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125

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19723	AMTB hydrochloride AMTB	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMTB hydrochloride (AMTB HCl) 是TRPM8通道的选择性阻滞剂。它抑制 icilin 诱导的 TRPM8 通道激活，pIC50为 6.23。它在膀胱过度活动和膀胱疼痛综合征中有研究的价值。它是电压门控钠通道的非选择性抑制剂 (NaV)。
T0939	Phenytoin 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T15260	Evenamide NW-3509	Sodium Channel	Membrane transporter/Ion channel
	Evenamide (NW-3509) 是一种口服有效的电压门控钠通道 (sodium channel, VGSC) 阻滞剂，Ki 为 0.4 µM，在精神分裂症中有研究价值。Evenamide 在精神病，躁狂症，抑郁和攻击性的各种啮齿动物模型中具有显著功效。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T0008	Phenytoin sodium 5,5-Diphenylhydantoin sodium salt,Diphantoine,苯妥英钠,Dilantin sodium,Diphenylhydantoin Sodium	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin sodium (Diphantoine) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T11990	Meclofenamic acid 甲氯芬那酸,Meclofenamate	Others; Gap Junction Protein	Cytoskeletal Signaling; Others
	Meclofenamic acid (Meclofenamate) 是一种非特异性 gap-junction 阻滞剂和特异性脂肪量和肥胖相关 (FTO) 酶抑制剂。 Meclofenamic acid 具有抗炎活性。
T77712	Calcium Channel antagonist 3	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcium Channel antagonist 3 是一种电压门控钙通道抑制剂（IC50 : 5-20μM）。
T60010	BTT-266	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	BTT-266 是一种电压门控钙通道阻滞剂，用于疼痛管理。
T31716	Etidocaine Hydrochloride W-19053,Duranest,W19053,W 19053	Sodium Channel	Membrane transporter/Ion channel
	Etidocaine Hydrochloride (W19053) 是一种长效麻醉剂和电压门控钠通道阻滞剂。
T6571	Lomerizine dihydrochloride Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lomerizine dihydrochloride (KB-2796) 是双重 L 和 T 型电压门控钙通道拮抗剂。
T22675	Co 102862 V 102862	Others; Sodium Channel	Membrane transporter/Ion channel; Others
	Co 102862 是一种电压门控钠通道阻滞剂。 Co 102862 可用于抗惊厥的研究。
T9751	Transfluthrin	Others	Others
	Transfluthrin 是一种挥发性拟除虫菊酯类杀虫剂，针对昆虫电压门控钠通道 (VGSC)。
T2523	Rufinamide CGP 33101,E 2080,卢非酰胺,RUF 331	Sodium Channel	Membrane transporter/Ion channel
	Rufinamide (E 2080) 是一种新型镇痫化合物，可用于研究 Lennox-Gastaut 综合症。
T77711	Calcium Channel antagonist 4	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcium Channel antagonist 4 是一种电压门控钙通道抑制剂（IC50 : 5-20μM）。
T12424	PF-06305591 PF-6305591	Others	Others
	PF-06305591是一种有效的、选择性的电压门钠通道NaV1.8的阻断剂（IC50=15 nM）。
T23497	UK 78282 hydrochloride	Potassium Channel	Membrane transporter/Ion channel
	UK 78282 hydrochloride，一种新型有效且具有选择性的 Kv1.3 阻滞剂。UK 78282 hydrochloride 抑制 Kv1.3 电压门控钾通道，抑制人 T 细胞活化。
T7066	Fosphenytoin disodium Fosphenytoin sodium,ACC-9653,磷苯妥英钠	Sodium Channel	Membrane transporter/Ion channel
	Fosphenytoin disodium (ACC-9653) 是 phenytoin 的前体药物，具有抗惊厥等活性。它是电压门控钠通道阻滞剂。
T12181	NaV1.7 inhibitor-1	Sodium Channel	Membrane transporter/Ion channel
	NaV1.7 inhibitor-1 是有效的、选择性的电压门控钠通道 (Nav) 1.7 抑制剂，对于hNaV1.7的IC50为 0.6 nM，其选择性是 hNaV1.5 的 80 倍。
T6782L	Benzocaine xHCl(94-09-7(free base))	Sodium Channel	Membrane transporter/Ion channel
	Benzocaine xHCl(94-09-7(free base)) 与电压门控 Na+ 通道中的所有其他 rLA 共享一个共同受体（测试的 IC50 为 0.8 mM，电位为 +30 mV）。
T12786	RY785	Potassium Channel	Membrane transporter/Ion channel
	RY785 是电压门控钾 (KV2)通道的选择性抑制剂， KV2.2 的 IC50为 0.05 μM。它在缓解疼痛方面具有研究价值。
T0796	Prilocaine hydrochloride Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因	ATPase; Sodium Channel	Membrane transporter/Ion channel
	Prilocaine hydrochloride (Prilocaine HCl) 是一种氨基酰胺类局部麻醉剂，作用于神经元膜上的钠通道并限制癫痫发作的扩散。它是Na/K-ATPase 抑制剂，具有神经毒性作用。
T8639	Phenibut (hydrochloride) 3-Amino-4-phenylbutyric acid hydrochloride,3-氨基-4-苯基丁酸盐酸盐	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Phenibut hydrochloride (3-Amino-4-phenylbutyric acid hydrochloride) 是 GABA-B 激动剂，口服有活性，可作用于 GABAB 受体，充当 GABA 类似物。它具有促智 (增强认知) 及抗焦虑的能力。
T0018	Procainamide hydrochloride Procapan,Procainamide HCl,Pronestyl,Procanbid,盐酸普鲁卡因胺	DNA Methyltransferase; Sodium Channel; AChR; Autophagy	Autophagy; Chromatin/Epigenetic; Membrane transporter/Ion channel; Neuroscience
	Procainamide hydrochloride (Procapan) 是一种用于研究心律失常的抗心律失常制剂。
T0024	Primidone Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360	GABA Receptor; Sodium Channel; GluR; AChR	Membrane transporter/Ion channel; Neuroscience
	Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。
T68073	Flosatidil	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Flosatidil是一种小分子电压门控性钙通道复合体(VDCCs)阻滞剂，可用于治疗神经系统疾病和心血管疾病，可用于研究心绞痛。
T7502	PF 05089771 tosylate	Sodium Channel	Membrane transporter/Ion channel
	PF 05089771 tosylate 是口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF 05089771 tosylate 具有用于疼痛和糖尿病神经性疾病的研究。
T22361	Mepivacaine Carbocaine	Sodium Channel	Membrane transporter/Ion channel
	Mepivacaine (Carbocaine) 是一种可用于局部麻醉的酰胺类化合物，可使人或动物短暂的失去自知觉。Mepivacaine 通过与神经细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化来发挥作用。Mepivacaine 适用于神经阻滞和硬膜外麻醉。
T77642	1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride 对 L 氨基酸转运蛋白和电压门控钙通道 α2δ 亚基具有抑制作用。1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride 可作为生物模块，用于合成有活性的生化试剂。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T50030	1-(2,4-difluorophenyl)guanidine hydrochloride	Others	Others
	1-(2,4-difluorophenyl)guanidine hydrochloride 是一种化合物，是电压门控钠通道Nav1.7的强效选择性抑制剂，Nav1.7是疼痛信号传输的关键参与者，因此它能够减少疼痛信号的传递，从而产生镇痛作用。
T4612	NS309	EGFR; Potassium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂，在 BK 通道上没有激活作用。
T1046	Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律	AhR; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂，是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流，从而降低心脏动作电位（0相）上升速率，并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T4996	Atosiban 阿托西班,RWJ22164,RW22164	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T0267	Zonisamide AD 810,唑尼沙胺,CI 912	Calcium Channel; Sodium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性，在癫痫、癫痫发作和帕金森病的研究中具有价值。
T5148	Atosiban acetate RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班	Oxytocin Receptor; Vasopressin Receptor	Endocrinology/Hormones; GPCR/G Protein
	Atosiban acetate (RW22164) 是一种脱氨基催产素类似物，是一种九肽，也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂，可用于自发早产的研究。
T22925	Linopirdine dihydrochloride	Others	Others
	KV7 (KCNQ) voltage-gated potassium channels blocker
T31843	Fomocaine HCl P-652 HCl,Fomocaine,P652 hydrochloride,P-652 hydrochloride,Panacaine hydrochloride,P 652 hydrochloride
	Fomocaine is an type of anaesthetic agent blocking voltage-gated Na(+) currents in neurons.
T24137	HENA
	HENA is a novel activator of large conductance, voltage- and Ca2+-gated K+ (BK) channels.
T26319	Vincanol Vincanolum
	Vincanol is a potent voltage-gated Na+ channels blocker.
T13830	Propoxycaine hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
T70139	MSD-D
	MSD-D is an inhibitor of voltage-gated K(+) (Kv) channels Kv1.5.
T22887	KC 12291 hydrochloride	Others	Others
	voltage-gated sodium channel blocker
T27040	Clathrodin
	Clathrodin is a voltage-gated sodium (NaV) channels modulator.
T70224	Bupivacaine tartrate
	Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells.
T69866	photoGBI1
	photoGBI1 is a photocontrol inhibitor of the voltage-gated proton channel Hv1.
T68748	Saxitoxinol
	Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.
T14201	AM-2099	Others	Others
	AM-2099 is a voltage-gated sodium channel Nav1.7 inhibitor (IC50: 0.16 μM).
T33943	PF-04856264 PF-4856264,PF4856264,PF 4856264
	PF-04856264 is a potent and selective human Nav1.7 voltage-gated sodium channel inhibitor (IC50 = 28 nM).

化合物

AMTB hydrochloride

Cat.No: T19723

Synonym: AMTB

Target: TRP/TRPV Channel

Cat.No: T0939

Synonym: 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin

Target: Virus Protease, Sodium Channel

Cat.No: T15260

Synonym: NW-3509

Target: Sodium Channel

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Phenytoin sodium

Cat.No: T0008

Synonym: 5,5-Diphenylhydantoin sodium salt,Diphantoine,苯妥英钠,Dilantin sodium,Diphenylhydantoin Sodium

Target: Virus Protease, Sodium Channel

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Meclofenamic acid

Cat.No: T11990

Synonym: 甲氯芬那酸,Meclofenamate

Target: Others, Gap Junction Protein

Calcium Channel antagonist 3

Cat.No: T77712

Target: Calcium Channel

Cat.No: T60010

Target: Calcium Channel

Etidocaine Hydrochloride

Cat.No: T31716

Synonym: W-19053,Duranest,W19053,W 19053

Target: Sodium Channel

Lomerizine dihydrochloride

Cat.No: T6571

Synonym: Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796

Target: Calcium Channel

Cat.No: T22675

Synonym: V 102862

Target: Others, Sodium Channel

Cat.No: T9751

Target: Others

Cat.No: T2523

Synonym: CGP 33101,E 2080,卢非酰胺,RUF 331

Target: Sodium Channel

Calcium Channel antagonist 4

Cat.No: T77711

Target: Calcium Channel

Cat.No: T12424

Synonym: PF-6305591

Target: Others

UK 78282 hydrochloride

Cat.No: T23497

Target: Potassium Channel

Fosphenytoin disodium

Cat.No: T7066

Synonym: Fosphenytoin sodium,ACC-9653,磷苯妥英钠

Target: Sodium Channel

NaV1.7 inhibitor-1

Cat.No: T12181

Target: Sodium Channel

Benzocaine xHCl(94-09-7(free base))

Cat.No: T6782L

Target: Sodium Channel

Cat.No: T12786

Target: Potassium Channel

Prilocaine hydrochloride

Cat.No: T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest,盐酸丙胺卡因

Target: ATPase, Sodium Channel

Phenibut (hydrochloride)

Cat.No: T8639

Synonym: 3-Amino-4-phenylbutyric acid hydrochloride,3-氨基-4-苯基丁酸盐酸盐

Target: GABA Receptor

Procainamide hydrochloride

Cat.No: T0018

Synonym: Procapan,Procainamide HCl,Pronestyl,Procanbid,盐酸普鲁卡因胺

Target: DNA Methyltransferase, Sodium Channel, AChR, Autophagy

Cat.No: T0024

Synonym: Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360

Target: GABA Receptor, Sodium Channel, GluR, AChR

Cat.No: T68073

Target: Calcium Channel

PF 05089771 tosylate

Cat.No: T7502

Target: Sodium Channel

Cat.No: T22361

Synonym: Carbocaine

Target: Sodium Channel

1-(aminomethyl)cyclopropanecarboxylic acid hydrochloride

Cat.No: T77642

Target: Calcium Channel

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

1-(2,4-difluorophenyl)guanidine hydrochloride

Cat.No: T50030

Target: Others

Cat.No: T4612

Target: EGFR, Potassium Channel, HER

Mexiletine hydrochloride

Cat.No: T1046

Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律

Target: AhR, Sodium Channel

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

Cat.No: T4996

Synonym: 阿托西班,RWJ22164,RW22164

Target: Oxytocin Receptor, Vasopressin Receptor

Cat.No: T0267

Synonym: AD 810,唑尼沙胺,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Atosiban acetate

Cat.No: T5148

Synonym: RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班

Target: Oxytocin Receptor, Vasopressin Receptor

Linopirdine dihydrochloride

Cat.No: T22925

Target: Others

Cat.No: T31843

Synonym: P-652 HCl,Fomocaine,P652 hydrochloride,P-652 hydrochloride,Panacaine hydrochloride,P 652 hydrochloride

Cat.No: T24137

Cat.No: T26319

Synonym: Vincanolum

Propoxycaine hydrochloride

Cat.No: T13830

Target: Sodium Channel

Cat.No: T70139

KC 12291 hydrochloride

Cat.No: T22887

Target: Others

Cat.No: T27040

Bupivacaine tartrate

Cat.No: T70224

Cat.No: T69866

Cat.No: T68748

Cat.No: T14201

Target: Others

Cat.No: T33943

Synonym: PF-4856264,PF4856264,PF 4856264

Cat. No.	Product Name	Target	Signaling Pathways
T2173	Veratridine	Sodium Channel	Membrane transporter/Ion channel
	Veratridine 是一种生物碱，来自百合科植物。Veratridine 是一种钠通道激动剂，对 Nav1.7 的峰值电流具有抑制作用，IC50为 18.39 µM。
T3013	Catharanthine tartrate Catharanthine hemitartrate,酒石酸长春质碱	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱，可抑制电压门控 L 型钙离子通道，具有抗肿瘤和降血压活性。
T3021	Bulleyaconitine A 草乌甲素,Bulleyaconi cine A	Sodium Channel	Membrane transporter/Ion channel
	Bulleyaconitine A (Bulleyaconi cine A) 是一种分离自乌头属植物的抗炎活性化合物，也可用于缓解疼痛的研究。
TN6713	6-Benzoylheteratisine Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱	Sodium Channel	Membrane transporter/Ion channel
	6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) 是乌头碱的拮抗剂，乌头碱是天然 Na+通道激活剂。
T4S1869	12-Epinapelline 12-表欧乌头碱,12-表-欧乌头碱	Others	Others
	12-Epinapelline 是一种二萜生物碱，分离自Aconitum baikalense 中。它具有抗炎作用，能刺激成纤维细胞前体克隆的生长。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T8716	physalin F 酸浆苦味素F,酸浆苦素 F	Apoptosis	Apoptosis
	Physalin F 是一种分泌型甾体，诱导人外周血单个核细胞凋亡，降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生，具有强烈抗炎和免疫调节作用。
TN2322	Yangambin	Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
TN1254	3'-Methoxydaidzein 3'-甲氧基大豆苷元	Sodium Channel	Membrane transporter/Ion channel
	3'-Methoxydaidzein 是一种异黄酮和 Sodium Channel 双重抑制剂。3'-Methoxydaidzein 对NaV1.7、NaV1.8 和 NaV1.3有抑制作用，IC50 分别为 181 nM、397 nM 和 505 nM。 3'-Methoxydaidzein 对胶原诱导的血小板聚集具有特异性，IC50值分别为12.3和61.5µM。。3'-Methoxydaidzein 通过抑制电压门控钠通道发挥镇痛作用。 3'-Methoxydaidzein 具有抗氧化活性和抗血小板聚集活性。
T10609	Brevetoxin-3 PbTx-3	Others	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
T10278	Alamethicin	Others	Others
	Alamethicin is isolated from Trichoderma viride. It is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes.
T27564	Hymenidin	5-HT Receptor	GPCR/G Protein; Neuroscience
	Hymenidin是一种从冲绳海绵Hymeniacidon sp。中分离出的生物碱，是一种5-羟色胺能受体拮抗剂和电压门控钾通道抑制剂，具有潜在的抗原生动物作用，可选择性结合 FOXO1 DNA ，可降低去极化诱导的细胞钙升高。
T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

Cat.No: T2173

Target: Sodium Channel

Catharanthine tartrate

Cat.No: T3013

Synonym: Catharanthine hemitartrate,酒石酸长春质碱

Target: Others, Calcium Channel

Bulleyaconitine A

Cat.No: T3021

Synonym: 草乌甲素,Bulleyaconi cine A

Target: Sodium Channel

6-Benzoylheteratisine

Cat.No: TN6713

Synonym: Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱

Target: Sodium Channel

12-Epinapelline

Cat.No: T4S1869

Synonym: 12-表欧乌头碱,12-表-欧乌头碱

Target: Others

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T8716

Synonym: 酸浆苦味素F,酸浆苦素 F

Target: Apoptosis

Cat.No: TN2322

Target: Calcium Channel, PAFR

3'-Methoxydaidzein

Cat.No: TN1254

Synonym: 3'-甲氧基大豆苷元

Target: Sodium Channel

Cat.No: T10609

Synonym: PbTx-3

Target: Others

Cat.No: T10278

Target: Others

Cat.No: T27564

Target: 5-HT Receptor

Cat.No: T36068

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