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80

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9063	Clathrin-IN-1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Clathrin-IN-1 是一种网格蛋白抑制剂，可通过与网格蛋白的末端域相关联来抑制网格蛋白介导的内吞作用，有潜力用于抗癌的研究。
T22012	7BIO	FLT; DYRK; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	7BIO 是靛玉红的衍生物，抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化，并减轻 Aβ 寡聚体诱导的小鼠认知障碍。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T0192	Levetiracetam 左乙拉西坦,UCB L059,SIB-S1	DNA Methyltransferase; Others; Calcium Channel	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others
	Levetiracetam (SIB-S1) 是一种化学增敏剂，增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平，最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药，可结合突触小泡蛋白 SV2A。
TP1559L	Ziconotide Acetate (107452-89-1 free base) 醋酸齐考诺肽,Prialt,Ziconotide Acetate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂，已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用，因此通过有效的镇痛作用减少突触传递。
TP1868	Proctolin 直肠肽	Others	Others
	Proctolin 是内源性五肽，也是兴奋性神经调节剂。
T1279	Vilazodone 维拉佐酮,SB659746A,EMD 68843	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Vilazodone (SB659746A) 是一种可口服的选择性 5 -羟色胺再摄取抑制剂 (SSRI) 和部分5-HT1A 受体激动剂。它有抗抑郁作用，可用于抑郁症和情绪性疾病的研究。
T7516	ZD7288 N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288	HCN Channel	Membrane transporter/Ion channel
	ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂，可抑制海马突触可塑性。
T10893	CS-722 Free base	Others	Others
	CS-722 Free base是一种合成的中枢作用肌肉松弛剂，它展现出肌肉松弛效果并抑制脊髓反射。可能通过限制钠和钙流动，从而在海马培养物中减少自发的抑制性和兴奋性突触后电流。
T19812	Propentofylline HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE	Metabolism
	Propentofylline (Hextol) 是一种甲基黄嘌呤衍生物，具有神经保护、抗增殖和抗炎活性，可增强的突触腺苷信号传导，可用于研究阿尔茨海默病、血管性痴呆、认知障碍、痴呆和慢性疼痛。
T0869	Atomoxetine hydrochloride Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Atomoxetine hydrochloride (LY 139603) 是苯氧基-3-丙胺衍生物和选择性非兴奋剂，是去甲肾上腺素再摄取抑制剂，具有认知增强活性。与人 NET，SERT 和 DAT 的放射性配体结合的 Ki 分别为5，77和1451 nM。
T30549	BMY-21502 Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168	Antioxidant	oxidation-reduction
	BMY-21502 是一种潜在认知增强剂，在KCN-缺氧模型中显示出抗缺氧作用，可在体外延缓海马突触增强的衰变，可用于研究阿尔茨海默症。
T5512	JNJ16259685 .TN.T 16259685	GluR	Neuroscience
	JNJ16259685 (TN.T 16259685) 是选择性mGlu1 受体拮抗剂，可浓度依赖性地抑制 mGlu1 的突触的活化，IC50值为 19 nM。
T21153	Clothianidin TI435,TI-435,TI 435,噻虫胺,Celero	AChR	Neuroscience
	Clothianidin (TI 435) 是一种杀虫剂，作为乙酰胆碱的激动剂，可刺激 nAChR，从而激活突触后乙酰胆碱受体，但不抑制 AChE。
T11684	Isoguvacine hydrochloride 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride,异四氢烟酸	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) 是 GABA 受体激动剂。它与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。
T26357	Pitstop 2	Apoptosis	Apoptosis
	Pitstop2 是一种选择性的两性蛋白结合的网格蛋白末端结构域抑制剂，IC50 值为 12 μM。 Pitstop2 严重干扰受体介导的内吞作用、HIV 进入和突触小泡循环。
T1566	Aripiprazole 阿立哌唑,OPC-14597	5-HT Receptor	GPCR/G Protein; Neuroscience
	Aripiprazole (OPC-14597) 是血清素受体 5-HT1A 和多巴胺 D2 受体的部分激动剂，还用作突触后拮抗剂和血清素受体 5-HT2A 的拮抗剂。
T50041	N-(4-methoxyphenyl)prop-2-enamide N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺	Others	Others
	N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) 是一种用作分子结构单元的丙烯酰胺类化合物。它可以抑制乙酰胆碱酯酶，增加突触间隙中的乙酰胆碱水平；也可以抑制多巴胺的分解，导致大脑中多巴胺水平的升高。
T0991	Desipramine hydrochloride NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T7218	Endomorphin 2 内吗啡肽 2	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Endomorphin 2 是一种高亲和力和选择性的 μ-阿片受体激动剂，对 kappa3 结合位点具有合理的亲和力，Ki 为 20 到 30 nM 之间。
T9172	Simufilam dihydrochloride PTI-125 dihydrochloride	Others	Others
	Simufilam dihydrochloride (PTI-125 dihydrochloride) 是口服具有活力的、毒性低的 filamin A 激活剂。它可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。它可用于研究阿尔茨海默症。
TP1924L1	ZIP acetate(863987-12-6 free base)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	ZIP acetate(863987-12-6 free base) 是一种新型的细胞渗透性蛋白激酶 Mζ (PKMζ) 抑制剂，它是一种参与 LTP 维持的组成型活性非典型 PKC 同工酶。在体外选择性阻断 PKMζ 诱导的海马切片突触增强。逆转晚期 LTP (IC50 = 1 - 2.5 μM) 并在体内中央给药后导致 1 天前的空间记忆持续丧失。
T11800	L-803087	Somatostatin	GPCR/G Protein
	L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂，对 sst4 的 Ki 值为 0.7 nM，比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应，在体内增加了海藻酸盐促使的小鼠癫痫发作。
TP1895L1	KYL acetate(676657-00-4 free base)	Ephrin Receptor	Tyrosine Kinase/Adaptors
	KYL acetate(676657-00-4 free base) 是EphA4受体酪氨酸激酶抑制剂（Kd = 0.8 μM）；抑制 EphA4-EphrinA5 相互作用 (IC50 = 6.34 μM)。防止 AβO 诱导的突触损伤、树突棘丢失并防止海马 CA3-CA1 传输中 LTP 的阻断。在细胞培养基中表现出较长的半衰期（在 PC3 和 C2C12 培养基中分别为 8 和 12 小时）。它有神经保护作用。
T50008	2,2-Dimethyl-5-(2,5-xylyloxy)valeramide 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide	Others	Others
	2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) 是一种苯氧基家族化合物。它已被证明对神经系统具有刺激作用，包括神经元放电率的增加、突触传递的增加和神经递质释放的增加；还被证明对心血管系统有刺激作用，包括提高心率和血压。
T111959	IFB-088 acetate
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T76863	Elezanumab AE12-1Y-QL,ABT-555	TGF-beta/Smad	Stem Cells
	Elezanumab(ABT-555) 是一种有效的人抗 RGMa 单克隆抗体。Elezanumab 通过 SMAD1/5/8 通路发挥对 RGMa 介导的 BMP 信号传导的抑制作用，IC50 约为 97 pM。在神经元损伤和脱髓鞘模型中，Elezanumab 促进神经再生、神经保护和神经恢复。Elezanumab 促进皮质脊髓轴突生长为脊髓灰质，并增强腹角的血清素能神经支配，形成颈部病变尾部的突触连接。
T35856	BMS-986176	AAK1 (AP2 associated kinase 1)	Neuroscience
	BMS-986176 是一种有效的AAK1 抑制剂，IC50为 2.2 nM。BMS-986176在神经退行性疾病中有研究的价值。
T17174	Troriluzole BHV-4157	Others	Others
	Troriluzole is an orally active glutamate modulator. Troriluzole reduces the synaptic glutamate level and increases synaptic glutamate absorption.
T31903	Galphimine B
	Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect.
T32423	KS 5-2 KS-5-2
	KS 5-2 has affinity to isolated synaptic membranes from rat brain.
T24934	Vesamicol AH-5183,AH 5183,AH5183
	Vesamicol is an experimental drug. It acting presynaptically by inhibiting acetylcholine uptake into synaptic vesicles and reducing its release.
T69339	Org 24461
	Org 24461 is a synaptic and nonsynaptic glycine transporter type-1 inhibitor.
T71854	AA43279
	AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons.
T34458	Ryanodol
	Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T68960	F-15599 Fumarate
	F-15599 Fumarate is a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
T39069	UCB-J
	UCB-J is a radioligand for the synaptic vesicle protein 2A (SV2A), utilized in positron emission tomography (PET)[4].
T62127	AMPA-IN-1
	AMPA-IN-1 是一种 AMPA 受体的有效抑制剂。AMPA 受体是一种在大脑中广泛表达的受体，在调节快速兴奋性突触传递和突触可塑性中具有核心作用。AMPA-IN-1 对包括癫痫在内的多种中枢疾病具有潜在的研究价值。
T27326	FK960 FK 59960,FK-960,FK-59960,FK59960
	FK962 is an enhancer of somatostatin release, which exerts cognitive-enhancing actions in rats. FK960 increases synaptic density in the hippocampal CA3 region of aged rats.
T41193	FFN 270
	FFN 270 is a fluorescent false neurotransmitter (FFN). Fluorescent substrate for NET and VMAT2. Labels noradrenergic neurons and their synaptic vesicles, and enables imaging of synaptic vesicle content release from specific axonal sitesin vivo. Selectively labels NA neurons over other monoamine and CNS targets. Exhibits two resolved absorption/excitation maxima depending on solvent pH (excitation maxima: 320 nm or 365 nm, emission maxima: 475 nm).
T74759	18:0,18:1 PS sodium
	18:0,18:1 PS sodium 是突触囊泡和胆固醇的脂质组成成分，可用于代谢研究。
T26879	BNC-1 BNC 1
	BNC-1 is a modulator of amyloid pathology. BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in well-established mouse models of amyloid deposition by promoting phosphorylation and activation of Elk-1.
T68289	Nicotine hemicitrate
	Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T68439	Nicotine dicitrate
	Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T74758	18:0,22:6 PS sodium
	18:0,22:6 PS sodium 是突触囊泡和胆固醇的脂质组成成分，可用于代谢研究。
T69804	Nicotine monomethiodide
	Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T69439	Nicotine tartrate
	Nicotine tartrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T41088	Diadenosine pentaphosphate pentalithium
	Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide, isolated from thrombocytes. It is a member of the diadenosine polyphosphates (ApnA, n=2–7) and is found in secretory vesicles of platelets, chromaffin cells, Torpedo synaptic terminals, and brain synaptosomes.
TP1471	Ziconotide TFA (107452-89-1 free base) Ziconotide TFA
	Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.

化合物

Cat.No: T9063

Target: HIV Protease

Cat.No: T22012

Target: FLT, DYRK, Aurora Kinase

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Cat.No: T0192

Synonym: 左乙拉西坦,UCB L059,SIB-S1

Target: DNA Methyltransferase, Others, Calcium Channel

Ziconotide Acetate (107452-89-1 free base)

Cat.No: TP1559L

Synonym: 醋酸齐考诺肽,Prialt,Ziconotide Acetate

Target: Calcium Channel

Cat.No: TP1868

Synonym: 直肠肽

Target: Others

Cat.No: T1279

Synonym: 维拉佐酮,SB659746A,EMD 68843

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T7516

Synonym: N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288

Target: HCN Channel

CS-722 Free base

Cat.No: T10893

Target: Others

Propentofylline

Cat.No: T19812

Synonym: HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285

Target: PDE

Atomoxetine hydrochloride

Cat.No: T0869

Synonym: Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,盐酸托莫西汀,LY 139603,Atomoxetine HCl,LY 139603 HCl

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Cat.No: T30549

Synonym: Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168

Target: Antioxidant

Cat.No: T5512

Synonym: .TN.T 16259685

Target: GluR

Cat.No: T21153

Synonym: TI435,TI-435,TI 435,噻虫胺,Celero

Target: AChR

Isoguvacine hydrochloride

Cat.No: T11684

Synonym: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride,异四氢烟酸

Target: GABA Receptor

Cat.No: T26357

Target: Apoptosis

Cat.No: T1566

Synonym: 阿立哌唑,OPC-14597

Target: 5-HT Receptor

N-(4-methoxyphenyl)prop-2-enamide

Cat.No: T50041

Synonym: N-(4-Methoxyphenyl)acrylamide,N-(4-甲氧苯基)丙烯酰基酰胺

Target: Others

Desipramine hydrochloride

Cat.No: T0991

Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Cat.No: T7218

Synonym: 内吗啡肽 2

Target: Opioid Receptor

Simufilam dihydrochloride

Cat.No: T9172

Synonym: PTI-125 dihydrochloride

Target: Others

ZIP acetate(863987-12-6 free base)

Cat.No: TP1924L1

Target: PKC

Cat.No: T11800

Target: Somatostatin

KYL acetate(676657-00-4 free base)

Cat.No: TP1895L1

Target: Ephrin Receptor

2,2-Dimethyl-5-(2,5-xylyloxy)valeramide

Cat.No: T50008

Synonym: 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Target: Others

IFB-088 acetate

Cat.No: T111959

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Cat.No: T76863

Synonym: AE12-1Y-QL,ABT-555

Target: TGF-beta/Smad

Cat.No: T35856

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T17174

Synonym: BHV-4157

Target: Others

Cat.No: T31903

Cat.No: T32423

Synonym: KS-5-2

Cat.No: T24934

Synonym: AH-5183,AH 5183,AH5183

Cat.No: T69339

Cat.No: T71854

Cat.No: T34458

F-15599 Fumarate

Cat.No: T68960

Cat.No: T39069

Cat.No: T62127

Cat.No: T27326

Synonym: FK 59960,FK-960,FK-59960,FK59960

Cat.No: T41193

18:0,18:1 PS sodium

Cat.No: T74759

Cat.No: T26879

Synonym: BNC 1

Nicotine hemicitrate

Cat.No: T68289

Nicotine dicitrate

Cat.No: T68439

18:0,22:6 PS sodium

Cat.No: T74758

Nicotine monomethiodide

Cat.No: T69804

Nicotine tartrate

Cat.No: T69439

Diadenosine pentaphosphate pentalithium

Cat.No: T41088

Ziconotide TFA (107452-89-1 free base)

Cat.No: TP1471

Synonym: Ziconotide TFA

Cat. No.	Product Name	Target	Signaling Pathways
T9299	D-Leucine D-亮氨酸,(R)-Leucine	Endogenous Metabolite	Metabolism
	D-Leucine ((R)-Leucine) 具有抗癫痫特性，活性比L-leucine，能够有效终止癫痫发作。在体外，它能够抑制长期点位，但基底突触传递无影响。
T0958	Penicillin G sodium salt 青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium	GABA Receptor; Antibacterial; Antibiotic	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Penicillin G sodium(Benzylpenicillin sodium) salt 是一种 β-内酰胺类抗生素。
TN1202	(-)-α-Pinene 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene	Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。
T4S1962	beta-Asarone β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB; JNK	MAPK; NF-κB
	beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分，具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障，能够预防帕金森病。
T4881	Phosphorylethanolamine O-Phosphorylethanolamine,乙醇胺磷酸酯	Others; Endogenous Metabolite	Metabolism; Others
	Phosphorylethanolamine (O-Phosphorylethanolamine) 是磷脂代谢的一种磷酸单酯代谢物。Phosphorylethanolamine 是磷脂合成的前体，也是磷脂分解的产物。与其他器官相比，大脑中磷酸单酯的含量要高得多。在大脑发育过程中，磷单酯通常在神经增生期间升高。这也与大脑发育过程中正常的程序性细胞死亡和突触修剪的发生相吻合。这些发现与磷酸单酯在膜生物合成中的作用是一致的。Phosphorylethanolamine 与抑制性神经递质GABA和GABAB受体部分激动剂 3-氨基丙基膦酸具有很强的结构相似性。Phosphorylethanolamine 是一种磷单酯，在阿尔茨海默病患者的大脑中减少。

天然产物

Cat.No: T9299

Synonym: D-亮氨酸,(R)-Leucine

Target: Endogenous Metabolite

Penicillin G sodium salt

Cat.No: T0958

Synonym: 青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium

Target: GABA Receptor, Antibacterial, Antibiotic

Cat.No: TN1202

Synonym: 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene

Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

Cat.No: T4S1962

Synonym: β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin

Target: NF-κB, JNK

Phosphorylethanolamine

Cat.No: T4881

Synonym: O-Phosphorylethanolamine,乙醇胺磷酸酯

Target: Others, Endogenous Metabolite

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