首页 工具
登录
购物车

搜索结果

Search Results for " erk2 "
Targets Recommended: ERK

45

抑制剂 & 化合物

4

天然产物

17

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求,可以联系我们专业顾问为您提供针对性的合理建议。     QQ咨询       网站留言咨询

提交您的定制咨询

点击图片重新获取验证码
Cat. No. Product Name Target Signaling Pathways
T11228 ERK2 IN-1

ERK MAPK
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
T9034 MK2-IN-3

MK2 Inhibitor III

MAPK MAPK
MK2-IN-3 (MK2 Inhibitor III) 是选择性的 MAPKAP-K2 (MK-2)抑制剂(IC50:8.5 nM),能够抑制 U937 细胞及体内 TNFα 的生成。
T7005 Ulixertinib

BVD-523,VRT752271,优立替尼

ERK MAPK
Ulixertinib (VRT752271) 是一种有效且可逆的 ERK1/ERK2 抑制剂,可抑制 ERK2 和下游蛋白 RSK 的磷酸化,对 ERK2 的IC50值小于 0.3 nM。
T10429 Tizaterkib

AZD-0364

ERK MAPK
Tizaterkib (AZD-0364) 是一种选择性ERK2抑制剂,IC50为 0.6 nM。
T1956 FR 180204

FR180204

Apoptosis; ERK Apoptosis; MAPK
FR 180204 是一种 ATP 竞争性的选择性ERK 抑制剂,对ERK1和ERK2的Ki 值分别为 0.31 μM 和 0.14 μM,IC50值分别为0.51 μM 和0.33 μM。
T11226 ERK1/2 inhibitor 1

ERK MAPK
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
T5358 Longdaysin

ERK; Casein Kinase; CDK Cell Cycle/Checkpoint; MAPK; Metabolism; Stem Cells
Longdaysin 是一种 CK1α 和 CK1δ 的抑制剂,IC50为5.6和8.8 µM。它还抑制ERK2,IC50值为52 µM。它是Wnt/β-catenin 信号通路的抑制剂,通过阻断CK1δ/ε依赖性 Wnt 信号通路发挥抗肿瘤作用。
T6066 SCH772984

ERK; MEK MAPK
SCH772984 是高选择性和 ATP 竞争性ERK 抑制剂,对 ERK1 和 ERK2 的IC50分别为 4 和 1 nM。它在含有 BRAF 或 RAS 突变的 MAPK 抑制剂初治和 MAPK 抑制剂耐药细胞中具有抗肿瘤活性。
T3074 CHIR 98024

CHIR98014

GSK-3; S6 Kinase MAPK; PI3K/Akt/mTOR signaling; Stem Cells
CHIR 98024是一种有效的 GSK-3α/β 抑制剂,在无细胞试验中 IC50 为 0.65 nM/0.58 nM,能够区分 GSK-3 与其接近的同源物 Cdc2ERK2
T6511 Ravoxertinib

GDC-0994

ERK MAPK
Ravoxertinib (GDC-0994) 是可口服的ERK 激酶抑制剂,抑制ERK1和ERK2的IC50分别为 6.1 和 3.1 nM。
T4091 Temuterkib

LY3214996

ERK MAPK
Temuterkib (LY3214996) 是高效选择性的ERK1和ERK2抑制剂,IC50为 5 nM,具有潜在的抗肿瘤活性。
TP1970L Prosaptide TX14(A) acetate

Prosaptide TX14(A) acetate(196391-82-9 free base)

ERK; GPR Endocrinology/Hormones; GPCR/G Protein; MAPK
Prosaptide TX14(A) acetate 是一种有效的 GPR37L1 和 GPR37 激动剂。 它增加雪旺细胞中的 ERK1 和 ERK2 磷酸化。
T4092 AG126

Tyrphostin AG126,AG 126

ERK; COX Immunology/Inflammation; MAPK; Neuroscience
AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂,可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。
T6324 (E/Z)-BIX02188

334949-59-6

ERK; MEK; TGF-beta/Smad MAPK; Stem Cells
BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM),也抑制 ERK5 催化活性 (IC50: 810 nM),并且不抑制密切相关的激酶 MEK1/2、JNK2ERK2
T6673 SKI II

SphK-I2

Apoptosis; Wnt/beta-catenin; S1P Receptor Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂,抑制 SK1 和 SK2,IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解,不可逆地抑制SK1。
T3623 Cobimetinib

可美替尼,考比替尼,RG7420,XL518,GDC-0973

Apoptosis; MEK Apoptosis; MAPK
Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂,抑制MEK1的IC50为4.2 nM。
T2310L CHIR-99021 HCl

CT99021 HCl,Laduviglusib HCl

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
CHIR-99021 HCl (Laduviglusib HCl) 是GSK-3α/β的高效选择性抑制剂,IC50值分别为10 nM和6.7 nM。它对GSK-3表现出显著的选择性,对CDC2ERK2和其他蛋白激酶的选择性超过500倍。此外,CHIR-99021 HCl 是Wnt/β-catenin信号通路的强大激活剂。此外,它在小鼠和人类胚胎干细胞中都表现出增强自我更新的能力。此外,拉杜维格西单盐酸盐诱导自噬[1][2][3]。
T2608 CHIR-98014

CHIR 98014,CT98014,CHIR98014

FGFR; GSK-3; Src; S6 Kinase Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
CHIR-98014 (CT98014) 是有效的,细胞通透的GSK-3抑制剂,可抑制 GSK-3α (IC50:0.65 nM) 和 GSK-3β (IC50:0.58 nM) 的活性,对 cdc2erk2 的作用较弱。
T62929 RLX-33

ERK; RXFP receptor GPCR/G Protein; MAPK
RLX-33 是一种有效的、选择性的、能够透过血脑屏障的松弛素家族肽 3 (RXFP3) 拮抗剂,也能够阻断松弛素 3 (relaxin 3) 诱导的 ERK1/2 磷酸化。RLX-33 作用于 RXFP3、ERK1 和 ERK2 磷酸化的 IC50 分别为 2.36 μM、7.82 μM 和 13.86 μM。RLX-33 可以阻断 RXFP3 选择性激动剂 R3/I5 诱导的大鼠食物摄取增加。RLX-33 能够用于研究代谢综合征。
T36675 ERK-IN-4

ERK Inhibitor

ERK MAPK
ERK-IN-4 是一种具有细胞渗透性的 ERK 抑制剂,具有潜在的抗增殖作用,可用于研究免疫功能异常引起的疾病。
T12069 MK-8353

SCH900353

ERK MAPK
MK-8353 (SCH900353) 是口服有效的ERK1/2选择性抑制剂,IC50分别为 23.0 nM 和 8.8 nM。它显示出抗肿瘤活性。
T3166 VX-11e

Vertex-11e,VTX-11e,TCS ERK 11e

ERK; GSK-3; FLT; CDK; Aurora Kinase Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
VX-11e (TCS ERK 11e) 是可口服的ERK 高效选择性抑制剂,Ki 值小于 2 nM。
T11225 ERK-IN-2

ERK MAPK
ERK-IN-2ERK2抑制剂,IC50值为 1.8 nM。 ERK-IN-2 在剂量 >10 μM 可能引起脱靶毒性和/或脱靶活性。
T15377 Ravoxertinib hydrochloride

GDC-0994 (hydrochloride)

ERK MAPK
Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
T78143 (R)-VX-11e

ERK MAPK
(R)-VX-11e(化合物1)为ERK2抑制剂,具有选择性地阻断ERK2活性的能力。
T63331 ERK1/2 inhibitor 8

ERK1/2 inhibitor 8 是 ERK 的有效抑制剂,能够作用于 ERK2 (IC50: 0.48 nM)。
T62933 ERK1/2 inhibitor 7

ERK1/2 inhibitor 7 是一种 ERK 的有效抑制剂,作用于 ERK2 (IC50: 0.94 nM)。
T76556 MEK1 Derived Peptide Inhibitor 1

MEK1Derived Peptide Inhibitor 1,一种肽抑制剂,以IC50值30 μM抑制MEK1激活ERK2。适用于细胞渗透性研究。
T72517 ERK-IN-2 free base

ERK-IN-2 free base是ERK2抑制剂,IC50为1.8 nM。使用剂量>10 μM时,可能引起脱靶毒性和/或脱靶活性。
T36672 CAY10561

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561...
T81387 Prosaptide Tx14(A) TFA

Prosaptide Tx14(A) TFA 为prosaposin衍生的肽类化合物,可有效激活GPR37L1及GPR37,其EC50值分别为5 nM与7 nM。该化合物亦能促进Schwann细胞内ERK1与ERK2的磷酸化作用。
T62939 SHR2415

SHR2415 是一种选择性的、高效的、口服具有活力的 ERK1/2 抑制剂。SHR2415 能够抑制 ERK1 (IC50: 2.8 nM) 和 ERK2 (IC50: 5.9 nM)。SHR2415 在 Colo205 细胞中表现出高效力 (IC50: 44.6 nM)。SHR2415 能够用于癌症的研究。
T64001 MAP855

MAP855 是一种高效的、选择性的、口服具有活力的具、 ATP 竞争性的 MEK1/2 激酶抑制剂,对 MEK1 ERK2 cascade 的 IC50 值为 3 nM,pERKEC50 值为 5 nM。MAP855 对野生型和突变型 MEK1/2 表现出同等的抑制效果。
T61755 E6201

E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T8461 SKI V

Apoptosis; PI3K; S1P Receptor Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂,对 GST-hSK 的IC50为 2 μM。 它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成,可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K,对 hPI3k 的IC50为 6 μM。
T12058 MK2-IN-3 hydrate

MK-2 Inhibitor III

ERK; MAPK; MNK MAPK
MK2-IN-3 hydrate (MK-2 Inhibitor III) 是一种口服有活性的、ATP 竞争性的MAPKAP-K2 (MK-2)选择性抑制剂(IC50:0.85 nM)。
T38377 ADTL-EI1712

ADTL-EI1712

ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 μM. ADTL-EI1712 inhibits proliferation of HL-60 and MKN74, but not HeLa, cancer cells (IC50s = 1.26, 2.55, and >50 μM, respectively). It reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model when administered at a do...
T2029 Bohemine

ERK; CDK Cell Cycle/Checkpoint; MAPK
Bohemine 是一种合成的选择性CDK 抑制剂,是嘌呤类似物,具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。
T4444 A-674563 HCl (552325-73-2(free base))

ERK; Akt; PKA; CDK; PKC Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
A-674563 HCl (552325-73-2(free base)) 是一种口服的、ATP 竞争性的、可逆的 Akt 抑制剂(Akt1 的 Ki:11 nM)。它对 PKA 和 Cdk2 具有抑制活性(IC50:16/46 nM),但对 Akt1 的选择性比 CMGC、CAMK 和 TK 家族中的其他激酶高 10 至 >1800 倍。
T35696 Olomoucine II

Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively...
T2095 Seliciclib

Roscovitine,R-roscovitine,CYC202

CDK Cell Cycle/Checkpoint
Seliciclib (Roscovitine) 是 Cdk2/cyclin E 的有效抑制剂,IC50为0.1 µM。它还抑制 Cdk7/cyclin H、Cdk5/p35 和 Cdc2/cyclin B,IC50为 0.49、0.16和0.65 µM。
T12102 Mps1-IN-1

Others Others
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )
T14072 A-443654

ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
A-443654 是 pan-Akt 抑制剂,对Akt1,Akt2,和Akt3具有同等效力的抑制作用,Ki=均为 160 pM。
T23337 SCH772984 HCl

ERK; Others MAPK; Others
SCH772984 HCl 是一种特异性的 ERK1/2 抑制剂,具有 I 型和 II 型激酶抑制剂的特性,其 IC50 分别为 4 和 1 nM。 SCH772984 HCl 在 BRAF、NRAS 或 KRAS 突变的肿瘤细胞中具有纳摩尔级细胞效力,并诱导肿瘤消退。 SCH772984 HCl 可用于 MAPK 抑制剂难治性肿瘤的研究。
T21377 Aloisine A

Aloisine A is a potent and selective CDK/GSK-3 inhibitor. IC50 data of Aloisine A: Cdk1/cyclin B (IC50: 150nM), Cdk2/cyclin A (IC50: 120nM), Cdk2/cyclin E (IC50: 400nM), Cdk5/p25 (IC50: 200nM), Cdk5/p35 (IC50: 160nM), GSK-3α (IC50: 500nM), GSK-3β (IC50: 6

化合物

ERK2 IN-1
Cat.No: T11228
Synonym:
Target: ERK
MK2-IN-3
Cat.No: T9034
Synonym: MK2 Inhibitor III
Target: MAPK
Ulixertinib
Cat.No: T7005
Synonym: BVD-523,VRT752271,优立替尼
Target: ERK
Tizaterkib
Cat.No: T10429
Synonym: AZD-0364
Target: ERK
FR 180204
Cat.No: T1956
Synonym: FR180204
Target: Apoptosis, ERK
ERK1/2 inhibitor 1
Cat.No: T11226
Synonym:
Target: ERK
Longdaysin
Cat.No: T5358
Synonym:
Target: ERK, Casein Kinase, CDK
SCH772984
Cat.No: T6066
Synonym:
Target: ERK, MEK
CHIR 98024
Cat.No: T3074
Synonym: CHIR98014
Target: GSK-3, S6 Kinase
Ravoxertinib
Cat.No: T6511
Synonym: GDC-0994
Target: ERK
Temuterkib
Cat.No: T4091
Synonym: LY3214996
Target: ERK
Prosaptide TX14(A) acetate
Cat.No: TP1970L
Synonym: Prosaptide TX14(A) acetate(196391-82-9 free base)
Target: ERK, GPR
AG126
Cat.No: T4092
Synonym: Tyrphostin AG126,AG 126
Target: ERK, COX
(E/Z)-BIX02188
Cat.No: T6324
Synonym: 334949-59-6
Target: ERK, MEK, TGF-beta/Smad
SKI II
Cat.No: T6673
Synonym: SphK-I2
Target: Apoptosis, Wnt/beta-catenin, S1P Receptor
Cobimetinib
Cat.No: T3623
Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973
Target: Apoptosis, MEK
CHIR-99021 HCl
Cat.No: T2310L
Synonym: CT99021 HCl,Laduviglusib HCl
Target: GSK-3
CHIR-98014
Cat.No: T2608
Synonym: CHIR 98014,CT98014,CHIR98014
Target: FGFR, GSK-3, Src, S6 Kinase
RLX-33
Cat.No: T62929
Synonym:
Target: ERK, RXFP receptor
ERK-IN-4
Cat.No: T36675
Synonym: ERK Inhibitor
Target: ERK
MK-8353
Cat.No: T12069
Synonym: SCH900353
Target: ERK
VX-11e
Cat.No: T3166
Synonym: Vertex-11e,VTX-11e,TCS ERK 11e
Target: ERK, GSK-3, FLT, CDK, Aurora Kinase
ERK-IN-2
Cat.No: T11225
Synonym:
Target: ERK
Ravoxertinib hydrochloride
Cat.No: T15377
Synonym: GDC-0994 (hydrochloride)
Target: ERK
(R)-VX-11e
Cat.No: T78143
Synonym:
Target: ERK
ERK1/2 inhibitor 8
Cat.No: T63331
Synonym:
Target:
ERK1/2 inhibitor 7
Cat.No: T62933
Synonym:
Target:
MEK1 Derived Peptide Inhibitor 1
Cat.No: T76556
Synonym:
Target:
ERK-IN-2 free base
Cat.No: T72517
Synonym:
Target:
CAY10561
Cat.No: T36672
Synonym:
Target:
Prosaptide Tx14(A) TFA
Cat.No: T81387
Synonym:
Target:
SHR2415
Cat.No: T62939
Synonym:
Target:
MAP855
Cat.No: T64001
Synonym:
Target:
E6201
Cat.No: T61755
Synonym:
Target:
SKI V
Cat.No: T8461
Synonym:
Target: Apoptosis, PI3K, S1P Receptor
MK2-IN-3 hydrate
Cat.No: T12058
Synonym: MK-2 Inhibitor III
Target: ERK, MAPK, MNK
ADTL-EI1712
Cat.No: T38377
Synonym: ADTL-EI1712
Target:
Bohemine
Cat.No: T2029
Synonym:
Target: ERK, CDK
A-674563 HCl (552325-73-2(free base))
Cat.No: T4444
Synonym:
Target: ERK, Akt, PKA, CDK, PKC
Olomoucine II
Cat.No: T35696
Synonym:
Target:
Seliciclib
Cat.No: T2095
Synonym: Roscovitine,R-roscovitine,CYC202
Target: CDK
Mps1-IN-1
Cat.No: T12102
Synonym:
Target: Others
A-443654
Cat.No: T14072
Synonym:
Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase
SCH772984 HCl
Cat.No: T23337
Synonym:
Target: ERK, Others
Aloisine A
Cat.No: T21377
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T3001 Honokiol

和厚朴酚,NSC 293100

ERK; HCV Protease; MEK; Akt; Autophagy Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
Honokiol (NSC-293100) 是厚朴提取物的活性成分,靶向多种信号分子,具有抗氧化,抗炎,抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。
T3857 magnolin

木兰脂素,(+)-Magnolin,木兰苷

ERK MAPK
Magnolin 是辛夷的一种主要成分,靶向作用于ERK1和ERK2,IC50值分别为 87 和 16.5 nM,可抑制Ras/ERKs/RSK2信号通路。它在体内外降低肾脏氧化应激,抑制 caspase-3 活性,并增加 Bcl-2 表达,具有抗炎和抗氧化作用。
T6S0655 Corynoxeine

ERK MAPK
Corynoxeine 是从钩藤中分离的一种天然产物,是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的 ERK1/ERK2抑制剂。
T15542 Hypothemycin

Others Others
Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).

天然产物

Honokiol
Cat.No: T3001
Synonym: 和厚朴酚,NSC 293100
Target: ERK, HCV Protease, MEK, Akt, Autophagy
magnolin
Cat.No: T3857
Synonym: 木兰脂素,(+)-Magnolin,木兰苷
Target: ERK
Corynoxeine
Cat.No: T6S0655
Synonym:
Target: ERK
Hypothemycin
Cat.No: T15542
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-04571 ERK2 Protein, Mouse, Recombinant (His & GST)

PRKM2,C78273,mitogen-activated protein kin...

Mouse Baculovirus Insect Cells
ERK2 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.1 kDa and the accession number is P63085.
TMPY-04539 ERK2 Protein, Human, Recombinant (GST)

ERT1,ERK,PRKM1,ERK-2,p41,p41mapk,...

Human Baculovirus Insect Cells
ERK2 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 67 kDa and the accession number is P28482-1.
TMPJ-00166 SCF Protein, Mouse, Recombinant

SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...

Mouse E. coli
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPY-04572 MKK4 Protein, Mouse, Recombinant (His & GST)

MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated...

Mouse Baculovirus Insect Cells
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ...
TMPH-02268 AGTR2 Protein, Human, Recombinant (His & SUMO)

AT2 receptor,Angiotensin II type-2 recepto...

Human E. coli
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
TMPH-01347 FSHR Protein, Human, Recombinant (E. coli, His)

Human E. coli
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
TMPH-01348 FSHR Protein, Human, Recombinant (His)

Human HEK293 Cells
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 43.5 kDa and the accession number is P23945.
TMPY-04544 MEK2 Protein, Human, Recombinant (GST)

mitogen-activated protein kinase kinase 2,FLJ2<...

Human Baculovirus Insect Cells
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPJ-01378 Mp1 Protein, Human, Recombinant (His)

Mitogen-Activated Protein Kinase Kinase 1-Interacting Protei...

Human E. coli
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the eff...
TMPY-05095 RAF1 Protein, Human, Recombinant (His & GST)

Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N...

Human Baculovirus Insect Cells
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...
TMPJ-00894 SCF Protein, Rat, Recombinant (His)

Hematopoietic growth factor KL,Steel factor,Stem cell factor...

Rat E. coli
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPJ-00996 VHR Protein, Human, Recombinant (His)

DUSP3,VHR,Dual specificity protein phosphatase VHR,Vaccinia ...

Human E. coli
Human DUSP3 belongs to the dual specificity protein phosphatase subfamily. DUSPs are a heterogeneous group of protein phosphatases that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine residues within the one substrate. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. DUSPs are major modulators of critical signalling pathways that are dysregulated in various diseases. They negatively ...
TMPY-04399 TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)

DPK,MAP3K18,TAO kinase 3,JIK

Human Baculovirus Insect Cells
Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ...
TMPY-04460 OXSR1 Protein, Human, Recombinant (GST)

OSR1,oxidative stress responsive 1

Human Baculovirus Insect Cells
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of...
TMPY-04392 RSK3 Protein, Human, Recombinant (GST)

HU-2,ribosomal protein S6 kinase, 90kDa, polypeptid...

Human Baculovirus Insect Cells
Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a nucleus protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA2 / RSK-3 is expressed in many tissues. Highest expression is in lung and skeletal muscle. The expression of RPS6KA2 reduced proliferation, caused G1 a...
TMPY-04357 RSK4 Protein, Human, Recombinant (GST)

RSK4,ribosomal protein S6 kinase, 90kDa, polypeptide 6,PP90R...

Human Baculovirus Insect Cells
Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains one AGC-kinase C-terminal domain and two protein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2...
TMPH-01692 MAPK3 Protein, Human, Recombinant (His)

Human E. coli
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

ERK2 Protein, Mouse, Recombinant (His & GST)
Cat.No: TMPY-04571
Species: Mouse
Expression System: Baculovirus Insect Cells
ERK2 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04539
Species: Human
Expression System: Baculovirus Insect Cells
SCF Protein, Mouse, Recombinant
Cat.No: TMPJ-00166
Species: Mouse
Expression System: E. coli
MKK4 Protein, Mouse, Recombinant (His & GST)
Cat.No: TMPY-04572
Species: Mouse
Expression System: Baculovirus Insect Cells
AGTR2 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-02268
Species: Human
Expression System: E. coli
FSHR Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01347
Species: Human
Expression System: E. coli
FSHR Protein, Human, Recombinant (His)
Cat.No: TMPH-01348
Species: Human
Expression System: HEK293 Cells
MEK2 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04544
Species: Human
Expression System: Baculovirus Insect Cells
Mp1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01378
Species: Human
Expression System: E. coli
RAF1 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-05095
Species: Human
Expression System: Baculovirus Insect Cells
SCF Protein, Rat, Recombinant (His)
Cat.No: TMPJ-00894
Species: Rat
Expression System: E. coli
VHR Protein, Human, Recombinant (His)
Cat.No: TMPJ-00996
Species: Human
Expression System: E. coli
TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)
Cat.No: TMPY-04399
Species: Human
Expression System: Baculovirus Insect Cells
OXSR1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04460
Species: Human
Expression System: Baculovirus Insect Cells
RSK3 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04392
Species: Human
Expression System: Baculovirus Insect Cells
RSK4 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04357
Species: Human
Expression System: Baculovirus Insect Cells
MAPK3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01692
Species: Human
Expression System: E. coli
TargetMol Loading
联系我们
400-820-0310

上海市静安区江场三路238号8楼