31
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1237 |
Azathioprine
硫唑嘌呤,BW 57-322 |
Apoptosis; GPR; Rho | Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein |
Azathioprine (BW 57-322) 是一种免疫抑制剂。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T5000 |
Diflucortolone valerate
Afusona,戊酸双氟可龙,Diflucortolone 21-valerate |
Others; Antibacterial; Antifungal | Microbiology/Virology; Others |
Diflucortolone valerate (Diflucortolone 21-valerate) 是一种强效皮质类固醇,可研究各种皮肤疾病。 | |||
T4966 |
Ufenamate
氟芬那酸丁酯,Flufenamic acid butyl ester,Butyl flufenamate,氟灭酸丁酯 |
Others | Others |
Ufenamate (Flufenamic acid butyl ester) 是一种基于邻氨基苯甲酸的抗炎药。它可用于皮肤疾病研究。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T32114 |
Hydrocortisone aceponate
Suniderma,Efficort,Hydrocortisone 17-propionate 21-acetate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) 是一种有效的外用糖皮质激素,以乳膏的形式用于治疗各种皮肤病。 | |||
T4502 |
BISMUTH SUBGALLATE
次没食子酸铋,Dermatol Puder,Bismuth Gallate |
Others | Others |
Bismuth subgallate (Dermatol Puder) 是一种止血剂,可作用于凝血因子 XII ,促使凝血级联的激活,改善纤维蛋白凝块的早期形成。 | |||
T27710 |
K6PC-5
K6PC5,K6PC 5 |
S1P Receptor | GPCR/G Protein |
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes. | |||
T15095 |
Dehydroemetine
|
Others; Parasite | Microbiology/Virology; Others |
Dehydroemetine 是一种有效的抗原虫剂,是二盐酸艾美汀的合成类似物,可用于预防和治疗阿米巴感染和疾病,具有治疗伴有皮肤损伤的利什曼原虫感染和耐甲硝唑阿米巴病的作用。 | |||
T38683 |
SCD1 inhibitor-3
SCD1-IN-3,SCD1 inhibitor-3,SCD1 inhibitor 17a |
Dehydrogenase | Metabolism |
SCD1 inhibitor-3 (ML-270) 是一种高效、口服的化合物,可以抑制SCD1,且安全性极高。 SCD1 inhibitor-3 显示出在代谢疾病(包括肥胖、二型糖尿病和血脂异常,以及痤疮和癌症等各种皮肤病)方面的巨大研究潜力。 | |||
T77677 |
12R-LOX-IN-2
|
Lipoxygenase | Metabolism |
12R-LOX-IN-2 是一种 12R-脂氧合酶 (12R-LOX) 的抑制剂。12R-LOX-IN-2 抑制咪喹莫特 (IMQ) 诱导银屑病角质形成细胞过度增殖,并抑制细胞集落形成。12R-LOX-IN-2 还降低 IMQ 诱导细胞中 Ki67 的蛋白水平和 IL-17A 的 mRNA 表达。12R-LOX-IN-2 可用于牛皮癣和其他皮肤相关炎症性疾病的研究。 | |||
T21194 |
Orazamide
Aicorat dihydrate,Aica orotate dihydrate,Orazamide dihydrate,Aicamin dihydrate |
||
Orazamide may be useful to treat chronic hepatitis and various skin diseases. | |||
T32981 |
Lutenurine
Alkaloid complex of nuphar luteum,Liutenurin |
||
Lutenurine is an alkaloid from yellow water lily; in treatment of skin and mucosal diseases. | |||
T32113 |
Hydrocortamate Hydrochloride
UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort |
||
Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases. | |||
T34385 |
Ronacaleret HCl
SB 751689,SB 751689A,SB-751689A,SB-751689,SB751689A,SB751689 |
CaSR | GPCR/G Protein |
Ronacaleret HCl (SB-751689) 是一种小分子 CaSR 拮抗剂,可用于治疗内分泌与代谢疾病、皮肤和肌肉骨骼疾病。 | |||
T21074 |
Dexamethasone acetate
Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron |
||
Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics | |||
T13578 |
Betamethasone-17-butyrate-21-propionate
|
Others | Others |
Betamethasone-17-butyrate-21-propionate is a topical corticosteroid and may be used in the treatment of inflammatory skin diseases. | |||
T63658 |
JAK-IN-18
|
||
JAK-IN-18 是 JAK 的有效抑制剂,能够用于研究多种疾病,尤其是眼部、皮肤和呼吸系统疾病。 | |||
T73250 |
JAK-IN-17
|
||
JAK-IN-17 是一种有效的JAK 抑制剂。JAK-IN-17 可用于多种疾病的研究,尤其是眼部、皮肤和呼吸系统疾病[1]。 | |||
T60238 |
Acloproxalap
|
||
Acloproxalap 是一种基于喹啉的醛清除剂,可用于研究有毒醛积累的疾病,如眼部、皮肤等炎症性疾病,肺炎等呼吸系统疾病,器官疾病以及病毒感染相关性综合症等。 | |||
T71561 | LEO-29102 | ||
LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly formulations giving efficient drug delivery to the skin. LEO-29102 has reached phase 2 and demonstrated clinically relevant efficacy in the treatment of atopic dermatitis. | |||
T78207 |
Lepzacitinib
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Lepzacitinib为Janus激酶抑制剂,特异性针对JAK1/3,具备显著的抗炎效能,适用于治疗特应性皮炎及其他皮肤疾病。 | |||
T60981 | TRPC4/5-IN-1 | ||
TRPC4/5-IN-1 可用于研究皮肤炎性疾病和蛋白尿肾病。它是 TRP 通道 5/4 (TRPC5/4) 的有效抑制剂,IC50值分别为 0.54 μM 和2.06 μM。 | |||
T78208 |
Leramistat
HMC-C-01-A,MBS2320 |
Mitochondrial Metabolism | Metabolism |
Leramistat (HMC-C-01-A; MBS2320)为线粒体复合物1抑制剂,关与调控细胞代谢及免疫代谢。该化合物被用于抑制诸如特应性皮炎的皮肤病、自身免疫性与炎症性疾病和癌症,以及破骨细胞介导的疾病。 | |||
T71089 |
PF-00956980
|
||
PF-00956980 是一种可逆的 pan-JAK 抑制剂,作用于 JAK1、JAK2 和JAK3的IC50值分别是 2.2、23.1 和 59.9 μM,可用于肺部和皮肤炎症性疾病研究。 | |||
T69930 |
LEO 134310
|
||
LEO 134310 是一种选择性非甾体糖皮质激素受体 (GR) 激动剂,优化用于局部治疗。LEO 134310 在 GR 结合试验中显示出高亲和力(EC50为 14 nM)。LEO 134310 可用于皮肤病。 | |||
T77032 | Imsidolimab | ||
Imsidolimab (ANB 019) 是一种高亲和力、人源化的抗IL-36R 单克隆抗体。Imsidolimab 拮抗IL-36细胞因子信号传导。Imsidolimab 在泛发性脓疱型银屑病 (GPP) 和其他炎症性皮肤病中有潜在应用。 | |||
T62956 | RORγt inverse agonist 29 | ||
RORγt inverse agonist 29 是一种有效的、选择性的、口服具有活力的 RORγt 反向激动剂,其 IC50 值为 21 nM。RORγt inverse agonist 29 能够用于皮肤炎症和银屑病等自身免疫性疾病的研究。 | |||
T70642 |
Lanopepden camsylate
|
||
Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea... | |||
T76241 |
Trichomide A
|
||
Trichomide A 是一种有效的 SHP2激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A 具有研究免疫相关皮肤病的潜力。 | |||
T60438 |
PXS-6302
|
||
PXS-6302 是不可逆的赖氨酸氧化酶 (LOX) 抑制剂,对Bovine LOX、rh LOXL1、rh LOXL2、rh LOXL3、rh LOXL4的IC50分别为 3.7 μM,3.4 μM,0.4 μM,1.5 μM 和0.3 μM。PXS-6302 可以轻松渗透皮肤,减少胶原蛋白沉积和交联,显着改善疤痕外观而不降低组织强度。 PXS-6302 在其他纤维化疾病中也可能有更广泛的应用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4558 |
Trioxsalen
三甲沙林,Trimethylpsoralen,Trioxysalen,Trisoralen |
DNA Alkylator/Crosslinker; DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Trioxsalen (Trioxysalen) 是一种呋喃香豆素和补骨脂素衍生物,与 UV-A 一起用于光疗治疗白癜风和手部湿疹。它是一种光化学 DNA 交联剂,可用于激光激活定位的基因组链间交联可视化。 | |||
TN6464 |
Hemiphloin
半皮桉苷 |
Others | Others |
Hemiphloin 是一种天然黄酮化合物,研究表明它具有抗炎活性,是炎症性皮肤疾病的候选治疗药物。 | |||
T5S0993 |
Kurarinone
苦参酮,苦参黄素 |
BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells |
Kurarinone 是从灌木苦参中提取的黄酮类化合物,具有抗肿瘤、雌激素和抗炎活性,对免疫反应也有很强的抑制作用。 | |||
TQ0131 |
Rocaglamide
Rocaglamide A,楝酰胺,Roc-A |
HSP; NF-κB; PERK | Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB |
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T81099 | Staphyloferrin A | ||
Staphyloferrin A,一种铁载体蛋白,与抗生素结合对抗抗药性细菌性皮肤病进行研究。 | |||
T80680 |
γ-Isofagarine
Iso-γ-fagarine |
||
Isofagarine (Iso-γ-fagarine) 为一生物碱,源自Dictamnus angustifolius根皮。该化合物参与风湿、出血、瘙痒、黄疸、慢性肝炎和皮肤病等病态研究。 | |||
TN4213 |
Hirsutenone
|
ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-... |