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Search Results for " erk2 "

Targets Recommended: ERK

45

抑制剂 & 化合物

4

天然产物

17

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11228	ERK2 IN-1	ERK	MAPK
	ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
T9034	MK2-IN-3 MK2 Inhibitor III	MAPK	MAPK
	MK2-IN-3 (MK2 Inhibitor III) 是选择性的 MAPKAP-K2 (MK-2)抑制剂(IC50:8.5 nM)，能够抑制 U937 细胞及体内 TNFα 的生成。
T7005	Ulixertinib BVD-523,VRT752271,优立替尼	ERK	MAPK
	Ulixertinib (VRT752271) 是一种有效且可逆的 ERK1/ERK2 抑制剂，可抑制 ERK2 和下游蛋白 RSK 的磷酸化，对 ERK2 的IC50值小于 0.3 nM。
T10429	Tizaterkib AZD-0364	ERK	MAPK
	Tizaterkib (AZD-0364) 是一种选择性ERK2抑制剂，IC50为 0.6 nM。
T1956	FR 180204 FR180204	Apoptosis; ERK	Apoptosis; MAPK
	FR 180204 是一种 ATP 竞争性的选择性ERK 抑制剂，对ERK1和ERK2的Ki 值分别为 0.31 μM 和 0.14 μM，IC50值分别为0.51 μM 和0.33 μM。
T11226	ERK1/2 inhibitor 1	ERK	MAPK
	ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
T5358	Longdaysin	ERK; Casein Kinase; CDK	Cell Cycle/Checkpoint; MAPK; Metabolism; Stem Cells
	Longdaysin 是一种 CK1α 和 CK1δ 的抑制剂，IC50为5.6和8.8 µM。它还抑制ERK2，IC50值为52 µM。它是Wnt/β-catenin 信号通路的抑制剂，通过阻断CK1δ/ε依赖性 Wnt 信号通路发挥抗肿瘤作用。
T6066	SCH772984	ERK; MEK	MAPK
	SCH772984 是高选择性和 ATP 竞争性ERK 抑制剂，对 ERK1 和 ERK2 的IC50分别为 4 和 1 nM。它在含有 BRAF 或 RAS 突变的 MAPK 抑制剂初治和 MAPK 抑制剂耐药细胞中具有抗肿瘤活性。
T3074	CHIR 98024 CHIR98014	GSK-3; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	CHIR 98024是一种有效的 GSK-3α/β 抑制剂，在无细胞试验中 IC50 为 0.65 nM/0.58 nM，能够区分 GSK-3 与其接近的同源物 Cdc2 和 ERK2。
T6511	Ravoxertinib GDC-0994	ERK	MAPK
	Ravoxertinib (GDC-0994) 是可口服的ERK 激酶抑制剂，抑制ERK1和ERK2的IC50分别为 6.1 和 3.1 nM。
T4092	AG126 Tyrphostin AG126,AG 126	ERK; COX	Immunology/Inflammation; MAPK; Neuroscience
	AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。
T4091	Temuterkib LY3214996	ERK	MAPK
	Temuterkib (LY3214996) 是高效选择性的ERK1和ERK2抑制剂，IC50为 5 nM，具有潜在的抗肿瘤活性。
TP1970L	Prosaptide TX14(A) acetate Prosaptide TX14(A) acetate(196391-82-9 free base)	ERK; GPR	Endocrinology/Hormones; GPCR/G Protein; MAPK
	Prosaptide TX14(A) acetate 是一种有效的 GPR37L1 和 GPR37 激动剂。它增加雪旺细胞中的 ERK1 和 ERK2 磷酸化。
T6324	(E/Z)-BIX02188 334949-59-6	ERK; MEK; TGF-beta/Smad	MAPK; Stem Cells
	BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM)，也抑制 ERK5 催化活性 (IC50: 810 nM)，并且不抑制密切相关的激酶 MEK1/2、JNK2 和 ERK2。
T6673	SKI II SphK-I2	Apoptosis; Wnt/beta-catenin; S1P Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂，抑制 SK1 和 SK2，IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解，不可逆地抑制SK1。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T2310L	CHIR-99021 HCl CT99021 HCl,Laduviglusib HCl	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂，IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性，对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外，CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外，它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外，拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T2608	CHIR-98014 CHIR 98014,CT98014,CHIR98014	FGFR; GSK-3; Src; S6 Kinase	Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	CHIR-98014 (CT98014) 是有效的，细胞通透的GSK-3抑制剂，可抑制 GSK-3α (IC50:0.65 nM) 和 GSK-3β (IC50:0.58 nM) 的活性，对 cdc2 和 erk2 的作用较弱。
T62929	RLX-33	ERK; RXFP receptor	GPCR/G Protein; MAPK
	RLX-33 是一种有效的、选择性的、能够透过血脑屏障的松弛素家族肽 3 (RXFP3) 拮抗剂，也能够阻断松弛素 3 (relaxin 3) 诱导的 ERK1/2 磷酸化。RLX-33 作用于 RXFP3、ERK1 和 ERK2 磷酸化的 IC50 分别为 2.36 μM、7.82 μM 和 13.86 μM。RLX-33 可以阻断 RXFP3 选择性激动剂 R3/I5 诱导的大鼠食物摄取增加。RLX-33 能够用于研究代谢综合征。
T36675	ERK-IN-4 ERK Inhibitor	ERK	MAPK
	ERK-IN-4 是一种具有细胞渗透性的 ERK 抑制剂，具有潜在的抗增殖作用，可用于研究免疫功能异常引起的疾病。
T3166	VX-11e Vertex-11e,VTX-11e,TCS ERK 11e	ERK; GSK-3; FLT; CDK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	VX-11e (TCS ERK 11e) 是可口服的ERK 高效选择性抑制剂，Ki 值小于 2 nM。
T12069	MK-8353 SCH900353	ERK	MAPK
	MK-8353 (SCH900353) 是口服有效的ERK1/2选择性抑制剂，IC50分别为 23.0 nM 和 8.8 nM。它显示出抗肿瘤活性。
T11225	ERK-IN-2	ERK	MAPK
	ERK-IN-2 是ERK2抑制剂，IC50值为 1.8 nM。 ERK-IN-2 在剂量 >10 μM 可能引起脱靶毒性和/或脱靶活性。
T15377	Ravoxertinib hydrochloride GDC-0994 (hydrochloride)	ERK	MAPK
	Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
T78143	(R)-VX-11e	ERK	MAPK
	(R)-VX-11e（化合物1）为ERK2抑制剂，具有选择性地阻断ERK2活性的能力。
T63331	ERK1/2 inhibitor 8
	ERK1/2 inhibitor 8 是 ERK 的有效抑制剂，能够作用于 ERK2 (IC50: 0.48 nM)。
T62933	ERK1/2 inhibitor 7
	ERK1/2 inhibitor 7 是一种 ERK 的有效抑制剂，作用于 ERK2 (IC50: 0.94 nM)。
T76556	MEK1 Derived Peptide Inhibitor 1
	MEK1Derived Peptide Inhibitor 1，一种肽抑制剂，以IC50值30 μM抑制MEK1激活ERK2。适用于细胞渗透性研究。
T72517	ERK-IN-2 free base
	ERK-IN-2 free base是ERK2抑制剂，IC50为1.8 nM。使用剂量>10 μM时，可能引起脱靶毒性和/或脱靶活性。
T36672	CAY10561
	The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561...
T81387	Prosaptide Tx14(A) TFA
	Prosaptide Tx14(A) TFA 为prosaposin衍生的肽类化合物，可有效激活GPR37L1及GPR37，其EC50值分别为5 nM与7 nM。该化合物亦能促进Schwann细胞内ERK1与ERK2的磷酸化作用。
T62939	SHR2415
	SHR2415 是一种选择性的、高效的、口服具有活力的 ERK1/2 抑制剂。SHR2415 能够抑制 ERK1 (IC50: 2.8 nM) 和 ERK2 (IC50: 5.9 nM)。SHR2415 在 Colo205 细胞中表现出高效力 (IC50: 44.6 nM)。SHR2415 能够用于癌症的研究。
T64001	MAP855
	MAP855 是一种高效的、选择性的、口服具有活力的具、 ATP 竞争性的 MEK1/2 激酶抑制剂，对 MEK1 ERK2 cascade 的 IC50 值为 3 nM，pERKEC50 值为 5 nM。MAP855 对野生型和突变型 MEK1/2 表现出同等的抑制效果。
T8461	SKI V	Apoptosis; PI3K; S1P Receptor	Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
	SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂，对 GST-hSK 的IC50为 2 μM。它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成，可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K，对 hPI3k 的IC50为 6 μM。
T61755	E6201
	E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T12058	MK2-IN-3 hydrate MK-2 Inhibitor III	ERK; MAPK; MNK	MAPK
	MK2-IN-3 hydrate (MK-2 Inhibitor III) 是一种口服有活性的、ATP 竞争性的MAPKAP-K2 (MK-2)选择性抑制剂(IC50:0.85 nM)。
T38377	ADTL-EI1712 ADTL-EI1712
	ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do...
T2029	Bohemine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。
T4444	A-674563 HCl (552325-73-2(free base))	ERK; Akt; PKA; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	A-674563 HCl (552325-73-2(free base)) 是一种口服的、ATP 竞争性的、可逆的 Akt 抑制剂（Akt1 的 Ki：11 nM）。它对 PKA 和 Cdk2 具有抑制活性（IC50：16/46 nM），但对 Akt1 的选择性比 CMGC、CAMK 和 TK 家族中的其他激酶高 10 至 >1800 倍。
T35696	Olomoucine II
	Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively...
T2095	Seliciclib Roscovitine,R-roscovitine,CYC202	CDK	Cell Cycle/Checkpoint
	Seliciclib (Roscovitine) 是 Cdk2/cyclin E 的有效抑制剂，IC50为0.1 µM。它还抑制 Cdk7/cyclin H、Cdk5/p35 和 Cdc2/cyclin B，IC50为 0.49、0.16和0.65 µM。
T12102	Mps1-IN-1	Others	Others
	Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )
T14072	A-443654	ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-443654 是 pan-Akt 抑制剂，对Akt1，Akt2，和Akt3具有同等效力的抑制作用，Ki=均为 160 pM。
T23337	SCH772984 HCl	ERK; Others	MAPK; Others
	SCH772984 HCl 是一种特异性的 ERK1/2 抑制剂，具有 I 型和 II 型激酶抑制剂的特性，其 IC50 分别为 4 和 1 nM。 SCH772984 HCl 在 BRAF、NRAS 或 KRAS 突变的肿瘤细胞中具有纳摩尔级细胞效力，并诱导肿瘤消退。 SCH772984 HCl 可用于 MAPK 抑制剂难治性肿瘤的研究。
T21377	Aloisine A
	Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6

化合物

Cat.No: T11228

Target: ERK

Cat.No: T9034

Synonym: MK2 Inhibitor III

Target: MAPK

Cat.No: T7005

Synonym: BVD-523,VRT752271,优立替尼

Target: ERK

Cat.No: T10429

Synonym: AZD-0364

Target: ERK

Cat.No: T1956

Synonym: FR180204

Target: Apoptosis, ERK

ERK1/2 inhibitor 1

Cat.No: T11226

Target: ERK

Cat.No: T5358

Target: ERK, Casein Kinase, CDK

Cat.No: T6066

Target: ERK, MEK

Cat.No: T3074

Synonym: CHIR98014

Target: GSK-3, S6 Kinase

Cat.No: T6511

Synonym: GDC-0994

Target: ERK

Cat.No: T4092

Synonym: Tyrphostin AG126,AG 126

Target: ERK, COX

Cat.No: T4091

Synonym: LY3214996

Target: ERK

Prosaptide TX14(A) acetate

Cat.No: TP1970L

Synonym: Prosaptide TX14(A) acetate(196391-82-9 free base)

Target: ERK, GPR

Cat.No: T6324

Synonym: 334949-59-6

Target: ERK, MEK, TGF-beta/Smad

Cat.No: T6673

Synonym: SphK-I2

Target: Apoptosis, Wnt/beta-catenin, S1P Receptor

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T2310L

Synonym: CT99021 HCl,Laduviglusib HCl

Target: GSK-3

Cat.No: T2608

Synonym: CHIR 98014,CT98014,CHIR98014

Target: FGFR, GSK-3, Src, S6 Kinase

Cat.No: T62929

Target: ERK, RXFP receptor

Cat.No: T36675

Synonym: ERK Inhibitor

Target: ERK

Cat.No: T3166

Synonym: Vertex-11e,VTX-11e,TCS ERK 11e

Target: ERK, GSK-3, FLT, CDK, Aurora Kinase

Cat.No: T12069

Synonym: SCH900353

Target: ERK

Cat.No: T11225

Target: ERK

Ravoxertinib hydrochloride

Cat.No: T15377

Synonym: GDC-0994 (hydrochloride)

Target: ERK

Cat.No: T78143

Target: ERK

ERK1/2 inhibitor 8

Cat.No: T63331

ERK1/2 inhibitor 7

Cat.No: T62933

MEK1 Derived Peptide Inhibitor 1

Cat.No: T76556

ERK-IN-2 free base

Cat.No: T72517

Cat.No: T36672

Prosaptide Tx14(A) TFA

Cat.No: T81387

Cat.No: T62939

Cat.No: T64001

Cat.No: T8461

Target: Apoptosis, PI3K, S1P Receptor

Cat.No: T61755

MK2-IN-3 hydrate

Cat.No: T12058

Synonym: MK-2 Inhibitor III

Target: ERK, MAPK, MNK

Cat.No: T38377

Synonym: ADTL-EI1712

Cat.No: T2029

Target: ERK, CDK

A-674563 HCl (552325-73-2(free base))

Cat.No: T4444

Target: ERK, Akt, PKA, CDK, PKC

Cat.No: T35696

Cat.No: T2095

Synonym: Roscovitine,R-roscovitine,CYC202

Target: CDK

Cat.No: T12102

Target: Others

Cat.No: T14072

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Cat.No: T23337

Target: ERK, Others

Cat.No: T21377

Cat. No.	Product Name	Target	Signaling Pathways
T3001	Honokiol 和厚朴酚,NSC 293100	ERK; HCV Protease; MEK; Akt; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Honokiol (NSC-293100) 是厚朴提取物的活性成分，靶向多种信号分子，具有抗氧化，抗炎，抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。
T3857	magnolin 木兰脂素,(+)-Magnolin,木兰苷	ERK	MAPK
	Magnolin 是辛夷的一种主要成分，靶向作用于ERK1和ERK2，IC50值分别为 87 和 16.5 nM，可抑制Ras/ERKs/RSK2信号通路。它在体内外降低肾脏氧化应激，抑制 caspase-3 活性，并增加 Bcl-2 表达，具有抗炎和抗氧化作用。
T6S0655	Corynoxeine	ERK	MAPK
	Corynoxeine 是从钩藤中分离的一种天然产物，是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的 ERK1/ERK2抑制剂。
T15542	Hypothemycin	Others	Others
	Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).

天然产物

Cat.No: T3001

Synonym: 和厚朴酚,NSC 293100

Target: ERK, HCV Protease, MEK, Akt, Autophagy

Cat.No: T3857

Synonym: 木兰脂素,(+)-Magnolin,木兰苷

Target: ERK

Cat.No: T6S0655

Target: ERK

Cat.No: T15542

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04571	ERK2 Protein, Mouse, Recombinant (His & GST) PRKM2,C78273,mitogen-activated protein kin...	Mouse	Baculovirus Insect Cells
	ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.1 kDa and the accession number is P63085.
TMPY-04539	ERK2 Protein, Human, Recombinant (GST) ERT1,ERK,PRKM1,ERK-2,p41,p41mapk,...	Human	Baculovirus Insect Cells
	ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 67 kDa and the accession number is P28482-1.
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,FLJ2<...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST) MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated...	Mouse	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ...
TMPH-02268	AGTR2 Protein, Human, Recombinant (His & SUMO) AT2 receptor,Angiotensin II type-2 recepto...	Human	E. coli
	Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
TMPH-01347	FSHR Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
TMPH-01348	FSHR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945.
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N...	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...
TMPJ-01378	Mp1 Protein, Human, Recombinant (His) Mitogen-Activated Protein Kinase Kinase 1-Interacting Protei...	Human	E. coli
	Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the eff...
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor,Stem cell factor...	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPJ-00996	VHR Protein, Human, Recombinant (His) DUSP3,VHR,Dual specificity protein phosphatase VHR,Vaccinia ...	Human	E. coli
	Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ...
TMPY-04399	TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST) DPK,MAP3K18,TAO kinase 3,JIK	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ...
TMPY-04460	OXSR1 Protein, Human, Recombinant (GST) OSR1,oxidative stress responsive 1	Human	Baculovirus Insect Cells
	Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of...
TMPY-04392	RSK3 Protein, Human, Recombinant (GST) HU-2,ribosomal protein S6 kinase, 90kDa, polypeptid...	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a...
TMPY-04357	RSK4 Protein, Human, Recombinant (GST) RSK4,ribosomal protein S6 kinase, 90kDa, polypeptide 6,PP90R...	Human	Baculovirus Insect Cells
	Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His)	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

ERK2 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04571

Species: Mouse

Expression System: Baculovirus Insect Cells

ERK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04539

Species: Human

Expression System: Baculovirus Insect Cells

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

MKK4 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04572

Species: Mouse

Expression System: Baculovirus Insect Cells

AGTR2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02268

Species: Human

Expression System: E. coli

FSHR Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01347

Species: Human

Expression System: E. coli

FSHR Protein, Human, Recombinant (His)

Cat.No: TMPH-01348

Species: Human

Expression System: HEK293 Cells

RAF1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

Mp1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01378

Species: Human

Expression System: E. coli

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

VHR Protein, Human, Recombinant (His)

Cat.No: TMPJ-00996

Species: Human

Expression System: E. coli

TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)

Cat.No: TMPY-04399

Species: Human

Expression System: Baculovirus Insect Cells

OXSR1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04460

Species: Human

Expression System: Baculovirus Insect Cells

RSK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04392

Species: Human

Expression System: Baculovirus Insect Cells

RSK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04357

Species: Human

Expression System: Baculovirus Insect Cells

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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