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Search Results for " nadph-oxidase "

41

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4359	VAS2870	NADPH	Metabolism
	VAS2870 是一种NADPH 氧化酶抑制剂。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T8107	GLX351322	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GLX351322 抑制 NADPH 氧化酶 4 (Nox4) 。在 NOX4 过表达的细胞中，抑制过氧化氢的产生，IC50值为 5 μM。
T15433	GSK2795039	Apoptosis; Reactive Oxygen Species; ROS; NADPH	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	GSK2795039 是一种 NADPH 氧化酶 2 抑制剂，可抑制活性氧产生和 NADPH 消耗，同时可减少细胞凋亡。
T6099	Setanaxib GKT137831	NADPH-oxidase; Ferroptosis; NADPH	Apoptosis; Immunology/Inflammation; Metabolism
	Setanaxib (GKT137831) 是一种有效的特异性双重 NADPH 氧化酶 (NOX1/4) 抑制剂，Ki 分别为140和110nM。
T22990	ML-090 Fluoflavine	NADPH-oxidase; Others	Immunology/Inflammation; Others
	ML-090 是 NOX1 特异性抑制剂 (IC50 = 90 nM)，对 NOX1 的特异性高于 NOX2、NOX3、NOX4（所有 IC50 > 10 μM）100倍。
T7042	1,5-Isoquinolinediol	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T7191	Diphenyleneiodonium chloride 二苯基氯化碘盐,DPI	NOS; Reactive Oxygen Species; NADPH; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Diphenyleneiodonium chloride (DPI) 是 NADPH 氧化酶抑制剂，也是 TRPA1激活剂，EC50为 1 - 3 μM 。它选择性抑制胞内活性氧。
T10353	APX-115 free base Ewha-18278 free base	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T38423	CL097 CL097	Reactive Oxygen Species; TLR	Immunology/Inflammation; Metabolism; NF-κB
	CL097 是 TLR7 和 TLR8 的有效激动剂。 CL097 诱导巨噬细胞中的促炎细胞因子和 NADPH 氧化酶引发，从而增加 fMLF 刺激的 ROS 产生。
T83625	iNOS-IN-14 3-bromo-1H-indazole-7-carbonitrile	NOS	Immunology/Inflammation
	iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) 是一种有效的一氧化氮合酶(NOS)抑制剂，抑制nNOS的NADPH氧化酶活性。
T29097	VAS 3947 VA-S3947,VA S3947,VAS3947	Apoptosis; NADPH-oxidase	Apoptosis; Immunology/Inflammation
	VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂。VAS 3947具有强大的抗血小板作用, 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡。
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)	NADPH-oxidase	Immunology/Inflammation
	NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T22096	L 012 sodium salt
	L 012 sodium salt 是一种 luminol 类似物，是一种广泛使用的活性氧和活性氮的化学发光(CL)探针的化学发光 (CL) 探针。L 012 sodium salt 广泛用于检测 NADPH 氧化酶 (Nox) 衍生的超氧化物 (O2•−) ，用于发现 Nox 抑制剂。
T15300	Fluorofenidone AKF-PD	Others	Others
	Fluorofenidone (AKF-PD) 是 AMR69 的类似物，抗纤维化活性与 AMR69相同，但 Fluorofenidone 的毒性更低，半衰期长。它部分通过 PI3K/Akt 信号通路抑制 NADPH 氧化酶和细胞外基质 (ECM) 的沉积，能够减少肾间质纤维化的发生。
T10354	APX-115 Ewha-18278	NADPH-oxidase	Immunology/Inflammation
	APX-115 (Ewha-18278) (Ewha-18278) 是一种有效的，口服活性的，非选择性 Nox 抑制剂，对 Nox1，Nox2 和 Nox4 的 Ki 值分别为 1.08 μM，0.57 μM 和 0.63 μM。APX-115 可有效预防糖尿病小鼠的肾损伤。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T69630	Diphenyleneiodonium (free base)
	Diphenyleneiodonium (free base) is an NADPH oxidase inhibitor.
T71513	GK-136901
	GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor.
T80243	gp91 ds-tat
	gp91 ds-tat 是一种生物活性肽，作为(NADPH氧化酶组装肽抑制剂)。
T78592	Diapocynin Dehydrodiacetovanillone
	Diapocynin (DeHydrodiacetovanillone)，Apocynin的二聚体，是具有口服活性的NADPH氧化酶抑制剂。具备抗炎、神经保护及抗氧化效果。
T11333	Fulvene-5	Others	Others
	Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector.
TP2083	Ac9-25
	N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
T75813	Ac9-25 TFA
	Ac9-25 TFA, 膜联蛋白 I N 端肽，作为甲酰肽受体(FPR)的激动剂，能激活中性粒细胞NADPH氧化酶通过FPR。
T75949	NoxA1ds TFA
	NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits NOX1-derived O2- production in HT-29 human colon cancer cells and attenuates VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro.
T35393	gp91ds-tat gp91ds-tat	NADPH-oxidase	Immunology/Inflammation
	gp91ds-tat 是一种 NADPH 氧化酶(NADPH oxidase)的肽抑制剂，由与人类免疫缺陷病毒-tat 肽相连的 gp91phox 序列组成。tat 序列促进了这种肽进入细胞。
T73896	Glucose-6-phosphate dehydrogenase
	Glucose-6-phosphate dehydrogenase 是戊糖磷酸途径的限速酶。Glucose-6-phosphate dehydrogenase 是抗氧化途径、一氧化氮合酶、NADPH 氧化酶、细胞色素 p450 等系统中 NADPH 的主要来源。Glucose-6-phosphate dehydrogenase 可用于糖尿病、醛固酮诱导的内皮功能障碍和癌症的研究。
TP1886	NoxA1ds
	Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary
T60517	CL097 hydrochloride
	CL097 hydrochloride 是一种有效的 TLR7和 TLR8激动剂。CL097 hydrochloride 可在巨噬细胞中诱导促炎细胞因子和 NADPH 氧化酶启动活性，从而增加 fMLF 刺激的ROS 产生。
TP1585	sgp91 ds-tat Peptide 2, scrambled
	This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat.
T38646	GKT136901 hydrochloride GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. This compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties.
TP1948	PBP10 PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh
T75815	WKYMVM-NH2 TFA
	WKYMVM-NH2 TFA 是一种高效的 N-甲酰肽受体 FPR1 与 FPRL1/2 激动剂，具备激活白细胞功效特性，包括趋化性、补体受体-3 的激活以及 NADPH 氧化酶的激活。
T14021	20-HETE 20-hydroxy Arachidonic Acid	Others	Others
	20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH oxidase, ROS, and NF-κB activity, a
T62004	(Rac)-Nebivolol
	(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种选择性的β1 肾上腺素能受体拮抗剂（IC50= 0.8 nM）。Nebivolol 显示血管舒张活性。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。
T13112	Tat-NR2B9c Tat-NR2Bct,NA-1	NO Synthase; iGluR	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tat-NR2B9c (NA-1) 是一种突触后密度-95（PSD-95）抑制剂，具有神经保护和抗癫痫作用。Tat-NR2B9c 可抑制PSD-95d2、 PSD-95d1 和 PSD-95，可阻止NMDA诱导的神经元NADPH氧化酶的激活，从而阻断超氧化物的产生，可减少中风后急性期的缺血性损伤。
T63847	1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
	Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) 是一种改性 PS 产品，经由 NADPH 氧化酶激活及 Lyso-PS 信号转导后得到。Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 能够利用巨噬细胞 G2A 功能，增强现有的受体/配体系统，进而解决中性粒细胞炎症。
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proi
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T37583	XTT (sodium salt hydrate)
	XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas...

化合物

Cat.No: T4359

Target: NADPH

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Cat.No: T8107

Target: NADPH-oxidase, NADPH

Cat.No: T15433

Target: Apoptosis, Reactive Oxygen Species, ROS, NADPH

Cat.No: T6099

Synonym: GKT137831

Target: NADPH-oxidase, Ferroptosis, NADPH

Cat.No: T22990

Synonym: Fluoflavine

Target: NADPH-oxidase, Others

1,5-Isoquinolinediol

Cat.No: T7042

Target: PARP

Diphenyleneiodonium chloride

Cat.No: T7191

Synonym: 二苯基氯化碘盐,DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

APX-115 free base

Cat.No: T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Cat.No: T38423

Synonym: CL097

Target: Reactive Oxygen Species, TLR

Cat.No: T83625

Synonym: 3-bromo-1H-indazole-7-carbonitrile

Target: NOS

Cat.No: T29097

Synonym: VA-S3947,VA S3947,VAS3947

Target: Apoptosis, NADPH-oxidase

NoxA1ds acetate(1435893-78-9 free base)

Cat.No: TP1886L1

Target: NADPH-oxidase

L 012 sodium salt

Cat.No: T22096

Cat.No: T15300

Synonym: AKF-PD

Target: Others

Cat.No: T10354

Synonym: Ewha-18278

Target: NADPH-oxidase

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Cat.No: T12781

Target: Others

Diphenyleneiodonium (free base)

Cat.No: T69630

Cat.No: T71513

Cat.No: T80243

Cat.No: T78592

Synonym: Dehydrodiacetovanillone

Cat.No: T11333

Target: Others

Cat.No: TP2083

Cat.No: T75813

Cat.No: T75949

Cat.No: T35393

Synonym: gp91ds-tat

Target: NADPH-oxidase

Glucose-6-phosphate dehydrogenase

Cat.No: T73896

Cat.No: TP1886

CL097 hydrochloride

Cat.No: T60517

sgp91 ds-tat Peptide 2, scrambled

Cat.No: TP1585

GKT136901 hydrochloride

Cat.No: T38646

Synonym: GKT136901 hydrochloride

Cat.No: TP1948

Synonym: PBP 10

Cat.No: T75815

Cat.No: T14021

Synonym: 20-hydroxy Arachidonic Acid

Target: Others

(Rac)-Nebivolol

Cat.No: T62004

Cat.No: T13112

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium

Cat.No: T63847

Cat.No: TP1891

Cat.No: T71328

XTT (sodium salt hydrate)

Cat.No: T37583

Cat. No.	Product Name	Target	Signaling Pathways
T6391	Apocynin 香草乙酮,Acetovanillone,Acetoguaiacone,NSC 2146,罗布麻宁	Apoptosis; NADPH; Autophagy	Apoptosis; Autophagy; Metabolism
	Apocynin (NSC 2146) 是一种选择性NADPH-氧化酶抑制剂，IC50为10 μM。
TN2126	Quercetin-3-O-glucose-6''-acetate 6"-O-Acetylisoquercitrin,槲皮素-3-O-葡萄糖苷-6′′-乙酯	NADPH-oxidase; ROS; NADPH	Immunology/Inflammation; Metabolism
	Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) 是 NADPH 氧化酶的抑制剂。 Quercetin-3-O-glucose-6''-acetate 具有抗氧化活性。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN2039	Panaxydol	cAMP; p38 MAPK; JNK	GPCR/G Protein; MAPK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria.
TN6515	Selaginellin
	Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression of klotho gene. Selaginellin shows

天然产物

Cat.No: T6391

Synonym: 香草乙酮,Acetovanillone,Acetoguaiacone,NSC 2146,罗布麻宁

Target: Apoptosis, NADPH, Autophagy

Quercetin-3-O-glucose-6''-acetate

Cat.No: TN2126

Synonym: 6"-O-Acetylisoquercitrin,槲皮素-3-O-葡萄糖苷-6′′-乙酯

Target: NADPH-oxidase, ROS, NADPH

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: TN2039

Target: cAMP, p38 MAPK, JNK

Cat.No: TN6515

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