Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) 是竞争性的人类中性粒细胞弹性蛋白酶的抑制剂,其 IC50 值为 44 nM, Ki 值为 200 nM。Sivelestat (EI546) sodium tetrahydrate 有潜力用于 COVID-19的急性肺损伤/急性呼吸窘迫综合征或弥散性血管内凝血的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 163 | 现货 | ||
5 mg | ¥ 359 | 现货 | ||
10 mg | ¥ 578 | 现货 | ||
25 mg | ¥ 1,080 | 现货 | ||
50 mg | ¥ 1,990 | 现货 | ||
100 mg | ¥ 2,890 | 现货 | ||
200 mg | ¥ 4,160 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 638 | 现货 |
产品描述 | Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. |
体外活性 | Sivelestat (ONO-5046) does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM[1]. Sivelestat (ONO-5046) exhibits IC50 values of 44 nM, 36 nM, 19 nM, 37 nM and 49 nM for human, rabbit, rat, hamster and mouse neutrophil elastase, respectively[1]. |
体内活性 | Sivelestat (ONO-5046, 0.021-2.1 mg/kg, intratracheally) suppresses lung hemorrhage in hamster (ID50 = 82 pg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which are induced by human neutrophil elastase[1]. Sivelestat (10 mg/kg, infusion via the tail vein) ameliorates lung injury after hemorrhagic shock in rats[2]. Sivelestat (15, 60 mg/kg, ip) prevents ischemia–reperfusion injury in the rat bladder[3]. |
别名 | ONO-5046 sodium tetrahydrate, Elaspol, ONO 5046, ONO5046 sodium tetrahydrate, Elaspol sodium tetrahydrate, ONO-5046, Sivelestat Sodium, Sivelestat Sodium Hydrate, ONO5046 |
分子量 | 528.51 |
分子式 | C20H29N2NaO11S |
CAS No. | 201677-61-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225 mg/mL (425.7 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8921 mL | 9.4606 mL | 18.9211 mL | 47.3028 mL |
5 mM | 0.3784 mL | 1.8921 mL | 3.7842 mL | 9.4606 mL | |
10 mM | 0.1892 mL | 0.9461 mL | 1.8921 mL | 4.7303 mL | |
20 mM | 0.0946 mL | 0.473 mL | 0.9461 mL | 2.3651 mL | |
50 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9461 mL | |
100 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.473 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sivelestat sodium tetrahydrate 201677-61-4 Proteases/Proteasome Serine Protease ONO-5046 sodium tetrahydrate Elaspol ONO-5046 sodium Tetrahydrate ONO 5046 ONO5046 sodium tetrahydrate Elaspol sodium tetrahydrate Elaspol sodium ONO-5046 ONO5046 sodium Sivelestat Sodium Sivelestat sodium ONO5046 sodium Tetrahydrate ONO-5046 sodium Elaspol sodium Tetrahydrate Sivelestat sodium Tetrahydrate Sivelestat Sodium Hydrate ONO5046 Inhibitor inhibitor inhibit