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139

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T81316	Rabbit neutrophil peptide 3b
	Rabbit Neutrophil Peptide 3b，一种源自兔腹膜中性粒细胞的抗菌肽。
T79397	Neutrophil elastase inhibitor 4
	Neutrophilelastase inhibitor4 (compound 4f) 是竞争性抑制HNE的化合物，具有较低的半抑制浓度(IC50: 42.30 nM)和解离常数(Ki: 8.04 nM)。此外，该化合物能够诱导T47D细胞的apoptosis，并在多种细胞系中展现出抗增殖作用，分别在T47D、RPMI 8226、A549、HSF细胞系的IC50值为21.25、34.17、29.93、99.11 nM。
T80323	Bovine neutrophil beta-defensin 12 BNBD-12
	Bovine neutrophil beta-defensin 12，一种牛中性粒细胞来源的抗菌肽，展现针对大肠杆菌(Escherichia coli)和金黄色葡萄球菌(Staphylococcus aureus)的抗菌活性。
T9964	BOS-318	Others	Others
	BOS-318是一种Furin 抑制剂，具有缓慢解离，高选择性，细胞通透性等特点。
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T2121	SW033291	Dehydrogenase	Metabolism
	SW033291 是有效的15-PGDH 抑制剂，与15-PGDH 亲和力高，Ki 为 0.1 nM。它增加骨髓和其他组织中前列腺素 PGE2 的水平。它还可促进组织再生。
T16850	SB-265610 GSK-CXCR2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂，可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 和 70 nM。
T13951	UCB-9260	TNF	Apoptosis
	UCB-9260 是口服活性小分子，通过稳定三聚体的不对称形式抑制肿瘤坏死因子信号传导。它对肿瘤坏死因子的选择性高于其他超家族成员，并与肿瘤坏死因子结合，其Kd 值为 13 nM。
T11179	Elubrixin SB-656933	IL Receptor; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Elubrixin (SB-656933) 是一种有效和特异性的 CXCR2 和 IL-8 受体拮抗剂。 Elubrixin 可用于炎症性疾病的研究，例如炎症性肠病和气道炎症。
T39789	BMS-986235 BMS-986235,LAR-1219	Others	Others
	BMS-986235 (LAR-1219) 是一种特异性和口服活性的甲酰肽受体 2 (FPR2) 激动剂，对 hFPR2 和 mFPR2 的 EC50 分别为 0.41 nM 和 3.4 nM。 BMS-986235 可用于预防心力衰竭的研究。
T14667	BLT-1	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	BLT-1 是一种氨基硫脲铜螯合剂，是一种选择性清除受体 B1 型 (SR-BI) 抑制剂，抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。
T9516	Binodenoson WRC 0470,MRE-0470,比诺地松,2-(cyclohexylmethylidenehydrazino)adenos	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Binodenoson (WRC 0470) 是一种选择性A2A 腺苷受体激动剂，KD 为270 nM。它是一种短效冠状动脉血管扩张剂，作为放射性示踪剂的辅助剂，用于心肌应激成像。
T13389	ZD-0892	PI3K	PI3K/Akt/mTOR signaling
	ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectively).
T6986	Sivelestat ONO5046,EI546,西维来司他,LY544349	Others; SARS-CoV; Serine Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂，其 IC50值为 44 nM，Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。
T3107	Alvelestat AZD9668,Avelestat	Others; Serine Protease	Others; Proteases/Proteasome
	Alvelestat (AZD9668) 是一种口服活性，亲和性和选择性的中性粒细胞弹性蛋白酶 (NE) 抑制剂，pIC50=7.9 nM，Ki=为 9.4 nM，Kd=9.5 nM。
T8563	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one	Serine Protease	Proteases/Proteasome
	2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one 是一种人类中性粒细胞弹性蛋白酶抑制剂。
T11828	LDC7559	Pyroptosis	Apoptosis; Immunology/Inflammation
	LDC7559 通过在晚期阻断中性粒细胞胞外陷阱 (NET)来抑制gasdermin D (GSDMD)。
T12613L	BAY-85-8501	Serine Protease	Proteases/Proteasome
	BAY-85-8501 是选择性的人类中性脂酶抑制剂，IC50=65 pM。
T7130	Navarixin MK-7123,SCH 527123	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Navarixin (MK-7123) 是一种可口服的 CXCR1和 CXCR2变构拮抗剂，对猕猴 CXCR1的 Kd 值为 41 nM，对大小鼠和猕猴 CXCR2的 Kd 值分别为 0.20、0.20 和 0.08 nM。
T35367	Thioacetamide TAA,硫代乙酰胺	Others	Others
	Thioacetamide 是一种肝毒剂，广泛用于诱导实验性肝损伤，在大鼠中引起肝细胞坏死和随后的炎症（主要是 M1-/M2-巨噬细胞，没有中性粒细胞浸润）。
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE	Serine Protease	Proteases/Proteasome
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE 靶向中性粒细胞弹性蛋白酶（人）。
T68099	midesteine MR-889	Others	Others
	Midesteine (MR-889) 是一种可逆、慢结合、完全竞争的蛋白酶抑制剂。
TP2083L	Ac9-25 acetate Ac9-25 acetate(284040-76-2 free base)	Others	Others
	Ac9-25 acetate 通过 FPR 激活中性粒细胞还原的烟酰胺腺嘌呤二核苷酸磷酸氧化酶。
T28974	Ticolubant	Calcium Channel; LTR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ticolubant 是一种具有口服活性的白三烯 B4 拮抗剂，对人类中性粒细胞 LTB4 受体具有很高的亲和力（Ki = 0.78 nM），能阻断 LTB4 诱导的 Ca2+ 迁移，IC50 为 6.6±1.5 nM，并在小鼠皮肤炎症模型中显示出局部抗炎活性。
T10473	BAY-678	Others	Others
	BAY-678是一种人中性粒细胞弹性蛋白酶（HNE；IC50：20 nM）抑制剂，具有口服生物活性、高效性和选择性。BAY-678 是被基因结构组学联盟 (SGC) 推荐的化学探针。
T25131	AZD8309 AZD 8309,AZD-8309	Glutathione Peroxidase; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism
	AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂，能够调节中性粒细胞的转运，可显著降低胰腺和肺部的MPO，并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
T22277L	BMS-P5 free base	PAD	Chromatin/Epigenetic
	BMS-P5 free base 是一种特异性，可口服的肽精氨酸二亚胺酶抑制剂，可阻断多发性骨髓瘤诱导的 NET 形成，并延缓肿瘤进程。
T10831L	Cl-amidine hydrochloride	Apoptosis; PAD	Apoptosis; Chromatin/Epigenetic
	Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。
TP2334	PMX 53 acetate(219639-75-5 free base)	Complement System	Immunology/Inflammation
	PMX 53 acetate(219639-75-5 free base) 是一种有效的口服活性 CD88 (C5aR) 拮抗剂 (IC50: 20 nM)，抑制 C5a 诱导的中性粒细胞髓过氧化物酶释放和趋化性，IC50 值分别为 22 nM 和 75 nM。 PMX-53 也是 Mas 相关基因 2 (MrgX2) 的激动剂。
T20762	Sivelestat sodium tetrahydrate ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046	Serine Protease	Proteases/Proteasome
	Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂，其 IC50 值为 44 nM， Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
T76884	Spesolimab BI 655130	IL Receptor	Immunology/Inflammation
	Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用，与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。
T74485	STC314	Others	Others
	STC314 具有抗感染作用，通过中和胞外组蛋白和中性粒细胞诱捕网来逆转机体过度免疫反应造成的器官损伤，可用于研究脓毒症和急性呼吸窘迫综合征(ARDS)。STC314 可保护脂质双层的稳定性，抑制血小板活化和红细胞损伤。
T36503	Sodium Hydrogen Sulfide (hydrate)	Others	Others
	Sodium Hydrogen Sulfide (hydrate) 与一氧化氮一样，是一种重要的气体介质，对哺乳动物的免疫、神经、心血管和肺系统有重要影响。Sodium Hydrogen Sulfide (hydrate)是一种H2S 供体，常用于细胞和整个动物实验系统。例如，它被用来证明H2S 促进中性粒细胞迁移，减少气道炎症，保护神经轴突、心脏和肠道免受化学或缺血再灌注损伤。
T15285	FK706	Serine Protease	Proteases/Proteasome
	FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef
T3107L	Alvelestat tosylate
	Alvelestat can inhibit neutrophil elastase (NE), which acts an important role in NET formation.
T10254	AE-3763	Serine Protease	Proteases/Proteasome
	AE-3763 is a peptide-based human neutrophil elastase inhibitor (IC50: 29 nM).
T17288	ZD8321	Serine Protease	Proteases/Proteasome
	ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).
T31877	Freselestat ONO-PO 736,ONO-6818,ONO 6818,ONO6818
	Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9. Freselestat reduces inflammatory mediators during simulated cardiopulmonary bypass.
T25520	ICI 200355 ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355
	ICI 200355 is an inhibitor of human neutrophil elastase.
T26929	BVT173187 BVT 173187,BVT-173187
	BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.
T25781	MDL 101146 MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146
	MDL 101146 is an orally active neutrophil elastase inhibitor.
T11525L	GW311616 hydrochloride GW311616A	Others	Others
	GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).
T69790	GW-475151
	GW-475151 inhibits human neutrophil elastase (HNE).
T25783	MDL 27399 MDL-27,399,MDL 27,399,MDL27399,MDL27,399
	MDL 27399 suppresses human neutrophil cathepsin G.
T25784	MDL-101146, (R)- MDL101146, (R)-
	MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.
T38227	Quin C1
	Potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory. Zhou et al (2007) Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 72 976 PMID:17652444 \|Corminboeuf et al (2014) FPR2/ALXR agonist...
T70219	ISP-VT
	ISP-VT is a Novel inhibitor of COX and neutrophil migration.
T25782	MDL 27324 MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324
	MDL 27324 is an inhibitor of human neutrophil elastase.
T24156	ICI 195739 DO870,D0870,D 0870,D-0870
	ICI 195739 is a newer antifungal agent. It inhibits neutrophil random migration, chemotaxis, and hexose monophosphate shunt activity.

化合物

Rabbit neutrophil peptide 3b

Cat.No: T81316

Neutrophil elastase inhibitor 4

Cat.No: T79397

Bovine neutrophil beta-defensin 12

Cat.No: T80323

Synonym: BNBD-12

Cat.No: T9964

Target: Others

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Cat.No: T21938

Target: PI3K

Cat.No: T2121

Target: Dehydrogenase

Cat.No: T16850

Synonym: GSK-CXCR2

Target: CXCR

Cat.No: T13951

Target: TNF

Cat.No: T11179

Synonym: SB-656933

Target: IL Receptor, CXCR

Cat.No: T39789

Synonym: BMS-986235,LAR-1219

Target: Others

Cat.No: T14667

Target: Others, HCV Protease

Cat.No: T9516

Synonym: WRC 0470,MRE-0470,比诺地松,2-(cyclohexylmethylidenehydrazino)adenos

Target: Adenosine Receptor

Cat.No: T13389

Target: PI3K

Cat.No: T6986

Synonym: ONO5046,EI546,西维来司他,LY544349

Target: Others, SARS-CoV, Serine Protease

Cat.No: T3107

Synonym: AZD9668,Avelestat

Target: Others, Serine Protease

2-(2-bromophenyl)-5-chloro-4H-3,1-benzoxazin-4-one

Cat.No: T8563

Target: Serine Protease

Cat.No: T11828

Target: Pyroptosis

Cat.No: T12613L

Target: Serine Protease

Cat.No: T7130

Synonym: MK-7123,SCH 527123

Target: CXCR

Cat.No: T35367

Synonym: TAA,硫代乙酰胺

Target: Others

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE

Cat.No: T8602

Target: Serine Protease

Cat.No: T68099

Synonym: MR-889

Target: Others

Cat.No: TP2083L

Synonym: Ac9-25 acetate(284040-76-2 free base)

Target: Others

Cat.No: T28974

Target: Calcium Channel, LTR

Cat.No: T10473

Target: Others

Cat.No: T25131

Synonym: AZD 8309,AZD-8309

Target: Glutathione Peroxidase, CXCR

BMS-P5 free base

Cat.No: T22277L

Target: PAD

Cl-amidine hydrochloride

Cat.No: T10831L

Target: Apoptosis, PAD

PMX 53 acetate(219639-75-5 free base)

Cat.No: TP2334

Target: Complement System

Sivelestat sodium tetrahydrate

Cat.No: T20762

Synonym: ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046

Target: Serine Protease

Cat.No: T76884

Synonym: BI 655130

Target: IL Receptor

Cat.No: T74485

Target: Others

Sodium Hydrogen Sulfide (hydrate)

Cat.No: T36503

Target: Others

Cat.No: T15285

Target: Serine Protease

Alvelestat tosylate

Cat.No: T3107L

Cat.No: T10254

Target: Serine Protease

Cat.No: T17288

Target: Serine Protease

Cat.No: T31877

Synonym: ONO-PO 736,ONO-6818,ONO 6818,ONO6818

Cat.No: T25520

Synonym: ICI-200,355,ICI 200,355,ICI-200355,ICI200,355,ICI200355

Cat.No: T26929

Synonym: BVT 173187,BVT-173187

Cat.No: T25781

Synonym: MDL-101146,MD 101,146,MDL101146,MDL 101,146,MDL-101,146

GW311616 hydrochloride

Cat.No: T11525L

Synonym: GW311616A

Target: Others

Cat.No: T69790

Cat.No: T25783

Synonym: MDL-27,399,MDL 27,399,MDL27399,MDL27,399

MDL-101146, (R)-

Cat.No: T25784

Synonym: MDL101146, (R)-

Cat.No: T38227

Cat.No: T70219

Cat.No: T25782

Synonym: MDL-27,324,MDL-27324,MDL27,324,MDL 27,324,MDL27324

Cat.No: T24156

Synonym: DO870,D0870,D 0870,D-0870

Cat. No.	Product Name	Target	Signaling Pathways
TN6737	(25R)-Spirost-4-ene-3,12-dione	Others	Others
	(25R)-Spirost-4-ene-3,12-dione 是一种天然产物。
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
TN1006	Tirucallol	NOS; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Tirucallol 是一种四环三萜，分离自Euphorbia lacteal 乳胶。它能够抑制小鼠模型中的耳部水肿，并阻碍脂多糖刺激的巨噬细胞中亚硝酸盐的产生，具有局部消炎作用。
TJS0314	5,7-Dihydroxy-4-methylcoumarin Methyl-2H-Chromen-2-One,5,7-二羟基-4-甲基香豆素,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin	Others; Antibacterial; Antifungal	Microbiology/Virology; Others
	5,7-Dihydroxy-4-methylcoumarin (Methyl-2H-Chromen-2-One) 是墨西哥龙蒿中的一种香豆素衍生物。它抑制人类中性粒细胞氧化代谢和弹性蛋白酶活性，有抗真菌和抗细菌活性。
T4S2063	Tetrahydrocoptisine 人血草碱,STYLOPINE	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用，这可能涉及抑制肺部炎症过程。它具有胃保护活性，归因于减少 NO 产生和调节促炎细胞因子，抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分，通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T13661	Docosatrienoic Acid cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid	Others	Others
	Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane.
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
T5768	bruceine B	TNF; Parasite	Apoptosis; Microbiology/Virology
	Bruceine B 是一种有效的白细胞-内皮细胞粘附抑制剂，可抑制蛋白质和核酸合成。
TN4303	Isokaempferide	ATPase; Potassium Channel; Calcium Channel; TNF; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea.
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
TN5228	Vestitol	Antifection	Microbiology/Virology
	Vestitol is a phytoalexin with insect feeding-deterrent activity, it has antioxidant, anti-inflammatory and antimicrobial activities, it can inhibit neutrophil migration at a dose of 10 mg/kg, and shows MICs ranging from 25-50 to 50-100 ug/mL and MBCs ranging from 25-50 to 50-100 ug/mL.Vestitol exerts a limited inhibitory effect on S. hermonthica germination, it can significantly inhibit seedling growth, it also contributes, at least in part, to the host's defence mechanism and acts as a chemica...
TN4584	Morolic acid	IL Receptor; COX; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro

天然产物

(25R)-Spirost-4-ene-3,12-dione

Cat.No: TN6737

Target: Others

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Cat.No: TN1006

Target: NOS, NO Synthase, Prostaglandin Receptor

5,7-Dihydroxy-4-methylcoumarin

Cat.No: TJS0314

Synonym: Methyl-2H-Chromen-2-One,5,7-二羟基-4-甲基香豆素,4-Methyllimetol,4-Methyl-5,7-Dihydroxycoumarin

Target: Others, Antibacterial, Antifungal

Tetrahydrocoptisine

Cat.No: T4S2063

Synonym: 人血草碱,STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Docosatrienoic Acid

Cat.No: T13661

Synonym: cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid

Target: Others

Cat.No: TN5880

Antibiotic PF 1052

Cat.No: T38097

Cat.No: T5768

Target: TNF, Parasite

Cat.No: TN4303

Target: ATPase, Potassium Channel, Calcium Channel, TNF, Prostaglandin Receptor

Cat.No: TN5221

Cat.No: TN5228

Target: Antifection

Cat.No: TN4584

Target: IL Receptor, COX, HIV Protease

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