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Search Results for " e2 "

155

抑制剂 & 化合物

35

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35991	ent-Prostaglandin E2 ent-Prostaglandin E2
	Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), g...
T37918	Prostaglandin E2 isopropyl ester Prostaglandin E2 isopropyl ester
	Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by endogenous esterases upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of PGs show greatly diminished receptor activity in vitro compared to the parent free acids.
T36144	11β-Prostaglandin E2 11β-PGE2,11β-Prostaglandin E2
	11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] .
T37839	20-hydroxy Prostaglandin E2 20-hydroxy Prostaglandin E2
	20-hydroxy Prostaglandin E2 (20-hydroxy PGE2) is a product of cytochrome P450 metabolism of PGE2 . ω-Oxidation at C-20 followed by β-oxidation and the loss of up to four carbons from the lower side chain is a prominent metabolic pathway for PGE2. 20-hydroxy PGE2 is the putative first intermediate in this chain of chemical transformations.
T36161	8-iso Prostaglandin E2 isopropyl ester 8-iso Prostaglandin E2 isopropyl ester
	8-iso PGE2 isopropyl ester is a more lipophilic form of the free acid, 8-iso PGE2. Prostaglandin esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid upon in vivo administration, making the esters useful prodrugs. In general, the C-1 esters of prostaglandins show greatly diminished agonist activity in vitro compared to the parent free acids.
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T38342	11-deoxy Prostaglandin E2 11-deoxy Prostaglandin E2
	11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2 . In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and contracts human respiratory tract smooth muscle with potencies ranging from 5 to 30 times higher than PGF2α .
T36160	8-iso Prostaglandin E2 8-iso Prostaglandin E2
	8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μM, respectively. When infused into the renal artery of the rat at a concentration of 4 μg/kg/min, 8-iso PGE2 decreases the GFR and renal plasma flow by 80% without affecting blood pressure.
T37996	17-phenyl trinor Prostaglandin E2 ethyl amide 17-phenyl trinor Prostaglandin E2 ethyl amide
	17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively). 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 μM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters. Modification of the C-1 carboxyl group to an ethyl amide serves to inc...
T32720	Levuglandin E2
	Levuglandin E2 is a secoprostanoid from prostaglandin endoperoxide.
T36154	15(S)-15-methyl Prostaglandin E2 15(S)-15-methyl Prostaglandin E2
	15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2. It is a potent gastric antisecretory and antiulcer compound. 15(S)-15-methyl PGE2 binds to human myometrium with twice the affinity of PGE2 and is ten times more potent than PGE1 in contracting uterine smooth muscle.
T36168	8-iso-16-cyclohexyl-tetranor Prostaglandin E2 8-iso-16-cyclohexyl-tetranor Prostaglandin E2
	8-iso Prostaglandin E2 (8-iso PGE2) is one of several isoprostanes produced from polyunsaturated fatty acids during lipid peroxidation. 8-iso-16-cyclohexyl-tetranor PGE2 is a synthetic analog of 8-iso PGE2. There are no published studies on the pharmacological properties of 8-iso-16-cyclohexyl-tetranor PGE2.
T36829	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF1α is very effective in terminating early pregnancy. This prostaglandin mixture is ineffective on monkeys in their third trimes...
T36045	1a,1b-dihomo Prostaglandin E2 1a,1b-dihomo Prostaglandin E2
	1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
T36728	9-deoxy-9-methylene Prostaglandin E2 9-deoxy-9-methylene Prostaglandin E2
	9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2 . 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.
T83773	Prostaglandin E2 Inhibitor 3 PGE2 Inhibitor 3
	Prostaglandin E2抑制剂3是一种microsomal prostaglandin E合酶-1 (mPGES-1; IC50 = 0.2 µM)的抑制剂，相较于COX-1、COX-2、5-lipoxygenase (5-LO)和soluble epoxide hydrolase (sEH)，在10 µM的无细胞试验中表现出对mPGES-1的选择性。在10 µM和1 µM的浓度下，该抑制剂能抑制A549细胞中IL-1β诱导的PGE2生成以及在J774A.1巨噬细胞中，LPS诱导的IL-6和PGE2生成。同时，它还能抑制由钙离子载体A23187单独或结合花生四烯酸和A23187诱导的5-LO产物形成，包括白三烯B4 (LTB4) 和5-H(p)ETE（IC50s分别为4.9和5.2 µM）。在体内，10 mg/kg剂量的Prostaglandin E2抑制剂3能防止在zymosan诱导的小鼠腹膜炎模型中白细胞渗入腹腔液中。
T71851	5-trans-Prostaglandin E2
	5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
T24136	Heclin	E1/E2/E3 Enzyme	Ubiquitination
	Heclin 是一种 HECT E3 泛素连接酶抑制剂，通过抑制 Smurf2、Nedd4 和 WWP1 起作用，IC50 值分别为 6.8、6.3 和 6.9 μM。
T78582	15-keto-Prostaglandin E2 15-keto-PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	15-keto-Prostaglandin E2为内源性代谢产物，通过与STAT3Cys259残基结合，抑制STAT3激活作用。该化合物能够结合并稳定EP2与EP4受体，进而抑制乳腺癌细胞生长与进展，并通过激活PPAR-γ促进真菌生长。
T10046	16,16-Dimethyl prostaglandin E2 16,16-dimethyl PGE2	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an interaction with the Wnt pathway.
T16102	ML-792	E1/E2/E3 Enzyme	Ubiquitination
	ML-792 是特异性的小泛素样修饰物活化酶抑制剂。ML-792选择性抑制SAE/SUMO1和SAE/SUMO2，IC50分别为 3 和 11 nM，对 NAE/NEDD8 和 UAE/ubiquitin 抑制作用微弱，IC50分别为 32 μM 和 >100 μM。
T12261	NSC232003	E1/E2/E3 Enzyme	Ubiquitination
	NSC232003 是高效的UHRF1抑制剂，能够抑制 DNA 甲基化，并破坏 DNMT1/UHRF1 相互作用。
T16901	SMIP004	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。
T76514	HCV-1 e2 Protein (554-569)
	HCV-1 e2 Protein (554-569) 是一段重要的丙型肝炎病毒(HCV) e2 蛋白的抗原区域，具有一个推定的 N-糖基化位点，这个位点被认为之前影响了e2蛋白的免疫识别。
T2158	Nutlin-3 Nutlin3	E1/E2/E3 Enzyme	Ubiquitination
	Nutlin-3 是一种 MDM2 拮抗剂，抑制 MDM2-p53 相互作用，Ki 为 90 nM，并激活 p53。
T16888	SJ-172550	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SJ-172550 是 MDMX 的小分子抑制剂，EC50为5 μM。
T8428	Subasumstat TAK-981	E1/E2/E3 Enzyme	Ubiquitination
	Subasumstat (TAK-981) 是SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤特性。
T7379	2-D08	E1/E2/E3 Enzyme; TAM Receptor	Tyrosine Kinase/Adaptors; Ubiquitination
	2-D08是小泛素样修饰蛋白抑制剂。2-D08也能抑制 Axl，IC50=0.49 nM。
T5199	COH000	E1/E2/E3 Enzyme	Ubiquitination
	COH000 是不可逆的泛素样激活酶1 共价变构抑制剂，体外测得对 SUMO 化修饰的IC50=0.2 μM。
T16699	PYZD-4409	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	PYZD-4409 是一种特异性 UBA1 抑制剂，IC50 为 20 μM。 PYZD-4409 在恶性细胞中诱导细胞死亡，并且对恶性细胞的细胞毒性优于对正常造血细胞的细胞毒性。
T9236	WSB1 Degrader 1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	WSB1 Degrader 1 是具有口服活性的 WSB1降解剂，具有抗癌活性。
T13244	Ubiquitination-IN-1	Others	Others
	Ubiquitination-IN-1 是一种有效的泛素化和Cksl-Skp2蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂，增加 p27 水平，可通过阻断肿瘤抑制因子的降解发挥作用。
T7415	DKM 2-93	E1/E2/E3 Enzyme	Ubiquitination
	DKM 2-93是相对选择性 UBA5抑制剂，IC50=430 μM。
T7889	C25-140	Others; TNF; E1/E2/E3 Enzyme; NF-κB	Apoptosis; NF-κB; Others; Ubiquitination
	C25-140 是一种具有口服活性和一定选择性的 TRAF6-Ubc13相互作用抑制剂。它直接与 TRAF6 结合，阻断 TRAF6 和 Ubc13 的相互作用，降低 TRAF6 和 NF-κB 的活性，并与自身免疫对抗。
T76516	HCV-1 e2 Protein (484-499)
	HCV-1 e2 蛋白 (484-499) 是由 16 个氨基酸组成的肽。 HCV-1 e2 蛋白 (484-499) 来源于具有 HCV 抗体的个体血清中丙型肝炎病毒的包膜 2 蛋白。
T5374	NAcM-OPT	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。
T6629	PYR-41 PYR41,PYR 41	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	PYR-41 是一种选择性，可透过细胞的泛素活化酶 E1抑制剂，IC50值小于10 μM。
T10703	Mezigdomide CC-92480	Apoptosis; E1/E2/E3 Enzyme; Molecular Glues	Apoptosis; PROTAC; Ubiquitination
	Mezigdomide (CC-92480) 是一种有效的、新型的、具有选择性的和具有活性的 cereblon E3 泛素连接酶调节剂 (CELMoD)，常以分子胶的方式发挥作用。Mezigdomide 具有抗骨髓瘤活性。
T23371	SMER3 SMER 3	Others; Ligand for E3 Ligase	Others; PROTAC
	SMER3 是选择性的 Skp1-Cullin-F-box (SCF)Met30泛素连接酶抑制剂。SMER 3 通过抑制 SCFMet30来增强 Rapamycin 的生长抑制作用。
T3653	MX69	Mdm2; E1/E2/E3 Enzyme; IAP	Apoptosis; Ubiquitination
	MX69 是用于抗癌研究的一种MDM2/XIAP 抑制剂。
T6149	YH239-EE	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	YH239-EE 是 YH239 的乙酯，是 p53-MDM2 拮抗剂和凋亡诱导剂。
T3517	RO8994	Mdm2; E1/E2/E3 Enzyme; p53	Apoptosis; Ubiquitination
	RO8994是一种高效且特异性的螺吲哚酮小分子 MDM2 抑制剂，MTT 增殖试验和HTRF 结合试验的IC50 为 20 nM 和 5 nM。
T8564	BC-1382	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	BC-1382 是E3泛素连接酶HECTD2抑制剂，能够特异性破坏 HECTD2/PIAS1 相互作用 (IC50≈ 5 nM)。BC-1382具有抗炎活性。
T4253	Skp2 Inhibitor C1 SKPin C1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Skp2 Inhibitor C1 (SKPin C1)(SKPin C1)是Skp2介导p27降解的特异性抑制剂。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T3110	PRT4165 NSC600157,PRT 4165	BMI-1; Others; E1/E2/E3 Enzyme	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; Ubiquitination
	PRT4165 (NSC600157) 是有效的 PRC1介导 H2A 泛素化的抑制剂。
T80089	HCV-1 e2 Protein (554-569) (TFA)
	HCV-1 e2 Protein (554-569) TFA 为丙型肝炎病毒（HCV）e2 蛋白关键抗原区段，含一个假定 N-糖基化位点，该位点早先推测会影响 e2 蛋白的免疫识别。
T6254	Idasanutlin RG7388,Ro 5503781,依达奴林	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	Idasanutlin (Ro 5503781) 是一种有效且特异性的 p53-MDM2 抑制剂，IC50值为 6 nM。
T11980	MD-224	Mdm2; E1/E2/E3 Enzyme; PROTACs	Apoptosis; PROTAC; Ubiquitination
	MD-224是一种基于蛋白水解靶向嵌合体（PROTAC）概念的高效、高效的MDM2降解剂，是一类新型抗癌剂。

化合物

ent-Prostaglandin E2

Cat.No: T35991

Synonym: ent-Prostaglandin E2

Prostaglandin E2 isopropyl ester

Cat.No: T37918

Synonym: Prostaglandin E2 isopropyl ester

11β-Prostaglandin E2

Cat.No: T36144

Synonym: 11β-PGE2,11β-Prostaglandin E2

20-hydroxy Prostaglandin E2

Cat.No: T37839

Synonym: 20-hydroxy Prostaglandin E2

8-iso Prostaglandin E2 isopropyl ester

Cat.No: T36161

Synonym: 8-iso Prostaglandin E2 isopropyl ester

Cat.No: T35881

11-deoxy Prostaglandin E2

Cat.No: T38342

Synonym: 11-deoxy Prostaglandin E2

8-iso Prostaglandin E2

Cat.No: T36160

Synonym: 8-iso Prostaglandin E2

17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T37996

Synonym: 17-phenyl trinor Prostaglandin E2 ethyl amide

Cat.No: T32720

15(S)-15-methyl Prostaglandin E2

Cat.No: T36154

Synonym: 15(S)-15-methyl Prostaglandin E2

8-iso-16-cyclohexyl-tetranor Prostaglandin E2

Cat.No: T36168

Synonym: 8-iso-16-cyclohexyl-tetranor Prostaglandin E2

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

Cat.No: T36829

Synonym: 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2

1a,1b-dihomo Prostaglandin E2

Cat.No: T36045

Synonym: 1a,1b-dihomo Prostaglandin E2

9-deoxy-9-methylene Prostaglandin E2

Cat.No: T36728

Synonym: 9-deoxy-9-methylene Prostaglandin E2

Prostaglandin E2 Inhibitor 3

Cat.No: T83773

Synonym: PGE2 Inhibitor 3

5-trans-Prostaglandin E2

Cat.No: T71851

Cat.No: T24136

Target: E1/E2/E3 Enzyme

15-keto-Prostaglandin E2

Cat.No: T78582

Synonym: 15-keto-PGE2

Target: Prostaglandin Receptor

16,16-Dimethyl prostaglandin E2

Cat.No: T10046

Synonym: 16,16-dimethyl PGE2

Target: Prostaglandin Receptor

Cat.No: T16102

Target: E1/E2/E3 Enzyme

Cat.No: T12261

Target: E1/E2/E3 Enzyme

Cat.No: T16901

Target: Apoptosis, Others, E1/E2/E3 Enzyme

HCV-1 e2 Protein (554-569)

Cat.No: T76514

Cat.No: T2158

Synonym: Nutlin3

Target: E1/E2/E3 Enzyme

Cat.No: T16888

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T8428

Synonym: TAK-981

Target: E1/E2/E3 Enzyme

Cat.No: T7379

Target: E1/E2/E3 Enzyme, TAM Receptor

Cat.No: T5199

Target: E1/E2/E3 Enzyme

Cat.No: T16699

Target: Others, E1/E2/E3 Enzyme

WSB1 Degrader 1

Cat.No: T9236

Target: Others, E1/E2/E3 Enzyme

Ubiquitination-IN-1

Cat.No: T13244

Target: Others

Cat.No: T7415

Target: E1/E2/E3 Enzyme

Cat.No: T7889

Target: Others, TNF, E1/E2/E3 Enzyme, NF-κB

HCV-1 e2 Protein (484-499)

Cat.No: T76516

Cat.No: T5374

Target: E1/E2/E3 Enzyme, NEDD8

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Cat.No: T6629

Synonym: PYR41,PYR 41

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T10703

Synonym: CC-92480

Target: Apoptosis, E1/E2/E3 Enzyme, Molecular Glues

Cat.No: T23371

Synonym: SMER 3

Target: Others, Ligand for E3 Ligase

Cat.No: T3653

Target: Mdm2, E1/E2/E3 Enzyme, IAP

Cat.No: T6149

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T3517

Target: Mdm2, E1/E2/E3 Enzyme, p53

Cat.No: T8564

Target: Others, E1/E2/E3 Enzyme

Skp2 Inhibitor C1

Cat.No: T4253

Synonym: SKPin C1

Target: Others, E1/E2/E3 Enzyme

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T3110

Synonym: NSC600157,PRT 4165

Target: BMI-1, Others, E1/E2/E3 Enzyme

HCV-1 e2 Protein (554-569) (TFA)

Cat.No: T80089

Cat.No: T6254

Synonym: RG7388,Ro 5503781,依达奴林

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T11980

Target: Mdm2, E1/E2/E3 Enzyme, PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
T5014	Prostaglandin E2 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)	Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Prostaglandin E2 (PGE2) 是一种天然激素，参与人体内的各种生理过程，包括平滑肌收缩和放松、调节血管扩张和收缩、调节血压和炎症调节。
TN4862	Pulchinenoside E2 白头翁皂苷E2	Others	Others
	Pulchinenoside E2是一种天然产物，属于毛茛科白头翁属，其产品编号为 TN4862，CAS号为 244202-36-6。Pulchinenoside E2可用作对照参考。
TN4436	Licoricesaponin E2	Others	Others
	Licoricesaponin E2 displayed the inhibition on the growth of cancer cells with IC50 at 18.3-41.6 umol/L, it could significantly increase the cytotoxic activity after hydrolysis.
TN5976	Methyl lucidenate E2
	Methyl lucidenate E2 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5976，CAS号为 98665-12-4。
T80995	Theasaponin E2
	Theasaponin E2, 一种从茶树分离得到的化合物，对K562和HL60细胞表现出显著的细胞毒性，其半抑制浓度(IC50)为14.7 μg/mL。
T83904	Polymyxin E2 sulfate Colistin B sulfate
	Polymyxin E2 是一种肽类抗生素，也是最初从B. polymyxa分离出的阳离子脂肽抗生素colistin的主要成分。该化合物对植物致病菌X. oryzae具有活性（EC50 = 0.21 µg/ml），并且在温室研究中，当以200 µg/ml的浓度应用时，能够预防和逆转水稻细菌性叶枯病。
T4S0181	Hinokiflavone 日本扁柏黄酮,扁柏双黄酮	MMP; BCL; E1/E2/E3 Enzyme	Apoptosis; Proteases/Proteasome; Ubiquitination
	Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂，通过抑制剪接体装配来阻止pre-mRNA 底物的剪接，特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂，能够抑制前哨蛋白特异性蛋白酶 1 的活性。
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
TN1883	Lucidenic acid E 赤芝酸 E,赤芝酸E2	Others	Others
	Lucidenic acid E is a natural product
T1048	Estradiol 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estradiol (E2) 是一种天然的类固醇性激素，对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T6S2123	Ginkgolic Acid Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1	Others; E1/E2/E3 Enzyme	Others; Ubiquitination
	Ginkgolic Acid (Romanicardic acid) 是一种天然化合物，在体外实验中抑制SUMOylation，IC50=3.0 μM。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
TN6776	β-D-glucopyranosyl-[α-L-rhamnopyranosyl-(1→3)-βD-glucuronopyranosyl-(1→3)]-3β-hydroxyolean-12-ene28-oate Cyaonoside B,川牛膝皂苷B	Others	Others
	Cyaonoside B 是一种皂苷，有一个葡萄糖醛酸连接到碳 C-3，能够从单胞菌中分离。
T7053	p-Hydroxycinnamic acid p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260	Thrombin; Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	p-Hydroxycinnamic acid (NSC-59260) 是常见的食用酚，可抑制血小板活性，对血栓素 B2 和前列腺素 E2 的 IC50值分别为 371 和 126 μM。
T21518	Colistin methanesulfonate sodium salt 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)	Cell wall; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Colistin methanesulfonate sodium salt (Colistimethate Sodium) 是一种来自 Bacillus colistinus 的环状多肽抗生素，由多粘菌素 E1 和 E2 组成。
T3912	Saikosaponin B1 柴胡皂苷B1,柴胡皂苷 B1	Others	Others
	Saikosaponin B1 是柴胡的生物活性成分，具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路，显著抑制髓母细胞瘤模型中的肿瘤生长。
T3810	Saikosaponin B2 柴胡皂苷 B2,柴胡皂甙 B2	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Saikosaponin B2 是从柴胡根中分离得到的一种活性成分，可抑制 HCV 病毒感染的侵入，有抗癌作用。
T3411	Curdione 莪术二酮,(+)-Curdione	P450	Metabolism
	Curdione ((+)-Curdione) 是一种具有高生物活性的倍半萜类物质，从莪术中分离获得，具有抑制血小板聚集、抵抗血栓形成的作用。
T10619	Bromelain	Apoptosis; Others	Apoptosis; Others
	Bromelain 是来源于菠萝茎的一种抗炎药，可诱导细胞凋亡，具有纤维蛋白溶解、抗癌、抗水肿和抗血栓形成活性。它通过下调血浆激肽原，抑制前列腺素 E2 表达，降解晚期糖基化终产物受体，在COX 途径上游发生抗氧化作用以及调节血管生成生物标志物而发挥作用。
T1245	Colistin sulfate Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素	Cell wall; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Colistin sulfate (Colistin sulfate (1066-17-7 free base)) 是抑制革兰氏阴性细菌的一种多肽抗生素，与革兰氏阴性细菌的外细胞膜中的脂多糖和磷脂结合起作用。
T3903	Angoroside C 安格洛甙C,安格洛苷C	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Angoroside C 是一种苯丙苷，从 Radix Scrophulariae 中提取到，有益于心室重构。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
TN2091	Polygalacin D	Apoptosis; IAP	Apoptosis
	Polygalacin D 是从桔梗中分离的一种天然产物，具有抗癌和抗增殖特性。它通过 PI3K/Akt 途径诱导凋亡。它抑制 IAP 蛋白家族的表达，并通过抑制 GSK3β，Akt 的磷酸化和 PI3K 的表达来阻断 PI3K/Akt 途径。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。
T6S0077	Byakangelicol	COX	Immunology/Inflammation; Neuroscience
	Byakangelicol 是一种分离自白芷的白三醇，能够抑制环加氧酶-2的表达及活性，从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。
TN3567	Calanolide E 胡桐，海棠木	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Calanolide E2 has anti-HIV activity.
T75620	(+)-Oxypeucedanin methanolate
	(+)-Oxypeucedanin methanolate (compound 9) 是一种天然产物，可抑制前列腺素 E2 的产生。
TN1871	Ligustroside	EGFR; Lipoxygenase; COX	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustroside shows moderate antiviral activities against parainfluenza type 3 virus.
T73201	Stigmane B
	Stigmane B 是一个核因子 E2 相关因子 (Nrf2) 激活剂。Stigmane B 抑制细胞凋亡 (apoptosis) 和活性氧 (ROS) 生成，提高抗氧化酶活性。Stigmane B 具有神经保护效果。
T73066	Thielavin B
	Thielavin B为Thielavin terricola产生的前列腺素生物合成抑制剂。该化合物能有效抑制内过氧物酶介导的前列腺素E2合成，并在静脉注射后显著降低大鼠因角叉菜胶引发的水肿。
T3P2855	Chamigrenal	EGFR; NOS; PAFR; COX; Prostaglandin Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)
TN6667	Spinacetin
	Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Prostaglandin E2

Cat.No: T5014

Synonym: 地诺前列酮,前列腺素 E2,PGE2,Dinoprostone,Prostaglandin E2 (PGE2)

Target: Endogenous Metabolite, Prostaglandin Receptor

Pulchinenoside E2

Cat.No: TN4862

Synonym: 白头翁皂苷E2

Target: Others

Licoricesaponin E2

Cat.No: TN4436

Target: Others

Methyl lucidenate E2

Cat.No: TN5976

Cat.No: T80995

Polymyxin E2 sulfate

Cat.No: T83904

Synonym: Colistin B sulfate

Cat.No: T4S0181

Synonym: 日本扁柏黄酮,扁柏双黄酮

Target: MMP, BCL, E1/E2/E3 Enzyme

Cat.No: T9352

Target: Others

Lucidenic acid E

Cat.No: TN1883

Synonym: 赤芝酸 E,赤芝酸E2

Target: Others

Cat.No: T1048

Synonym: 雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Cat.No: T6S2123

Synonym: Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1

Target: Others, E1/E2/E3 Enzyme

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

β-D-glucopyranosyl-[α-L-rhamnopyranosyl-(1→3)-βD-glucuronopyranosyl-(1→3)]-3β-hydroxyolean-12-ene28-oate

Cat.No: TN6776

Synonym: Cyaonoside B,川牛膝皂苷B

Target: Others

p-Hydroxycinnamic acid

Cat.No: T7053

Synonym: p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260

Target: Thrombin, Endogenous Metabolite, Prostaglandin Receptor

Colistin methanesulfonate sodium salt

Cat.No: T21518

Synonym: 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)

Target: Cell wall, Antibacterial

Saikosaponin B1

Cat.No: T3912

Synonym: 柴胡皂苷B1,柴胡皂苷 B1

Target: Others

Saikosaponin B2

Cat.No: T3810

Synonym: 柴胡皂苷 B2,柴胡皂甙 B2

Target: Others, HCV Protease

Cat.No: T3411

Synonym: 莪术二酮,(+)-Curdione

Target: P450

Cat.No: T10619

Target: Apoptosis, Others

Colistin sulfate

Cat.No: T1245

Synonym: Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素

Target: Cell wall, Antibacterial, Antibiotic, Autophagy

Cat.No: T3903

Synonym: 安格洛甙C,安格洛苷C

Target: Prostaglandin Receptor

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Cat.No: TN2091

Target: Apoptosis, IAP

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

Cat.No: T6S0077

Target: COX

Cat.No: TN3567

Synonym: 胡桐，海棠木

Target: HIV Protease

(+)-Oxypeucedanin methanolate

Cat.No: T75620

Cat.No: TN1871

Target: EGFR, Lipoxygenase, COX

Cat.No: T73201

Cat.No: T73066

Cat.No: T3P2855

Target: EGFR, NOS, PAFR, COX, Prostaglandin Receptor

Cat.No: TN6667

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

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