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Search Results for " dermatitis "

62

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14981	Clobetasone butyrate	Glucocorticoid Receptor	Endocrinology/Hormones
	Clobetasone butyrate 是糖皮质类固醇，特别是在皮肤上，具有局部抗炎活性。它可用于改善皮质类固醇反应性症状，如特应性皮炎、牛皮癣。
T27172	Difamilast	PDE	Metabolism
	Difamilast 是局部的、选择性的非甾体磷酸二酯酶 4 抑制剂，对 B 亚型抑制作用较好 (IC50=11.2 nM)。它在研究轻度至中度特应性皮炎方面有研究的价值。
T7893	Bepotastine Bepotastine free base,贝托斯汀	Others; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others
	Bepotastine (Bepotastine free base) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T6405	Bepotastine Besilate Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bepotastine Besilate (TAU 284) 是一种选择性可口服的组胺 H1 受体拮抗剂，可用于过敏性鼻炎、过敏性结膜炎、荨麻疹和瘙痒症的研究。
T4966	Ufenamate 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯	Others	Others
	Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎药。它可用于皮肤疾病研究。
T2648	Pimecrolimus SDZ-ASM 981,ASM 981,吡美莫司	Others	Others
	Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体，能与胞质受体特异性的结合。
T1090	Perphenazine Perphenazin,Etaperazine,Trilafon,奋乃静	CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂，具有止吐和抗精神病特性。它能够抑制5-HT2A 受体，α1A 肾上腺素能受体，多巴胺D2、D3、D2L 受体，以及组胺H1受体，对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。
T0891	Dapsone DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone	Reactive Oxygen Species; Antibacterial; Antibiotic; Parasite	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Dapsone (Sulphadione) 是具有口服活性和血脑渗透通透性的磺酰类抗生素，具有抑菌、抗细菌和抗原虫活性。它有抗麻风活性，抑制麻风杆菌细胞提取物中叶酸的合成。它可研究皮肤病。
T29096L	Vapitadine R 129160	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Vapitadine 是一种非镇静性抗组胺化合物，可缓解特应性皮炎引起的瘙痒。
T31645	EO-1606 EO 1606,EO1606
	Eo-1606 is a potential immunosuppressant for the treatment of dermatitis.
T25982	Pramiconazole R-126638,R126638,R 126638,Azoline	Antifungal	Microbiology/Virology
	Pramiconazole (R126638) 是一种可口服的抗真菌化合物。Pramiconazole 是治疗皮肤癣菌和皮肤酵母菌感染的候选化合物，可用于治疗脂溢性皮炎。
T75113	GLPG2534 GLPG-2534	IRAK	Immunology/Inflammation; NF-κB
	GLPG2534 是一种具有口服活性、选择性和有效性的 IRAK4 抑制剂，具有抗炎活性。GLPG2534 对人和小鼠 IRAK4 具有抑制作用，可用于研究银屑病和特应性皮炎。
T16792	Rovazolac ALX-101	Liver X Receptor	Metabolism
	Rovazolac (ALX-101) 是一种肝脏x受体 (LXR)调节剂，可用于研究免疫系统疾病和特应性皮炎。
T0339	Resorcinol monoacetate 乙醯間二酚(1,3-苯二醇单乙酸酯 ),Resorcin monoacetate	Others	Others
	Resorcinol monoacetate (Resorcin monoacetate) 是一种防腐剂，及消毒剂，是用于合成其他药品的化学中间体。有用于痤疮，脂溢性皮炎，湿疹，银屑病和其它皮肤病的研究潜力。
T83624	Selenium sulfide	Antibiotic	Microbiology/Virology
	Selenium sulfide 具有抗菌活性，常用于控制头皮屑、脂溢性皮炎和牛皮癣。
T3987	Lotamilast E6005,RVT-501	PDE	Metabolism
	Lotamilast (RVT-501) 是一种磷酸二酯酶4(PDE4) 选择性抑制剂，IC50=2.8 nM。
T77369	Telazorlimab ISB-830,GBR-830	Immunology/Inflammation related	Immunology/Inflammation
	Telazorlimab (GBR-830) 是一种靶向活化 T 细胞上 OX40 共刺激受体的人源化单克隆抗体。Telazorlimab 可用于治疗红斑狼疮和特应性皮炎。
T24755	Salnacedin G-201,SCY,G-201,G201,SCY,G 201	Others	Others
	Salnacedin (G-201) 是一种小分子化合物，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究寻常痤疮、皮炎和银屑病。
T2200	Hydroxyzine dihydrochloride Hydroxyzine 2HCl,盐酸羟嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) 是一种苯二氮卓抗组胺剂，是可口服的组胺 H1 受体和血清素拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它还可以作为止吐剂和镇静剂，有缓解焦虑和紧张的作用。
T76775	Fezakinumab ILV 094	Interleukin	Immunology/Inflammation
	Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。
T0500	Chloroxine Capitrol,氯喔星	Antibacterial; Antibiotic	Microbiology/Virology
	Chloroxine (Capitrol) 是重要的 8-羟基喹啉衍生物之一，有抗细菌，抗真菌，抗原生动物和抗阿米巴虫活性，可研究肠道阿米巴病，还可研究头皮屑和头皮脂溢性皮炎。
T0053	Hydroxyzine Pamoate Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Hydroxyzine Pamoate (Bobsule) 是一种组胺 H1 受体拮抗剂，可有效治疗慢性荨麻疹、皮炎和组胺介导的瘙痒。它可作为止吐剂和镇静剂，缓解焦虑和紧张。
T13666	Dupilumab REGN-668,SAR-231893	IL Receptor	Immunology/Inflammation
	Dupilumab (REGN-668) 是一种用于AD 的全身免疫调节剂。Dupilumab 是一种针对白细胞介素-4受体α亚基的完全人类单克隆抗体，可抑制IL-4和IL-13下游信号传导，具有改善特应性皮炎的作用。
T0944	Levamisole hydrochloride (-)-Tetramisole hydrochloride,盐酸左旋咪唑	Phospholipase; AChR; Parasite; HSV	Metabolism; Microbiology/Virology; Neuroscience
	Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
T2392	Nafamostat mesylate 甲磺酸萘莫司他,FUT-175	Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease	Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂，血管舒缓素抑制剂，能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性，可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。
T2270	Trans-Tranilast Tranilast trans-,反式-曲尼司特,反-曲尼司特	RAAS	Endocrinology/Hormones
	Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。
T76704	Tralokinumab CAT-354,LP 0162	IL Receptor	Immunology/Inflammation
	Tralokinumab 是一种全人源 IgG4 单克隆抗体，对单独的 IL-13 亲和力较高。Tralokinumab 具有潜在的抗炎活性，可预防IL-13与受体相互作用和随后的下游信号传导，可用于研究特应性皮炎 (AD) 。
T76724	Nemolizumab CIM331	Interleukin	Immunology/Inflammation
	Nemolizumab (CIM331) 是一种人源化的抗人白细胞介素-31 受体 a 单克隆抗体，对白细胞介素-31 (IL-31) 与其受体的结合和随后的信号转导有抑制作用。Nemolizumab 可用于研究特应性皮炎伴瘙痒。
T76884	Spesolimab BI 655130	IL Receptor	Immunology/Inflammation
	Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用，与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。
T72391	Clocortolone pivalate
	Clocortolone pivalate是一种合成糖皮质激素和皮质类固醇酯，适用于治疗脂溢性皮炎、接触性皮炎、特应性皮炎及银屑病。
T14154	Alclometasone 7a-Chloro-16a-methyl prednisolone
	Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatitis, psoriasis, allergic dermatitis, and eczema [1].
T67202	Benvitimod
	Benvitimod is a non-steroidal anti-inflammatory drug (NSAID) potentially for the treatment of atopic dermatitis.
T20150	C.I. 37505 3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI)
	C.I. 37505 is an azo dye coupling component.It implicated in occupational pigmented contact dermatitis.
T70974	Cipamfylline
	Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human models of acute and chronic irritant contact dermatitis. The outcome of the study revealed that cipamfylline was more effective than vehicle in treating atopic dermatitis, but less effective than a group II steroid, hydrocortisone-17-butyrate both in the treatment of atopic derm...
T39646	Atinvicitinib
	Atinvicitinib, a pyrazole compound, exhibits promise for investigating atopic dermatitis.
T26555	Acreozast TYB 2285,TYB-2285,TYB2285
	Acreozast, a histamine release inhibitor, is used potentially for the treatment of asthma and atopic dermatitis.
T29039	UCB-35440 UCB 35440,UCB35440
	UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.
T38540	BAY 1003803
	BAY 1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis.
T35076	VTP-766
	VTP-766 is an effective orally active and selective liver X receptor β (lxrβ) agonist, targeted to treat atopic dermatitis and acute coronary syndrome.
T78207	Lepzacitinib	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Lepzacitinib为Janus激酶抑制剂，特异性针对JAK1/3，具备显著的抗炎效能，适用于治疗特应性皮炎及其他皮肤疾病。
T76816	Lokivetmab
	Lokivetmab（Anti-Canine IL31 Recombinant Antibody）为针对犬特应性皮炎（AD）研究的抗犬IL-31单克隆抗体。
T78333	Rocatinlimab AMG 451,KHK4083
	Rocatinlimab（AMG 451）（KHK4083）为全人源非岩藻糖化IgG1抗OX40单克隆抗体，旨在用于特应性皮炎（AD）研究。
T21374	Clocortolone Clocortolona,Clocortolonum,Cloderm
	Clocortolone is a Corticosteroid Hormone Receptor Agonist. It is used in the form of an ester, clocortolone pivalate, and applied as a cream. clocortolone pivalate is used to treat dermatitis and is considered a medium-strength corticosteroid.
T76679	Etokimab
	Etokimab（Antibody ANB 020），一种人源化单克隆抗体，靶向IL-33，主要用于特应性皮炎的研究。
T78299	Amlitelimab KY1005,SAR445229
	Alvircept sudotox是一种针对OX40配体（OX40L）的单克隆抗体（mAb），能够抑制OX40与OX40L之间的相互作用，其主要用途为特应性皮炎研究。
T69950	Delgocitinib EtOH
	Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
T71561	LEO-29102
	LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis.
T82074	Immune cell migration-IN-1
	Immune cell migration-IN-1（compound 2）是一种抑制免疫细胞迁移的有效化合物，适用于干眼病、湿疹、皮炎和牛皮癣等疾病研究。
T38002	LEO 39652
	LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) [1]. LEO 39652 shows unbound in vitro potency when measured as LPS induced TNF-α release in human peripheral blood mononuclear cells (PBMC), incubated in serum free medium. LEO 39652 shows a relatively high binding to human serum albumin...
T33914	Pentaerythrityl tetracaprate Pentaerythritol tetradecanoate,Pentaerythritol tetracaprate
	Pentaerythrityl tetracaprate is an ester found in cosmetics and beauty products because of its binding and moisturizing properties; it is also used as a viscosity increasing agent. It is a synthetic compound derived from fatty acids, according to research

化合物

Clobetasone butyrate

Cat.No: T14981

Target: Glucocorticoid Receptor

Cat.No: T27172

Target: PDE

Cat.No: T7893

Synonym: Bepotastine free base,贝托斯汀

Target: Others, Histamine Receptor

Bepotastine Besilate

Cat.No: T6405

Synonym: Talion,TAU 284,苯磺酸贝托司汀,Bepreve,Bepotastine Beslilate

Target: Histamine Receptor

Cat.No: T4966

Synonym: 氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯

Target: Others

Cat.No: T2648

Synonym: SDZ-ASM 981,ASM 981,吡美莫司

Target: Others

Cat.No: T1090

Synonym: Perphenazin,Etaperazine,Trilafon,奋乃静

Target: CaMK, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T0891

Synonym: DDS,4,4‘-Sulfonyldianiline,氨苯砜,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone

Target: Reactive Oxygen Species, Antibacterial, Antibiotic, Parasite

Cat.No: T29096L

Synonym: R 129160

Target: Histamine Receptor

Cat.No: T31645

Synonym: EO 1606,EO1606

Cat.No: T25982

Synonym: R-126638,R126638,R 126638,Azoline

Target: Antifungal

Cat.No: T75113

Synonym: GLPG-2534

Target: IRAK

Cat.No: T16792

Synonym: ALX-101

Target: Liver X Receptor

Resorcinol monoacetate

Cat.No: T0339

Synonym: 乙醯間二酚(1,3-苯二醇单乙酸酯 ),Resorcin monoacetate

Target: Others

Selenium sulfide

Cat.No: T83624

Target: Antibiotic

Cat.No: T3987

Synonym: E6005,RVT-501

Target: PDE

Cat.No: T77369

Synonym: ISB-830,GBR-830

Target: Immunology/Inflammation related

Cat.No: T24755

Synonym: G-201,SCY,G-201,G201,SCY,G 201

Target: Others

Hydroxyzine dihydrochloride

Cat.No: T2200

Synonym: Hydroxyzine 2HCl,盐酸羟嗪

Target: Histamine Receptor

Cat.No: T76775

Synonym: ILV 094

Target: Interleukin

Cat.No: T0500

Synonym: Capitrol,氯喔星

Target: Antibacterial, Antibiotic

Hydroxyzine Pamoate

Cat.No: T0053

Synonym: Hydroxyzine embonate,双羟萘酸羟嗪,Bobsule,Equipose

Target: Histamine Receptor

Cat.No: T13666

Synonym: REGN-668,SAR-231893

Target: IL Receptor

Levamisole hydrochloride

Cat.No: T0944

Synonym: (-)-Tetramisole hydrochloride,盐酸左旋咪唑

Target: Phospholipase, AChR, Parasite, HSV

Nafamostat mesylate

Cat.No: T2392

Synonym: 甲磺酸萘莫司他,FUT-175

Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease

Trans-Tranilast

Cat.No: T2270

Synonym: Tranilast trans-,反式-曲尼司特,反-曲尼司特

Target: RAAS

Cat.No: T76704

Synonym: CAT-354,LP 0162

Target: IL Receptor

Cat.No: T76724

Synonym: CIM331

Target: Interleukin

Cat.No: T76884

Synonym: BI 655130

Target: IL Receptor

Clocortolone pivalate

Cat.No: T72391

Cat.No: T14154

Synonym: 7a-Chloro-16a-methyl prednisolone

Cat.No: T67202

Cat.No: T20150

Synonym: 3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI)

Cat.No: T70974

Cat.No: T39646

Cat.No: T26555

Synonym: TYB 2285,TYB-2285,TYB2285

Cat.No: T29039

Synonym: UCB 35440,UCB35440

Cat.No: T38540

Cat.No: T35076

Cat.No: T78207

Target: JAK

Cat.No: T76816

Cat.No: T78333

Synonym: AMG 451,KHK4083

Cat.No: T21374

Synonym: Clocortolona,Clocortolonum,Cloderm

Cat.No: T76679

Cat.No: T78299

Synonym: KY1005,SAR445229

Delgocitinib EtOH

Cat.No: T69950

Cat.No: T71561

Immune cell migration-IN-1

Cat.No: T82074

Cat.No: T38002

Pentaerythrityl tetracaprate

Cat.No: T33914

Synonym: Pentaerythritol tetradecanoate,Pentaerythritol tetracaprate

Cat. No.	Product Name	Target	Signaling Pathways
T4S0398	Rosin 松香树脂	p38 MAPK	MAPK
	Rosin 分离自松木或松树桩中，是一种频繁接触的过敏原，能够导致过敏性接触性皮炎。
T5320	Tulipalin A α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯	Others; Drug Metabolite	Metabolism; Others
	Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)，在低剂量影响免疫细胞的功能，例如 Jurkat T 细胞。
T6S0232	Eriodictyol 圣草酚,Huazhongilexone	Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物，具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 18 nM。它可诱导Nrf2信号通路。
TN6512	Tectol	Transferase; Parasite	Metabolism; Microbiology/Virology
	Tectol 是从Lippia sidoides 中分离的，对人白血病细胞株 HL60 和 CEM 具有显著的抑制作用。它是法尼基转移酶抑制剂，在人和布氏锥虫的IC50分别为 2.09 和 1.73 μM。它具有抗疟原虫活性，是一种中等活性的生长抑制剂，IC50 为 3.44±0.20μM。
TN1236	3',4',7-Trihydroxyisoflavone	MAPK; JNK	MAPK
	3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物，是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂，具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用，可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能，可用于研究特应性皮炎。
T33033	Lyngbyatoxin A
	Lyngbyatoxin A is an indole alkaloid from blue-green alga Lyngbya majuscula Gomont; responsible for dermatitis known as "swimmers' itch" in Hawaii.

天然产物

Cat.No: T4S0398

Synonym: 松香树脂

Target: p38 MAPK

Cat.No: T5320

Synonym: α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯

Target: Others, Drug Metabolite

Cat.No: T6S0232

Synonym: 圣草酚,Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

Cat.No: TN6512

Target: Transferase, Parasite

3',4',7-Trihydroxyisoflavone

Cat.No: TN1236

Target: MAPK, JNK

Cat.No: T33033

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