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33

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5827	BI-6C9	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂，可阻止线粒体外膜电位和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T14912	CD3254	Retinoid Receptor	Metabolism
	CD3254 是一种具有选择性和强效性的类视黄醇 X 受体 (RXR) 激动剂，可抑制伴有OGD/再氧合的神经元细胞死亡。
T1880	P7C3	Others	Others
	P7C3 是一种 aminopropyl carbazole 类化合物，具有口服活性，可透过血脑屏障，具有神经保护作用。它可用于神经退行性疾病，如帕金森病的研究。
T126461	Aloenin B
	Aloenin B 是一种从芦荟的叶和根中分离得到的化合物,对谷氨酸诱导的HT22细胞神经元死亡具有神经保护活性。
TP2054L	Calcineurin Autoinhibitory Peptide acetate	Phosphatase	Metabolism
	Calcineurin Autoinhibitory Peptide acetate 是一种选择性的钙调磷酸酶抑制剂 (IC50 ~ 10 μM)。它可用于保护神经元免受兴奋性神经元死亡。
T27947L	LY339434 HCl LY339434 HCl(219566-62-8 Free base)	GluR; NMDAR	Neuroscience
	LY339434 HCl是一种亲和力很低的GluR5红氨酸受体激动剂。LY339434 HCl 主要通过影响 N-甲基-D-天冬氨酸（NMDA）受体来快速的神经元死亡。
T12160	N6-Cyclohexyladenosine CHA,A1受体促进剂	Adenosine Receptor	GPCR/G Protein; Neuroscience
	N6-Cyclohexyladenosine (CHA) 是一种选择性腺苷 A1 受体激动剂，EC50 为 8.2 nM。
T3714	SUN11602 SUN 11602	ERK; FGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	SUN11602 是新型的碱性苯胺化合物，具有成纤维细胞生长因子特性。
T36851L	Peptide5 acetate	Others	Others
	Peptide5 acetate 可减少脊髓损伤后的动物肿胀、星形胶质细胞增生和神经元细胞死亡。 Peptide5 acetate 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。
T13536	Afoxolaner	Chloride channel; GABA Receptor; Parasite	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Afoxolaner 是一种异恶唑啉杀虫剂/杀螨剂，可对抗犬的肩胛硬蜱。它作用于昆虫的 γ-氨基丁酸(GABA)受体谷氨酸受体，抑制 GABA 和谷氨酸调节的氯离子吸收，导致过度的神经元刺激和节肢动物死亡。
T21509	CA 074	Cysteine Protease	Proteases/Proteasome
	CA 074 是一种高效的组织蛋白酶B (cathepsin B) 抑制剂， Ki 值为2 to 5 nM。CA 074 抑制灵长类动物缺血性海马神经元死亡，可减轻 SJL/J 小鼠诱导的实验性自身免疫性脑脊髓炎的视网膜病变和视神经炎。
T72662	NMDAR/TRPM4-IN-2	ERK; TRP/TRPV Channel; NMDAR; iGluR	MAPK; Membrane transporter/Ion channel; Neuroscience
	NMDAR/TRPM4-IN-2 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。NMDAR/TRPM4-IN-2 具有神经保护活性，可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍，其 IC50 值为 2.1 μM。
T60671	MAO-B-IN-9	Beta Amyloid; Serotonin Transporter; Monoamine Oxidase	Neuroscience
	MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂（IC50：0.18μM），具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用，可以防止Aβ1-42诱导的神经元细胞死亡，这可能与Aβ1-42的抗聚集作用有关。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T15671	KU-32	HSP	Cytoskeletal Signaling; Metabolism
	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
T25148	beta-Neuroprotectin Ala-asp-leu-ile-ala-tyr-leu-NH2
	beta-Neuroprotectin is a (3H)TCP binding inhibitor and provides protection against NMDA mediated neuronal cell death at low concentration.
T14187	ALLM Calpain inhibitor II	Others	Others
	ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].
TP1524	AGA-(C8R) HNG17, Humanin derivative
	This peptide is a potent humanin (HN) derivative. It completely suppresses neuronal cell death by Alzheimer's disease-relevant insults.
T24158	ICL-SIRT078 ICLSIRT078,ICL SIRT 078,ICL SIRT078,ICL-SIRT-078
	ICL-SIRT078 is a highly selective inhibitor of substrate-competitive SIRT2 that acts by displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell line.
T28766	SGE-516 SGE516
	SGE516 is a neuroactive steroid and a positive allosteric modulator of both gamma- and delta-containing GABAA receptors. SGE516 reduces neuronal firing rates and epileptiform activity in vitro. SGE-516 protects against acute seizures and reduces neuronal
T36851	Peptide5
	Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain. O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID:18649176 \|Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats....
TP2078	AC 253
	Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks el
T36328	Termitomycamide B
	Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid i...
T14187L	ALLM acetate（110115-07-6 Free base)
	ALLM acetate（110115-07-6 Free base) 是一种有效的钙蛋白酶和组织蛋白酶抑制剂，不仅可以防止神经元细胞死亡，还可以增强脊髓损伤（SCI）后的慢性神经功能。
T80118	α-Synuclein (61-95) (human)
	α-Synuclein(61-95) (human) 是 α-Synuclein 的疏水核心区段，具有诱导神经元死亡的能力。该肽段在神经退行性疾病的研究中有应用，涉及阿尔茨海默病 (AD) 与帕金森病 (PD)。
T78061	Peptide5 TFA	Gap Junction Protein	Cytoskeletal Signaling
	Peptide5 TFA，一种connexin 43模拟肽，能够降低动物脊髓损伤后的肿胀、抑制星形胶质细胞增生和神经元死亡。该化合物还可抑制NLRP3炎症小体，具有抗炎作用。
T71855	Z640
	Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from amyloid‑β (Aβ) oligomer‑induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose‑dependent manner and shift amyloid precursor protein processing towards the non‑amyloid pathway
T75864	Calcineurin autoinhibitory peptide TFA
	Calcineurin autoinhibitory peptide TFA 为选择性Ca2+/钙调蛋白依赖性蛋白磷酸酶（钙调神经磷酸酶）抑制剂，IC50约为10 μM。该化合物能够保护神经元不受兴奋性神经元死亡影响。
T76221	Leptin (116-130)
	Leptin(116-130)是一种生物活性的瘦素片段，能促进AMPA受体运输至突触并加强活动依赖性的海马突触可塑性。此外，Leptin(116-130)在抗淀粉样蛋白毒性模型中有效阻止海马突触损伤和神经元细胞死亡，显示出对研究阿尔茨海默病(AD)具有重要潜力。
T73930	(-)-Eseroline fumarate
	(-)-Eseroline fumarate 是一种 AChE 抑制剂 Physostigmine 的代谢产物。(-)-Eseroline fumarate 引起癌细胞的乳酸脱氢酶 (LDH) 泄漏。(-)-Eseroline fumarate 还诱导神经元细胞释放腺嘌呤核苷酸和5-羟色胺 (5-HT)，从而诱导细胞死亡。(-)-Eseroline fumarate 抑制小鼠输精管和豚鼠回肠的电诱发抽搐。
T68743	AZD4877 HCl
	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T75916	Dynorphin A TFA
	Dynorphin A TFA, 作为一种内源性阿片肽，主要在中枢神经系统（CNS）中发挥抑制性神经传导的作用。该化合物不仅是kappa阿片受体（KOR）的高效激动剂，还能激活其他阿片受体，包括mu（MOR）和delta（DOR）。Dynorphin A TFA具有诱导神经元死亡的能力，因此在神经系统疾病的研究中具有应用价值。
T35687	Collismycin A
	Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc...

化合物

Cat.No: T5827

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T14912

Target: Retinoid Receptor

Cat.No: T1880

Target: Others

Cat.No: T126461

Calcineurin Autoinhibitory Peptide acetate

Cat.No: TP2054L

Target: Phosphatase

Cat.No: T27947L

Synonym: LY339434 HCl(219566-62-8 Free base)

Target: GluR, NMDAR

N6-Cyclohexyladenosine

Cat.No: T12160

Synonym: CHA,A1受体促进剂

Target: Adenosine Receptor

Cat.No: T3714

Synonym: SUN 11602

Target: ERK, FGFR

Peptide5 acetate

Cat.No: T36851L

Target: Others

Cat.No: T13536

Target: Chloride channel, GABA Receptor, Parasite

Cat.No: T21509

Target: Cysteine Protease

NMDAR/TRPM4-IN-2

Cat.No: T72662

Target: ERK, TRP/TRPV Channel, NMDAR, iGluR

Cat.No: T60671

Target: Beta Amyloid, Serotonin Transporter, Monoamine Oxidase

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cat.No: T15671

Target: HSP

beta-Neuroprotectin

Cat.No: T25148

Synonym: Ala-asp-leu-ile-ala-tyr-leu-NH2

Cat.No: T14187

Synonym: Calpain inhibitor II

Target: Others

AGA-(C8R) HNG17, Humanin derivative

Cat.No: TP1524

Cat.No: T24158

Synonym: ICLSIRT078,ICL SIRT 078,ICL SIRT078,ICL-SIRT-078

Cat.No: T28766

Synonym: SGE516

Cat.No: T36851

Cat.No: TP2078

Termitomycamide B

Cat.No: T36328

ALLM acetate（110115-07-6 Free base)

Cat.No: T14187L

α-Synuclein (61-95) (human)

Cat.No: T80118

Cat.No: T78061

Target: Gap Junction Protein

Cat.No: T71855

Calcineurin autoinhibitory peptide TFA

Cat.No: T75864

Leptin (116-130)

Cat.No: T76221

(-)-Eseroline fumarate

Cat.No: T73930

Cat.No: T68743

Dynorphin A TFA

Cat.No: T75916

Cat.No: T35687

Cat. No.	Product Name	Target	Signaling Pathways
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
TN1038	Galgravin	Apoptosis	Apoptosis
	Galgravin 是望春花中的一种天然产物，具有抗炎和体外细胞毒活性，能诱导白血病细胞凋亡。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
T26288	Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa	Apoptosis; Influenza Virus; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Clovamide (trans-Clovamide) 是一种天然存在的咖啡酰结合物，具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。
TN1831	Macranthoside A Kalopanaxsaponin H	Antioxidant	oxidation-reduction
	Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷，属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性，抑制促炎细胞因子的产生和抑制炎症信号通路的激活，有助于中和有害的自由基，保护细胞免受氧化损伤，可以促进神经元的存活和生长，并防止氧化应激或神经毒性化合物引起的神经元细胞死亡，具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
TN4435	Licopyranocoumarin	P450; ROS; JNK	Immunology/Inflammation; MAPK; Metabolism
	Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.
TN1653	Fustin	ERK; Beta Amyloid; AChR	MAPK; Neuroscience
	Fustin 是植物漆树 (Rhus verniciflua Stokes) 的植物性黄烷醇成分。 Fustin 对 6-羟基多巴胺诱导的神经元细胞死亡具有保护作用。
TN2149	Reynosin	BCL; Others; TNF	Apoptosis; Others
	Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regulation of α±-synuclein protein expr
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

Cat.No: TN1038

Target: Apoptosis

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

Cat.No: T26288

Synonym: trans-Clovamide,N-trans-Caffeoy-L-dopa

Target: Apoptosis, Influenza Virus, ROS, Antibacterial

Macranthoside A

Cat.No: TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Licopyranocoumarin

Cat.No: TN4435

Target: P450, ROS, JNK

Cat.No: TN1653

Target: ERK, Beta Amyloid, AChR

Cat.No: TN2149

Target: BCL, Others, TNF

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

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