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16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38565 |
Testosterone glucuronide
|
Others | Others |
Testosterone glucuronide 是睾酮的主要尿液代谢物,是一种潜在的尿液生物标记物。 | |||
T9170 |
Testosterone decanoate
|
Others | Others |
Testosterone decanoate 是天然存在的雄激素睾酮酯,具有长效男性抗生育活性。 | |||
T9035 |
Testosterone undecanoate
|
Others; Androgen Receptor | Endocrinology/Hormones; Others |
Testosterone undecanoate 是一种睾酮酯,是睾酮的代谢产物,睾酮是很有前途的男性激素避孕雄激素。 | |||
T38572 |
Testosterone buciclate
|
||
Testosterone buciclate, a long-acting androgen ester, shows promise as a research agent for male hypogonadism. | |||
T34813 |
Testosterone ketolaurate
Testosterone 3-oxododecanoate,Testosteroni ketolauras,十二酮酸睾酮 |
||
Testosterone ketolaurate is an androgen and anabolic steroid and a testosterone ester. | |||
T28952 |
Testosterone glucoside
|
||
Testosterone glucoside is an androgen receptor agonist. | |||
T40653 |
Testosterone phenylacetate
|
||
Testosterone phenylacetate, an analogue of Testosterone, is an androgen. | |||
T13921 |
Testosterone tridecanoate
|
Others | Others |
Testosterone tridecanoate is a prodrug of testosterone. Testosterone is an anabolic steroid and primary male sex hormone. | |||
T34814 |
Testosterone, amidinohydrazone
V-2052,V2052,V 2052 |
||
Testosterone, amidinohydrazone is a biochemical. | |||
TMIH-0560 |
Testosterone-d3
|
||
Testosterone-d3 是 Testosterone 的氘代化合物。 | |||
TMIH-0561 |
Testosterone-d5
|
||
Testosterone-d5 是 Testosterone 的氘代化合物。 | |||
TMIH-0562 |
Testosterone propionate-d3
|
||
Testosterone propionate-d3 是 Testosterone propionate 的氘代化合物。 | |||
T7313 |
Enclomiphene citrate
恩氯米芬柠檬酸盐,Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Enclomiphene citrate (trans-Clomiphene citrate) 是口服具有活力的 oestrogen receptor 拮抗剂,具有抗雌激素活性。 | |||
TP1015 |
NFAT Inhibitor
VIVIT peptide |
Others | Others |
NFAT Inhibitor (VIVIT peptide) 是NFAT 的细胞渗透性肽抑制剂,能够选择性抑制钙调磷酸酶介导的NFAT 脱磷酸作用。 | |||
T34303 |
Retrotestosterone
Lumitestosterone |
||
Retrotestosterone, a biochemical, can affect testosterone. | |||
T70409 |
6alpha-Fluorotestosterone
|
||
6alpha-Fluorotestosterone is a synthetic nonaromatizable androgen analog of testosterone. It binds to and activates specific nuclear receptors inhibits and is equipotent to testosterone. | |||
T84319 |
5α-Dihydrotestosterone
Stanolone,DHT,Dihydrotestosterone,Androstanolone |
||
二氢睾酮 (DHT) 是一种内源性雄激素类固醇和激素,可作为雄激素受体的激动剂。 DHT 可促进肾脏释放促红细胞生成素 (EPO)。 刺激骨髓中G0期造血干细胞增殖分化为红细胞系,促进红细胞增加。 主要用于慢性再生障碍性贫血及任何原因引起的骨髓造血功能衰竭。 | |||
T1167 |
Cyproterone acetate
Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮 |
Androgen Receptor | Endocrinology/Hormones |
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。 | |||
T3630 |
Relugolix
RVT-601,瑞卢戈利,TAK-385 |
GNRH Receptor | GPCR/G Protein |
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。 | |||
T14116 |
ACP-105
|
Androgen Receptor | Endocrinology/Hormones |
ACP-105 是选择性的、可口服的雄激素受体调节剂 , 能够作用于野生型 AR (pEC50:9.0)和 T877A 突变型 AR (pEC50:9.3)。 | |||
T22025 |
AG 045572
|
P450; GNRH Receptor | GPCR/G Protein; Metabolism |
AG 045572 是一种有效的 GnRH 受体拮抗剂,对人类和大鼠的 GnRH receptor 具有抑制作用, Ki 值分别为 6.0 nM 和 3.8 nM。AG 045572 通过 CYP3A 代谢并抑制睾酮。 | |||
T13187 |
Topterone
Win 17665 |
Androgen Receptor | Endocrinology/Hormones |
Topterone(Win 17,665) 是一种有效的局部抗雄激素,抑制睾酮和二氢睾酮对阉割未成熟雄性仓鼠腰部器官发育的刺激。 | |||
T0488 |
Finasteride
非那雄胺,MK-906 |
Reductase | Endocrinology/Hormones; Metabolism |
Finasteride (MK-906) 是 5α-还原酶的竞争性抑制剂,对 II 型 5α-还原酶的IC50为 4.2 nM,对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。 | |||
T26539 |
AC-262536
AC262536,4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈 |
Androgen Receptor | Endocrinology/Hormones |
AC-262536 是非甾体雄激素受体选择性调节剂,具有有益的合成代谢作用。它可以强效激动雄激素受体,亲和力为1-10 nM。 | |||
T2556 |
Nandrolone decanoate
癸酸诺龙,19-Nortestosterone decanoate |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素,通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。 | |||
T2408 |
Ostarine
MK-2866,GTX-024,Enobosarm |
Androgen Receptor | Endocrinology/Hormones |
Ostarine (MK-2866) 是一种具有合成代谢活性的非甾体药物。选择性雄激素受体调节剂 (SARM) GTx-024 旨在像睾酮一样发挥作用,从而促进和/或维持性欲、生育能力、前列腺生长以及肌肉生长和力量。模仿睾酮的作用,这种药物可以增加瘦体重,从而改善癌症恶病质高代谢状态下的肌肉萎缩。 | |||
T20681 |
Estramustine
NSC-89201,NSC 89201,LEO 275,LEO275,雌莫司汀,NSC89201,LEO-275 |
Microtubule Associated | Cytoskeletal Signaling |
Estramustine (LEO-275) 是一种与雌二醇相连的氮芥,通常为磷酸盐。它已被用于治疗前列腺肿瘤;还具有防辐射功能。它被前列腺细胞选择性吸收,并通过干扰微管动力学和降低血浆睾酮水平发挥抗肿瘤作用。 | |||
T0679 |
Ketoconazole
R-41400,Xolegel,(±)-Ketoconazol,酮康唑,Extina |
NADPH-oxidase; P450; Hydroxylase; Antifungal; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology |
Ketoconazole (R-41400) 是一种咪唑类抗真菌剂,也是一种 CYP3A4 抑制剂。 | |||
T30647 |
C 881
C-881,C881 |
||
C 881 is a raw testosterone propionate material. | |||
T71341 |
Myclobutanil hydroxide
|
||
Myclobutanil hydroxide is a 14-α demethylase inhibitor that inhibits ergosterol synthesis and fungal cell wall formation. It also weakly inhibits testosterone production. | |||
T68757 |
RMI-18341
|
||
RMI-18341 is a Testosterone 5 alpha reductase inhibitor. | |||
T24084 |
Gamendazole
|
||
Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels. | |||
T70266 |
Acyline
|
||
Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels. Acyline inhibits basal and GnRH-stimulated serum testosterone concentrations in male dogs. Acyline prevented ovulation, but did not affect ovarian follicular development or gestational corpora lutea in the domestic cat. A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in hea... | |||
T19194 |
Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)-
Androst-4-ene-3β,17β-diol, dipropionate |
Others | Others |
Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- is a metabolite of testosterone. | |||
T75244 |
Acyline TFA
|
||
Acyline TFA,GnRH 多肽类似物,是一种GnRH 拮抗剂,可以抑制促性腺激素和睾酮 (T) 水平。 | |||
TP1094 |
TAK-448
MVT-602 |
||
TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism. | |||
T69492 |
Ozarelix
|
||
Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,... | |||
T68292 |
GTX-758
|
||
GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in ... | |||
T81390 |
Prolactin-Releasing Peptide (1-31) (rat)
|
||
Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入,有效提升血浆LH、FSH及睾酮水平。 | |||
T79183 | SOS1-IN-16 | Ras | GPCR/G Protein; MAPK |
SOS1-IN-16(Comp 54)为SOS1的选择性抑制剂,IC50值为7.2 nM。在以睾酮作为底物的情况下,该化合物对CYP3A4也显示出抑制活性,IC50为8.9 μM,适用于肿瘤学研究。 | |||
T62572 |
Enclomiphene hydrochloride
|
||
Enclomiphene ((E)-Clomiphene) hydrochloride 是一种口服具有活力的、有效的非甾体雌激素受体 (estrogen receptor) 拮抗剂,具有抗雌激素作用。Enclomiphene hydrochloride 能够用于研究卵巢功能障碍、睾酮缺乏、男性性腺功能减退症和 type 2 型糖尿病。 | |||
T68701 |
Abarelix acetate
|
||
Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseli... | |||
T74284 | SH379 | ||
SH379为2-甲基嘧啶-稠合三环二萜衍生物,是具有口服活性的有效抗迟发性性腺机能减退剂。它显著促进StAR与3β-HSD等关键睾酮合成相关酶的表达,并通过调节AMPK/mTOR信号通路刺激自噬。 | |||
T76048 |
TAK-683 acetate
|
||
TAK-683 acetate是一种高效的KISS1R激动剂(IC50=170 pM),改善了代谢稳定性。作为九肽metastin的类似物,对人和大鼠的EC50值分别为0.96 nM和1.6 nM。该化合物通过消耗下丘脑GnRH,能够降低血浆FSH、LH、睾酮水平,展示了对研究激素依赖性前列腺癌的潜力。 | |||
T35676 |
17β-hydroxy Exemestane
|
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17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (IC50 = 69 nM using human placental microsomes) and an androgen receptor (AR) agonist (IC50 = 39.6 nM) that is selective for AR over estrogen receptor α (ERα; IC50 = 21.2 μM). It stimulates growth of AR- and ERα-positive MCF-7 (EC50 = 2.7 μM) and T47D breast cancer cells (EC50s = ... | |||
T76047 |
TAK-683 TFA
|
||
TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM),拥有较好的代谢稳定性,是九肽metastin的类似物,对KISS1R有激动效应,其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平,进而减少血浆FSH、LH、睾酮的浓度,显示出对激素依赖性前列腺癌研究的可能性。 | |||
T71142 |
Tebuconazole-d9
|
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Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3130 |
Testosterone phenylpropionate
Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate |
Others | Others |
Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。 | |||
TC0026 |
Testosterone benzoate
|
Others | Others |
Testosterone benzoate 是一种合成的注射合成代谢雄激素类固醇 (AAS) 和一种雄激素酯。 | |||
TC0025 |
Testosterone acetate
NSC523836,NSC-523836,NSC 523836,醋酸睾酮 |
Others | Others |
Testosterone acetate (NSC-523836) 是一种 Testosterone 前药,是一种天然存在的雄激素睾酮酯。它可用于阳痿、虚弱、疲劳和性腺机能减退的研究。 | |||
T19470 |
Nandrolone propionate
|
Others; Androgen Receptor | Endocrinology/Hormones; Others |
Nandrolone propionate 是合成代谢类固醇,主要由雄激素和保氮剂组成,具有作用时间相对较长的特点。 | |||
T8709 |
Nandrolone phenylpropionate
Nandrolone phenpropionate,苯丙酸诺龙 |
Androgen Receptor | Endocrinology/Hormones |
Nandrolone phenylpropionate (Nandrolone phenpropionate) 是一种合成代谢类固醇,是一种 19-nortestosterone 的衍生物。它能够促进蛋白质合成,用于缓解组织分解代谢,可以用于骨质疏松症和特纳综合征的研究。 | |||
T5264 |
Androsterone
5alpha-Androsterone,Androkinin,5α-Androstan-3α-ol-17-one,雄甾酮,雄酮 |
FXR; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Androsterone 是睾酮的代谢产物,可以激活法尼醇 X 受体。 | |||
T5S0543 |
Isocurcumenol
|
Apoptosis; Estrogen Receptor/ERR; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Isocurcumenol 是从莪术中分离得到的一种天然产物,是一种ERα抑制剂,对 DLA 和 KB 癌细胞的IC50分别为 99.1 µg/mL 和 178.2 µg/mL,具有抗肿瘤活性。 | |||
T3329 |
4',7-Dimethoxyisoflavone
4',7-二甲氧基异黄酮,Dimethoxydaidzein,Daidzein dimethyl ether |
Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology |
4',7-Dimethoxyisoflavone (Daidzein dimethyl ether) 是从阔荚合欢中分离的黄酮类化合物,有抗真菌作用,可抑制大鼠前列腺睾酮5α-还原酶。 | |||
T1009 |
Estrone
Oestrone,雌酮,Fluoroethyl,Aquacrine |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estrone (Aquacrine) 是内源性雌激素的主要代表,由多种组织产生,尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。 | |||
T4885 |
(-)-Aspartic acid
(R)-Aspartic acid,Asp,D-(-)-Aspartic acid,D-天门冬氨酸,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
(-)-Aspartic acid (L-Homoproline) 是一种存在于无脊椎动物和脊椎动物中的内源性氨基酸,是 NMDA 受体激动剂,可调节睾酮合成。 | |||
T20976 |
Clostebol acetate
Clostebolacetate,Clostene,Alfa-Trofodermin,4-CLTA |
||
Clostebol acetate is a synthetic anabolic-androgenic steroid (AAS) and a derivative of testosterone. It acts as a prodrug of clostebol in the body. | |||
TN4604 | Myricanone | BCL; HSP; NF-κB; ROS; Caspase; STAT | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Proteases/Proteasome; Stem Cells |
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-κB and STAT3 signalling cascades. Myricanone shows in vitro testost | |||
TN2144 |
Resveratroloside
|
P450; NO Synthase | Immunology/Inflammation; Metabolism |
Resveratroloside 是α-glucosidase 的竞争性抑制剂,可以对血糖水平进行调节,对心脏具有保护作用。 | |||
TN5682 |
2,6,4'-Trihydroxy-4-methoxybenzophenone
|
||
2,6,4'-Trihydroxy-4-methoxybenzophenone shows weak inhibitory activity of testosterone 5alpha-reductase, it also shows significant inhibition of pancreatic lipase activity. 2,6,4'-Trihydroxy-4-methoxybenzophenone has neurotrophic activity, it induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml. 2,6,4â²-Trihydroxy-4-methoxybenzophenone exhibits low cytotoxic effect against HeLa and 3T3 cell lines with IC50 values of 132 ug/ml and 158 ug/ml, repectively. It also shows antiox... | |||
T37452 |
Stephacidin B
|
||
Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... | |||
TN5153 |
Torilin
|
MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome |
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症,它可以减轻关节炎的严重程度,改变 dLN 或关节中的白细胞活化,并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成,IC(50)值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性,它可能通过抑制肿瘤侵袭来抑制肿瘤发生,逆转癌细胞的多药耐药性,它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。 |