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Search Results for " rankl "

22

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9917	Denosumab	RANKL/RANK	NF-κB
	Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性，可降髋部、低椎骨以及非椎骨骨折的风险。
T7844	4-IPP 4-Iodo-6-phenylpyrimidine	Others	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物，也是 MIF 的不可逆抑制剂。
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T13324	VUF11207 fumarate	CXCR; Arrestin	Autophagy; GPCR/G Protein; Immunology/Inflammation
	VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体，pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化，pEC50分别为 8.8 和 7.9。
T62189	sRANKL-IN-1
	sRANKL-IN-1 (compound S3) 是一种 sRANKL (soluble RANKL) 的抑制剂。sRANKL-IN-1 能够较强的抑制破骨细胞 (IC50: 0.096 μM，Kd: 34.80 μM)。sRANKL-IN-1 能够用于研究骨质疏松症。
T61531	NFATc1-IN-1	RANKL/RANK	NF-κB
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].
T77567	BCPA	Others	Others
	BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化，减弱 Pin1 蛋白的减少，从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。
T15718	Latanoprost acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	Latanoprost acid 是前列腺素受体的选择性激动剂，通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。拉坦前列素酸可用于降低眼内压力的研究。
T2188	Thonzonium Bromide 嘧苯十六铵,通佐溴胺	Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。
T27526	Halenaquinone
	Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells.
T72008	E09241
	E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.
T80618	Narlumosbart	RANKL/RANK	NF-κB
	Narlumosbart（JMT103）是一种IgG4κ型抗体，专一性靶向核因子-κB 配体受体激活剂（RANKL）。
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T73061	Amakusamine
	Amakusamine以IC50值为10.5 μM，抑制NF-κB配体受体激活剂(RANKL)在RAW264.7细胞中诱导的多核破骨细胞形成。
T81171	SH491
	SH491（Compound 33）是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞（BMM）分化为破骨细胞（IC50: 11.8 nM）。同时，SH491降低了破骨细胞形成的相关标记基因（TRAP、CTSK、MMP-9和ATPase v0d2）以及相应蛋白（TRAP、CTSK、MMP-9）的表达。
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T19848	Cyclosporin B 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also
T78816	Anti-osteoporosis agent-4	NF-κB	NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化，减弱RANKL诱导的破骨细胞生成，并展示出强抑制作用，具有 IC50 值为358.29 nM。此外，该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活，表明其在防治骨质疏松症中的潜在应用价值。

化合物

Cat.No: T9917

Target: RANKL/RANK

Cat.No: T7844

Synonym: 4-Iodo-6-phenylpyrimidine

Target: Others

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

VUF11207 fumarate

Cat.No: T13324

Target: CXCR, Arrestin

Cat.No: T62189

Cat.No: T61531

Target: RANKL/RANK

Cat.No: T77567

Target: Others

Latanoprost acid

Cat.No: T15718

Target: GPR

Thonzonium Bromide

Cat.No: T2188

Synonym: 嘧苯十六铵,通佐溴胺

Target: Proton pump, Antibacterial, Autophagy

Cat.No: T27526

Cat.No: T72008

Cat.No: T80618

Target: RANKL/RANK

Cat.No: T71479

Cat.No: T69205

Kahweol palmitate

Cat.No: T68642

Cat.No: T73061

Cat.No: T81171

Kahweol linoleate

Cat.No: T71480

Kahweol stearate

Cat.No: T71478

Kahweol Acetate

Cat.No: T68641

Cat.No: T19848

Synonym: 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2

Anti-osteoporosis agent-4

Cat.No: T78816

Target: NF-κB

Cat. No.	Product Name	Target	Signaling Pathways
T5528	Cyanidin Chloride	Antioxidant	oxidation-reduction
	Cyanidin Chloride 是一种花青素的亚类，具有抗氧化和抗癌活性。它能够抑制破骨细胞形成，羟基磷灰石吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活。
T0683	Mevastatin Compactin,ML236B,美伐他汀	Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性，用于心血管疾病的研究。
TN1215	(2S)-2'-Methoxykurarinone 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt; Antifection	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物，具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号，抑制破骨细胞形成和骨吸收。
T2789	Scutellarin 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt; HIV Protease; STAT	Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Scutellarin (Scutellarein-7-glucuronide) 是从黄芩中分离的黄酮，可抑制破骨细胞中 RANKL 介导的 MAPK 和 NF-κB 信号通路，并下调 HCC 细胞中的 STAT3/Girdin/Akt 信号通路。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T5770	Alisol B	RANKL/RANK	NF-κB
	Alisol B 是一种具有用于骨科疾病研究潜力的化合物，通过分化破骨细胞发挥其功能。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T3849	Kinsenoside 金线莲苷,(+)-Kinsenoside	Apoptosis; Nrf2	Apoptosis; Immunology/Inflammation
	Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分，以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力，防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。
T2755	Rhoifolin 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy	Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors
	Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌，胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。
T5720	Boldine 1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus	RANKL/RANK	NF-κB
	Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱，从山苍子根中提取获得，具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成，并利用下调 OPG/RANKL/RANK 信号途径，改善骨破坏。它可用于研究类风湿性关节炎。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5S2129	Sciadopitysin	TNF; NF-κB	Apoptosis; NF-κB
	Sciadopitysin 是一种双黄酮类化合物，来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。
TN3209	3′,4′,7-Trihydroxyflavone	ATPase; Others; p38 MAPK; NF-κB	MAPK; Membrane transporter/Ion channel; NF-κB; Others
	3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。
T38799	2,3-Bis(3-indolylmethyl)indole
	2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.
T83151	Ajudecunoid A
	Ajudecunoid A, 一种从Ajuga decumbens分离的天然产物，具有抑制RANKL诱导的破骨细胞生成的活性。
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂，能抑制RANKL诱导的破骨细胞分化。
T16846	Sauristolactam Saurolactam	Others	Others
	Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi
T27711	Kahweol Eicosanate J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast
T79932	Eudebeiolide B Plebeiolide D	NF-κB	NF-κB
	Eudebeiolide B，一种自荔枝草分离得的化合物，能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成，适用于研究与破骨细胞相关的疾病。
TN2775	2-Methoxystypandrone	MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

天然产物

Cyanidin Chloride

Cat.No: T5528

Target: Antioxidant

Cat.No: T0683

Synonym: Compactin,ML236B,美伐他汀

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

(2S)-2'-Methoxykurarinone

Cat.No: TN1215

Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Cat.No: T2789

Synonym: 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T5770

Target: RANKL/RANK

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Cat.No: T3849

Synonym: 金线莲苷,(+)-Kinsenoside

Target: Apoptosis, Nrf2

Cat.No: T2755

Synonym: 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Cat.No: T5720

Synonym: 1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus

Target: RANKL/RANK

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Cat.No: T5S2129

Target: TNF, NF-κB

3′,4′,7-Trihydroxyflavone

Cat.No: TN3209

Target: ATPase, Others, p38 MAPK, NF-κB

2,3-Bis(3-indolylmethyl)indole

Cat.No: T38799

Cat.No: T83151

Anti-osteoporosis agent-2

Cat.No: T83033

Cat.No: T16846

Synonym: Saurolactam

Target: Others

Kahweol Eicosanate

Cat.No: T27711

Synonym: J002075,J 002075,J-002075

Cat.No: T79932

Synonym: Plebeiolide D

Target: NF-κB

2-Methoxystypandrone

Cat.No: TN2775

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

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