45
4
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11228 |
ERK2 IN-1
|
ERK | MAPK |
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM. | |||
T9034 |
MK2-IN-3
MK2 Inhibitor III |
MAPK | MAPK |
MK2-IN-3 (MK2 Inhibitor III) 是选择性的 MAPKAP-K2 (MK-2)抑制剂(IC50:8.5 nM),能够抑制 U937 细胞及体内 TNFα 的生成。 | |||
T7005 |
Ulixertinib
BVD-523,VRT752271,优立替尼 |
ERK | MAPK |
Ulixertinib (VRT752271) 是一种有效且可逆的 ERK1/ERK2 抑制剂,可抑制 ERK2 和下游蛋白 RSK 的磷酸化,对 ERK2 的IC50值小于 0.3 nM。 | |||
T10429 |
Tizaterkib
AZD-0364 |
ERK | MAPK |
Tizaterkib (AZD-0364) 是一种选择性ERK2抑制剂,IC50为 0.6 nM。 | |||
T1956 |
FR 180204
FR180204 |
Apoptosis; ERK | Apoptosis; MAPK |
FR 180204 是一种 ATP 竞争性的选择性ERK 抑制剂,对ERK1和ERK2的Ki 值分别为 0.31 μM 和 0.14 μM,IC50值分别为0.51 μM 和0.33 μM。 | |||
T11226 |
ERK1/2 inhibitor 1
|
ERK | MAPK |
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. | |||
T5358 |
Longdaysin
|
ERK; Casein Kinase; CDK | Cell Cycle/Checkpoint; MAPK; Metabolism; Stem Cells |
Longdaysin 是一种 CK1α 和 CK1δ 的抑制剂,IC50为5.6和8.8 µM。它还抑制ERK2,IC50值为52 µM。它是Wnt/β-catenin 信号通路的抑制剂,通过阻断CK1δ/ε依赖性 Wnt 信号通路发挥抗肿瘤作用。 | |||
T6066 |
SCH772984
|
ERK; MEK | MAPK |
SCH772984 是高选择性和 ATP 竞争性ERK 抑制剂,对 ERK1 和 ERK2 的IC50分别为 4 和 1 nM。它在含有 BRAF 或 RAS 突变的 MAPK 抑制剂初治和 MAPK 抑制剂耐药细胞中具有抗肿瘤活性。 | |||
T3074 |
CHIR 98024
CHIR98014 |
GSK-3; S6 Kinase | MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
CHIR 98024是一种有效的 GSK-3α/β 抑制剂,在无细胞试验中 IC50 为 0.65 nM/0.58 nM,能够区分 GSK-3 与其接近的同源物 Cdc2 和 ERK2。 | |||
T6511 |
Ravoxertinib
GDC-0994 |
ERK | MAPK |
Ravoxertinib (GDC-0994) 是可口服的ERK 激酶抑制剂,抑制ERK1和ERK2的IC50分别为 6.1 和 3.1 nM。 | |||
T4091 |
Temuterkib
LY3214996 |
ERK | MAPK |
Temuterkib (LY3214996) 是高效选择性的ERK1和ERK2抑制剂,IC50为 5 nM,具有潜在的抗肿瘤活性。 | |||
TP1970L |
Prosaptide TX14(A) acetate
Prosaptide TX14(A) acetate(196391-82-9 free base) |
ERK; GPR | Endocrinology/Hormones; GPCR/G Protein; MAPK |
Prosaptide TX14(A) acetate 是一种有效的 GPR37L1 和 GPR37 激动剂。 它增加雪旺细胞中的 ERK1 和 ERK2 磷酸化。 | |||
T4092 |
AG126
Tyrphostin AG126,AG 126 |
ERK; COX | Immunology/Inflammation; MAPK; Neuroscience |
AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂,可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。 | |||
T6324 |
(E/Z)-BIX02188
334949-59-6 |
ERK; MEK; TGF-beta/Smad | MAPK; Stem Cells |
BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM),也抑制 ERK5 催化活性 (IC50: 810 nM),并且不抑制密切相关的激酶 MEK1/2、JNK2 和 ERK2。 | |||
T6673 |
SKI II
SphK-I2 |
Apoptosis; Wnt/beta-catenin; S1P Receptor | Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells |
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。 | |||
T3623 |
Cobimetinib
可美替尼,考比替尼,RG7420,XL518,GDC-0973 |
Apoptosis; MEK | Apoptosis; MAPK |
Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂,抑制MEK1的IC50为4.2 nM。 | |||
T2310L |
CHIR-99021 HCl
CT99021 HCl,Laduviglusib HCl |
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2、ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。 | |||
T2608 |
CHIR-98014
CHIR 98014,CT98014,CHIR98014 |
FGFR; GSK-3; Src; S6 Kinase | Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
CHIR-98014 (CT98014) 是有效的,细胞通透的GSK-3抑制剂,可抑制 GSK-3α (IC50:0.65 nM) 和 GSK-3β (IC50:0.58 nM) 的活性,对 cdc2 和 erk2 的作用较弱。 | |||
T62929 |
RLX-33
|
ERK; RXFP receptor | GPCR/G Protein; MAPK |
RLX-33 是一种有效的、选择性的、能够透过血脑屏障的松弛素家族肽 3 (RXFP3) 拮抗剂,也能够阻断松弛素 3 (relaxin 3) 诱导的 ERK1/2 磷酸化。RLX-33 作用于 RXFP3、ERK1 和 ERK2 磷酸化的 IC50 分别为 2.36 μM、7.82 μM 和 13.86 μM。RLX-33 可以阻断 RXFP3 选择性激动剂 R3/I5 诱导的大鼠食物摄取增加。RLX-33 能够用于研究代谢综合征。 | |||
T36675 |
ERK-IN-4
ERK Inhibitor |
ERK | MAPK |
ERK-IN-4 是一种具有细胞渗透性的 ERK 抑制剂,具有潜在的抗增殖作用,可用于研究免疫功能异常引起的疾病。 | |||
T12069 |
MK-8353
SCH900353 |
ERK | MAPK |
MK-8353 (SCH900353) 是口服有效的ERK1/2选择性抑制剂,IC50分别为 23.0 nM 和 8.8 nM。它显示出抗肿瘤活性。 | |||
T3166 |
VX-11e
Vertex-11e,VTX-11e,TCS ERK 11e |
ERK; GSK-3; FLT; CDK; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
VX-11e (TCS ERK 11e) 是可口服的ERK 高效选择性抑制剂,Ki 值小于 2 nM。 | |||
T11225 |
ERK-IN-2
|
ERK | MAPK |
ERK-IN-2 是ERK2抑制剂,IC50值为 1.8 nM。 ERK-IN-2 在剂量 >10 μM 可能引起脱靶毒性和/或脱靶活性。 | |||
T15377 |
Ravoxertinib hydrochloride
GDC-0994 (hydrochloride) |
ERK | MAPK |
Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively). | |||
T78143 |
(R)-VX-11e
|
ERK | MAPK |
(R)-VX-11e(化合物1)为ERK2抑制剂,具有选择性地阻断ERK2活性的能力。 | |||
T63331 | ERK1/2 inhibitor 8 | ||
ERK1/2 inhibitor 8 是 ERK 的有效抑制剂,能够作用于 ERK2 (IC50: 0.48 nM)。 | |||
T62933 | ERK1/2 inhibitor 7 | ||
ERK1/2 inhibitor 7 是一种 ERK 的有效抑制剂,作用于 ERK2 (IC50: 0.94 nM)。 | |||
T76556 |
MEK1 Derived Peptide Inhibitor 1
|
||
MEK1Derived Peptide Inhibitor 1,一种肽抑制剂,以IC50值30 μM抑制MEK1激活ERK2。适用于细胞渗透性研究。 | |||
T72517 |
ERK-IN-2 free base
|
||
ERK-IN-2 free base是ERK2抑制剂,IC50为1.8 nM。使用剂量>10 μM时,可能引起脱靶毒性和/或脱靶活性。 | |||
T36672 |
CAY10561
|
||
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561... | |||
T81387 |
Prosaptide Tx14(A) TFA
|
||
Prosaptide Tx14(A) TFA 为prosaposin衍生的肽类化合物,可有效激活GPR37L1及GPR37,其EC50值分别为5 nM与7 nM。该化合物亦能促进Schwann细胞内ERK1与ERK2的磷酸化作用。 | |||
T62939 | SHR2415 | ||
SHR2415 是一种选择性的、高效的、口服具有活力的 ERK1/2 抑制剂。SHR2415 能够抑制 ERK1 (IC50: 2.8 nM) 和 ERK2 (IC50: 5.9 nM)。SHR2415 在 Colo205 细胞中表现出高效力 (IC50: 44.6 nM)。SHR2415 能够用于癌症的研究。 | |||
T64001 | MAP855 | ||
MAP855 是一种高效的、选择性的、口服具有活力的具、 ATP 竞争性的 MEK1/2 激酶抑制剂,对 MEK1 ERK2 cascade 的 IC50 值为 3 nM,pERKEC50 值为 5 nM。MAP855 对野生型和突变型 MEK1/2 表现出同等的抑制效果。 | |||
T61755 |
E6201
|
||
E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2]. | |||
T8461 |
SKI V
|
Apoptosis; PI3K; S1P Receptor | Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling |
SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂,对 GST-hSK 的IC50为 2 μM。 它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成,可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K,对 hPI3k 的IC50为 6 μM。 | |||
T12058 |
MK2-IN-3 hydrate
MK-2 Inhibitor III |
ERK; MAPK; MNK | MAPK |
MK2-IN-3 hydrate (MK-2 Inhibitor III) 是一种口服有活性的、ATP 竞争性的MAPKAP-K2 (MK-2)选择性抑制剂(IC50:0.85 nM)。 | |||
T38377 |
ADTL-EI1712
ADTL-EI1712 |
||
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do... | |||
T2029 |
Bohemine
|
ERK; CDK | Cell Cycle/Checkpoint; MAPK |
Bohemine 是一种合成的选择性CDK 抑制剂,是嘌呤类似物,具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。 | |||
T4444 |
A-674563 HCl (552325-73-2(free base))
|
ERK; Akt; PKA; CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
A-674563 HCl (552325-73-2(free base)) 是一种口服的、ATP 竞争性的、可逆的 Akt 抑制剂(Akt1 的 Ki:11 nM)。它对 PKA 和 Cdk2 具有抑制活性(IC50:16/46 nM),但对 Akt1 的选择性比 CMGC、CAMK 和 TK 家族中的其他激酶高 10 至 >1800 倍。 | |||
T35696 |
Olomoucine II
|
||
Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively... | |||
T2095 |
Seliciclib
Roscovitine,R-roscovitine,CYC202 |
CDK | Cell Cycle/Checkpoint |
Seliciclib (Roscovitine) 是 Cdk2/cyclin E 的有效抑制剂,IC50为0.1 µM。它还抑制 Cdk7/cyclin H、Cdk5/p35 和 Cdc2/cyclin B,IC50为 0.49、0.16和0.65 µM。 | |||
T12102 |
Mps1-IN-1
|
Others | Others |
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) | |||
T14072 |
A-443654
|
ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
A-443654 是 pan-Akt 抑制剂,对Akt1,Akt2,和Akt3具有同等效力的抑制作用,Ki=均为 160 pM。 | |||
T23337 |
SCH772984 HCl
|
ERK; Others | MAPK; Others |
SCH772984 HCl 是一种特异性的 ERK1/2 抑制剂,具有 I 型和 II 型激酶抑制剂的特性,其 IC50 分别为 4 和 1 nM。 SCH772984 HCl 在 BRAF、NRAS 或 KRAS 突变的肿瘤细胞中具有纳摩尔级细胞效力,并诱导肿瘤消退。 SCH772984 HCl 可用于 MAPK 抑制剂难治性肿瘤的研究。 | |||
T21377 | Aloisine A | ||
Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3001 |
Honokiol
和厚朴酚,NSC 293100 |
ERK; HCV Protease; MEK; Akt; Autophagy | Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Honokiol (NSC-293100) 是厚朴提取物的活性成分,靶向多种信号分子,具有抗氧化,抗炎,抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。 | |||
T3857 |
magnolin
木兰脂素,(+)-Magnolin,木兰苷 |
ERK | MAPK |
Magnolin 是辛夷的一种主要成分,靶向作用于ERK1和ERK2,IC50值分别为 87 和 16.5 nM,可抑制Ras/ERKs/RSK2信号通路。它在体内外降低肾脏氧化应激,抑制 caspase-3 活性,并增加 Bcl-2 表达,具有抗炎和抗氧化作用。 | |||
T6S0655 |
Corynoxeine
|
ERK | MAPK |
Corynoxeine 是从钩藤中分离的一种天然产物,是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的 ERK1/ERK2抑制剂。 | |||
T15542 |
Hypothemycin
|
Others | Others |
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively). |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04571 |
ERK2 Protein, Mouse, Recombinant (His & GST)
PRKM2,C78273,mitogen-activated protein kin... |
Mouse | Baculovirus Insect Cells |
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.1 kDa and the accession number is P63085. | |||
TMPY-04539 |
ERK2 Protein, Human, Recombinant (GST)
ERT1,ERK,PRKM1,ERK-2,p41,p41mapk,... |
Human | Baculovirus Insect Cells |
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 67 kDa and the accession number is P28482-1. | |||
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPY-04572 |
MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated... |
Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... | |||
TMPH-02268 |
AGTR2 Protein, Human, Recombinant (His & SUMO)
AT2 receptor,Angiotensin II type-2 recepto... |
Human | E. coli |
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | |||
TMPH-01347 |
FSHR Protein, Human, Recombinant (E. coli, His)
|
Human | E. coli |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945. | |||
TMPH-01348 |
FSHR Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945. | |||
TMPY-04544 |
MEK2 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase kinase 2,FLJ2<... |
Human | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ... | |||
TMPJ-01378 |
Mp1 Protein, Human, Recombinant (His)
Mitogen-Activated Protein Kinase Kinase 1-Interacting Protei... |
Human | E. coli |
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the eff... | |||
TMPY-05095 |
RAF1 Protein, Human, Recombinant (His & GST)
Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N... |
Human | Baculovirus Insect Cells |
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p... | |||
TMPJ-00894 |
SCF Protein, Rat, Recombinant (His)
Hematopoietic growth factor KL,Steel factor,Stem cell factor... |
Rat | E. coli |
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase... | |||
TMPJ-00996 |
VHR Protein, Human, Recombinant (His)
DUSP3,VHR,Dual specificity protein phosphatase VHR,Vaccinia ... |
Human | E. coli |
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ... | |||
TMPY-04399 |
TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)
DPK,MAP3K18,TAO kinase 3,JIK |
Human | Baculovirus Insect Cells |
Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ... | |||
TMPY-04460 |
OXSR1 Protein, Human, Recombinant (GST)
OSR1,oxidative stress responsive 1 |
Human | Baculovirus Insect Cells |
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of... | |||
TMPY-04392 |
RSK3 Protein, Human, Recombinant (GST)
HU-2,ribosomal protein S6 kinase, 90kDa, polypeptid... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a... | |||
TMPY-04357 |
RSK4 Protein, Human, Recombinant (GST)
RSK4,ribosomal protein S6 kinase, 90kDa, polypeptide 6,PP90R... |
Human | Baculovirus Insect Cells |
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2... | |||
TMPH-01692 |
MAPK3 Protein, Human, Recombinant (His)
|
Human | E. coli |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |