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Search Results for " caspase-3-in-1 "

44

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T63479	Caspase-3-IN-1
	Caspase-3-IN-1 是 Caspase-3 的有效抑制剂 (IC50: 14.5 nM)。
T12412L	PDK4-IN-1 hydrochloride	Apoptosis; PDK	Apoptosis; PI3K/Akt/mTOR signaling
	PDK4-IN-1 hydrochloride 是一种蒽醌衍生物，对丙酮酸脱氢酶激酶 4有抑制作用，IC50为 84 nM，具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏，抗糖尿病和抗癌作用。
T28178	NLRP3-IN-9 INF-4E,INF 4E,INF4E	NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用，以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。
T26326	VU0285655-1 VU-0285655,VU0285655,BML 280,VU 0285655,BML280,BML-280	TNF; Phospholipase; Interleukin	Apoptosis; Immunology/Inflammation; Metabolism
	VU0285655-1(BML-280) 是一种有效的选择性磷脂酶 D2 (PLD2) 抑制剂，可抑制PLD2 缺陷细胞的增殖。VU0285655-1 对高糖诱导的 caspase-3 裂解和细胞活力降低有抑制作用。VU0285655-1 可用于研究糖尿病视网膜病。
T10896L	CSRM617 hydrochloride CSRM617 hydrochloride(787504-88-5 Free base)	Apoptosis; Others; Androgen Receptor	Apoptosis; Endocrinology/Hormones; Others
	CSRM617 hydrochloride 是转录因子ONECUT2(OC2，雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂，在 SPR 测定中Kd 为 7.43 uM，直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过裂解 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中具有良好的耐受性。
T80659	Z-YVAD-CMK	Caspase	Apoptosis; Proteases/Proteasome
	Z-YVAD-CMK为一种针对caspase-1及caspase-3的抑制剂。
T62997	PI3K/AKT-IN-1
	PI3K/AKT-IN-1 是一种有效的、双重的 PI3K/AKT 抑制剂，能够作用于 PI3Kγ (IC50: 6.99 μM)、PI3Kδ (IC50: 4.01 μM) 和 AKT (IC50: 3.36 μM)。PI3K/AKT-IN-1 通过抑制 PI3K/AKT 通路，诱导 caspase 3 依赖性凋亡，表现出抗癌作用。
T82774	Caspase-3 activator 3	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 3 (compound 2h) 通过激活caspase 3诱导HL-60和K562细胞apoptosis，表现出抗白血病活性。其对HL-60细胞的IC50值为42.89 μM，对K562细胞的IC50值为33.61 μM。
T75706	Ac-DEVD-CMK TFA
	Ac-DEVD-CMK (Caspase-3 Inhibitor III) TFA 是一种选择性且不可逆的caspase-3抑制剂。Ac-DEVD-CMK TFA 显着抑制由高水平葡萄糖或 3,20-dibenzoate (IDB) 诱导的凋亡。Ac-DEVD-CMK TFA 可以用于多种实验方法以抑制细胞凋亡。
T79743	Caspase-3 activator 1	Pyroptosis	Apoptosis; Immunology/Inflammation
	Caspase-3 activator 1 (compound 4b) 是一种Ru(III)金属复合物，它能够有效抑制胃肿瘤细胞的生长与转移。该化合物通过介导caspase-3的活化而促进GSDME的裂解，产生GSDME-N末端，导致胃肿瘤细胞发生膜穿孔。Caspase-3 activator 1还能诱导焦亡及其引发的免疫应答，并可与地西他滨（DCT）构建成4b-DCT-Lip脂质纳米粒子，用于高效药物递送。
T82775	Caspase-3 activator 2	Caspase	Apoptosis; Proteases/Proteasome
	Caspase-3 activator 2 (Compound 2f) 是诱导细胞凋亡的caspase 3激活剂，适用于癌症研究。该化合物对 HL-60 细胞和 K562 细胞展示出细胞毒性，IC50 值分别为 33.52 μM 和 76.90 μM。
T76038	Ac-Nle-Pro-Nle-Asp-AMC
	Ac-Nle-Pro-Nle-Asp-AMC 是26S 蛋白酶体(26Sproteasome)的特异性底物，适用于分析26S 蛋白酶体中caspase样活性。
T79497	M826	Caspase	Apoptosis; Proteases/Proteasome
	M826是一种高效、选择性及可逆的非肽类caspase-3抑制剂，具备0.005 μM的caspase-3酶活性IC50值。在体内外动物模型中，M826显示出显著的抗细胞凋亡效应，适用于神经系统疾病研究。
T79791	Immunosuppressant-1	Apoptosis	Apoptosis
	Immunosuppressant-1（Compound 31）抑制抗-CD3/抗-CD28共刺激的T细胞增殖，具备免疫抑制活性。该化合物能激活活化的淋巴结细胞中的caspase-3和PARP，从而诱导细胞凋亡（apoptosis）。
T83205	Ac-DNLD-CHO Ac-Asp-Asn-Leu-Asp-CHO	Caspase	Apoptosis; Proteases/Proteasome
	Ac-DNLD-CHO（Ac-Asp-Asn-Leu-Asp-CHO）是一种有效的Caspase-3/7抑制剂，具有较低的IC50（分别为9.89, 245 nM）和Kiapp（分别为0.68、55.7 nM）。该化合物在研究caspase介导的细胞凋亡过程中具有重要应用价值，适用于神经退行性疾病和病毒感染疾病的相关研究。
TP1965	Parstatin(human) Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop
T79602	MTP	Autophagy	Autophagy
	MTP作为一种PKM2抑制剂，能够通过激活caspase-3来诱导癌细胞发生凋亡（apoptosis），同时诱导自噬（autophagy）过程并提高ROS的产生量。此外，MTP对JAK2信号传递通路也有抑制作用。该化合物主要用于研究口腔鳞状细胞癌。
T73792	(S)-(-)-Perillic acid
	(S)-(-)-Perillic acid 是一种萜类植物提取物，具有抗菌和抗癌活性。(S)-(-)-Perillic acid 诱导细胞凋亡和细胞周期阻滞，增加细胞内 Bax，Bcl2，p21和 caspase-3的蛋白水平。(S)-(-)-Perillic acid 可用于癌症和感染研究。
T60583	CDK1/2/4-IN-1
	CDK1/2/4-IN-1 (compound 3a) 是 CDK 的有效抑制剂，其对于 CDK1、CDK2 和 CDK4 的 IC50值分别为 1.47、0.78 和 0.87 μM。CDK1/2/4-IN-1 可用于癌症研究。CDK1/2/4-IN-1 可将细胞周期阻滞在 G2/M 期并诱导细胞凋亡。CDK1/2/4-IN-1 提高 Bax、caspase-3和 P53 的水平并降低 Bcl-2 水平。
TP1966	Parstatin(mouse) Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo
T36190	CAY10443 CAY10443
	Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 μM. These apoptotic activators represent therapeutic lead compounds for the developme...
T76007	RGD peptide (GRGDNP) (TFA)
	RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂，阻碍α5β1与细胞外基质(ECM)的结合，并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。
T21978	p-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T82388	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Apoptosis; Proteases/Proteasome
	Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone 是一种细胞渗透性且无毒的抑制剂，它能与活化的caspase-3在凋亡细胞内不可逆结合。该抑制剂的荧光强度可通过流式细胞仪、微孔板读数器或荧光显微镜检测。
T61823	Anticancer agent 63
	Anticancer agent 63 (compound 3h) exhibits significant cytotoxic activity against multiple cancer cell lines, including SW480, HeLa, A549, and MCF-7, with IC 50 values of 4.9, 11.5, 9.4, and 3.4 μM, respectively, after 24 hours of treatment. In particular, Anticancer agent 63 induces apoptosis in MCF-7 cells by down-regulating Bcl-2 expression and up-regulating IL-2 and Caspase-3 expression. Additionally, Anticancer agent 63 demonstrates antioxidative properties [1].
T73852	Ac-YVAD-CHO acetate
	Ac-YVAD-CHO(L-709049)醋酸盐是一种高效、可逆、特异的四肽白介素1β转化酶(ICE)抑制剂，小鼠和人类的Ki值分别为3.0 nM和0.76 nM。它同时也能抑制caspase-1，从而抑制成熟IL-lβ的产生。
T61433	HDAC1-IN-5
	HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and α-tubulin, leading to the activation of caspase 3 and induction of apoptosis. Additionally, HDAC1-IN-5 binds with DNA, causing chromatin damage. Furthermore, it demonstrated strong inhibitory activity against tumor growth in xenograft mice. [1]
T61358	AKN-028 acetate
	AKN-028 acetate 是一种新型酪氨酸激酶 (TKI) 抑制剂，是一种有效的口服活性的 FMS 样受体酪氨酸激酶 3 (FLT3) 抑制剂，其 IC50值为 6 nM。AKN-028 acetate 抑制 FLT3 自磷酸化。AKN-028 acetate 诱导剂量依赖性的细胞毒性反应 (平均IC50=1 μM)。AKN-028 acetate 通过激活 caspase 3 诱导细胞凋亡 (apoptosis)。AKN-028 acetate 可用于急性髓系白血病 (AML) 的研究。
T79608	DPP	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	DPP，一种含紫檀芪衍生轴向配体的铂(IV)络合物，能够抑制乳腺癌(BC)细胞的JAK2-STAT3通路并显示出抗增殖特性。它通过激活caspase-3和裂解聚ADP-核糖聚合酶诱导细胞凋亡(apoptosis)，同时促进树突状细胞成熟及抗原呈现功能，并已证明体内具有安全性。
T60348	N1,N11-Diethylnorspermine
	N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放，导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。
T63522	Anticancer agent 64
	Anticancer agent 64 (化合物 5m) 对 CCRF-CEM 细胞具有细胞毒性，其IC50为2.4 μM。Anticancer agent 64 通过诱导细胞凋亡表现出良好的抗癌活性。Anticancer agent 64 诱导caspase 3和 7 的激活和PARP 的裂解。Anticancer agent 64 具有明显的线粒体去极化作用。
T73683	AC-VEID-CHO TFA
	AC-VEID-CHO (TFA) 是一种源自多肽的半胱天冬酶抑制剂，针对Caspase-6、Caspase-3和Caspase-7展示出优异的抑制效果，其IC50值分别为16.2 nM、13.6 nM和162.1 nM。该化合物常用于研究阿尔茨海默病、亨廷顿病等神经退行性疾病。
T79713	JMJD3/HDAC-IN-1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JMJD3/HDAC-IN-1 (compound A5b) 是靶向 JMJD3 和 HDAC1（IC50=16 nM）的双重抑制剂。它能够促进 H3K27 高甲基化和 H3K9 高乙酰化，并通过裂解 caspase-7 和 PARP 导致细胞凋亡。此外，JMJD3/HDAC-IN-1 对抑制癌细胞克隆形成、迁移和侵袭也表现出有效性。
T79482	Anticancer agent 137	PI3K	PI3K/Akt/mTOR signaling
	Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂，展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡（apoptosis），并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。
T80173	BDS-I	Potassium Channel	Membrane transporter/Ion channel
	BDS-I，又名降血物质，源自苏卡达银莲花的海洋毒素。它作为钾通道特异性抑制剂，针对Kv3.4。BDS-I能够抑制由Aβ1-42诱导的Kv3.4活性增强，减少caspase-3的激活，阻止NGF诱导的PC-12细胞分化以及异常核形态的出现，并可逆转Aβ肽引发的细胞死亡。
T79714	HDAC3-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC3-IN-2 (compound 4i) 是一种具有纳摩尔级效力的吡嗪酰肼基HDAC3抑制剂，IC50值为14 nM，针对三阴性乳腺癌细胞表现出高效抑制作用。该化合物在细胞内毒性测定中显示，对4T1细胞株的IC50为0.55 μM，对MDA-MB-231细胞株的IC50为0.74 μM。HDAC3-IN-2通过增加乙酰化水平（如H3K9、H3K27和H4K12），促进细胞凋亡（涉及caspase-3、caspase-7和细胞色素c的水平提升），并抑制细胞增殖相关蛋白（如Bcl-2、CD44、EGFR和Ki-67）的表达，从而在荷瘤小鼠模型中表现出显著的体内抗肿瘤作用。
T61327	BRD4 Inhibitor-15
	BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells. Additionally, it effectively down-regulates the c-Myc level in 22RV1 cells. Due to its properties, BRD4 Inhibitor-15 is a valuable compound for research related to prostate cancer [1].
T74783	HDAC-IN-53	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC-IN-53是一种口服活性的选择性HDAC1-3抑制剂，其IC50分别为47 nM、125 nM和450 nM。该化合物不针对II类HDAC(HDAC4、5、6、7、9；IC50>10 μM)展现抑制作用。HDAC-IN-53能够诱导caspase依赖的细胞凋亡并在裸鼠中显著抑制人肿瘤异种移植物生长，同时抑制携带MC38结肠癌的免疫活性小鼠的肿瘤发展。
T78872	CTL-06
	CTL-06是一种Fatty Acid Synthase (FASN)抑制剂，具有3 μM的IC50，能够诱发细胞凋亡。CTL-12导致细胞周期在Sub-G1/S期停滞，并增加caspase-9和凋亡标志物Bax的表达，减少抗凋亡标志物Bcl-xL的表达。此外，CTL-12通过抑制脂肪酸的从头合成，剥夺肿瘤细胞代谢所需，主要用于乳腺癌和结直肠癌的研究。
T71287	CDKI-83
	CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be devel...
T71230	VMY-1-103
	VMY-1-103 is a potent CDK inhibitor, is also a novel dansylated analog of purvalanol B, was shown to inhibit cell cycle progression and proliferation in prostate and breast cancer cells more effectively than purvalanol B. VMY-1-103 , but not purvalanol B, significantly decreased the proportion of cells in S phase and increased the proportion of cells in G(2)/M. VMY-1-103 increased the sub G(1) fraction of apoptotic cells, induced PARP and caspase-3 cleavage and increased the levels of the Death ...
T75010	TD1092
	TD1092 是一种泛凋亡抑制蛋白 (IAP) 降解剂，可降解 cIAP1,cIAP2和 XIAP。TD1092 激活细胞凋亡蛋白酶 (apoptosis3/7)，并通过促进 IAP 降解，导致癌细胞凋亡 (apoptosis)。同时，TD1092 还能够阻断 TNFα介导的 NF-κB 信号通路，抑制 IKK，IkBα，p65，和 p38 的磷酸化。TD1092 可作为 PROTAC，用于癌症研究。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...

化合物

Caspase-3-IN-1

Cat.No: T63479

PDK4-IN-1 hydrochloride

Cat.No: T12412L

Target: Apoptosis, PDK

Cat.No: T28178

Synonym: INF-4E,INF 4E,INF4E

Target: NOD

Cat.No: T26326

Synonym: VU-0285655,VU0285655,BML 280,VU 0285655,BML280,BML-280

Target: TNF, Phospholipase, Interleukin

CSRM617 hydrochloride

Cat.No: T10896L

Synonym: CSRM617 hydrochloride(787504-88-5 Free base)

Target: Apoptosis, Others, Androgen Receptor

Cat.No: T80659

Target: Caspase

Cat.No: T62997

Caspase-3 activator 3

Cat.No: T82774

Target: Caspase

Ac-DEVD-CMK TFA

Cat.No: T75706

Caspase-3 activator 1

Cat.No: T79743

Target: Pyroptosis

Caspase-3 activator 2

Cat.No: T82775

Target: Caspase

Ac-Nle-Pro-Nle-Asp-AMC

Cat.No: T76038

Cat.No: T79497

Target: Caspase

Immunosuppressant-1

Cat.No: T79791

Target: Apoptosis

Cat.No: T83205

Synonym: Ac-Asp-Asn-Leu-Asp-CHO

Target: Caspase

Parstatin(human)

Cat.No: TP1965

Synonym: Parstatin (human)

Cat.No: T79602

Target: Autophagy

(S)-(-)-Perillic acid

Cat.No: T73792

Cat.No: T60583

Parstatin(mouse)

Cat.No: TP1966

Synonym: Parstatin (mouse)

Cat.No: T36190

Synonym: CAY10443

RGD peptide (GRGDNP) (TFA)

Cat.No: T76007

p-nitro-Pifithrin-α

Cat.No: T21978

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone

Cat.No: T82388

Target: Caspase

Anticancer agent 63

Cat.No: T61823

Ac-YVAD-CHO acetate

Cat.No: T73852

Cat.No: T61433

AKN-028 acetate

Cat.No: T61358

Cat.No: T79608

Target: JAK

N1,N11-Diethylnorspermine

Cat.No: T60348

Anticancer agent 64

Cat.No: T63522

AC-VEID-CHO TFA

Cat.No: T73683

JMJD3/HDAC-IN-1

Cat.No: T79713

Target: HDAC

Anticancer agent 137

Cat.No: T79482

Target: PI3K

Cat.No: T80173

Target: Potassium Channel

Cat.No: T79714

Target: HDAC

BRD4 Inhibitor-15

Cat.No: T61327

Cat.No: T74783

Target: HDAC

Cat.No: T78872

Cat.No: T71287

Cat.No: T71230

Cat.No: T75010

2-chloro Palmitic Acid

Cat.No: T36221

Cat.No: T37861

Cat. No.	Product Name	Target	Signaling Pathways
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
T4S1335	Daphnoretin Dephnoretin,西瑞香素,Thymelol	Influenza Virus; Caspase; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物，具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。
TN1880	Lucidenic acid B Lucidenicacid B	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Lucidenic acid B (Lucidenicacid B) 是从灵芝中提取得到的天然化合物，可诱导caspase-9 和 caspase-3 的活化和 PARP 的裂解，可通过线粒体介导诱导人白血病细胞凋亡。 Lucidenic acid B通过灭活MAPK / ERK信号转导途径和降低NF-kappaB和AP-1的结合活性来抑制PMA诱导的人肝癌细胞侵袭。。Lucidenic acid B 对细胞周期和坏死细胞没有影响。
T3S1227	Aristolactam I Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	Aristolactam I (Aristololactum) 是马兜铃酸 I (AA-I) 的主要代谢产物，参与导致肾损伤的过程。它具有细胞毒性，通过诱导半胱天冬酶 3 依赖性途径中的细胞凋亡介导。
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
T4S2126	Ginkgetin 银杏双黄酮,银杏素	Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Ginkgetin 是从银杏叶中分离得到的一种双黄酮，具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂，IC50值为 5.92 μM。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T3S2344	β,β-Dimethylacrylshikonin β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; MAPK; Metabolism
	β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物，从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达，促进血管生成，具有抗肿瘤活性。
T5S0661	Koumine	Others	Others
	Koumine 是一种从钩吻中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中，它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用，也可用于缓解疼痛的研究。
T6S0721	Orientin 荭草苷,Lutexin,Luteolin-8-glucoside	Others	Others
	Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮，是一种有前景的神经保护剂，具有多种生物特性，如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T14003	15-Acetoxyscirpenol	Caspase	Apoptosis; Proteases/Proteasome
	15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1].
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
TN6515	Selaginellin
	Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

Cat.No: T4S1335

Synonym: Dephnoretin,西瑞香素,Thymelol

Target: Influenza Virus, Caspase, PKC

Lucidenic acid B

Cat.No: TN1880

Synonym: Lucidenicacid B

Target: Apoptosis, Caspase

Cat.No: T3S1227

Synonym: Aristolactam,Aristololactam I,马兜铃内酰胺I,Aristololactum

Target: Apoptosis, Caspase

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Cat.No: T4S2126

Synonym: 银杏双黄酮,银杏素

Target: Apoptosis, Wnt/beta-catenin, COX, STAT, Autophagy

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

β,β-Dimethylacrylshikonin

Cat.No: T3S2344

Synonym: β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

Cat.No: T5S0661

Target: Others

Cat.No: T6S0721

Synonym: 荭草苷,Lutexin,Luteolin-8-glucoside

Target: Others

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

15-Acetoxyscirpenol

Cat.No: T14003

Target: Caspase

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Cat.No: TN6515

Cat.No: T36954

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