首页工具

登录

搜索结果

Search Results for " akt1 "

65

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T14152	Akt1 and Akt2-IN-1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.
T73255	Akt1-IN-1
	Akt1-IN-1 是一种有效的 Akt1抑制剂，对 MIA Paca-2 细胞的 IC50为 18.79 nM。Akt1-IN-1 不具有明显的致畸性、肝毒性和心脏毒性 (有害作用剂量大于 100 µM)。Akt1-IN-1 可用于抗癌研究。
T72885	Akt1&PKA-IN-1
	Akt1&PKA-IN-1 是一种有效的Akt/PKA 双重抑制剂，对 PKAa、Akt 和CDK2的IC50值分别为 0.03、0.11 μM 和 9.8 μM。Akt1&PKA-IN-1 对细胞周期蛋白依赖性激酶 2 (CDK2) 具有选择性。
T79214	Tubulin/AKT1-IN-1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Tubulin/AKT1-IN-1 (Compound D1-1) 作为一种抑制剂，能够阻碍微管蛋白的聚合和AKT通路的激活。在抑制H1975细胞增殖和迁移方面表现出显著效果，同时轻度诱导细胞凋亡（apoptosis），适用于非小细胞肺癌（NSCLC）研究。
T3467	Miransertib ARQ-092,AKT inhibitor 2	Akt; Parasite	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Miransertib (ARQ-092) 是一种具有口服活性的，选择性和变构性Akt 抑制剂。它有效抑制利什曼原虫，还是 AKT1-E17K 突变蛋白抑制剂，可研究PI3K/AKT 驱动的肿瘤和 Proteus 综合征。
T72886	Akt1&PKA-IN-2
	Akt1&PKA-IN-2 ((R)-29) 是一种具有周期蛋白依赖性激酶 2 (CDK2) 选择性的酰胺类 PKB/AKT 抑制剂。Akt1&PKA-IN-2 抑制 AKT1、PKAa 和 CDK2a，IC50值分别为 0.007 µM、0.01 µM 和 0.69 µM。
T6139	A-674563 A674563	ERK; GSK-3; Akt; PKA; CDK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-674563 是一种口服有效，选择性的Akt1抑制剂，Ki=11 nM。
T3346	AKT inhibitor VIII AKTi-1/2	Apoptosis; Akt	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT inhibitor VIII (AKTi-1/2) 是一种细胞渗透的喹喔啉化合物，可逆的选择性抑制Akt1、Akt2和Akt3的活性，IC50值分别为 58 nM、210 nM 和 2119 nM。
T38846	Vevorisertib trihydrochloride ARQ 751 trihydrochloride	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vevorisertib trihydrochloride(ARQ 751 trihydrochloride) 是一种具有选择性和有效性的 pan-AKT 和 AKT1-E17K 突变抑制剂，抑制 AKT1 、AKT2 和 AKT3 。 Vevorisertib trihydrochloride 可用于研究肝癌和晚期实体瘤。
T6252	Ipatasertib GDC-0068,RG7440,帕他色替	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Ipatasertib (GDC-0068) 是选择性的，ATP 竞争性的pan-Akt 抑制剂，能够抑制Akt1 (IC50:5 nM)，Akt2 (IC50:18 nM)，Akt3 (IC50:8 nM)。
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	ERK; Akt; PKA; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	A-674563 2HCl(552325-73-2(fb-2hcl)) 是一种 Akt1 抑制剂，Ki 为 11 nM，对 PKA 有效，对 Akt1 的选择性比 PKC 高 30 倍以上。
T2482	AT13148	ROCK; SGK; Akt; PKA; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AT13148 是一种 ATP 竞争性 AGC 激酶口服抑制剂，能够抑制 Akt1/Akt2/Akt3、p70S6K、PKA 和 ROCKI/ROCKII 的活性，IC50值分别为 38/402/50、8、3 和 6 nM/4 nM。
T4444	A-674563 HCl (552325-73-2(free base))	ERK; Akt; PKA; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	A-674563 HCl (552325-73-2(free base)) 是一种口服的、ATP 竞争性的、可逆的 Akt 抑制剂（Akt1 的 Ki：11 nM）。它对 PKA 和 Cdk2 具有抑制活性（IC50：16/46 nM），但对 Akt1 的选择性比 CMGC、CAMK 和 TK 家族中的其他激酶高 10 至 >1800 倍。
T15374	Ipatasertib dihydrochloride GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt; PKA	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂，抑制Akt1，Akt2，Akt3，IC50分别为 5，18，8 nM。
T7885	Afuresertib hydrochloride	ROCK; Akt; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Afuresertib hydrochloride 是一个口服有效的，ATP 竞争性的选择性泛Akt 抑制剂，作用于Akt1、Akt2和Akt3，Ki 值分别为 0.08、2和 2.6 nM。
T11928	M2698 MSC2363318A	Akt; mTOR	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	M2698 (MSC2363318A) 是 p70S6K、Akt1 和 Akt3 的抑制剂，IC50 为 1 nM。 M2698 显示出抗癌活性。
T1952	MK-2206 dihydrochloride MK-2206 2HCl	Apoptosis; Akt; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MK-2206 dihydrochloride (MK-2206 2HCl) 是一种变构 Akt 抑制剂，抑制 Akt1、Akt2 和 Akt3 (IC50=8/12/65 nM)，具有口服活性的、高效选择性。MK-2206 dihydrochloride 具有抗肿瘤活性。
T6304	AT7867	Akt; PKA; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AT7867 是 ATP 竞争性的Akt1/Akt2/Akt3和p70S6K/PKA 抑制剂，IC50分别为 32、17、47 和 85、20 nM。
T25017	AKT-I-1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-I-1 是一种特异性和可逆的 Akt1 抑制剂。
T23695	Akt-I-1,2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt-I-1,2 是 Akt1 和 Akt2 的选择性抑制剂。
T7315	BAY1125976	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	BAY1125976 是选择性Akt1/Akt2变构抑制剂。在10 μM ATP 时，它抑制 Akt1 和 Akt2 活性的IC50值分别为 5.2 nM 和 18 nM。
T6285	GSK-690693 GSK690693	Serine Protease; Akt; PKC; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	GSK-690693 是一种泛 Akt 抑制剂，对 Akt1、Akt2和 Akt3的 IC50分别为 2 nM、13 nM 和9 nM。它也是一种 AMPK 的抑制剂，影响 ULK1 的活性，并能显著抑制 STING 依赖的 IRF3 的激活。
T14072	A-443654	ERK; VEGFR; GSK-3; FLT; Casein Kinase; MAPK; Akt; PKA; Chk; CDK; Src; PKC; S6 Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	A-443654 是 pan-Akt 抑制剂，对Akt1，Akt2，和Akt3具有同等效力的抑制作用，Ki=均为 160 pM。
T1920	Capivasertib AZD5363	Akt; PKA; mTOR; Autophagy	Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Capivasertib (AZD5363) 是一种广谱的 AKT 抑制剂，对 Akt1、Akt2 和 Akt3 均有抑制活性 (IC50=3/7/7 nM)，具有口服活性。Capivasertib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T39733	Hu7691 free base	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 free base 是一种具有口服活性、高效性和选择性的 Akt 抑制剂，对多种神经母细胞瘤细胞系的抗增殖和神经发生作用。Hu7691 free base 抑制 Akt1、Akt2 和 Akt3 ，诱导神经母细胞瘤细胞分化。
T14860	CaMKII-IN-1	CaMK; Autophagy	Autophagy; Neuroscience
	CaMKII-IN-1是高效的 CaMKII 选择性抑制剂，IC50为63nM，对 CaMKIV, MLCK, p38a, Akt1,和 PKC 这些靶点几乎无作用。
T14034	3CAI	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	3CAI 是特异性的AKT1和AKT2抑制剂。
T9545	Compound 1T-0219 (SC)	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Compound 1T-0219 (SC) 是一种 AKT1-FAK 相互作用的阻断剂，可减少对人 SW620 结肠癌细胞中细胞外压力的 FAK 磷酸化的刺激，而不影响基础 FAK 磷酸化。
T9544	Compound 1T-0216	Others	Others
	Compound 1T-0216 是AKT1-FAK 相互作用的阻滞剂，在不影响基础FAK 磷酸化的情况下，减少对人类SW620结肠癌细胞细胞外压力的FAK 磷酸化的刺激。
T1911	Afuresertib GSK2110183C,GSK2110183	ROCK; Akt; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Afuresertib (GSK2110183) 是一个选择性，ATP 竞争性，口服有效的泛 Akt 抑制剂，作用于 Akt1、Akt2和 Akt3，Ki 值分别为 0.08、2、2.6 nM。
T6849	Uprosertib GSK2141795,GSK795,优普色替	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Uprosertib (GSK2141795) 是一种有效的，选择性的 Akt 广谱抑制剂，对 Akt1/Akt2/Akt3 的 IC50值分别为 180/328/38 nM。
T6419	BMS-536924 HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117	Apoptosis; FAK; MEK; IGF-1R; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	BMS-536924 (BMS 536924) 是一种具有口服活性，竞争性和选择性的胰岛素样生长因子受体激酶和胰岛素受体抑制剂，IC50分别为 100 nM 和 73 nM。它具有抗癌活性。
T15056	DB07107	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).
T10274	AKT-IN-2	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T11664	INY-03-041	Others	Others
	INY-03-041, a potent and highly selective PROTAC-based pan-AKT degrader, inhibits AKT1, AKT2, and AKT3 with IC50s of 2.0 nM, 6.8 nM, and 3.5 nM, respectively. This compound consists of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide.
T61680	AKT-IN-5
	AKT-IN-5 (Example 8) is a chemical compound known as an Akt inhibitor, specifically targeting Akt1 and Akt2. Its potency is reflected in IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1].
T15428	Uprosertib hydrochloride GSK2141795 (hydrochloride)	Others	Others
	Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).
T74983	MS15
	MS15 是一种有效且选择性的AKTPROTAC 降解剂。 MS15 可抑制 AKT1、-2 和 -3 活性，IC50值分别为 798 nM、90 nM 和 544 nM。
T62842	AKT-IN-8
	AKT-IN-8 是一种 AKT 的有效抑制剂，能够作用于 AKT1 (IC50: 4.46 nM)、AKT2 (IC50: 2.44 nM) 和 AKT3 (IC50: 9.47 nM)。
T25791	Merck-22-6 Merck 22 6,Merck226
	Merck-22-6 is an allosteric dual inhibitor of Akt1, Akt2.
T10275	AKT-IN-3	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1
T39930	MS98
	MS98 is a highly effective and specific PROTAC AKT degrader compound that effectively targets and depletes total AKT (T-AKT) within cells, exhibiting a DC 50 value of 78 nM. This compound readily binds to AKT1, AKT2, and AKT3 with respective dissociation constants (Kd s) of 4 nM, 140 nM, and 8.1 nM.
T39899	Hu7691	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 是一种具有口服活性、选择性和高效性的 Akt 抑制剂，抑制 Akt1、Akt2 和 Akt3，抑制神经母细胞瘤细胞增殖，诱导神经母细胞瘤细胞的分化。
T28203	NSC156529 NSC-156529,NSC 156529
	NSC156529 downregulates AKT1 signaling. NSC156529 efficiently decreases the proliferation of human cancer cells in vitro, and substantially inhibits the growth of prostate tumor xenografts in vivo.
T39928	MS170
	MS170 is a highly effective and specific PROTAC AKT degrader compound that exhibits potent activity. It efficiently reduces the levels of total AKT (T-AKT) within cells, with a DC 50 value of 32 nM. Furthermore, MS170 demonstrates strong binding affinity towards AKT isoforms, specifically AKT1, AKT2, and AKT3, with respective dissociation constants (Kd) of 1.3 nM, 77 nM, and 6.5 nM.
T22247	Miransertib (ARQ 092) HCl
	Miransertib hydrochloride (ARQ-092 hydrochloride) is a powerful, orally bioavailable, selective, and allosteric inhibitor of Akt. It exhibits an inhibitory concentration (IC50) of 2.7 nM, 14 nM, and 8.1 nM against Akt1, Akt2, and Akt3, respectively. In addition to its Akt inhibitory activity, Miransertib hydrochloride also demonstrates significant potency as an inhibitor of the AKT1-E17K mutant protein. This compound shows promise in research related to PI3K/AKT-driven tumors and Proteus syndrom...
T25394	ETB067 ETB-067,ETB 067
	ETB067, an H-89 analog, acts as a PKA and AKT1 inhibitor with specificity on no longer inhibiting CAMK2B and neither affecting viability of mice nor causing any detectable tissue damage at the dose given.
T39958	(32-Carbonyl)-RMC-5552
	(32-Carbonyl)-RMC-5552 is a highly effective mTOR inhibitor, exhibiting inhibitory effects on both mTORC1 and mTORC2 substrate phosphorylation. Specifically, it significantly suppresses the phosphorylation of p-P70S6K-(T389), p-4E-BP1-(T37/36), and p-AKT1/2/3-(S473) with pIC50 values > 9, >9 and 8~9, respectively.
T74001	INY-03-041 trihydrochloride
	INY-03-041 trihydrochloride 是一种有效的、高选择性的、基于PROTAC 的泛-AKT 降解剂，由ATP 竞争性AKT 抑制剂Ipatasertib 结合Lenalidomide 组成。INY-03-041 trihydrochloride 可抑制AKT1，AKT2和AKT3，IC50分别为 2.0 nM，6.8 nM 和 3.5 nM。
T63039	AKT-IN-13
	AKT-IN-13 (compound 4b) 是一种 Akt 的有效抑制剂，能够作用于 Akt1 (IC50: 1.6 nM)、Akt2 (IC50: 2.4 nM) 和 Akt3 (IC50: 0.3 nM) 。AKT-IN-13 能够用于研究抗癌。

化合物

Akt1 and Akt2-IN-1

Cat.No: T14152

Target: Akt

Cat.No: T73255

Akt1&PKA-IN-1

Cat.No: T72885

Tubulin/AKT1-IN-1

Cat.No: T79214

Target: Akt

Cat.No: T3467

Synonym: ARQ-092,AKT inhibitor 2

Target: Akt, Parasite

Akt1&PKA-IN-2

Cat.No: T72886

Cat.No: T6139

Synonym: A674563

Target: ERK, GSK-3, Akt, PKA, CDK

AKT inhibitor VIII

Cat.No: T3346

Synonym: AKTi-1/2

Target: Apoptosis, Akt

Vevorisertib trihydrochloride

Cat.No: T38846

Synonym: ARQ 751 trihydrochloride

Target: Akt

Cat.No: T6252

Synonym: GDC-0068,RG7440,帕他色替

Target: Akt

A-674563 2HCl(552325-73-2(fb-2hcl))

Cat.No: T6139L

Target: ERK, Akt, PKA, CDK, PKC

Cat.No: T2482

Target: ROCK, SGK, Akt, PKA, S6 Kinase

A-674563 HCl (552325-73-2(free base))

Cat.No: T4444

Target: ERK, Akt, PKA, CDK, PKC

Ipatasertib dihydrochloride

Cat.No: T15374

Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Target: Akt, PKA

Afuresertib hydrochloride

Cat.No: T7885

Target: ROCK, Akt, PKC

Cat.No: T11928

Synonym: MSC2363318A

Target: Akt, mTOR

MK-2206 dihydrochloride

Cat.No: T1952

Synonym: MK-2206 2HCl

Target: Apoptosis, Akt, Autophagy

Cat.No: T6304

Target: Akt, PKA, S6 Kinase

Cat.No: T25017

Target: Akt

Cat.No: T23695

Target: Akt

Cat.No: T7315

Target: Akt

Cat.No: T6285

Synonym: GSK690693

Target: Serine Protease, Akt, PKC, AMPK, Autophagy

Cat.No: T14072

Target: ERK, VEGFR, GSK-3, FLT, Casein Kinase, MAPK, Akt, PKA, Chk, CDK, Src, PKC, S6 Kinase

Cat.No: T1920

Synonym: AZD5363

Target: Akt, PKA, mTOR, Autophagy

Hu7691 free base

Cat.No: T39733

Target: Akt

Cat.No: T14860

Target: CaMK, Autophagy

Cat.No: T14034

Target: Akt

Compound 1T-0219 (SC)

Cat.No: T9545

Target: FAK

Compound 1T-0216

Cat.No: T9544

Target: Others

Cat.No: T1911

Synonym: GSK2110183C,GSK2110183

Target: ROCK, Akt, PKC

Cat.No: T6849

Synonym: GSK2141795,GSK795,优普色替

Target: Akt

Cat.No: T6419

Synonym: HY-10262,胰岛素样生长因子-1 受体拮抗剂,BMS 536924,CS-0117

Target: Apoptosis, FAK, MEK, IGF-1R, Src

Cat.No: T15056

Target: Akt

Cat.No: T10274

Target: Akt

Cat.No: T11664

Target: Others

Cat.No: T61680

Uprosertib hydrochloride

Cat.No: T15428

Synonym: GSK2141795 (hydrochloride)

Target: Others

Cat.No: T74983

Cat.No: T62842

Cat.No: T25791

Synonym: Merck 22 6,Merck226

Cat.No: T10275

Target: Akt

Cat.No: T39930

Cat.No: T39899

Target: Akt

Cat.No: T28203

Synonym: NSC-156529,NSC 156529

Cat.No: T39928

Miransertib (ARQ 092) HCl

Cat.No: T22247

Cat.No: T25394

Synonym: ETB-067,ETB 067

(32-Carbonyl)-RMC-5552

Cat.No: T39958

INY-03-041 trihydrochloride

Cat.No: T74001

Cat.No: T63039

Cat. No.	Product Name	Target	Signaling Pathways
T2790	Oridonin NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A	Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Oridonin (NSC-250682) 是从Rabdosia rubescens 中得到的二萜，是一种AKT 抑制剂，对 AKT1 和 AKT2 的IC50值分别为 8.4 和 8.9 μM，具有抗菌、抗炎、抗肿瘤等功效。
T40562	24-Methylenecycloartanyl ferulate
	24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.

天然产物

Cat.No: T2790

Synonym: NSC-250682,Rubescenin,冬凌草甲素,Isodonol,Rubescensin A

Target: Akt, Antibacterial

24-Methylenecycloartanyl ferulate

Cat.No: T40562

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼