Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ondansetron hydrochloride dihydrate (GR 38032) 是5- HT3受体拮抗剂,可治疗化疗后的恶心和呕吐,有抗焦虑和抗精神病作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 179 | 现货 | ||
10 mg | ¥ 248 | 现货 | ||
25 mg | ¥ 398 | 现货 | ||
50 mg | ¥ 578 | 现货 | ||
100 mg | ¥ 822 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 219 | 现货 |
产品描述 | Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties. |
靶点活性 | 5-HT3 receptor:810 nM |
体外活性 | Ondansetron is a potent, highly selective, competitive antagonist at 5-HT3 receptors. It demonstrates some affinity to other receptor subtypes, including 5-HT1B, 5-HT1C, 5-HT4, opioid, and 1-adrenergic receptors, and to the μ-opioid receptor. However, ondansetron has 1000:1 selectivity toward 5-HT3 receptors[1]. Ondansetron is found to be the most potent HERG-channel blocker among several 5-HT3 antagonists, with an IC50 of 810 nM and has been reported to block Na+ channels[2]. |
体内活性 | Ondansetron(Ond) is well tolerated and its side effects are mild. Ond acts on the CNS as well as on the peripheral nervous system (PNS). Ondansetron is available both for oral and intravenous administration. The bioavailability of orally administered ondansetron is only 60%. The low bioavailability is due to a significant first-pass metabolism. The peak plasma concentration of ondansetron is usually reached at approximately 1.5 h after oral administration. A major portion of this drug, about 75%, is bound to plasma proteins. Ondansetron is currently used to prevent and treat nausea and vomiting associated with chemotherapy, radiation treatment and general anesthesia. It has been shown to inhibit GABA and glycine receptor activity in animal models[1]. Therapeutic dose of Ond allows delivery of significantly higher amounts of Dox to the brain tissue in vivo, which is otherwise disallowed by the BBB. The rate of penetration of the blood-brain barrier by Ond is very low[3]. |
细胞实验 | Cells are plated in 60-mm Petri dishes (2×105 per dish) and cultured in serumcontained medium for 24 h. The next day the medium is removed and serum-contained medium with or without Dox (0.1 or 0.5 μg/ml) and Ond (10 or 30 μg/ml) in combination or respectively, is added. After 3 days, the cells are washed twice with PBS, trypsinized, and counted by using the trypan blue exclusion method.(Only for Reference) |
别名 | 盐酸昂丹司琼, SN 307, NSC 665799, GR 38032, Ondansetron hydrochloride |
分子量 | 365.86 |
分子式 | C18H19N3O·HCl·2H2O |
CAS No. | 103639-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 38 mg/mL (103.9 mM)
H2O: 67 mg/mL (183.1 mM)
DMSO: 68 mg/mL (185.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / H2O / DMSO | 1 mM | 2.7333 mL | 13.6664 mL | 27.3329 mL | 68.3321 mL |
5 mM | 0.5467 mL | 2.7333 mL | 5.4666 mL | 13.6664 mL | |
10 mM | 0.2733 mL | 1.3666 mL | 2.7333 mL | 6.8332 mL | |
20 mM | 0.1367 mL | 0.6833 mL | 1.3666 mL | 3.4166 mL | |
50 mM | 0.0547 mL | 0.2733 mL | 0.5467 mL | 1.3666 mL | |
100 mM | 0.0273 mL | 0.1367 mL | 0.2733 mL | 0.6833 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ondansetron hydrochloride dihydrate 103639-04-9 GPCR/G Protein Neuroscience 5-HT Receptor GR-38032 SN 307 hydrochloride dihydrate NSC-665799 NSC665799 SN307 Serotonin Receptor cancer surgery 盐酸昂丹司琼 SN 307 cancer chemotherapy vomiting NSC 665799 SN-307 radiation 5-hydroxytryptamine Receptor nausea Inhibitor GR38032 GR 38032 hydrochloride dihydrate Ondansetron hydrochloride Dihydrate inhibit GR 38032 Ondansetron Hydrochloride Ondansetron hydrochloride inhibitor