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44

抑制剂 & 化合物

16

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9782	Cytochrome C	Others	Others
	Cytochrome C 是一种属于 c 型细胞色素家族 1 类的蛋白质，根据其细胞定位和其工作条件发挥不同的功能。
T21688L	Cytochrome c - pigeon (88-104) Acetate Cytochrome c - pigeon (88-104) Acetate (86579-06-8 Free base)	Others	Others
	Cytochrome c - pigeon (88-104) Acetate (Cytochrome c - pigeon ) 对 COOH 末端序列 88-1041 内的肽具有特异性。
TP2237	Cytochrome c fragment (93-108)	Others	Others
	Cytochrome c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions
TP1855	Moth Cytochrome C (MCC) (88-103) Moth Cytochrome C (MCC) 88-103
	Moth Cytochrome C (MCC) (88-103), derived from the carboxyl terminus of moth cytochrome c, induces positive selection of TCR transgenic thymocytes.This peptide is derived from the carboxyl terminus of moth cytochrome c. Thymic positive and negative select
T6260	AMG-208 AMG 208	P450; c-Met/HGFR	Metabolism; Tyrosine Kinase/Adaptors
	AMG-208 是一种选择性的、口服有活性的c-Met/RON 双抑制剂，对c-Met 的IC50为 9 nM。他也是CYP3A4抑制剂(IC50:32 μM)。它具有抗癌作用。
T40732	TMPD dihydrochloride
	TMPD dihydrochloride 是酶促转化氧化还原的活性底物和用于还原血红素过氧化物酶的电子供体。
T22119	NS3694	Apoptosis	Apoptosis
	NS3694 是一种凋亡抑制剂，可抑制凋亡小体形成和半胱天冬酶活化。
T1290	Oxiconazole nitrate 硝酸奥昔康唑,Ro 13-8996	Others; Antibiotic; Antifection; Antifungal	Microbiology/Virology; Others
	Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物，抑制T. tonsurans 和T.rubrum 的生长，MIC90值分别为 0.25 和 0.5 μg/mL。
T15212	Emamectin Benzoate MK-244,甲胺基阿维菌素苯甲酸盐	Apoptosis; Reactive Oxygen Species; GABA Receptor; Parasite	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Emamectin Benzoate (MK-244) 是口服有效的神经系统毒物，其通过结合昆虫中的 GABA 受体发挥作用。它是阿维菌素的半合成衍生物之一，具有广谱的杀虫和杀螨活性。它诱导ROS 介导的 DNA 损伤和细胞凋亡。
T9335	1,1'-Methylenedi-2-naphthol 1，1-亚甲基-2-萘酚,Squoxin	Others	Others
	1,1'-Methylenedi-2-naphthol 靶向 CYP2C19 - 细胞色素 P450 家族 2 亚家族 C 成员 19（人）。
T14846	Bz 423 BZ48	Apoptosis; BCL	Apoptosis
	Bz 423 是一种有效的免疫调节剂，通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
T5210	BAI1	Apoptosis; BCL	Apoptosis
	BAI1 是一种选择性凋亡因子BAX 变构抑制剂。它结合 BAX 并变构抑制其激活，具有潜力研究 BAX 依赖性细胞死亡介导的疾病。
T60186	(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂，IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。
T22094	JGB1741 ILS-JGB-1741	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JGB1741 (ILS-JGB-1741) 是一种有效的选择性 SIRT1 抑制剂，IC50 为 15 μM。 JGB1741 调节 Bax/Bcl2 比率、细胞色素 c 释放和 PARP 裂解并增加乙酰化 p53 水平，导致 p53 介导的细胞凋亡。 JGB1741可用于乳腺癌研究。
T60143	MitoBloCK-6	Apoptosis	Apoptosis
	MitoBloCK-6 是一种有效的Erv1/ALR 抑制剂，IC50分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制Erv2，IC50值为1.4 μM。MitoBloCK-6 可通过释放细胞色素 c 诱导 hESCs 细胞凋亡。
T10953	Dafadine-A	P450	Metabolism
	Dafadine-A 是dafadine 的类似物，是C. elegans DAF-9 细胞色素P450抑制剂，同时对哺乳动物的CYP27A1具有抑制作用。
T6275	Obatoclax Mesylate Obatoclax,GX15-070,奥巴克拉甲磺酸盐	BCL; Parasite; Autophagy	Apoptosis; Autophagy; Microbiology/Virology
	Obatoclax Mesylate (GX15-070) 是泛 BCL-2家族蛋白抑制剂，对 BCL-2 的 Ki 值为 220 nM。它是 BH3 模拟物，具有抗癌和广谱抗寄生虫活性。它诱导自噬依赖性细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。
T6686	Sulconazole mononitrate Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病，花斑糠疹病，皮肤念珠菌病。
T2170	SKF-96365 hydrochloride 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365	Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism
	SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂，也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流，延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。
T12413	PETCM	Others	Others
	PETCM is a caspase-3 activator and acts as an cytochrome c (cyto c)-dependent manner.
TP2238	Cytochrome P450 CYP1B1 (190-198) [Homo sapiens]	Others	Others
	Cytochrome c is a small heme protein found loosely associated with the inner membrane of the mitochondrion. Cytochromes c from certain eukaryotes, including plants and fungi but not higher animals, contains methylated lysine residues at specific positions
T29590	Acetoxycycloheximide
	Acetoxycycloheximide induces cell surface TNF receptor 1. It also rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase.
T14126	ADDA 5 hydrochloride	Others	Others
	ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.
T83285	5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole
	5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole 是酿酒酵母细胞色素 bc1 复合物（细胞色素c氧化还原酶）Qo位点的竞争性抑制剂。
T40596	Tasisulam sodium LY 573636 sodium,Tasisulam sodium
	Tasisulam is an anti-cancer compound that induces apoptosis through the intrinsic pathway, leading to the release of cytochrome c and caspase-dependent cell death. Additionally, tasisulam inhibits mitotic progression and triggers vascular normalization.
T39686	1-Methoxynaphthalene
	1-Methoxynaphthalene is employed as a substrate for scrutinizing the enzymatic activity of cytochrome c peroxidase (CcP). Additionally, 1-Methoxynaphthalene can serve as a precursor for the synthesis of prenyl naphthalen-ols.
T37454	C16 dihydro Ceramide (d18:0/16:0) Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine
	C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability ...
T35730	Clindamycin Sulfoxide
	Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin . It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.
T80624	Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Apoptosis; Proteases/Proteasome
	Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO)是一款caspase抑制剂，能够阻止缺氧细胞内MMP的降解以及细胞色素c的释出。
T36662	Imidafenacin Metabolite M4 Imidafenacin Metabolite M4
	Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007)
T76315	HKPao
	HKPao (Hunter-killer peptide ao) 是一种具有抗肥胖和抗肿瘤促凋亡活性的生物活性肽，能够促使细胞释放囊泡中的细胞色素 c。
T82620	DAB tetrahydrochloride dihydrate 3,3-Diaminobenzidine tetrahydrochloride dihydrate
	3,3-Diaminobenzidine tetrahydrochloride dehydrate 作为染料，在组织化学（HC）及免疫组织化学（IHC）中应用广泛。该化合物主要用于过氧化物酶体染色和线粒体细胞色素c氧化酶活性的检测。
T22202	iMAC2
	iMAC2 是一种有效的MAC 抑制剂，IC50为 28 nM，LD50为15000 nM。iMAC2 显示出抗凋亡作用，并且iMAC2 阻断细胞色素 c 的释放。
TP1724	PUMA BH3
	PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.This is a PUMA BH3 domain peptide. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C releas
T37839	20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2
	20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE2. 20-hydroxy PGE2 is the putative first intermediate in this chain of chemical transformations.
T36190	CAY10443 CAY10443
	Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is one such molecule. In a cell free, multi-component assay, it activated caspase-3 with an EC50 of 5 μM. These apoptotic activators represent therapeutic lead compounds for the developme...
T60348	N1,N11-Diethylnorspermine
	N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放，导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...
T4620	Siramesine 西拉美新,Lu 28-179	Sigma receptor	GPCR/G Protein
	Siramesine (Lu 28-179) 是sigma-2受体激动剂，通过线粒体的不稳定溶酶体触发细胞死亡，有强大的抗癌活性。它对 sigma-2 受体具有亚纳摩尔亲和力，IC50为 0.12 nM。它对 sigma-2 受体的选择性是 sigma-1 受体的 140倍，IC50为 17 nM。
T38090	3'-sulfo Galactosylsphingosine (ammonium salt)
	3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) d...
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T79714	HDAC3-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDAC3-IN-2 (compound 4i) 是一种具有纳摩尔级效力的吡嗪酰肼基HDAC3抑制剂，IC50值为14 nM，针对三阴性乳腺癌细胞表现出高效抑制作用。该化合物在细胞内毒性测定中显示，对4T1细胞株的IC50为0.55 μM，对MDA-MB-231细胞株的IC50为0.74 μM。HDAC3-IN-2通过增加乙酰化水平（如H3K9、H3K27和H4K12），促进细胞凋亡（涉及caspase-3、caspase-7和细胞色素c的水平提升），并抑制细胞增殖相关蛋白（如Bcl-2、CD44、EGFR和Ki-67）的表达，从而在荷瘤小鼠模型中表现出显著的体内抗肿瘤作用。
T36215	17R(18S)-EpETE
	17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells (VSMCs) at +60 mV when used at a concentration of 50 nM.2It has negative chronotropic effects in isolated neonatal rat cardiomyocytes (NRCMs; EC50= ~1-2 nM) and prevents calcium-induced increases ...
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T9782

Target: Others

Cytochrome c - pigeon (88-104) Acetate

Cat.No: T21688L

Synonym: Cytochrome c - pigeon (88-104) Acetate (86579-06-8 Free base)

Target: Others

Cytochrome c fragment (93-108)

Cat.No: TP2237

Target: Others

Moth Cytochrome C (MCC) (88-103)

Cat.No: TP1855

Synonym: Moth Cytochrome C (MCC) 88-103

Cat.No: T6260

Synonym: AMG 208

Target: P450, c-Met/HGFR

TMPD dihydrochloride

Cat.No: T40732

Cat.No: T22119

Target: Apoptosis

Oxiconazole nitrate

Cat.No: T1290

Synonym: 硝酸奥昔康唑,Ro 13-8996

Target: Others, Antibiotic, Antifection, Antifungal

Emamectin Benzoate

Cat.No: T15212

Synonym: MK-244,甲胺基阿维菌素苯甲酸盐

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, Parasite

1,1'-Methylenedi-2-naphthol

Cat.No: T9335

Synonym: 1，1-亚甲基-2-萘酚,Squoxin

Target: Others

Cat.No: T14846

Synonym: BZ48

Target: Apoptosis, BCL

Cat.No: T5210

Target: Apoptosis, BCL

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

Cat.No: T60186

Target: Discoidin Domain Receptor (DDR)

Cat.No: T22094

Synonym: ILS-JGB-1741

Target: Sirtuin

Cat.No: T60143

Target: Apoptosis

Cat.No: T10953

Target: P450

Obatoclax Mesylate

Cat.No: T6275

Synonym: Obatoclax,GX15-070,奥巴克拉甲磺酸盐

Target: BCL, Parasite, Autophagy

Sulconazole mononitrate

Cat.No: T6686

Synonym: Exelderm,Sulconazole Nitrate,RS 44872,硝酸硫康唑

Target: Antibacterial, Antibiotic, Antifungal

SKF-96365 hydrochloride

Cat.No: T2170

Synonym: 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

Cat.No: T12413

Target: Others

Cytochrome P450 CYP1B1 (190-198) [Homo sapiens]

Cat.No: TP2238

Target: Others

Acetoxycycloheximide

Cat.No: T29590

ADDA 5 hydrochloride

Cat.No: T14126

Target: Others

5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole

Cat.No: T83285

Tasisulam sodium

Cat.No: T40596

Synonym: LY 573636 sodium,Tasisulam sodium

1-Methoxynaphthalene

Cat.No: T39686

C16 dihydro Ceramide (d18:0/16:0)

Cat.No: T37454

Synonym: Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine

Clindamycin Sulfoxide

Cat.No: T35730

Cat.No: T80624

Synonym: Ac-Val-Ala-Asp-CHO

Target: Caspase

Imidafenacin Metabolite M4

Cat.No: T36662

Synonym: Imidafenacin Metabolite M4

Cat.No: T76315

DAB tetrahydrochloride dihydrate

Cat.No: T82620

Synonym: 3,3-Diaminobenzidine tetrahydrochloride dihydrate

Cat.No: T22202

Cat.No: TP1724

20-hydroxy Prostaglandin E2

Cat.No: T37839

Synonym: 20-hydroxy Prostaglandin E2

Cat.No: T36190

Synonym: CAY10443

N1,N11-Diethylnorspermine

Cat.No: T60348

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Cat.No: T4620

Synonym: 西拉美新,Lu 28-179

Target: Sigma receptor

3'-sulfo Galactosylsphingosine (ammonium salt)

Cat.No: T38090

Cat.No: T69200

Cat.No: T79714

Target: HDAC

Cat.No: T36215

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T3149	Salvianolic Acid C 丹酚酸C,丹酚酸 C	Others; P450	Metabolism; Others
	Salvianolic acid C 是一种细胞色素 P4502C8(CYP2C8)的非竞争性抑制剂及细胞色素 P4502J2(CYP2J2)中等强度的混合抑制剂，对 CYP2C8 和 CYP2J2 的 Ki 分别为 4.82 μM 和 5.75 μM。
T9503	PHYTOSPHINGOSINE	Apoptosis	Apoptosis
	Phytosphingosine 是具有抗癌作用的一种磷脂。在癌细胞中，它通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡。
T2770	Gentiopicroside Gentiopicrin,龙胆苦甙,龙胆苦苷	P450; HCV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Gentiopicroside (Gentiopicrin) 是天然环烯醚萜苷，具有抗炎和抗氧化活性。它抑制P450的活性，对 CYP2A6 的 IC50和 Ki 值分别为 61 µM 和 22.8 µM，
T3811	Ginsenoside C-K 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K	P450; cell cycle arrest; COX; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Ginsenoside C-K (Ginsenoside K) 是 Ginsenoside Rb1 的细菌代谢物，可通过抑制诱生型一氧化氮合酶和COX-2来发挥抗炎作用。它在人肝微粒体中抑制CYP2C9和CYP2A6活性，IC50分别为 32.0±3.6 和 63.6±4.2 μM。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T1192	Protoporphyrin IX PPIX,原卟啉,原卟啉IX	Others; Endogenous Metabolite	Metabolism; Others
	Protoporphyrin IX (PPIX) 是一种四吡咯，是血红素、细胞色素 c 和叶绿素的代谢前体。
T2S1086	Nepitrin 假荆芥属苷,Nepetin-7-glucoside	Antioxidant	oxidation-reduction
	Nepitrin (Nepetin-7-glucoside) 分离自Scrophularia striata 中，具有强大的抗炎、抗关节炎作用。
T3771	Methyl protodioscin 山药,Smilax saponin B,NSC-698790	Apoptosis	Apoptosis
	Methyl protodioscin (Smilax saponin B) 是一种甾二糖苷，能诱导细胞周期阻滞，具有抗肿瘤活性。
T3902	Atractylenolide III 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide	Apoptosis	Apoptosis
	Atractylenolide III (ICodonolactone) 是白术根茎主要成分，通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子，是治疗人肺癌的潜力。
T3867	Alpinetin 山姜素,(-)-alpinetin	BCL; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Alpinetin ((-)-alpinetin) 是从草豆蔻中分离得到的一种黄酮类天然产物，能够活化PPAR-γ，具有抗炎、抗菌活性。它通过抑制增殖、调节 Bcl-2 家族和 XIAP 表达、释放细胞色素 c 和激活 caspase 具有很强的抗肝癌和胰腺癌细胞作用。
T2909	Fraxetin 7,8-dihydroxy-6-methoxy coumarin,秦皮素,弗拉西汀	Apoptosis; Others	Apoptosis; Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) 是从秦皮中分离出来的一种天然产物，可诱导细胞凋亡，具有抗肿瘤、抗氧化作用和抗炎作用。
T9113	Myristicin Myristicine,肉豆蔻醚	IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用，还具有抗炎作用，其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡，其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。
T3895	Polyphyllin I 重楼皂苷I,重楼皂甙	Apoptosis; Akt; JNK; PDK; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Polyphyllin I 是从七叶一枝花中提取的生物活性成分，具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂，也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬，G2/M 期阻滞和细胞凋亡。
T83026	Antioxidant agent-18
	Antioxidant agent-18（compound 5）为一种从银杏（Ginkgo biloba）中提取的黄酮醇苷，展现出显著的抗氧化特性。本化合物能有效清除DPPH自由基（IC50: 15.8 μM），同时具有还原细胞色素c的能力（IC50: 14.7 μM）。
TN6419	Chamaejasmine
	Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate
TN5201	Uncarinic acid E	BCL; MEK; Caspase; PI3K; Antifection; p53	Apoptosis; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p-(

天然产物

Salvianolic Acid C

Cat.No: T3149

Synonym: 丹酚酸C,丹酚酸 C

Target: Others, P450

PHYTOSPHINGOSINE

Cat.No: T9503

Target: Apoptosis

Gentiopicroside

Cat.No: T2770

Synonym: Gentiopicrin,龙胆苦甙,龙胆苦苷

Target: P450, HCV Protease

Ginsenoside C-K

Cat.No: T3811

Synonym: 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K

Target: P450, cell cycle arrest, COX, NO Synthase

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Protoporphyrin IX

Cat.No: T1192

Synonym: PPIX,原卟啉,原卟啉IX

Target: Others, Endogenous Metabolite

Cat.No: T2S1086

Synonym: 假荆芥属苷,Nepetin-7-glucoside

Target: Antioxidant

Methyl protodioscin

Cat.No: T3771

Synonym: 山药,Smilax saponin B,NSC-698790

Target: Apoptosis

Atractylenolide III

Cat.No: T3902

Synonym: 白术内酯 III,ICodonolactone,8β-Hydroxyasterolide

Target: Apoptosis

Cat.No: T3867

Synonym: 山姜素,(-)-alpinetin

Target: BCL, PPAR

Cat.No: T2909

Synonym: 7,8-dihydroxy-6-methoxy coumarin,秦皮素,弗拉西汀

Target: Apoptosis, Others

Cat.No: T9113

Synonym: Myristicine,肉豆蔻醚

Target: IL Receptor, Anti-infection, BCL, P450, PARP, 5-HT Receptor, Caspase, GABA Receptor, NO Synthase

Cat.No: T3895

Synonym: 重楼皂苷I,重楼皂甙

Target: Apoptosis, Akt, JNK, PDK, mTOR, Autophagy

Antioxidant agent-18

Cat.No: T83026

Cat.No: TN6419

Uncarinic acid E

Cat.No: TN5201

Target: BCL, MEK, Caspase, PI3K, Antifection, p53

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