target: Others

Fomivirsen sodium

Cat.No: T39068

Cat.No: T38554

Synonym: 依特立生；依特普森,AVI 4658

Cat.No: T74842

Cat.No: T38464

Synonym: SPC-3649,Miravirsen

Cat.No: T38860

Synonym: Golodirsen,SRP-4053

Cat.No: T38899

Synonym: E2027,Irsenontrine

Cat.No: T38829

Synonym: RG-012,SAR339375

Cat.No: T74436

Cat.No: T73749

Cat.No: T39517

Synonym: WVE-210201

Firsocostat (S enantiomer)

Cat.No: T75251

Irsenontrine maleate

Cat.No: T39108

Synonym: E2027 maleate

Cat.No: T74250

Cimdelirsen sodium

Cat.No: T75157L

Cat.No: T73993

(R)-Irsenontrine

Cat.No: T61770

Cat.No: T74569

Cat.No: T75157

Cat.No: T4605

Target: IGF-1R, STAT

Cat. No.	Product Name	Target	Signaling Pathways
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T0760	Cholesterol Cholesterin,Cholesteryl alcohol,胆固醇	Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR	Endocrinology/Hormones; Immunology/Inflammation; Metabolism
	Cholesterol (Cholesteryl alcohol) 属于天然产物，是哺乳动物中的主要固醇，是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜，也是合成几种重要荷尔蒙及胆酸的材料。
TQ0119	Cirsimaritin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Cirsimaritin 具有抗菌、抗炎、抗肿瘤、抗氧化特性和肾脏保护作用。 Cirsimaritin 与 GABAA 受体上的苯二氮卓位点结合较弱。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T10822	Cirsimarin Cirsitakaoside	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Cirsimarin (Cirsitakaoside) 是一种从 Microtea debilis 中分离出来的黄酮类化合物。它具有很强的抗脂肪生成作用，能减少小鼠脂肪组织的沉积。Cirsimarin 对腺苷 A1 受体有拮抗作用，对磷酸二酯酶有抑制作用
TN6975	Cirsiumaldehyde 5,5’-oxydimethylenebis(2-furfural)	Platelet aggregation	Others
	Cirsiumaldehyde 是一种从Lobelia chinensis、Cornus officinalis 成熟果实和 Hippophae rhamnoides 果实中分分离出的化合物。Cirsiumaldehyde 在胶原蛋白存在下对 U46619 诱导（1~5 uM）的大鼠血小板聚集的抑制浓度为 0.8~1.0 ug/mL。
TN1081	Hirsuteine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Hirsuteine 是提取自钩藤属植物中的吲哚生物碱。它可阻断离子渗透通过烟碱受体通道复合物，非竞争性地拮抗烟碱介导的多巴胺释放。
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate	NADPH-oxidase; P450; MAO	Immunology/Inflammation; Metabolism; Neuroscience
	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
T10821	Cirsiliol	Lipoxygenase	Metabolism
	Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
TN3295	8alpha-(2-Methylacryloyloxy)hirsutinolide	Others	Others
	8alpha-(2-Methylacryloyloxy)hirsutinolide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3295，CAS号为 188293-70-1。
T75532	Cirsiliol 4′-glucoside
	Cirsiliol 4′-glucoside，从Ruellia tuberosaL 中提取，是一种具有抗糖尿病潜力的自由基清除剂。
TN3298	8alpha-Hydroxyhirsutinolide	TNF; NF-κB	Apoptosis; NF-κB
	8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-ÎºB activity with the IC(50) value of 1.9 uM.
TN3293	8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate	Others	Others
	8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3293，CAS号为 883872-71-7。
T19886	Cirsilineol Fastigenin,SPM 927,Eupatrin	Apoptosis; COX; STAT	Apoptosis; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Cirsilineol (Eupatrin) 是从 Artemisia vestita Wall 的草本植物中分离出来的，具有免疫抑制、抗增殖和抗肿瘤特性。 Cirsilineol 通过线粒体途径选择性诱导细胞凋亡。
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
TN4211	Hirsutanonol 5-O-glucoside	Others	Others
	Hirsutanonol 5-O-glucoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4211，CAS号为 93915-36-7。
TN4212	Hirsutanonol	COX; Antifection	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Hirsutanonol 是来自桤木树皮的次生代谢物。 Hirsutanonol 具有有效的抗氧化和自由基清除活性，并对线粒体脂质过氧化具有抑制作用。 Hirsutanonol 可用于治疗特应性皮炎的研究。
TN4213	Hirsutenone	ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-...
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate	NADPH-oxidase; P450; MAO	Immunology/Inflammation; Metabolism; Neuroscience
	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29
T4S1545	Licarin B (-)-Licarin B,Licarine B,(-)-利卡灵B	transporter; Antibacterial; PPAR	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Licarin B (Licarine B) 是来源于肉豆蔻种子的一种天然产物，是 NO 生成抑制剂，可通过激活 IRS-1/PI3K/AKT 通路中的PPARγ和GLUT4 改善胰岛素敏感性。
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.

天然产物

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

Cat.No: T0760

Synonym: Cholesterin,Cholesteryl alcohol,胆固醇

Target: Estrogen Receptor/ERR, MRP, Endogenous Metabolite, ROR

Cat.No: TQ0119

Target: GABA Receptor

Cat.No: TN1065

Target: Apoptosis

Cat.No: T10822

Synonym: Cirsitakaoside

Target: Adenosine Receptor

Cirsiumaldehyde

Cat.No: TN6975

Synonym: 5,5’-oxydimethylenebis(2-furfural)

Target: Platelet aggregation

Cat.No: TN1081

Target: Dopamine Receptor

8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate

Cat.No: TN3294

Target: NADPH-oxidase, P450, MAO

Cat.No: T10821

Target: Lipoxygenase

8alpha-(2-Methylacryloyloxy)hirsutinolide

Cat.No: TN3295

Target: Others

Cirsiliol 4′-glucoside

Cat.No: T75532

8alpha-Hydroxyhirsutinolide

Cat.No: TN3298

Target: TNF, NF-κB

8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate

Cat.No: TN3293

Target: Others

Cat.No: T19886

Synonym: Fastigenin,SPM 927,Eupatrin

Target: Apoptosis, COX, STAT

Cat.No: T38016

Hirsutanonol 5-O-glucoside

Cat.No: TN4211

Target: Others

Cat.No: TN4212

Target: COX, Antifection

Cat.No: TN4213

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

8alpha-Tigloyloxyhirsutinolide 13-O-acetate

Cat.No: TN3300

Target: NADPH-oxidase, P450, MAO

Cat.No: T4S1545

Synonym: (-)-Licarin B,Licarine B,(-)-利卡灵B

Target: transporter, Antibacterial, PPAR

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

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