67
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2553 |
Etofenamate
|
COX | Immunology/Inflammation; Neuroscience |
Etofenamate 是非甾体类抗炎小分子,也是非选择性的 COX 抑制剂,具有抗风湿和解热抗炎作用,可用于缓解疼痛、关节炎等炎症相关疾病的研究。 | |||
T16124 |
MMP13-IN-3
|
MMP | Proteases/Proteasome |
MMP13-IN-3 是口服有效的MMP-13选择性抑制剂,IC50为 1 nM,比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。 | |||
T1748 |
Kartogenin
KGN |
TGF-beta/Smad | Stem Cells |
Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A,破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用,并通过调节 CBFβ-RUNX1 转录程序,诱导软骨形成,可用于研究骨关节炎。 | |||
T0291 |
Flurbiprofen
氟比洛芬,dl-Flurbiprofen |
Apoptosis; COX; MRP | Apoptosis; Immunology/Inflammation; Neuroscience |
Flurbiprofen (dl-Flurbiprofen) 是一种高效的,具有口服活性的非甾体抗炎化合物,有退热止痛活性, 常用于炎症性疾病的研究。它是一种非选择性的环氧合酶抑制剂,可研究结肠癌。 | |||
T1421 |
Aceclofenac
醋氯芬酸,Preservex,Airtal |
COX | Immunology/Inflammation; Neuroscience |
Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药,可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。 | |||
T9977 |
SGK1-IN-4
|
SGK | Metabolism |
SGK1-IN-4 是 SGK1 的特异性抑制剂,可用于骨关节炎研究。 | |||
T9711 |
OGT-IN-2
|
Others | Others |
OGT-IN-2 是 OGT 抑制剂,抑制 sOGT 和 ncOGT 的 IC50分别为 30 μM 和 53 μM。它在关节疾病方面有研究的价值,如关节软骨疾病、骨关节炎。 | |||
T4561 |
Tiaprofenic acid
Tiaprofensaeure,噻洛芬酸,Acido tiaprofenico,Surgam |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
Tiaprofenic acid (Acido tiaprofenico) 是可口服的非甾体抗炎药,通过抑制环氧化酶抑制前列腺素合成,可用于风湿性疾病的研究。 | |||
T6574 |
Lumiracoxib
Prexige,罗美昔布,COX-189 |
COX | Immunology/Inflammation; Neuroscience |
Lumiracoxib (Prexige) 是强选择性有口服活性的 COX-2抑制剂,Ki 值为 0.06 μM。它是非选择性非甾体抗炎试剂,具有抗炎和解热活性,可用于骨关节炎和骨癌研究。 | |||
T4552 |
Fursultiamine
Diteftin,呋喃硫胺,Judolor,Alinamin F |
Others | Others |
Fursultiamine (Alinamin F) 是维生素 B1衍生物,具有抗伤害和抗肿瘤作用。它可用于研究维生素 B1缺乏病、骨关节炎和癌症。 | |||
T0859 |
Fenbufen
芬布芬,CL-82204,Lederfen |
ATPase; Caspase; COX | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome |
Fenbufen (Lederfen) 是一种非甾体抗炎药,主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折,具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性,其 IC50分别为 3.9 μM 和 8.1 μM。 | |||
T1780 |
Parecoxib
SC 69124,帕瑞昔布,Vorth-P,Valus-P |
COX | Immunology/Inflammation; Neuroscience |
Parecoxib (SC 69124) 是一种有效的选择性 COX-2 抑制剂,是 Valdecoxib 的前药。 | |||
T5099 |
Gefapixant
RO 4926219,AF219,MK-7264 |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
Gefapixant (AF219) 是一个 P2X3 受体拮抗剂,其对人同源重组 hP2X3 和 hP2X2/3 的 IC50值分别是约 30 和 100-250 nM。 | |||
T28394 |
PG-116800
PG-530742,PGE-7113313,PGE 7113313,PG 530742 |
MMP | Proteases/Proteasome |
PG-116800 (PG-530742) 是一种基质金属蛋白酶 (MMP) 抑制剂。 PG-116800 可用于骨关节炎治疗的研究。 | |||
T14283 |
amyloid P-IN-1
|
Beta Amyloid | Neuroscience |
amyloid P-IN-1 可用于研究血清淀粉样蛋白 P 成分耗尽的疾病,例如阿尔茨海默病、淀粉样变性、骨关节炎和 2 型糖尿病。 | |||
T1109 |
(Z)-Capsaicin
Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素 |
TRP/TRPV Channel; HSV | Membrane transporter/Ion channel; Microbiology/Virology |
(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体,用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂,可研究神经性疼痛。 | |||
T77502 |
Wnt pathway inhibitor 3
|
Wnt/beta-catenin; Adenylyl cyclase | Cytoskeletal Signaling; Neuroscience; Stem Cells |
Wnt pathway inhibitor 3 是一种有效的 AC1 抑制剂,IC50 值为 45 nM。Wnt pathway inhibitor 3 具有抗增殖活性,可用于研究改善实验性骨关节炎小鼠模型中的骨关节炎。 | |||
T15358 |
Funapide
TV 45070,XEN402 |
Sodium Channel | Membrane transporter/Ion channel |
Funapide (TV 45070) 是一个有效的钠通 Nav1.7 抑制剂,据有潜在的抗炎活性,可用来治疗红斑性肢痛症、肌肉骨骼疼痛、膝关节炎以及疱疹后神经。 | |||
T1586 |
Tenoxicam
Ro-12-0068,替诺昔康,Tenoxicamum,Mobiflex,Tilcotil |
COX | Immunology/Inflammation; Neuroscience |
Tenoxicam (Tilcotil) 是一种抗炎化合物,具有退热止痛作用。 | |||
T67805 |
Oxepinac
|
||
oxepinac 是一种治疗疼痛性骨关节炎的有效且耐受性良好的化合物。oxepinac 在动物实验中对小鼠和家兔胎儿无致畸作用。 | |||
T27312 |
Fentiazac
Donorest,Flogene,BR-700 |
Others | Others |
Fentiazac(BR-700) 是一种口服活性的非甾体烷酸衍生物,具有显著的镇痛、抗炎和解热活性。Fentiazac 可用于研究类风湿关节炎、骨关节炎、牙周炎和肌腱炎等炎症性疾病。 | |||
T35859 |
Aldumastat
GLPG1972,S201086,G504572 |
Others | Others |
Aldumastat(GLPG1972)是一种具有高效性、特异性和口服活性的 ADAMTS-5抑制剂。Aldumastat 可用于研究膝骨关节炎。 | |||
T6568 |
Licofelone
利克飞龙,ML-3000 |
Apoptosis; Lipoxygenase; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Licofelone (ML-3000) 是一种 COX/LOX 双重抑制剂,IC50分别为 0.21和0.18 μM,有潜力研究骨关节炎,具有抗炎和抗增殖作用。它可诱导细胞凋亡,减少促炎性白三烯和前列腺素的产生。 | |||
T77092 |
Nadecnemab
REGN-5069 |
Others | Others |
Nadecnemab 是一种靶向胶质细胞源性神经营养因子家族受体 GFRA3 的 IgG4κ 抗体。Nadecnemab 可用于膝骨关节炎和神经系统疾病。 | |||
T29663 |
ADL-5747
ADL-5747 (free base),ADL5747,ADL-5747 free base |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
ADL-5747 (ADL-5747 (free base)) (free base)是一种δ opioid 受体激动剂,可用于治疗神经系统疾病、皮肤和肌肉骨骼疾病,可用于研究疱疹后神经痛、膝关节炎和疼痛。 | |||
T0219 |
Valdecoxib
伐地考昔,代他考昔,SC 65872 |
COX | Immunology/Inflammation; Neuroscience |
Valdecoxib (SC 65872) 是可口服的高选择性 COX-2抑制剂,对 COX-2 和 COX-1 的 IC50值分别为 5 nM 和 140 μM,可用于治疗骨关节炎、类风湿性关节炎以及痛经和经期症状。 | |||
T14978 |
CL-82198
|
MMP | Proteases/Proteasome |
CL-82198 是 MMP-13选择性抑制剂。它能够与 MMP-13 的整个 S1' 口袋结合,这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。它可用于研究骨关节炎。 | |||
T78169 |
Enpp-1-IN-16
|
PDE | Metabolism |
Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂,具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。 | |||
T1641 |
Strontium ranelate
Distrontium renelate,S12911,雷尼酸锶 |
Calcium Channel; CaSR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Strontium ranelate (S12911) 是抗骨质疏松的药物,能够抑制骨吸收,促进骨形成,进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR),进而促进肌醇 1,4,5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。 | |||
T7724 |
Tepoxalin
RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485 |
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
Tepoxalin (RWJ 20485) 是有效的5-脂氧合酶和环氧合酶抑制剂,表现出强大的抗炎活性和较小的胃肠道刺激性。 | |||
T8785 |
HALOFUGINONE LACTATE
|
DNA/RNA Synthesis; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Stem Cells |
HALOFUGINONE LACTATE 是 febrifugine 的卤化衍生物,它是一种天然的含有喹唑啉酮的化合物,存在于中草药 D. febrifuga 中。Halofuginone 以 ATP 依赖性方式抑制脯氨酰-tRNA 合成酶,Ki 为 18.3 nM。 Halofuginone 是 I 型胶原合成的特异性抑制剂,通过抑制 TGF-β 活性来减轻骨关节炎 (OA) | |||
T27233 |
Enflicoxib
E 6087,E6087,E-6087 |
||
E-6087 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain. | |||
T68444 |
Dircin
|
||
Dircin is an anti-inflammatory agent, prescribed for osteoarthritis and chronic inflammatory arthritis. It works by inhibiting interleukin-1. | |||
T17027 |
Tedalinab
GRC-10693 |
Cannabinoid Receptor | GPCR/G Protein |
Tedalinab is an effective and selective cannabinoid receptor 2 agonist. Tedalinab has the potential for neuropathic pain and osteoarthritis treatment. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. | |||
T38595 |
EP4 receptor antagonist 3
EP4 receptor antagonist 3 |
||
EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor. It is intended for research purposes in studying EP4 receptor-mediated diseases such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, and cancer. | |||
T28032 |
MF266-1
MF 266-1,MF-266-1 |
||
MF266-1, a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of osteoarthritis and rheumatoid. | |||
T30939 |
Cindunistat HCl maleate
PHA 728669F,SD 6010,PHA-728669F,SD6010 PF-00572986,SD-6010,PHA728669F |
||
Cindunistat( PHA-728669F, PF-00572986, PHA-84250, SD-6010, and SC-084250) is a potent and oral selective iNOS inhibitor which is expected to be used in patients with symptomatic osteoarthritis of the knee. | |||
T29084 |
V116517
V-116517,V 116517 |
||
V-116517, a TRPV1 antagonist, is used potentially for the treatment of severe pain due to osteoarthritis and chronic pain due postherpetic neuralgia (PHN). | |||
T16291 | NF157 | COX | Immunology/Inflammation; Neuroscience |
NF157 significantly decreases the expression of metalloproteinase (MMP)-3, MMP-13, which can be used in the treatment of osteoarthritis (OA). NF157 is a highly selective nanomolar P2Y11 antagonist (pKi: 7.35). The IC50s are 463 nM, 1811 µM, 170 µM for P2Y | |||
T26531 |
ABT-963
ABT963 |
||
ABT-963 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain. ABT-963 has excellent selectivity in human whole blood, high oral anti-inflammatory potency in vivo, and gastric safety in the animal studies. | |||
T16504 |
PF-4693627
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA). | |||
T39000 |
Zaloglanstat
GRC-27864,ISC-27864 |
||
Zaloglanstat (ISC-27864) is a potent inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). It is utilized in the research of various conditions, including asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain, and neurodegenerative diseases. | |||
T16570 |
Pralnacasan
VX-740,HMR 3480 |
Others | Others |
Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a | |||
T14352 |
Autotaxin-IN-1
|
PDE | Metabolism |
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1]. | |||
T39047 |
DDR2-IN-1
DDR2-IN-1 |
||
DDR2-IN-1 (Compound 129) is recognized as a highly effective DDR2 inhibitor, displaying an IC50 value of 26 nM. It is a suitable choice for conducting osteoarthritis research. | |||
T80025 |
Bovine Type II Collagen
Collagen, Type II, Immunization Grade |
||
Type II collagen 是一种治疗骨关节炎的有效蛋白质。在减缓小鼠胶原性关节炎疼痛和炎症方面,Type II collagen 显示了显著的效果。 | |||
T76077 |
MMP-13 Substrate
|
||
MMP-13Substrate 是MMP-13的底物。MMP-13Substrate 可用于骨关节炎 (OA) 的研究。 | |||
T0184L |
Fenoprofen
Nalgesic,Fenoprofen Calcium,Nalfon |
||
Fenoprofen is a non-steroidal anti-inflammatory drug used to relieve symptoms of rheumatoid arthritis, osteoarthritis, and mild to moderate pain. It can block the enzyme that produces prostaglandin (cyclooxygenase), resulting in a decrease in the concentr | |||
T72868 | ADAMTS-5-IN-2 | ||
ADAMTS-5-IN-2 是一种有效的ADAMTS-5抑制剂,IC50值为 0.71 µM。ADAMTS-5-IN-2 具有改善骨关节炎的研究潜力。 | |||
T26563 |
Adavivint HCl (1467093-03-3 free base)
SM-04690,Adavivint HCl,Adavivint,SM04690,SM 04690 |
||
Adavivint, also known as SM04690, is a small-molecule inhibitor of the Wnt pathway which is being investigated as a potential disease modifying agent for the treatment of osteoarthritis of the knee |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5689 |
20-DEOXYINGENOL
|
Others; Autophagy | Autophagy; Others |
20-Deoxyingenol 是从甘遂的根中分离出的一种二萜类天然产物。它可通过促进体外转录因子 EB 的核易位来促进自噬和溶酶体生物发生,可研究骨关节炎。 | |||
T3803 |
Specnuezhenide
特女贞苷,Nuzhenide,Nuezhenide |
Others; NF-κB; Wnt/beta-catenin | Cytoskeletal Signaling; NF-κB; Others; Stem Cells |
Specnuezhenide (Nuezhenide) 是分离自女贞子的果实中。它可抑制 NF-κB 和 wnt/β-catenin 信号传导,进而抑制 IL-1β 诱导的软骨细胞炎症。它可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。 | |||
T5029 |
Oxaceprol
奥沙西罗,N-Acetyl-L-hydroxyproline,N-乙酰-L-4-羟基脯氨酸 |
Others | Others |
Oxaceprol (N-Acetyl-L-hydroxyproline) 是一种可口服的、具有显著抗炎作用的 L-脯氨酸衍生物,常用于研究骨关节炎和类风湿性关节炎。 | |||
T6S0117 |
Avicularin
Fenicularin,扁蓄苷 |
ERK | MAPK |
Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中,它通过抑制 ERK 信号通路产生抗炎活性。 | |||
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T7475 |
S-Adenosyl-L-methionine
AdoMet,Ademetionine,SAMe,S-Adenosyl methionine,S-腺苷-L-蛋氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
S-Adenosyl-L-methionine (Ademetionine) 是一种具有有效的抗抑郁和减轻疼痛作用的膳食补充剂,是通过蛋氨酸腺苷转移酶的作用由蛋氨酸和 ATP 内源性生产的,是一种重要的口服具有活力的甲基供体,能够用于肝病和骨关节炎的研究。 | |||
T2941 |
Glucosamine hydrochloride
Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride |
Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy | Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB |
Glucosamine hydrochloride (Chitosamine hydrochloride) 是软骨基质和滑液中糖胺聚糖的天然成分,常用作骨关节炎的治疗方法。它也是一种氨基糖,是糖基化蛋白和脂质生化合成的突出前体,用作膳食补充剂。 | |||
T4S2157 |
Campesterol
菜油甾醇,(24R)-5-Ergosten-3β-ol |
Endogenous Metabolite | Metabolism |
Campesterol ((24R)-5-Ergosten-3β-ol) 是一种植物甾醇,具有降胆固醇和抗癌的活性。 | |||
T1273 |
Diacerein
双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein |
IL Receptor; Interleukin | Immunology/Inflammation |
Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。 | |||
T4447 |
S-(5'-Adenosyl)-L-methionine tosylate
S-腺苷蛋氨酸对甲苯磺酸盐,SAMe,S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt |
Others | Others |
S-(5'-Adenosyl)-L-methionine tosylate (SAMe) 是一种普遍存在的甲基供体,参与多种生物反应,包括由 DNA 和蛋白质甲基转移酶介导的反应。它可改善抑郁、与骨关节炎和纤维肌痛相关的疼痛以及肝毒性。 | |||
T3388 |
Calycosin-7-O-β-D-glucoside
毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside |
MMP; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome |
Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮,从黄芪中分离得到。它具有多种生物活性,包括心脏保护、神经保护、抗炎和抗氧化作用。 | |||
T30048 |
Anemonin (6CI)
Pulsatilla camphor,Anemonin,Anemone camphor |
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Anemonin is a furanone dimer found in the Buttercup (Ranunculaceae) family. Anemonin has been shown to regulate tyrosinase-related proteins and mRNA in human melanocytes and may be useful in attenuting osteoarthritis progression. | |||
T12576 |
Pterosin B
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Others | Others |
Pterosin B is an salt-inducible kinase 3 (Sik3) signaling inhibitor. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis by inhibiting Sik3. | |||
T4116 |
S-Adenosyl-DL-Methionine
Ademetionine,S-腺苷蛋氨酸,S-ADENOSYL-L-METHIONINE |
Others | Others |
S-Adenosyl-DL-Methionine (Ademetionine) 是一种 Ademetionine 的衍生物。其中Ademetionine 是蛋氨酸的中间代谢产物。 | |||
T78468 |
Yohimbic acid hydrate
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Yohimbic acid hydrate,一种Yohimbine的两性脱甲基衍生物,具有血管舒张效果,且在骨关节炎(OA)研究中展现出潜在应用价值。 |