82
19
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9984 |
Antimalarial agent 13
N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine |
Parasite | Microbiology/Virology |
Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) 是一种有效的抗疟剂。 | |||
T22381 |
Antimalarial agent 14
4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone |
Others | Others |
Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。 | |||
T7167 |
Purvalanol B
NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇 |
CDK; Parasite | Cell Cycle/Checkpoint; Microbiology/Virology |
Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。 | |||
T14324 |
Artemisone
BAY 44-9585,Artemifone,青蒿酮 |
Others; Parasite | Microbiology/Virology; Others |
Artemisone (BAY 44-9585) 是一种半合成的有效抗疟疾剂,还是一种人CMV 的有效抑制剂,可抑制多种P. falciparum,平均IC50值为 0.83 nM。 | |||
T16697 |
Pyronaridine tetraphosphate
|
Topoisomerase | DNA Damage/DNA Repair |
Pyronaridine tetraphosphate 是一种具有口服活性的、含甘露醇的DNA 拓扑异构酶 2 的抑制剂和红细胞裂殖杀灭剂,具有抗疟活性和抗肿瘤活性。Pyronaridine tetraphosphate 可治疗 P. falciparum 和 Echinococcus granulosus感染,可减轻埃博拉病毒传播。 | |||
T16326 |
Cipargamin
KAE609,NITD609 |
Parasite | Microbiology/Virology |
Cipargamin (NITD609) 是一种有效的抗疟药物,对恶性疟原虫的IC50值约为 1 nM。 | |||
T9591 |
YCN47284
|
Parasite | Microbiology/Virology |
YCN47284 是一种抗疟化合物,对恶性疟原虫的 IC50 为 1 μM。 | |||
T14766 |
BPH-715
|
Others; Parasite | Microbiology/Virology; Others |
BPH-715 抑制恶性疟原虫的肝脏阶段生长,对 HepG2 细胞中的恶性疟原虫外红细胞的形成的 IC50 为 10 μM。 | |||
T16125 |
MMV390048
|
Parasite; PI4K | Microbiology/Virology; PI3K/Akt/mTOR signaling |
MMV390048 是一种抗疟药,是一种新型化学疟原虫 PI4K 抑制剂。它与疟原虫 PI4K 的 ATP 结合位点结合,不与除人类 PIP4K2C 外的其他恶性疟原虫和人类激酶结合。 | |||
T27214 |
DSM421
DSM 421,DSM-421 |
Dehydrogenase | Metabolism |
DSM421 (DSM-421)是一种二氢酸脱氢酶抑制剂(DHODH),作为疟疾的潜在治疗选择处于临床前开发阶段,对恶性疟原虫和间日疟原虫的田间分离株均表现出活性。 | |||
T0860 |
Mefloquine hydrochloride
Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹 |
Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB |
Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药,是抗 SARS-CoV-2进入抑制剂,可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂,IC50约为 1 μM。 | |||
T5493 |
Pyronaridine
|
Others | Others |
Pyronaridine 是一种具有口服活性的、含甘露醇的抗疟疾化合物,通过干扰红细胞内疟疾寄生虫(疟原虫)的复制而起作用。Pyronaridine 常与其他药联用来治疗疟疾,对对 P. falciparum 和 Echinococcus granulosus 具有抗感染活性。 | |||
T9741 |
INE963
|
Others | Others |
INE963 是快速有效的血液阶段抗疟剂,EC50为 3-6 nM。INE963 有单纯性疟疾的研究潜力。 | |||
T3266 |
Lumefantrine
Benflumetol,dl-Benflumelol,苯芴醇 |
Others; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Lumefantrine (dl-Benflumelol) 是一种抗疟药,用于治疗急性单纯性疟疾。与Artemether 联用,可提高疗效。 | |||
T1491 |
Atovaquone
Atavaquone,阿托伐醌 |
Others; P450; Dehydrogenase; Antibiotic; Parasite | Metabolism; Microbiology/Virology; Others |
Atovaquone (Atavaquone) 是具有口服活性的选择性寄生虫线粒体细胞色素bc1复合物的抑制剂。它抑制人类和P. falciparum 细胞色素bc1活性,IC50值分别为 460 nM 和 2.0 nM。它有抗疟作用,有潜力用于疟疾、弓形体病、肺孢子虫肺炎和巴贝斯虫病的相关研究。 | |||
T11039 |
Didesethyl chloroquine
Bisdesethylchloroquine |
Drug Metabolite | Metabolism |
Didesethyl chloroquine (Bisdesethylchloroquine) 是一种有效的心肌抑制剂。Didesethyl chloroquine 是抗疟药氯喹的主要代谢产物。 | |||
Fr13587 |
7-Chloro-4-(piperazin-1-yl)quinoline
|
||
7-Chloro-4-(piperazin-1-yl)quinolone 结构是药物化学中的重要支架,它单独或与其他活性药效团混合显示出多种药理特性。7-Chloro-4-(piperazin-1-yl)quinolone 是有效的sirtuin 抑制剂,并且抑制 5-羟色胺的摄取,IC50值为 50 μM。7-Chloro-4-(piperazin-1-yl)quinolone 对恶性疟原虫 D10 和 K1 菌株表现出抗疟疾活性,IC50分别为 1.18 μM 和 0.97 μM。 | |||
T9858 |
5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole
|
Parasite | Microbiology/Virology |
Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫(D10 和 W2 菌株)和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体,IC50 为 0.035、0.058、3.5 和 7.5 μM。 | |||
T40417 |
Ethylhydrocupreine hydrochloride
Optochin hydrochloride,乙氢去甲奎宁盐酸盐;奥普托欣盐酸盐 |
Antibacterial; Parasite | Microbiology/Virology |
Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物,具有抗菌作用,可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性,对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1,ggTas2r2和ggTas2r7) 激动剂。 | |||
T4220 |
BQR-695
BQR695,NVP-BQR695 |
PI3K; Parasite; PI4K | Microbiology/Virology; PI3K/Akt/mTOR signaling |
BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂,对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。 | |||
T14325 |
Arterolane
OZ 277,青蒿氧烷,RBx 11160 |
Others | Others |
Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM. | |||
T12909 |
SID 26681509
|
Cysteine Protease; Parasite | Microbiology/Virology; Proteases/Proteasome |
SID 26681509 是可逆的,竞争性的人组织蛋白酶 L 选择性抑制剂,IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖,IC50为15.4 μM,抑制Leishmania major,IC5012.5 μM。 | |||
T15173 |
DSM265
PfSPZ |
Dehydrogenase; Parasite | Metabolism; Microbiology/Virology |
DSM265 (PfSPZ) 是一种具有抗疟活性的二氢乳清酸脱氢酶抑制剂(IC50:8.9 nM)。DSM265 抑制 Pf3D7 寄生虫的生长可用于治疗和预防疟疾感染。 | |||
T11030 |
DHODH-IN-8
|
Dehydrogenase | Metabolism |
DHODH-IN-8 是一种人和恶性疟原虫二氢乳清酸脱氢酶的抑制剂,IC50 分别为 0.13 μM 和 47.4 μM,Ki 分别为 0.016 μM 和 5.6 μM。DHODH-IN-8 具有抗疟疾能力。 | |||
T20910 |
Dibemethine
Dibemetina,DBMA,AI3-26795,Dibemethinum |
||
Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT). | |||
T71841 |
MMV085203
|
||
MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites. | |||
T12084 |
MMV008138
|
Others | Others |
MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM). | |||
T83908 |
DXR Inhibitor 11a (free acid)
1-Deoxy-D-Xylulose-5-phosphate Reductoisomerase Inhibitor 11a |
||
DXR inhibitor 11a是一种针对P. falciparum 1-脱氧-D-木糖-5-磷酸还原异构酶(DXR; IC50 = 0.11 µM)的抑制剂。它能够抑制在分离的人类红细胞中P. falciparum的生长(IC50 = 0.37 µM)。 | |||
T68923 |
FTI-2628
|
||
FTI-2628 is a novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia. | |||
T27516 | GW844520 | ||
GW844520 is a potent and selective inhibitor of the cytochrome bc1 complex of mitochondrial electron transport in P. falciparum. | |||
T36649 | AN3661 | ||
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1]. AN3661 is active at nanomolar (IC50=20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is simi... | |||
T27444 |
GSK 932121
GSK-932121,GSK932121 |
||
GSK 932121 is a potent antimalarial agent. GSK 932121 inhibits selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III). | |||
T73466 |
Pulixin
|
||
Pulixin 阻碍了 FREP1 与恶性疟原虫感染细胞的裂解物的结合,防止传播至蚊子,其中EC50值为11 µM。同时,Pulixin 抑制无性期恶性疟原虫的增殖,EC50值达47 nM。 | |||
T11006 |
Desmethyl ferroquine
SSR97213 |
Others | Others |
Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial. | |||
T83885 |
DXR Inhibitor 11a sodium
1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitor 11a |
||
DXR抑制剂11a是P. falciparum 1-去氧-D-木糖-5-磷酸还原异构酶(DXR; IC50 = 0.11 µM)的抑制剂。它抑制在分离的人类红细胞中P. falciparum的生长(IC50 = 0.37 µM)。 | |||
T25826 |
MMV024101
MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101 |
||
MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incu | |||
T68382 |
Fumarranol
|
||
Fumarranol is an angiogenesis inhibitor. It also interacts with P. falciparum methionine aminopeptidase 2 to inhibit malaria parasite growth in vitro and in vivo. | |||
T17257 |
WR99210
|
DHFR; Antifolate; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
WR99210 是一种有效的、可口服的且毒性较低的二氢叶酸还原酶 (DHFR) 抑制剂 (IC50<0.075 nM)。WR99210 具有较好的抗寄生虫活性,对间日疟原虫和恶性疟原虫株 (包括耐 Pyrimethamine 的恶性疟原虫株) 以及弓形虫有良好的抑制作用。 | |||
T16677 |
Psicofuranine
|
Others | Others |
Psicofuranine also specifically inhibits GMP synthase and interrupts parasite growth. Psicofuramine is a nucleoside antibiotic. It has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine shows dose-dependent inhibition of P. falciparum growth | |||
T78952 | Antimalarial agent 26 | Parasite | Microbiology/Virology |
Antimalarial agent 26是一种1,4-萘醌衍生物,作为口服抗疟药物,对恶性疟原虫(P. falciparum)表现出细胞毒性,并具有优于哺乳动物细胞系的选择性。该化合物能够有效抑制体内P. berghei引起的寄生虫血症。 | |||
T32372 | Keenamide A | ||
Keenamide A, a cytotoxic cyclic hexapeptide, exhibits significant activity towards the P-388, A-549, MEL-20, and HT-29 tumor cell lines, but was inactive against the D6 and W2 Plasmodium falciparum malarial clones. | |||
T75640 | Thalifendine chloride | ||
Thalifendine chloride 是 Berberine 的一种代谢物,具有抗疟原虫和抗阿米巴虫活性。Thalifendine chloride 对 P. falciparum 和 E. histolytica 作用的 IC50值分别为 7.91 μM 和 116 μM。 | |||
T7532 |
Piperaquine
|
Parasite | Microbiology/Virology |
Piperaquine 是一种双喹啉化合物,可抑制来自疟疾感染患者的恶性疟原虫分离株的离体生长,IC50 范围为 11.8-217.3 nM。 | |||
T62936 |
Antimalarial agent 8
|
||
Antimalarial agent 8 (Compound 7e) 是一种新型的、口服具有活力的抗疟药。Antimalarial agent 8 在体外能够有效作用于 P. falciparum,且在体内疟疾小鼠模型中口服有效 (40 mg/kg)。 | |||
T79460 |
Antimalarial agent 28
|
Parasite | Microbiology/Virology |
Antimalarial agent 28 (Compound 2i)为具有针对P. berghei三个发育阶段活性的化合物。该化合物的IC50s针对肝期P. berghei为0.561 μM,对早期配子体为0.14 μM,以及对环期P. berghei为4.34 μM,表明其具有抑制该寄生虫的潜力。 | |||
T72396 |
Antimalarial agent 20
|
||
Antimalarial agent 20 是一种抗疟剂,在 NF54 蛋白测定中对P. falciparumNF54 寄生菌株的IC50为 0.6 nM。 | |||
T35740 |
FR900098 (sodium salt)
|
||
FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice. | |||
T61058 | JMI-105 | ||
JMI-105 具有用作抗疟剂的潜力。JMI-105 是恶性疟原虫 -2 蛋白酶(PfFP-2)的有效抑制剂,可抑制恶性疟原虫菌株的CQS 株 (3D7) 和 CQR 株 (RKL-9) 的生长,IC50值分别为8.8 μM 和14.3 μM。在伯氏疟原虫 ANKA 感染小鼠模型中,JMI-105 显著降低寄生虫血症并延长宿主存活期。 | |||
T27400 |
Ganaplacide
KAF 156,KAF-156,GNF-156,GNF 156,GNF156,KAF156 |
||
Ganaplacide is an antimalarials with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites. KAF156 showed antimalarial activity without evident safety concerns in a small number of adults with uncompli | |||
T28937 |
Tebuquine
WR-228,258,WR 228,258,CI 897,CI897,CI-897 |
||
Tebuquine is an antimalarial agent. Tebuquine is active against P. falciparum in vitro. Tebuquine in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from that of chloroquine. Tebuquine has no |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1905 |
Magnolioside
七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷 |
Antifection | Microbiology/Virology |
Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中,对谷氨酸诱导的毒性有显著的神经保护作用。 它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性,对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。 | |||
TCS2070 |
Homogentisic acid
高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid |
Antioxidant; Endogenous Metabolite | Metabolism; oxidation-reduction |
Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物,可用于尿黑酸尿症的诊断。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
T3327 |
Artemotil
SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether |
CXCR; CCR; Parasite | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology |
Artemotil (SM-227) 是一种新型的速效抗疟药,可研究耐Plasmodium falciparum 的恶性疟原虫疟疾,IC50值为 1.61 nM。 | |||
TN4883 |
Quinine sulfate dihydrate
奎宁树 |
Others | Others |
Quinine sulfate dihydrate 在钾通道阻滞剂中起主要作用。它也被用作抗疟疾、抗胆碱能、抗高血压和降糖药。它抑制线粒体atp 调节的钾通道。它也被用来研究生物结晶血红素,血红素,在疟疾寄生虫的代谢和研究血红素(FP)复合物的毒性。 | |||
TN4933 |
Sahandol
|
Antifection | Microbiology/Virology |
Sahandol shows antiprotozoal activity against P. falciparum and T. brucei rhodesiense. | |||
TN3987 |
Eriodictyol chalcone
|
Anti-infection; Aromatase | Endocrinology/Hormones; Microbiology/Virology |
Eriodictyol chalcone 具有抗芳香化酶和抗 17β-HSD 的活性。它对恶性疟原虫的生长具有抗疟原虫作用。 | |||
T79984 |
Chaparrinone
|
Parasite | Microbiology/Virology |
Chaparrinone为苦木素类化合物,源自Eurycoma Harmandiana根部提取。该物质对Plasmodium falciparum和P-388细胞展示出抗疟及细胞毒效应,IC50值分别为0.037 μg/mL和0.34 μg/mL。 | |||
T71896 |
Brevicompanine B
|
||
Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various genes involved in the regulation of plant circadian rhythm. It is active against P. falciparum. | |||
T16719 |
Radicicol
根赤壳菌素,Monorden |
HSP | Cytoskeletal Signaling; Metabolism |
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients, | |||
T75450 | P-orlandin | ||
P-orlandin,一种真菌代谢产物,具有阻止FREP1与其配子体或[卵动细胞]结合的功能。该化合物能有效抑制蚊子体内的恶性疟原虫感染。 | |||
T35483 |
19,20-Epoxycytochalasin D
|
||
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 &#181M, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 &#181M. | |||
T75676 | Orotidine 5′-monophosphate trisodium | ||
Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1] | |||
T35754 | Aszonapyrone A | ||
Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34... | |||
T35758 | Butyrolactone V | ||
Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also... | |||
T35751 |
Violacein
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Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 &#181M, respectively). It is also active aga... | |||
T11802 |
L-Canaline
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Others | Others |
L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. Additionally, L-Canaline acts as a cytotoxic metabolite produced from L-canavanine through arginase catalysis and serves as a potent and irreversible inhibitor of ornithine aminotransferase. | |||
TN2120 |
Quassin
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Others; Antifection | Microbiology/Virology; Others |
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. | |||
TN2190 |
Scoulerine
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Apoptosis; Beta-Secretase; BACE; Parasite | Apoptosis; Microbiology/Virology; Neuroscience |
Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖,阻止细胞周期,并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。 |