80
23
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T24805 |
SMA-12b
SMA 12b,SMA12b |
||
SMA-12b is an IL-1 inhibitor. | |||
T4283 |
SRI-011381
|
TGF-beta/Smad | Stem Cells |
SRI011381 是口服具有活力的 TGF-β信号通路的激活剂,具有神经保护活性。 | |||
T14080 |
AA147
ATF6-activator-147 |
Others | Others |
AA147 (ATF6-activator-147) 是小分子内质网蛋白稳态调节剂,能够选择性激活未折叠蛋白反应的 ATF6臂。 | |||
T16886 |
Sinefungin
Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP |
Others; Histone Methyltransferase; Antibiotic; Antifungal | Chromatin/Epigenetic; Microbiology/Virology; Others |
Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9,通过抑制H3K4甲基化来改善肾纤维化。 | |||
T4641 |
Branaplam
LMI 070,NVS-SM1 |
Others; Potassium Channel; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others |
Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂,对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期,也抑制 hERG,IC50为 6.3 μM。 | |||
T81149 | SMA4 | ||
SMA4是一款选择性的PKG1α激活剂,其对PKG1α的EC50为29 μM。该化合物能够在细胞内促进PKG1底物——血管扩张刺激磷蛋白(VASP)的磷酸化,同时能够抑制人肺动脉平滑肌细胞(hPASMC)的增殖,适用于心血管疾病研究。 | |||
T5129 |
SRI-011381 hydrochloride
SRI-011381 hydrochloride [1629138-41-5(free base)] |
TGF-beta/Smad | Stem Cells |
SRI-011381 hydrochloride 是口服具有活力的TGF-β信号通路的激活剂,具有神经保护活性。 | |||
T1606 |
Fasudil
HA-1077,AT877,法舒地尔 |
ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂,也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用,ROCK1 的 Ki 值为 0.33 μM,ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。 | |||
T3060 |
Fasudil hydrochloride
Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂,也抑制蛋白激酶,对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。 | |||
T28466 |
PSMA-11
HBED-CC-PSMA,Psma-hbed-CC,PSMA11 |
||
PSMA-11 (HBED-CC-PSMA)通过与前列腺特异性膜抗原(PSMA)的细胞外结构域结合来检测前列腺癌的复发和转移。PSMA-11常被用作正电子发射断层扫描(PET)中用作表达PSMA 的肿瘤的示踪剂,通过静脉注射镓Ga 68标记的PSMA-11,Glu-urea-Lys(Ahx)分子靶向并结合表达PSMA 的肿瘤细胞。内化后,PSMA 表达的肿瘤细胞可在PET 成像中被检测到。 | |||
T2277 |
Losmapimod
GSK-AHAB,GW856553X,6-[5-(环丙基氨基甲酰基)-3-氟-2-甲基苯基]-N-(2,2-二甲基丙基)吡啶-3-甲酰胺,GW856553,洛批莫德,SB856553 |
p38 MAPK; Autophagy | Autophagy; MAPK |
Losmapimod (GSK-AHAB) 是一种可口服的特异性 p38 MAPK 抑制剂,抑制 p38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。 | |||
T23370 |
SMANT hydrochloride
N-(4-Bromophenyl)-3,5-dimethyl-1-piperidinepropanamide hydrochloride,hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide,SMANT HCl,N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) 是一种 Smoothened 积聚的拮抗剂。 | |||
T13890 |
SMARCA-BD ligand 1 for Protac dihydrochloride
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物,基于 PROTAC 技术,使 SMARCA2 降解。 | |||
T9568 |
SGC-SMARCA-BRDVIII
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SGC-SMARCA-BRDVIII 是SMARCA2/4和PB1(5)选择性抑制剂,其Kd 值分别为 35 nM,36 nM 和 13 nM。它还抑制PB1(2)和PB1(3),Kd 值分别为 3.7 和 2.0 μM。它可阻断 3T3-L1 鼠成纤维细胞的脂肪生成。 | |||
T19957 |
Bismaleimide
XU 292A,XU-292A,XU292A |
Others | Others |
Bismaleimide (XU 292A) 具有抗热性、抗氧化性、抗辐射性,可用于制备电器绝缘材料、耐磨材料、增强塑料添加剂、砂轮粘结剂等。 | |||
T77019 |
Garetosmab
REGN 2477 |
TGF-beta/Smad | Stem Cells |
Garetosmab (REGN 2477) 是一种全人 IgG4 单克隆抗体,可选择性抑制激活素 A (activin A),可作用于 COVID-44。Garetosmab 具有潜在的抗癌活性,可用于研究骨化性纤维发育不良 (FOP) 和癌症。 | |||
T13848 |
SMARCA-BD ligand 1 for Protac
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合,可用于 PROTAC 技术,用于降解 SMARCA2。 | |||
TP1844L |
Small Cardioactive Peptide B SCPB acetate
Small Cardioactive Peptide B SCPB acetate(84746-43-0 free base) |
Others | Others |
Small Cardioactive Peptide B SCPB acetate (Small Cardioactive Peptide B SCPB acetate (84746-43-0 free base)) 是一种神经活性肽,可刺激心脏和鳃组织颗粒部分的腺苷酸环化酶活性,EC50 分别为 0.1 和 1.0 μM。 | |||
T77750 |
Rosmantuzumab
OMP-131R10 |
Others | Others |
Rosmantuzumab (OMP-131R10) 是一种 人源化抗 R-spondin 3 (RSPO3)单克隆抗体。Rosmantuzumab 具有潜在的抗肿瘤活性,可用于研究晚期复发难治性实体瘤。 | |||
T69924 | PSMA-1007 | ||
PSMA-1007 is a novel Glu-Ureido-type prostate-specific membrane antigen (PSMA) inhibitor. | |||
T11314 |
Fosmanogepix
APX001,E1211 |
Others | Others |
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections. | |||
T34660 | SMART-F | ||
SMART-F is a biochemical. | |||
T83738 |
SMAP 29 (ovine) TFA
Sheep Myeloid Antimicrobial Peptide 29 |
||
SMAP 29是一种抗微生物肽,同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下,对P. aeruginosa菌株PAO1具有杀菌作用,该作用在能量依赖的发光测定中表现出来(EC50s分别为0.05和0.06 µM)。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。 | |||
T12934 |
SMAP-2
DT-1154 |
Phosphatase | Metabolism |
SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers . | |||
T78412 |
Biotin-NH-PSMA-617
|
||
Biotin-NH-PSMA-617为标记有生物素的PSMA-617小分子,专门针对前列腺特异性膜抗原(PSMA),后者为肿瘤细胞所特有表达。 | |||
TP2407 |
Small cardioactive peptide A
SCPA |
||
Small cardioactive peptide A, as a neuropeptide that modulates neuromuscular synapsis in Aplysia, can also function as a neural cotransmitter in molluscs and exert a role in both the central and peripheral modulation of the control of feeding behavior. | |||
T79321 |
nSMase2-IN-1
|
Phospholipase | Metabolism |
nSMase2-IN-1是一款口服活性的nSMase2抑制剂,具有0.13 ± 0.06 μM的IC50。该化合物在肝脏微粒体内具有良好的代谢稳定性,口服给药后获得较高的脑血浆比值,适用于神经系统疾病研究。 | |||
T20053 |
Jasmacyclen
EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598 |
||
Jasmacyclen is a compound in which has an aroma. | |||
T80262 |
SMAP-18
|
||
SMAP-18是一种具有高生物活性的18氨基酸残基肽酰胺,为SMAP-29 (羊髓系抗菌肽-29) 的缩短版本。SMAP-29对假单胞菌菌株、其他革兰氏阴性菌及多重耐药病原体有很强的抗菌作用。SMAP-18相较于母体SMAP-29,表现出更高的细胞选择性,因其降低了溶血活性同时保留了抗菌能力。 | |||
TP1844 |
Small Cardioactive Peptide B (SCPB)
Small Cardioactive Peptide B SCPB |
||
Small Cardioactive Peptide B (SCPB), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC50s of 0.1 and 1.0 μM, respectively. | |||
TF0097 |
BisMalt-20
|
||
BisMalt-20 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TF0097,CAS号为 1423237-53-9。 | |||
T61403 |
Plasma kallikrein-IN-3
|
||
Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1]. | |||
T125437 |
14-Hydroxy-7-O-methylrosmanol
|
||
14-Hydroxy-7-O-methylrosmanol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125437,CAS号为 197649-67-5。 | |||
T35205 |
Xylosmacin
|
||
Xylosmacin is a biochemical. | |||
T126198 |
Rosmaquinone
|
||
Rosmaquinone 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126198。 | |||
T124419 | Clausmarin A | ||
Clausmarin A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124419。 | |||
T40312 | Plasma kallikrein-IN-1 | ||
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC 50 value of 0.5 nM. | |||
T30474 |
Bismark Brown Y
AI3 52758,AI352758,AI3-52758 |
||
Bismark Brown Y is a brown dye. | |||
T39172 |
SMAP-29
|
||
SMAP-29 is a broad spectrum antibacterial and antifungal α-helical cathelicidin-derived peptide with strong potential as an antiinfective agent. It effectively permeabilizes bacterial membranes and induces significant alterations in the surface morphology of susceptible microorganisms. | |||
T78927 |
PSMA-IN-3
|
||
PSMA-IN-3(compound 17)是一种高亲和力的新型PSMA抑制剂,IC50为13 nM。该化合物可作为开发18F标记的放射性配体的基础,用于前列腺癌PSMA的PET成像。 | |||
T40326 |
PSMA–DA1
PSMA–DA1 |
||
PSMA–DA1 may be a useful PSMA-targeting radiotheranostic agent. | |||
TF0006 |
BisMalt-22
|
||
BisMalt-22 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TF0006,CAS号为 1198081-47-8。 | |||
T28818 | SMAPP1 | ||
SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells. | |||
T35217 | Xysmalorin | ||
Xysmalorin is a biochemical. | |||
T34391 | Rosmarinine | ||
Rosmarinine is a non-toxic pyrrolizidine alkaloid. | |||
T81361 |
PSMA-Val-Cit-PAB-MMAE
|
||
PSMA-Val-Cit-PAB-MMAE是一种靶向前列腺特异性膜抗原(PSMA)的小分子化合物,用MMAE作为药效基团进行前列腺癌治疗。 | |||
T81376 |
PROTAC SMARCA2 degrader-2
|
PROTACs | PROTAC |
PROTACSMARCA2 degrader-2,作为一种高效的SMARCA2/4PROTAC降解剂,在HeLa HiBiT检测中显示出极低的IC50值(<0.1 μΜ)。该化合物对于SMARCA4相关或缺陷癌症研究具有潜在应用价值。 | |||
T71742 |
SMases D inhibitor-1
|
||
SMases D inhibitor-1 is a novel inhibitor of loxosceles sphingomyelinases d (smases d) | |||
TF0053 |
BisMalt-28
|
||
BisMalt-28 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TF0053,CAS号为 1198081-49-0。 | |||
T125796 |
Osmanthuside H
|
||
Osmanthuside H 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125796,CAS号为 149155-70-4。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7057 |
rosmarinate acid
(R)-rosmarinic acid,rosmarinic acid,迷迭香素,Rosemary acid |
MAO; Endogenous Metabolite; Transferase | Metabolism; Neuroscience |
Rosmarinate acid(Rosemary acid) 抑制 MAO-A、MAO-B 和 COMT 酶,IC50 分别为 50.1、184.6 和 26.7 μM。 | |||
TN1334 |
7-Methoxyrosmanol
7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol |
cAMP | GPCR/G Protein |
7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜,从迷迭香中分离得到,可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。 | |||
T7033 |
Rosmanol
|
Antioxidant; COX | Immunology/Inflammation; Neuroscience; oxidation-reduction |
Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达,抑制低密度脂蛋白的氧化,并具有抗炎作用。 | |||
TN6784 |
ethyl rosmarinate
迷迭香酸乙酯 |
MMP; Tyrosinase; Glucosidase | Metabolism; Proteases/Proteasome |
ethyl rosmarinate 抑制酪氨酸酶、α-葡萄糖苷酶和基质金属蛋白酶-1 (MMP-1) 的活性。 | |||
T9135 |
Epirosmanol
|
Others | Others |
Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性(基本中性)的化合物(基于其 pKa)。 | |||
TN1928 |
Methyl rosmarinate
|
MMP; Anti-infection; Tyrosinase | Microbiology/Virology; Proteases/Proteasome |
Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂,从 Rabdosia serra 中分离得到的,对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM,也能抑制a-glucosidase。 | |||
T2765 |
Rosmarinic acid
Labiatenic acid,迷迭香酸,Rosemary acid |
Apoptosis; IκB/IKK; MAO; Endogenous Metabolite; Transferase; Monoamine Oxidase | Apoptosis; Metabolism; Neuroscience; NF-κB |
Rosmarinic acid (Labiatenic acid) 广泛存在植物中,具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A,MAO-B 和 COMT,IC50分别为 50.1,184.6 和 26.7 μM。 | |||
T31728 | Eudesmane | ||
Eudesmane is a bicyclododecane terpenes. | |||
T4S0818 |
Chasmanine
|
||
Chasmanine, hypaconitine, and deoxyaconitine are anti-inflammatory pharmacodynamic components in Heishunpian (HSP) with positive relations with HSP efficacy. Chasmanine has insecticidal activities against larvae of Bradysia odoriphaga Yan et Zhang. | |||
TN4285 | Isodorsmanin A | Others | Others |
Isodorsmanin A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4285,CAS号为 118266-99-2。 | |||
T75538 | Alismanol M | ||
Alismanol M,一种法尼酯 X 受体 (FXR) 激动剂,具有 50.25 μM 的 EC50 值。作为一种源自东方红根茎的原丹类三萜化合物,Alismanol M 主要应用于胆汁淤积与非酒精性脂肪性肝炎的研究。 | |||
TN3257 |
7beta-Methoxyrosmanol
|
Transferase | Metabolism |
7beta-Methoxyrosmanol inhibited acyl CoA:diacylglycerol acyltransferase (DGAT)1 activity, with the IC50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. | |||
T35216 |
Xysmalogenin
BRN0051836,,BRN-0051836,BRN 0051836 |
||
Xysmalogenin is a biochemical. | |||
TN1798 |
Isorosmanol
异迷迭香酚 |
Beta Amyloid; AChR | Neuroscience |
Isorosmanol 具有抗氧化、神经保护和神经营养作用,可能用于老年性疾病,如认知功能下降和色素沉着。 | |||
TN3149 |
6,8-Cyclo-1,4-eudesmanediol
|
Others | Others |
6,8-Cyclo-1,4-eudesmanediol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3149,CAS号为 213769-80-3。 | |||
TN6523 |
Rosmarinyl glucoside
|
||
Rosmarinyl glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6523,CAS号为 910028-78-3。 | |||
TN3888 |
Dorsmanin A
|
Others | Others |
Dorsmanin A is a natural product from Psoralea corylifolia. | |||
TN4031 |
Eudesma-3,11-dien-2-one
|
Others | Others |
Eudesma-3,11-dien-2-one 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4031,CAS号为 86917-79-5。 | |||
T80009 |
Osmanthuside B
|
||
Osmanthuside B,从Pseuderanthemum carruthersii (Seem.) Guill. var.atropurpureum (Bull.) Fosb 中分离得到,展现出较弱的乙酰胆碱酯酶抑制活性。 | |||
TN6351 |
Dorsmanin I
|
||
Dorsmanin I 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6351,CAS号为 329703-46-0。 | |||
TN2495 |
1,4,7-Eudesmanetriol
|
Antifection | Microbiology/Virology |
1α,4β,7β-Eudesmanetriol and 1β,4β,7β-Eudesmanetriol can inhibit growth of Pseudomonas stutzeri with a MIC value of 117 uM, they also show remarkable activities against acetylcholinesterase enzyme with IC50 values ranging between 25 and 26 uM. | |||
TN1329 |
7-Ethoxyrosmanol
|
Antifection | Microbiology/Virology |
7-Ethoxyrosmanol has cytotoxic and antimicrobial activities. | |||
T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 |