Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 19,400 | 10-14周 | ||
50 mg | ¥ 25,800 | 10-14周 | ||
100 mg | ¥ 33,500 | 10-14周 |
Uprosertib hydrochloride 的其他形式现货产品:
产品描述 | Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively). |
靶点活性 | CDK7:2100 nM, Akt3:38 nM, ROCK1:1570 nM, ROCK2:1850 nM, Akt2:328 nM, Akt1:180 nM |
体外活性 | Protein targets that bind Uprosertib in the lysate display a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug display no reduction in binding. Uprosertib inhibits Akt1/2/3 (Kd: 16/49/5 nM, respectively) and it also potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts[1]. |
别名 | GSK2141795 (hydrochloride) |
分子量 | 465.71 |
分子式 | C18H17Cl3F2N4O2 |
CAS No. | 1047635-80-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Uprosertib hydrochloride 1047635-80-2 Others GSK 2141795 GSK-2141795 Uprosertib Hydrochloride GSK2141795 GSK2141795 (hydrochloride) Inhibitor inhibitor inhibit