45
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2747 |
Endothall
|
Others | Others |
Endothall 是一种有效的蛋白磷酸酶 2A (PP2A) 抑制剂,对 PP2A 和 PP1 具有抑制作用, IC50 分别为 90 nM 和 5 µM。Endothall 具有抗癌活性,可用于癌症化疗,可用作除草剂。 | |||
T9271 |
RAD51-IN-1
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
RAD51-IN-1 是 B02 的衍生物,是一种RAD51的有效抑制剂,可研究癌症。 | |||
T1478 |
Ondansetron hydrochloride dihydrate
盐酸昂丹司琼,SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂,可治疗化疗后的恶心和呕吐,有抗焦虑和抗精神病作用。 | |||
T2047 |
AG-1478
AG1478,NSC 693255,Tyrphostin AG-1478 |
EGFR; HCV Protease; Influenza Virus; HER; PDGFR | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
AG-1478 (NSC-693255) 是一种选择性 EGFR 酪氨酸激酶抑制剂,IC50为 3 nM。它对 HCV 和脑心肌炎病毒有抗病毒作用。 | |||
T16871 |
Semustine
|
DNA Alkylator/Crosslinker | DNA Damage/DNA Repair |
Semustine 是一种 DNA 烷化剂,是一种癌症化疗化合物,在接受辅助化疗的恶性黑色素瘤患者中具有肾毒性,可用于辅助治疗白血病。 | |||
T28187 |
Nonabine
|
||
Nonabine 是一种具有强烈止吐作用的化合物,可用来预防与癌症化疗有关的恶心和呕吐。 | |||
T24184 |
Itasetron
DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Itasetron (U 98079A) 是一种5-羟色胺3受体拮抗剂,可用于预防大鼠与年龄有关的记忆缺陷。Itasetron 在癌症化疗和放疗动物模型中的止吐活性,可用于研究健忘症。 | |||
T1755 |
LY2090314
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
LY2090314 是GSK-3抑制剂,抑制 GSK-3α (IC50:1.5 nM) 和 GSK-3β (IC50:0.9 nM)。 | |||
T6616 |
Ondansetron hydrochloride
SN 307,盐酸昂丹司琼,帕罗西汀杂质A,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ondansetron hydrochloride (Zofran) 是5-HT3受体的拮抗剂,可用作化疗后止吐剂。 | |||
T1042 |
Granisetron hydrochloride
盐酸格拉司琼,BRL 43694A,Granisetron HCl |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Granisetron hydrochloride (Granisetron HCl) 是一种5-HT3受体拮抗剂,可作为化疗后止吐剂。 | |||
T28935 | TDRL-551 | Others | Others |
TDRL-551 是一种新型有效的复制蛋白A (RPA) 抑制剂 (IC50=18 µM),具有潜在的抗癌活性。TDRL-551 对 RPA-DNA 相互作用有抑制作用,提高以铂为基础的肺癌和卵巢癌化疗的疗效。 | |||
T21876 |
DC_AC50
|
Apoptosis; Others | Apoptosis; Others |
DC_AC50 是一种 Atox 和 CCS 的双抑制剂,是一种抑制细胞内铜伴侣作为减少/预防获得性化疗耐药性的手段。它与 Atox1 和 CCS 结合并减少癌细胞增殖和肿瘤生长。 | |||
T6127 |
Rucaparib Phosphate
AG-014699 phosphate,PF-01367338,芦卡帕利,AG-014699,瑞卡帕布磷酸盐,PF-01367338 phosphate |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Rucaparib Phosphate (PF-01367338 phosphate) 是一种口服有效的PARP 蛋白抑制剂,对 PARP-1 的Ki 为 1.4 nM。它是六磷酸己糖脱氢酶 (H6PD) 抑制剂,有用于去势抵抗性前列腺癌 (CRPC) 的研究潜力。 | |||
T76788 |
Demcizumab
OMP 21M18 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。 | |||
T4451 |
Estramustine phosphate sodium
Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物,是一种具有口服活性抗微管化疗剂,通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡,可研究前列腺癌。 | |||
T4684 |
ML241 hydrochloride
|
p97 | Ubiquitination |
ML241 hydrochloride 是一种有效且选择性的 p97 ATPase 抑制剂,IC50值为 100 nM。 | |||
T2283 |
PX-12
2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12 |
Thioredoxin | Metabolism |
PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂,能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
T39024 |
PrNMI
|
Cannabinoid Receptor | GPCR/G Protein |
PrNMI是一种针对外周限制性大麻素1受体(CB1R)的高效、口服活性激动剂。它展现出显著的镇痛特性,有效抑制化疗引起的周围神经病痛症状及癌症引起的骨痛。 | |||
T29486 |
7-Methotrexate
7-Mtx |
||
7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T29391 |
3'-Chloromethotrexate
NSC 29631,NSC29631,SKI 23338,NSC-29631,AI3-50533 |
||
3'-Chloromethotrexate is a chemotherapy agent and immune system suppressant. It can be used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T68274 |
QZ59S-SSS
|
||
QZ59S-SSS acts as a potential inhibitor of human P-glycoprotein and may be used to improve the efficacy of cancer chemotherapy. | |||
T26283 |
TNP-351
Tnp 351 |
||
Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer. | |||
T70114 |
Paclitaxel Ceribate
|
||
Paclitaxel Ceribate is a mitotic inhibitor used in cancer chemotherapy. | |||
T22340 |
Granisetron
Sustol,Granisetronum,格拉司琼,Sancuso,Kevatril |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy. | |||
T25929 |
Pemetrexed tromethamine
Pemetrexed ditromethamine dihydrate |
||
Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer. | |||
T31837 |
FOLFIRI Regimen
FOLFIRI |
||
FOLFIRI Regimen is a chemotherapy regimen consisting of leucovorin calcium (calcium folinate), 5-fluorouracil, and irinotecan used during the treatment of advanced-stage and metastatic colorectal cancer. | |||
T71123 |
RG 12915
|
||
RG 12915 is a potent, selective 5-HT3 receptor antagonist developed for the treatment of emesis and nausea associated with cancer chemotherapy. | |||
T33326 |
Methotrexate-alpha glutamate
Meapa-glu-glu |
||
Methotrexate-alpha glutamate is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T10015 |
1-Deazaadenosine
|
Others | Others |
1-Deazaadenosine is a potent Adenosine deaminase inhibitor (Ki: 0.66 μM). It exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders. | |||
T71998 |
673-A
|
||
673-A is an aldehyde dehydrogenase (ALDH1A) inhibitor that depletes CD133+ cancer stem cells (CSC) in ovarian cancer cell lines. 673-A triggers necroptosis in ovarian CSCs and induces expression of mitochondrial uncoupling proteins (UCP). 673-A also overcomes chemotherapy resistance in vivo. | |||
T38692 |
Fabesetron
法贝司琼,FK1052 free base |
||
Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms. | |||
T68371 |
Rolapitant hydrochloride hydrate
|
||
Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of ... | |||
T25892 |
N-Trifluoroacetyladriamycin
NSC-283464,NSC 283464,AD 41,AD-41,NSC283464 |
||
N-Trifluoroacetyladriamycin is a metabolite of Valrubicin (N-trifluoroacetyladriamycin-14-valerate, trade name Valstar). Valrubicin is a chemotherapy drug utilized to treat bladder cancer. Valrubicin is the anthracycline doxorubicin analog and is administ | |||
T81361 |
PSMA-Val-Cit-PAB-MMAE
|
||
PSMA-Val-Cit-PAB-MMAE是一种靶向前列腺特异性膜抗原(PSMA)的小分子化合物,用MMAE作为药效基团进行前列腺癌治疗。 | |||
T35821 |
CAY10721
|
||
CAY10721 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (39% SIRT3 inhibition at 200 μM). Upregulation of SIRT3 transcription is associated with oral squamous cell carcinoma (OSCC) and breast cancer with lymph node involvement, while SIRT3 down-regulation inhibits the growth of OSCC cells and sensitizes them to radiation and chemotherapy. | |||
T22299 |
CPI-455 HCl
|
Histone Demethylase | Chromatin/Epigenetic |
CPI-455 is a specific KDM5 inhibitor with IC50 value of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with target | |||
T71177 |
LCRF-0004
|
||
LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. RON receptor tyrosine kinase is a potential as a therapeutic target. | |||
T61751 |
DNA-PK-IN-3
|
||
DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1]. | |||
T79146 |
MSU38225
|
||
MSU38225作为一种Nrf-2抑制剂,其作用机制包括提升活性氧(ROS)水平,能够有效抑制人肺癌细胞增殖,并提高其对化疗药物的敏感性,因此,在癌症研究中具有应用潜力。 | |||
T72991 | Bis-Pro-5FU | ||
Bis-Pro-5FU 是一种 5-FU 前体,可增强5-氟尿嘧啶 (5-FU) 的口服生物利用度并提高其疗效。5-FU 是一种抗肿瘤抗代谢物,广泛用于结直肠癌和胰腺癌的研究。 | |||
T36193 |
CAY10717
|
||
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth o... | |||
T36457 |
CAY10416
|
||
Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 ... | |||
T70928 |
CB-1158-analog
|
||
CB-1158-analog, also known as Numidargistat-analog and INCB01158-analog, is a potent and orally active arginase inhibitor with IC50=89 nM) . CB-1158 blocked myeloid cell-mediated suppression of T cell proliferation in vitro and reduced tumor growth in multiple mouse models of cancer, as a single agent and in combination with checkpoint blockade, adoptive T cell therapy, adoptive NK cell therapy, and the chemotherapy agent gemcitabine. CB-1158 increased tumor-infiltrating CD8+ T cells and NK cell... | |||
T36695 |
TAS-103
|
||
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2217 |
Cephalomannine
Baccatin III,三尖杉宁碱 |
Microtubule Associated | Cytoskeletal Signaling |
Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物,具有抗肿瘤活性,可用于癌症研究。 | |||
T0132 |
Etoposide
VP-16,依托泊苷,依托泊甙,VP-16-213 |
Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性,可以诱导细胞凋亡、自噬。 | |||
T6431 |
Levoleucovorin Calcium
左亚叶酸钙,Calcium Levofolinate,CL307782 |
Others; Antifolate | Cell Cycle/Checkpoint; Others |
Levoleucovorin Calcium (CL307782) 是一种亚叶酸的钙盐,在癌症化疗中用作辅助剂。 | |||
T3924 |
Astragaloside II
黄芪皂苷 II,Astrasieversianin VIII |
TGF-beta/Smad | Stem Cells |
Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。 | |||
T2S1120 |
Ganoderenic acid B
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Ganoderenic acid B 是一种从Ganoderma lucidum 中提取的天然产物,可以通过抑制ABCB1的转运功能,增强化疗药物对ABCB1介导的耐多药癌细胞的细胞毒性来发挥作用。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T37984 |
D-Fructose-1,6-bisphosphate sodium salt hydrate
|
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T3S0205 |
β-Hederin
Beta-Hederin,β-常春藤素 |
Parasite | Microbiology/Virology |
β-Hederin 是从 Hedera helix L.(Araliaceae) 分离得到的一种皂苷,具有抗利什曼虫活性。它对乳腺癌细胞有凋亡作用,有望成为乳腺癌化疗的候选药物。 |