Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DSM421 (DSM-421)是一种二氢酸脱氢酶抑制剂(DHODH),作为疟疾的潜在治疗选择处于临床前开发阶段,对恶性疟原虫和间日疟原虫的田间分离株均表现出活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 2,300 | 现货 | ||
5 mg | ¥ 5,570 | 现货 | ||
10 mg | ¥ 7,790 | 现货 | ||
25 mg | ¥ 11,500 | 现货 | ||
50 mg | ¥ 15,600 | 现货 | ||
100 mg | ¥ 20,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 6,530 | 现货 |
产品描述 | DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax. |
体内活性 | DSM421, a dihydroorotate dehydrogenase inhibitor, was in preclinical development as a potential treatment option for malaria. When tested in a core battery of safety pharmacology assays, DSM421 did not produce any effects at oral doses up to 750 mg/kg in an Irwin test in rats, but a respiratory study in rats using head-out plethysmography resulted in substantial changes in respiratory function as well as moribundity and mortality at that and lower doses.[1] |
别名 | DSM 421, DSM-421 |
分子量 | 358.27 |
分子式 | C14H11F5N6 |
CAS No. | 2011769-21-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (27.91 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7912 mL | 13.956 mL | 27.9119 mL | 69.7798 mL |
5 mM | 0.5582 mL | 2.7912 mL | 5.5824 mL | 13.956 mL | |
10 mM | 0.2791 mL | 1.3956 mL | 2.7912 mL | 6.978 mL | |
20 mM | 0.1396 mL | 0.6978 mL | 1.3956 mL | 3.489 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
DSM421 2011769-21-2 Metabolism Dehydrogenase DSM 421 DSM-421 Inhibitor inhibitor inhibit