Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SID 26681509 是可逆的,竞争性的人组织蛋白酶 L 选择性抑制剂,IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖,IC50为15.4 μM,抑制Leishmania major,IC5012.5 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 595 | 现货 | ||
5 mg | ¥ 1,490 | 现货 | ||
10 mg | ¥ 2,320 | 现货 | ||
25 mg | ¥ 4,000 | 现货 | ||
50 mg | ¥ 5,680 | 现货 | ||
100 mg | ¥ 7,950 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,770 | 现货 |
产品描述 | SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM). |
靶点活性 | Plasmodium falciparum:15.4 μM , Human cathepsin L:56 nM , Leishmania major:12.5 μM |
体外活性 | After a 4 hr preincubation with cathepsin L, SID 26681509 becomes more potent(IC50 : 1.0 nM). SID 26681509 is determined to be a slow-binding and slowly reversible competitive inhibitor. Through a transient kinetic analysis for single-step reversibility, inhibition rate constants are kon = 24,000 M-1s-1 and koff = 2.2 × 10-5 s-1 (Ki = 0.89 nM). Molecular docking studies are undertaken using the experimentally-derived X-ray crystal structure of papain/CLIK-148[1]. SID 26681509 inhibits papain and cathepsins B, K, S, and V with IC50 values determined after one hour ranging from 618 nM to 8.442 μM[1]. |
体内活性 | survival in murine models of sepsis significantly improved SID 26681509 by and reduces liver damage following warm liver ischemia/reperfusion (I/R) models[2]. |
分子量 | 539.65 |
分子式 | C27H33N5O5S |
CAS No. | 958772-66-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (101.92 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8531 mL | 9.2653 mL | 18.5305 mL | 46.3263 mL |
5 mM | 0.3706 mL | 1.8531 mL | 3.7061 mL | 9.2653 mL | |
10 mM | 0.1853 mL | 0.9265 mL | 1.8531 mL | 4.6326 mL | |
20 mM | 0.0927 mL | 0.4633 mL | 0.9265 mL | 2.3163 mL | |
50 mM | 0.0371 mL | 0.1853 mL | 0.3706 mL | 0.9265 mL | |
100 mM | 0.0185 mL | 0.0927 mL | 0.1853 mL | 0.4633 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SID 26681509 958772-66-2 Microbiology/Virology Proteases/Proteasome Cysteine Protease Parasite slow-binding falciparu Inhibitor propagation Leishmania major reversible Cathepsin inhibit SID26681509 Plasmodium SID-26681509 malaria Thiocarbazate inhibitor