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Search Results for " neurodegeneration "

36

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10122	Anti-neurodegeneration agent 1	Others	Others
	Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent.
T1880	P7C3	Others	Others
	P7C3 是一种 aminopropyl carbazole 类化合物，具有口服活性，可透过血脑屏障，具有神经保护作用。它可用于神经退行性疾病，如帕金森病的研究。
T9491	Pyraclostrobin	Antibacterial; Antifungal	Microbiology/Virology
	Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。
T4470	Pyridostatin TFA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T5827	BI-6C9	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂，可阻止线粒体外膜电位和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T6403	Siponimod 辛波莫德,BAF-312	S1P Receptor; LPL Receptor	GPCR/G Protein
	Siponimod (BAF-312) 是有效，选择性的鞘氨醇-1-磷酸 (S1P)受体调节剂，对 S1P1 和 S1P5 受体具有特异性，EC50 分别为 0.39 nM 和 0.98 nM。 BAF312 对 S1P1 和 S1P5 受体的特异性比 S1P2、S1P3 和 S1P4 受体高 1000 倍以上。
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
T0682	Lamivudine GR109714X,BCH-189,拉米夫定	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂，可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
T6561	Laquinimod LAQ,ABR-215062,拉喹莫德	Apoptosis; Others; NF-κB	Apoptosis; NF-κB; Others
	Laquinimod (LAQ) 是一种免疫调节剂，可预防中枢神经系统的神经变性和炎症。
T1899	Pyridostatin RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin (RR82) 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T10499	H3 receptor-MO-1	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	H3 receptor-MO-1 是一种有效的组胺 H3 受体 (histamine H3 receptor) 调节剂，可用于研究神经分裂和认知障碍。
T27710	K6PC-5 K6PC5,K6PC 5	S1P Receptor	GPCR/G Protein
	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
T73599	TSPO ligand-1	Autophagy	Autophagy
	TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白，可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运，可作为脑损伤和神经变性的生物标志物。
T12269	NUCC-390	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化，作用方式与 AMD3100相反。NUCC-390 在动物模型中，有助于神经退行性变后神经功能恢复。
T37621	Ezeprogind disulfate	Beta Amyloid	Neuroscience
	Ezeprogind disulfate 是一种神经营养诱导剂。 Ezeprogind disulfate 针对所有神经退行性变，包括 Abeta 蛋白或 tau 蛋白。 Ezeprogind disulfate 可用于神经系统疾病相关研究，包括进行性核上性麻痹（PSP）、tau 蛋白病、阿尔茨海默病和帕金森病等。
T5618	AK-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AK-1是一种特异性有效和细胞可渗透的SIRT2抑制剂，其IC50值为 12.5 μM。它可防止阿尔茨海默病模型中的海马神经退行性变并诱导结肠癌细胞中的细胞周期停滞。
T61268	Vutiglabridin HSG4112	Phosphatase	Metabolism
	Vutiglabridin (HSG4112) 是一种新型且安全的PON2调节剂，是一个外消旋化合物。Vutiglabridin 是Glabridin 的优化结构类似物，比Glabridin 在减重效果和化学稳定性方面更加优越。Vutiglabridin 通过靶向线粒体对氧磷酶-2改善mptp 诱导的帕金森病小鼠的神经变性。Vutiglabridin 是一种治疗肥胖的临床2期药物，在PD 模型中对对线粒体PON2具有治疗作用。Vutiglabridin 渗透到大脑，结合PON2，恢复1-甲基-4-苯基吡啶(MPP*)诱导的SH-SY5Y 神经母细胞瘤细胞线粒体功能障碍。Vutiglabridin 在小鼠实验中显著减轻了1-甲基-4苯基-1,2,3,6-四氢吡啶(MPTP)诱导的PD 模型小鼠的运动障碍和多巴胺能神经元损伤。
T27350	Fosmetpantotenate RE-024,RE024,RE 024
	Fosmetpantotenate, a immunomodulator, is used for treatment of Pantothenate Kinase Associated Neurodegeneration (PKAN).
T39827	c-ABL-IN-1
	C-ABL-IN-1 is a new and specific inhibitor of the c-Abl protein, which effectively prevents the progression of neurodegeneration observed in Parkinson's disease.
T82902	Beclin1-Bcl-2 interaction inhibitor 1
	Beclin1-Bcl-2 interaction inhibitor 1，有效地抑制Beclin 1/Bcl-2的结合作用，适用于癌症和神经退行性疾病的研究领域。
T38646	GKT136901 hydrochloride GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. This compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties.
T40701	Ezeprogind AZP-2006
	Ezeprogind (AZP-2006) is an orally active neurotrophic inducer that effectively addresses the underlying factors contributing to neurodegeneration, with a broad scope extending beyond the conventional targets like Abeta protein and tau protein. Exhibiting potent neuroprotective properties, Ezeprogind is a valuable tool for studying a range of neurological disorders, including progressive supranuclear palsy (PSP), tauopathies, Alzheimer's disease, Parkinson's disease, and others.
T37533	DOPAL
	DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as wel...
T38279	C2-8 C2-8
	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2...
T63524	ATX inhibitor 10
	ATX inhibitor 10 是一种含氮杂环化合物，是一种 ATX 的有效抑制剂。其中 ATX 在引起包括纤维化、神经变性、关节炎、神经性疼痛和癌症在内的病理中发挥作用。ATX inhibitor 10 对 ATX 相关疾病表现出研究潜力。
T80701	β Amyloid (1-16) rat
	β-Amyloid (1-16) rat 是β-淀粉样肽 (Abeta) 金属结合域的片段，含有三个与人类相异的氨基酸替代，因此在大鼠和小鼠中降低了 AD 样神经退行性变的易感性。
T63004	NUCC-390 dihydrochloride
	NUCC-390 dihydrochloride 是新型的选择性小分子CXCR4receptor 受体激动剂。NUCC-390 dihydrochloride 可以诱导CXCR4受体的内化，作用方式与 AMD3100 相反。NUCC-390 dihydrochloride 在动物模型中，有助于神经退行性变后神经功能恢复。
T35836	PMX-205 (trifluoroacetate salt)
	PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela...
T60489	hMAO-B/MB-COMT-IN-1
	hMAO-B/MB-COMT-IN-1 是 MAO-B/MB-COMT 的双重抑制剂，对 hMAO-B 的IC50值为 2.5 μM，对MB-COMT 的IC50值为 3.84 μM。hMAO-B/MB-COMT-IN-1 能保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD)等的研究。
T60658	hMAO-B/MB-COMT-IN-2
	hMAO-B/MB-COMT-IN-2 是MAO-B/MB-COMT 的双重抑制剂，对hMAO-B 和MB-COMT 的IC50值分别为 4.27 μM 和 2.69 μM。hMAO-B/MB-COMT-IN-2 保护细胞免受氧化损伤，可用于神经退行性疾病，如帕金森病 (PD) 等的研究。
T79299	hAChE-IN-3	Monoamine Oxidase	Neuroscience
	hAChE-IN-3（compounds 5c）是一种穿透血脑屏障的有效AChE、BuChE、MAO-B-IN-1和BACE-1抑制剂，IC50值依次为0.44、0.08、5.15和0.38μM。该化合物展现出抗氧化特性和金属离子螯合作用，能结合外周阴离子位点，干预Amyloid-β（Aβ）的聚集，减轻与阿尔兹海默症相关的神经退行性变化，适用于阿尔兹海默症的研究。
T78876	DNL343
	DNL343是一种可穿透血脑屏障的eIF2B激活剂，能够有效地抑制异常的整合应激反应(ISR)。该化合物能降低中枢神经系统(CNS)中的ISR活性，逆转神经退行性变化和神经炎症反应。DNL343还能预防带有eIF2B功能丧失(LOF)突变的小鼠模型出现运动障碍和过早死亡现象。此外，DNL343在治疗由eIF2B LOF和慢性ISR激活导致的白质消失病(VWMD)方面显示出明显的治疗潜力。
T38071	HPF
	The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.[1] There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). [2] HPF is a cell-permeable aroma...
T61607	Laquinimod sodium
	Laquinimod (ABR-215062) sodium 是一种可口服的羧酰胺衍生物，是一种有效的免疫调节剂，可防止中枢神经系统的神经变性和炎症。Laquinimod sodium 减少星形胶质细胞NF-κB 的活化以防止铜酮 (Cuprizone) 诱导的脱髓鞘。Laquinimod sodium 具有用于多发性硬化症 (MS；RRMS 或 CPMS) 的复发缓解 (RR) 和慢性进行性 (CP) 形式以及神经退行性疾病研究的潜力。
T35796	Lactosylceramides (bovine buttermilk)
	Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid. It is expressed on the plasma membrane of human phagocytes and mediates phagocytosis, chemotaxis, and superoxide generation. LacCer forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors, suggesting a role in cell signaling. Elevated LacCer levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic...

化合物

Anti-neurodegeneration agent 1

Cat.No: T10122

Target: Others

Cat.No: T1880

Target: Others

Cat.No: T9491

Target: Antibacterial, Antifungal

Pyridostatin TFA

Cat.No: T4470

Target: DNA/RNA Synthesis

Cat.No: T5827

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Cat.No: T6403

Synonym: 辛波莫德,BAF-312

Target: S1P Receptor, LPL Receptor

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T0682

Synonym: GR109714X,BCH-189,拉米夫定

Target: HIV Protease, Reverse Transcriptase

Cat.No: T6561

Synonym: LAQ,ABR-215062,拉喹莫德

Target: Apoptosis, Others, NF-κB

Cat.No: T1899

Synonym: RR82,Pyridostatin Trifluoroacetate Salt

Target: DNA/RNA Synthesis

H3 receptor-MO-1

Cat.No: T10499

Target: Histamine Receptor

Cat.No: T27710

Synonym: K6PC5,K6PC 5

Target: S1P Receptor

Cat.No: T73599

Target: Autophagy

Cat.No: T12269

Target: CXCR

Ezeprogind disulfate

Cat.No: T37621

Target: Beta Amyloid

Cat.No: T5618

Target: Sirtuin

Cat.No: T61268

Synonym: HSG4112

Target: Phosphatase

Fosmetpantotenate

Cat.No: T27350

Synonym: RE-024,RE024,RE 024

Cat.No: T39827

Beclin1-Bcl-2 interaction inhibitor 1

Cat.No: T82902

GKT136901 hydrochloride

Cat.No: T38646

Synonym: GKT136901 hydrochloride

Cat.No: T40701

Synonym: AZP-2006

Cat.No: T37533

Cat.No: T38279

Synonym: C2-8

ATX inhibitor 10

Cat.No: T63524

β Amyloid (1-16) rat

Cat.No: T80701

NUCC-390 dihydrochloride

Cat.No: T63004

PMX-205 (trifluoroacetate salt)

Cat.No: T35836

hMAO-B/MB-COMT-IN-1

Cat.No: T60489

hMAO-B/MB-COMT-IN-2

Cat.No: T60658

Cat.No: T79299

Target: Monoamine Oxidase

Cat.No: T78876

Cat.No: T38071

Laquinimod sodium

Cat.No: T61607

Lactosylceramides (bovine buttermilk)

Cat.No: T35796

Cat. No.	Product Name	Target	Signaling Pathways
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T12295	Oleoylcarnitine Oleoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Oleoylcarnitine (Oleoyl-L-carnitine) 抑制腺嘌呤核苷酸转位酶（AdNT）活性，ic50为14 μM。Oleoylcarnitine 是检测神经分裂的重要指标。
T5S1467	Cucurbitacin E	CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T65135	Kynurenic acid Fibrostop 2,Quinurenic acid	GPR; GluR; NMDAR	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物，是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂，也是 GPR35/CXCR8 激动剂，具有神经保护和抗惊厥特性，可用于研究神经分裂和与代谢相关的疾病。
T5S0754	Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷	NF-κB; Wnt/beta-catenin; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells
	Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T72733	Geissoschizoline (+)-Geissoschizoline
	Geissoschizoline ((+)-Geissoschizoline) 是一种有效的人AChE/BChE 抑制剂，其IC50s 分别为 20.40 µM 和 10.21 µM。Geissoschizoline 可用于预防神经变性和恢复神经传递方面的研究。Geissoschizoline 还具有抗炎作用。
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Oleoylcarnitine

Cat.No: T12295

Synonym: Oleoyl-L-carnitine

Target: Endogenous Metabolite

Cat.No: T5S1467

Target: CDK, Autophagy

Cat.No: T65135

Synonym: Fibrostop 2,Quinurenic acid

Target: GPR, GluR, NMDAR

Cat.No: T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷

Target: NF-κB, Wnt/beta-catenin, NO Synthase

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Geissoschizoline

Cat.No: T72733

Synonym: (+)-Geissoschizoline

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

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