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1273

抑制剂 & 化合物

105

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11615	IDO-IN-12	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T7660	IDO inhibitor 1 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO inhibitor 1 是一种有效的吲哚胺-2,3 双加氧酶 (IDO) 抑制剂 (IC50 <100 nM)。具有潜在的免疫调节和抗肿瘤活性。
T7181	IDO-IN-1 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T1806	IDO-IN-7 NLG919,Navoximod,NLG-919 analogue,GDC-0919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂，IC50=38 nM。
T4142	PCC0208009 IDO inhibitor 1,DO-IN-2,IDO-IN-2	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PCC0208009 (IDO-IN-2) 是一种有效的 IDO 抑制剂，其在 HeLa 细胞中的 IC50=4.52 nM。它调节 ACC 和杏仁核的突触可塑性，减少神经性疼痛和合并症。
T3548	Epacadostat INCB 024360,艾卡哚司他,IDO Inhibitor 1	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Epacadostat (INCB 024360) 是选择性的IDO1抑制剂，IC50=71.8 nM。
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T40093	IDO-IN-15
	IDO-IN-15 is an IDO1 inhibitor ( IC 50 < 0.51 nM).
T11618	IDO-IN-4	Others	Others
	IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
T11619	IDO-IN-5 NLG-1489	IDO	Metabolism
	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11617	IDO-IN-3	IDO	Metabolism
	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11622	IDO-IN-9	IDO	Metabolism
	IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11614	IDO-IN-11	IDO	Metabolism
	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11623	IDO/TDO-IN-1	Others	Others
	IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
T11621	IDO-IN-8 NLG-1487	IDO	Metabolism
	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11620	IDO-IN-6 NLG-1486	IDO	Metabolism
	IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T11626	IACS-8968 IDO/TDO Inhibitor	IDO	Metabolism
	IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11627	IACS-8968 R-enantiomer IDO/TDO Inhibitor (R-enantiomer)	IDO	Metabolism
	IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T62130	IDO-IN-16
	IDO-IN-16 (compound 5) 是一种 IDO 抑制剂 (IC50: 36 nM)。
T2647	IDO5L INCB024360 analogue,INCB14943	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。
T62270	IDO-IN-14
	IDO-IN-14 是一种 IDO 抑制剂 (IC50: 0.6928 nM)。
T11628	IACS-8968 S-enantiomer IDO/TDO Inhibitor (S-enantiomer)	IDO	Metabolism
	IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T74536	IDO/Tubulin-IN-2
	IDO/Tubulin-IN-2 (HT2) 是一种对TDO和微管蛋白 (tubulin)展现出高效抑制作用的化合物。该抑制剂对多种癌细胞系（包括U87、HepG2、A549、HCT-116和LO2）均表现出强抗肿瘤活性，其半抑制浓度（IC50）分别为0.43、0.036、0.041、0.095和1.04 μM，有效提升了抗肿瘤效果。
T39888	IDO1-IN-7 IDO1-IN-7
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T39839	IDO1-IN-11 IDO1-IN-11
	IDO1-IN-11 is an IDO1 inhibitor with an IC 50 value of 0.6 nM.
T39946	IDO1-IN-12 IDO1-IN-12
	IDO1-IN-12 is a potent and orally available IDO1 inhibitor.
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T10199	GNF-PF-3777 8-Nitrotryptanthrin	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	GNF-PF-3777 (8-Nitrotryptanthrin) 是人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，能够降低IDO2活性，Ki=为 0.97 μM。
T9164	BMS-986242 BMS986242	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T4307	PF-06840003 EOS200271,PF 06840003	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂，抑制 hIDO-1， dIDO-1和 mIDO-1 的IC50分别为 0.41 μM， 0.59 μM，和 1.5 μM。
TQ0071	Navoximod GDC-0919,NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Navoximod (GDC-0919) 是 IDO(indoleamine-(2,3)-dioxygenase) 抑制剂，Ki=7 nM/，EC50=75 nM。
T4532	Linrodostat BMS-986205	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂，能够有效抑制 IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T1847	Necrostatin-1 Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO); Ferroptosis; Autophagy; RIP kinase	Apoptosis; Autophagy; Metabolism; NF-κB
	Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂，具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T11624	IDO1-IN-2	IDO	Metabolism
	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11625	IDO1 and HDAC1 Inhibitor	Others	Others
	IDO1 and HDAC1 Inhibitor is a dual IDO1 and HDAC1 inhibitor (IC50s: 69.0 nM and 66.5 nM).
T6543	Indoximod NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。
T12801	(S)-IDO1-IN-5	Others	Others
	(S)-IDO1-IN-5 is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL(IC50 value less than 1.5 µΜ).
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T61789	IDO1-IN-14
	IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeLa cells with an EC50 value of 3393 nM [1].
T82082	IDO1-IN-23	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-23（化合物41）是一种有效的人类IDO1抑制剂，具备13 μM的IC50值。
T78687	IDO1-IN-21	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-21（化合物10m）为IDO1抑制剂，其IC50值为0.64 μM。该化合物在小鼠体内可有效抑制肿瘤生长。
T61944	IDO1-IN-15
	IDO1-IN-15 是有效的IDO1抑制剂，IC50为127 nM。IDO1-IN-15与Epacadostat 在体外对抗 IDO1 酶的效力相当。
T74507	IDO1-IN-20
	IDO1-IN-20是一种催化色氨酸氧化代谢的酶，能在肿瘤微环境中对肿瘤进行免疫抑制。
T63814	IDO2-IN-1
	IDO2-IN-1 是一种口服活性的强效IDO2抑制剂，其IC50为112 nM。该化合物适用于炎症性自身免疫研究。
T7504	Necrostatin 2 racemate 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate	RIP kinase	Apoptosis; NF-κB
	Necrostatin 2 racemate (Necrostatin-2 racemate) 是一种特异性的RIPK1抑制剂，是一种稳定型 Nec-1。
T63034	IDO1-IN-13
	IDO1-IN-13 (compound 27a) 是一种 IDO1 的有效抑制剂 (IC50: 61.6 nM)。IDO1-IN-13 能够抑制细胞 IDO1，对 HeLa 的 EC50 值为 30 nM。在 SK-OV-3 异种移植肿瘤组织中，IDO1-IN-13 减少了 51% 的 kyn/trp 比率。
T73111	IDO1-IN-17
	IDO1-IN-17 (I-4) 是IDO1的抑制剂，其在 hela 细胞中的IC50值为 0.44 μM。
T63082	IDO1-IN-19
	IDO1-IN-19 (Compound 17) 是一种 IDO1 的有效抑制剂，具有潜力进行癌症疾病的研究。

化合物

Cat.No: T11615

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

IDO inhibitor 1

Cat.No: T7660

Synonym: 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T7181

Synonym: 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T1806

Synonym: NLG919,Navoximod,NLG-919 analogue,GDC-0919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4142

Synonym: IDO inhibitor 1,DO-IN-2,IDO-IN-2

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3548

Synonym: INCB 024360,艾卡哚司他,IDO Inhibitor 1

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T40093

Cat.No: T11618

Target: Others

Cat.No: T11619

Synonym: NLG-1489

Target: IDO

Cat.No: T11617

Target: IDO

Cat.No: T11622

Target: IDO

Cat.No: T11614

Target: IDO

Cat.No: T11623

Target: Others

Cat.No: T11621

Synonym: NLG-1487

Target: IDO

Cat.No: T11620

Synonym: NLG-1486

Target: IDO

Cat.No: T11626

Synonym: IDO/TDO Inhibitor

Target: IDO

IACS-8968 R-enantiomer

Cat.No: T11627

Synonym: IDO/TDO Inhibitor (R-enantiomer)

Target: IDO

Cat.No: T62130

Cat.No: T2647

Synonym: INCB024360 analogue,INCB14943

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T62270

IACS-8968 S-enantiomer

Cat.No: T11628

Synonym: IDO/TDO Inhibitor (S-enantiomer)

Target: IDO

IDO/Tubulin-IN-2

Cat.No: T74536

Cat.No: T39888

Synonym: IDO1-IN-7

Cat.No: T39839

Synonym: IDO1-IN-11

Cat.No: T39946

Synonym: IDO1-IN-12

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Cat.No: T10199

Synonym: 8-Nitrotryptanthrin

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9164

Synonym: BMS986242

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4307

Synonym: EOS200271,PF 06840003

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: TQ0071

Synonym: GDC-0919,NLG-919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4532

Synonym: BMS-986205

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

Cat.No: T11624

Target: IDO

IDO1 and HDAC1 Inhibitor

Cat.No: T11625

Target: Others

Cat.No: T6543

Synonym: NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德

Target: Indoleamine 2,3-Dioxygenase (IDO)

(S)-IDO1-IN-5

Cat.No: T12801

Target: Others

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

Cat.No: T61789

Cat.No: T82082

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T78687

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T61944

Cat.No: T74507

Cat.No: T63814

Necrostatin 2 racemate

Cat.No: T7504

Synonym: 5-[(7-氯-1H-吲哚-3-基)甲基]-3-甲基-2,4-咪唑烷二酮,Necrostatin-2 racemate

Target: RIP kinase

Cat.No: T63034

Cat.No: T73111

Cat.No: T63082

Cat. No.	Product Name	Target	Signaling Pathways
T4S0051	Coptisine sulfate	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T2718	Palmatine chloride	Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others
	Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，并改善 DSS 诱发的结肠炎。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T5S0056	Coptisine chloride 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754	Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus; Antibacterial	Metabolism; Microbiology/Virology
	Coptisine chloride (NSC-119754) 是从黄连中分离到的一种生物碱，是一种非竞争性 IDO 抑制剂，Ki 值为 5.8 μM，IC50值为 6.3 μM。它是一种 H1N1 神经氨酸酶抑制剂，可用于甲型流感病毒感染，IC50为 104.6 μg/mL。
T8214	Kushenol E 苦参醇E,Flemiphilippinin D	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮，是一种IDO1的非竞争性抑制剂，其IC50=7.7 µM，Ki=为 9.5 µM，具有抗肿瘤特性。
T5085	Pyridoxal 5'-phosphate hydrate Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal 5'-phosphate hydrate (PLP) 是内源性代谢产物的一种。
T7916	4-Acetamidobenzenesulfonyl azide	Others	Others
	4-Acetamidobenzenesulfonyl azide 用于各种科学研究应用，包括药物、肽和其他生物活性分子的合成，也被用作聚合反应和聚合物合成中的催化剂。
T14011	2-Arachidonoylglycerol	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	2-Arachidonoylglycerol 属于人内源性代谢物，是中枢神经系统中的一种内源性大麻素配体。
T19962	Xyloidone NSC-106453,NSC106453,Dehydro-α-lapachone,NSC 106453,Dehydrolapachone,脱氢拉帕醌,NSC 629748	Antifungal	Microbiology/Virology
	Xyloidone (NSC-106453) 具有抗真菌活性，在 0.4-33.3 mg/L 的范围内完全抑制 B. cinerea、Colletotrichum acutatum Simmonds、Colletotrichum gloeosporioides Simmonds、M. grisea 和 Pythium ultimum Trow 的菌丝生长。
T4728	4-Acetamidobutanoic acid N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID,4-乙酰氨基丁酸	GABA Receptor; Endogenous Metabolite; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) 可在血液、粪便和尿液以及人体前列腺组织中找到，也存在于从酵母到人类的所有真核生物中。它是GABA 衍生物，具有抗氧化和抗菌活性。
T0076	Paliperidone 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Paliperidone (9-hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 拮抗剂和5-HT2A 拮抗剂。它用作非典型抗精神病药，用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和 H1组胺能受体也有拮抗作用。
T5226	2-(2-Methylbenzamido)acetic acid 2-Methylhippuric acid,2-甲基马尿酸,O-Toluric acid,N-(O-Toluoyl)glycine	Others; Endogenous Metabolite	Metabolism; Others
	2-(2-Methylbenzamido)acetic acid (O-Toluric acid) 是一种能够在尿液中检测到的代谢物。
T4805	α-Pyridone 2-Hydroxypyridine,2-羟基吡啶	Others; Endogenous Metabolite	Metabolism; Others
	α-Pyridone (2-Hydroxypyridine) 是内源性代谢产物的一种。
T0436	6-Acetamidohexanoic acid 醋氨己酸,6-Acetamidocaproic acid,Acexamic Acid	Amino Acids and Derivatives; COX	Immunology/Inflammation; Metabolism; Neuroscience
	6-Acetamidohexanoic acid (Acexamic Acid) 是一种医药中间体。
T9279	nerolidol acetate	Others	Others
	Nerolidol acetate是一种具有抗癌、抗炎、抗菌和抗虫的活性的天然倍半萜。Nerolidol acetate可抑制寄生虫活动，抑制吸血虫病、线虫病以及疟疾等。Nerolidol acetate可保护细胞免受脂质、蛋白质和 DNA 的氧化损伤，对小鼠海马神经细胞具有保护作用。
T5217	2-(2-Phenylacetamido)acetic acid Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine	Others; Endogenous Metabolite	Metabolism; Others
	2-(2-Phenylacetamido)acetic acid (Phenyl-ac-Gly-OH) 是内源性代谢产物的一种。
TN1035	Irisolidone 尼泊尔鸢尾异黄酮,葛花苷元	IL Receptor; NF-κB; Chloride channel	Immunology/Inflammation; Membrane transporter/Ion channel; NF-κB
	Irisolidone 是葛根花中的一种异黄酮，具有较强的保肝活性。它是一种有效的体积调节阴离子通道 (VRAC) 电流抑制剂，有高效阻断作用，IC50 为 5-13 μM。
T20003	Acridone	Antibacterial; ABC	Membrane transporter/Ion channel; Microbiology/Virology
	Acridone 具有抗菌、抗疟、抗病毒和抗肿瘤活性。它可诱导细胞凋亡，抑制 ABCG2 蛋白，并调节激素水平。
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T12588	Pyridoxylamine pyridoxamine,吡多胺	Endogenous Metabolite	Metabolism
	Pyridoxylamine (pyridoxamine) 是脂质化终产物和糖基化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T0973	Pyridoxine 吡哆醇,Pyridoxol,Vitamin B6,Gravidox,吡多素（维生素B6）	PLK; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism
	Pyridoxine (Vitamin B6) 是一种吡啶衍生物，通过 Nrf-2/HO-1 途径发挥抗氧化作用，作用于阿尔茨海默病细胞模型。
T2790	Oridonin NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A	Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Oridonin (NSC-250682) 是从Rabdosia rubescens 中得到的二萜，是一种AKT 抑制剂，对 AKT1 和 AKT2 的IC50值分别为 8.4 和 8.9 μM，具有抗菌、抗炎、抗肿瘤等功效。
T5558	Chelidonic acid Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质，用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂，Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。
T6795	Carbidopa 卡比多巴,(S)-(-)-Carbidopa,Lodosyn	Decarboxylase; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism; Others
	Carbidopa (Lodosyn) 是一种选择性芳香烃受体(AhR)调节剂，是外周型脱羧酶抑制剂，抑制胰腺癌细胞和肿瘤生长，可用于帕金森病的研究。
T25114	Ascaridole NSC-406266,NSC 406266,NSC406266	Parasite	Microbiology/Virology
	Ascaridole (NSC-406266) 可作为驱虫化合物，能驱除人体和植物中的寄生蠕虫(蠕虫)，具有较弱的抗疟活性。
TN7032	4'-O-Methylpyridoxine 4-methoxymethylpyridoxine,Ginkgotoxin	Antioxidant	oxidation-reduction
	4'-O-Methylpyridoxine（MPN）是从银杏叶中发现的维生素类化合物，具有抗氧化活性和细胞毒性。
T8083	Pyridoxal 5'-phosphate monohydrate Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛	Others	Others
	Pyridoxal 5'-phosphate monohydrate 是维生素 B6的活性形式，也是多种酶的重要辅因子。它是维生素 B6 在细胞内磷酸化过程中重要的辅酶变异体，能够与其他变异体（如 PNP 、 PMP）发生互换。
T7324	Chelidonine hydrochloride	Others	Others
	Chelidonine hydrochloride 是 Chelidonium majus 的生物碱之一，具有广泛的药理活性。
T36473	trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re...
T4754	Pyridoxylamine dihydrochloride 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxylamine dihydrochloride (Pyridorin) 是一种糖基化终产物和脂质化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T4129	Arachidonic acid Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar	Others; Endogenous Metabolite	Metabolism; Others
	Arachidonic acid (Immunocytophyte) 是不饱和的必需脂肪酸。它存在于动物和人类脂肪以及肝脏、大脑和腺体器官中，是动物磷脂的成分。它由膳食亚油酸合成而成，是前列腺素、血栓素和白三烯生物合成的前体。
T2S2172	nerolidol (±)-Nerolidol,Peruviol,橙花叔醇	Others; Endogenous Metabolite; Antibacterial; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Nerolidol (Peruviol) 是天然膜活性倍半萜，有抗肿瘤、抗细菌、抗真菌和抗寄生虫活性。它对动物有镇静作用，氧化过程对神经元病理后果起关键作用。
T3799	Isorhamnetin-3-O-neohespeidoside Isorhamnetin 3-O-neohesperidin,异鼠李素-3-O-新橙皮糖苷,Isorhamnetin 3-O-neohesperoside,Calendoflavoside,异鼠李素-3-O-新橙皮苷	Antioxidant	oxidation-reduction
	Isorhamnetin-3-O-neohespeidoside (Calendoflavoside) 是一种黄酮类化合物，分离自Pollen typhae 中。
T0973L	Pyridoxine hydrochloride Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6	Nrf2; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中，通过 Nrf-2/HO-1 途径发挥抗氧化作用。
T4761	Pyridoxal hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal hydrochloride 是内源性代谢产物的一种。
T4107	4-Pyridoxic Acid 4-吡哆酸,Pyridoxic Acid,4-Pyridoxinsaeure	Endogenous Metabolite	Metabolism
	4-Pyridoxic Acid (4-Pyridoxinsaeure) 是一种维生素B6的分解代谢产物，从尿液中分泌得到。
T4919	Ureidopropionic acid Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid	Endogenous Metabolite	Metabolism
	Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说，它是二氢尿嘧啶的分解产物，由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。
T4933	(S)-2-acetamido-4-amino-4-oxobutanoic acid Nα-Acetyl-L-asparagine,N-乙酰-L-天门冬酰胺	Endogenous Metabolite	Metabolism
	(S)-2-acetamido-4-amino-4-oxobutanoic acid (Nα-Acetyl-L-asparagine)，也称为acasn，属于一种内源性代谢产物。
TN1819	Kaempferol 3-neohesperidoside Kaempferol 3-O-neohesperidoside,堪非醇 3-新橙皮糖苷	GSK-3; MEK; PI3K	MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) 是一种类黄酮，对大鼠比目鱼肌具有拟胰岛素作用。
T15703	Lactimidomycin	Others	Others
	Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i
T82325	Gentiiridosides A
	Gentiiridosides A为从龙胆中提取的一种化合物，采用无水乙醇作为萃取溶剂。
T72730	D-Isofloridoside
	D-Isofloridoside 是多糖前体之一，具有清除自由基、抑制ROS 表达、抑制MMP-2和MMP-9的活性。
T79980	Flaccidoside III	Glucosidase	Metabolism
	Flaccidoside III, 分离自黑种草（N. sativa）地上部分的一种类黄酮和三萜类化合物，具有抑制α-Glucosidase（IC50：256.7 μM）的活性，表现出潜在的抗氧化和抗糖尿病效应。
TN6244	Hainanolidol
	Hainanolidol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6244，CAS号为 73213-63-5。
T19885	Methyllucidone
	Methyllucidone is an inhibitor of STAT3 that acts by regulating the expression of the protein tyrosine phosphatase MEG2.
TN2590	11alpha,12alpha-Oxidotaraxerol palmitate	Others	Others
	11alpha,12alpha-Oxidotaraxerol palmitate shows selective cytotoxicity against HCT-8, Bel-7402, BGC-823, A549 and A2780.
TN1044	Quercetin 3-O-neohesperidoside	Others	Others
	Quercetin 3-O-neohesperidoside shows anti-atherosclerosis, and antiplatelet aggregation activities.
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天然产物

Coptisine sulfate

Cat.No: T4S0051

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Palmatine chloride

Cat.No: T2718

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Coptisine chloride

Cat.No: T5S0056

Synonym: 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754

Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial

Cat.No: T8214

Synonym: 苦参醇E,Flemiphilippinin D

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Pyridoxal 5'-phosphate hydrate

Cat.No: T5085

Synonym: Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate

Target: Others, Endogenous Metabolite

4-Acetamidobenzenesulfonyl azide

Cat.No: T7916

Target: Others

2-Arachidonoylglycerol

Cat.No: T14011

Target: Cannabinoid Receptor, Endogenous Metabolite

Cat.No: T19962

Synonym: NSC-106453,NSC106453,Dehydro-α-lapachone,NSC 106453,Dehydrolapachone,脱氢拉帕醌,NSC 629748

Target: Antifungal

4-Acetamidobutanoic acid

Cat.No: T4728

Synonym: N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID,4-乙酰氨基丁酸

Target: GABA Receptor, Endogenous Metabolite, Antibacterial

Cat.No: T0076

Synonym: 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

2-(2-Methylbenzamido)acetic acid

Cat.No: T5226

Synonym: 2-Methylhippuric acid,2-甲基马尿酸,O-Toluric acid,N-(O-Toluoyl)glycine

Target: Others, Endogenous Metabolite

Cat.No: T4805

Synonym: 2-Hydroxypyridine,2-羟基吡啶

Target: Others, Endogenous Metabolite

6-Acetamidohexanoic acid

Cat.No: T0436

Synonym: 醋氨己酸,6-Acetamidocaproic acid,Acexamic Acid

Target: Amino Acids and Derivatives, COX

nerolidol acetate

Cat.No: T9279

Target: Others

2-(2-Phenylacetamido)acetic acid

Cat.No: T5217

Synonym: Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine

Target: Others, Endogenous Metabolite

Cat.No: TN1035

Synonym: 尼泊尔鸢尾异黄酮,葛花苷元

Target: IL Receptor, NF-κB, Chloride channel

Cat.No: T20003

Target: Antibacterial, ABC

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T12588

Synonym: pyridoxamine,吡多胺

Target: Endogenous Metabolite

Cat.No: T0973

Synonym: 吡哆醇,Pyridoxol,Vitamin B6,Gravidox,吡多素（维生素B6）

Target: PLK, Nrf2, Endogenous Metabolite

Cat.No: T2790

Synonym: NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A

Target: Akt, Antibacterial

Chelidonic acid

Cat.No: T5558

Synonym: Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid

Target: NF-κB, Caspase

Cat.No: T6795

Synonym: 卡比多巴,(S)-(-)-Carbidopa,Lodosyn

Target: Decarboxylase, Aryl Hydrocarbon Receptor

Cat.No: T25114

Synonym: NSC-406266,NSC 406266,NSC406266

Target: Parasite

4'-O-Methylpyridoxine

Cat.No: TN7032

Synonym: 4-methoxymethylpyridoxine,Ginkgotoxin

Target: Antioxidant

Pyridoxal 5'-phosphate monohydrate

Cat.No: T8083

Synonym: Pyridoxal phosphate monohydrate,Pyridoxal 5-phosphate monohydrate,5-磷酸吡哆醛

Target: Others

Chelidonine hydrochloride

Cat.No: T7324

Target: Others

trans-Nerolidol

Cat.No: T36473

Pyridoxylamine dihydrochloride

Cat.No: T4754

Synonym: 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride

Target: Others, Endogenous Metabolite

Arachidonic acid

Cat.No: T4129

Synonym: Immunocytophyte,花生四烯酸,arachidonate,Immunocytophyt,Vevodar

Target: Others, Endogenous Metabolite

Cat.No: T2S2172

Synonym: (±)-Nerolidol,Peruviol,橙花叔醇

Target: Others, Endogenous Metabolite, Antibacterial, Parasite, Antifungal

Isorhamnetin-3-O-neohespeidoside

Cat.No: T3799

Synonym: Isorhamnetin 3-O-neohesperidin,异鼠李素-3-O-新橙皮糖苷,Isorhamnetin 3-O-neohesperoside,Calendoflavoside,异鼠李素-3-O-新橙皮苷

Target: Antioxidant

Pyridoxine hydrochloride

Cat.No: T0973L

Synonym: Pyridoxine HCl,吡哆醇盐酸盐,Pyridoxol (hydrochloride),吡哆醇盐酸盐(维生素B6),Vitamin B6 (hydrochloride),Vitamin B6

Target: Nrf2, Endogenous Metabolite

Pyridoxal hydrochloride

Cat.No: T4761

Target: Others, Endogenous Metabolite

4-Pyridoxic Acid

Cat.No: T4107

Synonym: 4-吡哆酸,Pyridoxic Acid,4-Pyridoxinsaeure

Target: Endogenous Metabolite

Ureidopropionic acid

Cat.No: T4919

Synonym: Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid

Target: Endogenous Metabolite

(S)-2-acetamido-4-amino-4-oxobutanoic acid

Cat.No: T4933

Synonym: Nα-Acetyl-L-asparagine,N-乙酰-L-天门冬酰胺

Target: Endogenous Metabolite

Kaempferol 3-neohesperidoside

Cat.No: TN1819

Synonym: Kaempferol 3-O-neohesperidoside,堪非醇 3-新橙皮糖苷

Target: GSK-3, MEK, PI3K

Cat.No: T15703

Target: Others

Gentiiridosides A

Cat.No: T82325

D-Isofloridoside

Cat.No: T72730

Flaccidoside III

Cat.No: T79980

Target: Glucosidase

Cat.No: TN6244

Cat.No: T19885

11alpha,12alpha-Oxidotaraxerol palmitate

Cat.No: TN2590

Target: Others

Quercetin 3-O-neohesperidoside

Cat.No: TN1044

Target: Others

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