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18
Cat. No. | Product Name | Target | Signaling Pathways |
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T12579 |
RAMB4
PTP1B-IN-9 |
Proteasome | Proteases/Proteasome; Ubiquitination |
RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源,是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。 | |||
T20029 |
Buformin hydrochloride
NSC528218,NSC-528218,盐酸丁双胍,NSC 528218 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂,是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收,增加胰岛素敏感性和葡萄糖对细胞的吸收,并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性,可用于各种癌症研究。 | |||
T23867 |
Cdc7-IN-7c
Cdc7 inhibitor-7c,Cdc7 inhibitor 7c,Cdc7 IN 7c |
CDK | Cell Cycle/Checkpoint |
Cdc7-IN-7c (Cdc7 inhibitor-7c) 具有抗肿瘤活性,对肝癌,肺癌,肾癌,脑癌,宫颈癌有抑制作用。 | |||
T27612 |
INI-43
INI 43,INI43 |
Others | Others |
INI-43 是Nuclear Import-43 的抑制剂,通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用,并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。 | |||
T20742 |
TG-89
|
FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG-89是 JAK2、JAK3、RET 和 FLT3的抑制剂,对 JAK2的 IC50值为11.2 μM,在卵巢癌和宫颈癌的治疗中显示出抗癌活性。 | |||
T23888 |
CID-5056270
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
CID-5056270具有抗癌活性,对肺癌肛门癌、膀胱癌、宫颈癌、外阴癌、阴茎癌、伯基特淋巴瘤乳腺癌和骨癌具有抑制作用,可用来研究高血压、老年痴呆症度、阿尔茨海默病和动脉硬化。 | |||
T9939 |
JMJD6 inhibitor WL12
2H-1-Benzopyran-2-one, 3-(3H-imidazo[4,5-c]pyridin-2-yl)-6-methyl-,ZINC6733033 |
Others | Others |
JMJD6 inhibitor WL12 (ZINC6733033) 是一种JMJD6 抑制剂,能够抑制JMJD6依赖的癌细胞增殖,包括宫颈癌细胞和肝癌细胞,为研究JMJD6在癌症发展中的生物学功能提供了一个小分子探针。 | |||
T17228 |
Sabizabulin
ABI-231,VERU-111 |
Microtubule Associated | Cytoskeletal Signaling |
Sabizabulin (ABI-231) 是一种有效且具有口服生物利用度的 α 和 β 微管蛋白抑制剂,可对抗黑色素瘤和前列腺癌细胞系。 Sabizabulin 通过靶向 HPV E6 和 E7 抑制宫颈癌细胞的肿瘤生长和转移表型。 Sabizabulin 显示出抗增殖活性,可用于前列腺癌研究。 | |||
T60485 |
DIF-3
|
||
DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. This compound exerts a potent antiproliferative effect on the HeLa human cervical cancer cell line by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression [1]. | |||
T16773 |
Ro 90-7501
RO-90-7501 |
Apoptosis; Phosphatase; ATM/ATR; Gamma-secretase | Apoptosis; DNA Damage/DNA Repair; Metabolism; Neuroscience; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维和 TPR 依赖性 PP5 抑制剂,是一种新型宫颈癌细胞放射增敏剂,可抑制 ATM 磷酸化 ,促进细胞凋亡,诱导细胞周期停滞。Ro 90-7501 具有抗病毒活性和潜在的抗癌活性,抑制 ATM 磷酸化和 DNA 修复,抑制HCMV。 | |||
T77423 |
Lirilumab
ONO-4483,IPH2102 |
Virus Protease | Microbiology/Virology |
Lirilumab (IPH2102) 是一种针对杀伤性免疫球蛋白样受体抗体 KIR2D 的抗体,具有抗肿瘤活性,通过 Vav1 依赖性 NF-κB 去抑制增强自然杀伤细胞的抗 HPV+ 宫颈癌活性,可用于研究白血病、头颈部鳞状细胞癌 (SCCHN)。 | |||
T34508 |
Sanazole
AK2123,AK-2123,AK 2123 |
||
Sanazole is a 3-nitrotriazole cpd. It can affect the human cervical cancer cell line. | |||
T70594 |
Gliotoxin monoacetate
|
||
Gliotoxin monoacetate is a toxin found in Aspergillus. It induces apoptosis in cervical cancer cells and chondrosarcoma cells, suppresses the adaptive immune response in leukocytes, and inhibits the proteasome in Plasmodium falciparum. | |||
T76716 | Cadonilimab | ||
Cadonilimab (AK104) 为一种IgG1支架Fc工程化的人源化抗体,针对PD1/CTLA4。适用于转移性宫颈癌研究。 | |||
T60544 |
HPV18-IN-1
|
||
HPV18-IN-1 (Compound H1) 是有效的HPV18抑制剂,可防止宫颈癌细胞的过早和异常细胞增殖。它可抑制 E7-Rb-E2F 细胞通路和 DNA 甲基化, 具有癌症研究的潜力。 | |||
T76709 | Zimberelimab | ||
Zimberelimab 是一种全人源IgG4抗PD-1单克隆抗体,具有很高的亲和力和选择性。 Zimberelimab 具有抗肿瘤活性,可用于各种癌症研究,包括宫颈癌、非小细胞肺癌和霍奇金淋巴瘤。 | |||
T81732 |
Myosin light chain kinase fragment 11-19 amide
MLCK(11-19) amide |
||
Myosinlight chain kinase fragment 11-19 amide (MLCK(11-19) amide) 为MLCK专一性多肽抑制剂,具抑制低渗透压刺激下Ca2+入细胞的能力,并可应用于人类宫颈癌研究。 | |||
T60421 |
Antitumor agent-68
|
||
Antitumor agent-68 是一种有效的微管蛋白抑制剂,具有良好的抗肿瘤活性,对宫颈癌细胞系 HeLa 和乳腺癌细胞系 MCF-7 细胞的IC50值分别为 3.6 和 3.8 μM。Antitumor agent-68 以剂量依赖的方式表现出良好的 ROS 和DPPH 自由基的清除活性。 | |||
T76997 | Socazolimab | ||
Socazolimab (ZKAB001) 是一种针对PD-L1的单克隆抗体,在治疗复发或转移性宫颈癌方面展现了持久的安全性和有效性。此外,Socazolimab 也被认为在小细胞肺癌、食管鳞状细胞癌 (ESCC)、晚期尿路上皮癌及骨肉瘤治疗中具有潜在应用价值。 | |||
T36195 |
CAY10744
|
||
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074... | |||
T36404 |
PRLX-93936
|
||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM... | |||
T26366L |
Prasterone sulfate sodium hydrate
Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate |
||
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me | |||
T83741 |
S7 TFA
Leu-Ser-Leu-Iso-Thr-Arg-Leu-OH |
||
S7是一种IL-6受体的肽类拮抗剂,能够浓度依赖性地抑制IL-6与IL-6受体的结合。在C-33 A宫颈癌细胞和RPMI-8226 B细胞淋巴细胞中,S7 (50 µM) 能抑制IL-6诱导的VEGF水平增加。在每两天给药一次,剂量为50 mg/kg的条件下,S7能减少IL-6过表达的C-33 A宫颈癌小鼠异种移植模型中的肿瘤体积。当S7与半胱氨酸结合,并连接到包裹多柔比星的脂质纳米粒子(LNPs)表面时,能增强LNPs对胶质瘤的靶向性,并在U251胶质母细胞瘤小鼠异种移植模型中提高生存率。 | |||
T68667 |
Oxanosine
|
||
Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al... | |||
T71279 |
BPR1K653
|
||
BPR1K653 is a potent Aurora kinase inhibitor with potential anticancder activity. BPR1K653 specifically inhibited the activity of Aurora-A and Aurora-B kinase at low nano-molar concentrations in vitro. BPR1K653 was potent in targeting a variety of cancer cell lines regardless of the tissue origin, p53 status, or expression of MDR1. At the cellular level, BPR1K653 induced endo-replication and subsequent apoptosis in both MDR1-negative and MDR1-positive cancer cells. Importantly, it showed potent ... | |||
T68249 |
IRC-083927 HCl
|
||
IRC-083927 HCl is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two h... | |||
T60933 |
B-Raf IN 7
|
||
B-Raf IN 7 (compound 6a) 是 B-Raf 的有效抑制剂,IC50值为 110.23 nM。B-Raf IN 7 对结肠癌细胞(HCT-116)、乳腺癌细胞 (MCF-7)、肝癌细胞 (HEPG-2)、人宫颈癌细胞 (Hela) 和人前列腺癌细胞 (PC-3) 具有抗肿瘤活性。其 IC50值分别为 7.50、9.87、10.57、11.63 和 12.83 μM。 | |||
T35687 |
Collismycin A
|
||
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs = 6.25 and 100 μg/ml) and fungi (MICs = 12.5-100 μg/ml). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s = 0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50 = 56.6 μM) but not MDA-MD-231 breast canc... | |||
T83854 |
BRC4wt TFA
|
||
BRC4wt是一种从人类BRCA2的BRC4重复区(1521-1536)衍生而来的乙酰化肽,并且是BRCA2与RAD51之间的蛋白质-蛋白质相互作用的抑制剂。当与阳离子穿膜肽(Arg)9结合时,BRC4wt缩短了体外DNA复制轨迹长度,并降低了由DNA拓扑异构酶I抑制剂坎普特西汀引起的DNA损伤的同源修复频率,同时也增强了聚(ADP-核糖)聚合酶(PARP)抑制剂奥拉帕尼在HeLa人类宫颈癌细胞和U2OS人类骨肉瘤细胞中诱导的细胞死亡,但在非癌症细胞hTERT RPE-1、MRC-5或MCF-10A中则不然。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1133 |
Ganoderic acid D
灵芝酸D,灵芝酸 D |
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Ganoderic acid D 是高度氧化的四环三萜,是灵芝的主要活性成分,可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程,包括结肠癌细胞中的葡萄糖摄取,乳酸、丙酮酸和乙酰辅酶的产生。 | |||
TN6730 |
Epoxyazadiradione
|
NF-κB | NF-κB |
Epoxyazadiradione 是从印楝果实中得到的柠檬苦素。它能够可逆的、非竞争性的抑制人类、约氏疟原虫、疟原虫的互变异构酶活性。它具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。 | |||
T4036 |
Solasodine
Solancarpidine,Purapuridine,澳洲茄铵,Solasodin |
Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal | Apoptosis; Microbiology/Virology; Others; Ubiquitination |
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。 | |||
TN1393 |
(-)-Anonaine
番荔枝碱 |
Apoptosis; Antioxidant; Parasite; Antifungal | Apoptosis; Microbiology/Virology; oxidation-reduction |
(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来,具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌(HeLa)细胞的凋亡,诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。 | |||
T0122 |
Bergenin
Cuscutin,Bengenin,岩白菜素 |
Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal | Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚,有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。 | |||
T3425 |
Polyphyllin G
重楼皂苷VII,Polyphyllin VII,Polyphyllin VII,Y-0166,重楼皂苷G |
Others | Others |
Polyphyllin G (Polyphyllin VII) 是从Paris yunnanensis 的根茎中分离出来的,具有抗菌活性,抑制革兰氏阳性和革兰氏阴性细菌的生长。它是polyphyllin 家族的主要成员,对肺癌、乳腺癌、结直肠癌、宫颈癌、肝细胞癌和骨肉瘤等多种癌症具有很强的抗癌活性。 | |||
TN4109 |
Ganolucidic acid A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Ganolucidic acid A exhibits cytotoxicity, has inhibitory activities against human HeLa cervical cancer cell lines. It shows significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM. | |||
TN6010 |
Picrasidine S
|
||
Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus | |||
T69368 |
GKK1032B
|
||
GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | |||
TMA1008 |
Ganoderic acid S
|
Others | Others |
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca | |||
TN2328 |
Zeylenone
|
Apoptosis; ERK; MAPK; Akt; PI3K; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Zeylenone 是一种来自 Uvaria grandiflora的环己烯氧化物,具有抗肿瘤和抗癌细胞增殖活性,通过 PI3K/AKT/mTOR 和 MAPK/ERK 信号通路抑制宫颈癌细胞增殖,诱导细胞凋亡 (apoptosis)。 | |||
TN4194 |
Heliangin
|
IL Receptor; TNF; NF-κB; MAPK; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxicity against human oral epidermoid ( | |||
T35609 |
19-O-Acetylchaetoglobosin A
|
||
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
T75629 | Ganoderic acid Mk | ||
Ganoderic acid Mk (GA-Mk)为来源于灵芝菌丝的三萜酸类化合物,能有效抑制细胞增殖,并通过线粒体途径诱导HeLa细胞的细胞凋亡(apoptosis),在宫颈癌研究中具有应用价值。 | |||
TN3968 | Epifriedelanol acetate | Others | Others |
Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel | |||
T36448 |
(E)-Ajoene
|
||
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... | |||
T79941 |
Antimycin A2c
|
Apoptosis | Apoptosis |
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。 | |||
T36000 |
3-Hydroxyterphenyllin
|
||
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |