Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulconazole mononitrate (Exelderm) 是一种咪唑类广谱杀菌剂。它可研究皮肤真菌病,花斑糠疹病,皮肤念珠菌病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 498 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 197 | 现货 |
产品描述 | Sulconazole mononitrate (Exelderm) is the nitrate salt form of sulconazole, a synthetic imidazole derivative with the antifungal property. Sulconazole mononitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, Sulconazole mononitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. |
体外活性 | Sulconazole Nitrate possesses a broad spectrum of activity in vitro against dermatophytes, yeasts and some Gram-positive bacteria at concentrations below 5 mg/L in vitro. It has been shown that against representatives of pathogenic yeasts, dermatophytes and Aspergilli, the RIF values of sulconazole are broadly similar to those of other imidazoles. The fungicidal potency of sulconazole in vitro depends on its concentration and on the growth phase of the inoculum cells. Sulconazole has also demonstrated antibacterial activity in vitro, with MIC values below 12.5 mg/L. [1] |
体内活性 | The efficacy and safety of sulconazole 1% cream has been demonstrated in controlled clinical studies in patients with superficial dermatophyte or yeast infections. To minimise the risk of reinfection treatment should continue for 3 weeks in Candida infections, tinea cruris, tinea corporis and pityriasis versicolor, and for 4 weeks in patients with tinea pedis. [1] |
别名 | Exelderm, Sulconazole Nitrate, RS 44872, 硝酸硫康唑 |
分子量 | 460.76 |
分子式 | C18H15Cl3N2S·HNO3 |
CAS No. | 61318-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/mL (184.5 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1703 mL | 10.8516 mL | 21.7033 mL | 54.2582 mL |
5 mM | 0.4341 mL | 2.1703 mL | 4.3407 mL | 10.8516 mL | |
10 mM | 0.217 mL | 1.0852 mL | 2.1703 mL | 5.4258 mL | |
20 mM | 0.1085 mL | 0.5426 mL | 1.0852 mL | 2.7129 mL | |
50 mM | 0.0434 mL | 0.217 mL | 0.4341 mL | 1.0852 mL | |
100 mM | 0.0217 mL | 0.1085 mL | 0.217 mL | 0.5426 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sulconazole mononitrate 61318-91-0 Microbiology/Virology Antifungal Antibacterial Antibiotic anaerobes antimicrobial Inhibitor Exelderm Fungal antibacterial Bacterial RS-44872 Gram-positive inhibit (±)-Sulconazole mononitrate class antifungal imidazole RS44872 Sulconazole Nitrate RS 44872 硝酸硫康唑 Sulconazole Sulconazole Mononitrate inhibitor