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49

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9043	AS1810722	P450; STAT	JAK/STAT signaling; Metabolism; Stem Cells
	AS1810722 是口服有效的STAT6抑制剂，IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物，对有良好的CYP3A4抑制作用，具有用于过敏性疾病，如哮喘和特应性疾病的研究潜力。
T21694	(R)-Lisofylline (R)-Lisophylline	STAT	JAK/STAT signaling; Stem Cells
	(R)-Lisofylline ((R)-Lisophylline) 是溶血磷脂酸酰基转移酶的抑制剂 (IC50 = 0.6 µM)。 (R)-Lisofylline 可中断 IL-12 信号介导的 STAT4 激活，可用于治疗 1 型糖尿病和自身免疫性疾病的研究。
T8692	(Rac)-Benpyrine	TNF	Apoptosis
	(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂，是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T1781	GW9508 GW 9508	GPR; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。
T76637	IFN-γ Antagonist 1
	IFN-γAntagonist 1 (AYCRDGKIGPPKLDIRKEEKQI)，一种干扰素γ (IFN-γ) 拮抗剂，通过抑制IC50约为35 μM的IFN-γ诱导的HLR/DR抗原在Colo 205细胞上的表达展现作用。该化合物在免疫调节领域具有潜在应用。
T76638	IFN-γ Antagonist 1 acetate
	IFN-γAntagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate 作为一种干扰素 γ (IFN-γ) 拮抗剂，能够在 Colo 205 细胞中抑制 IFN-γ诱导的 HLR/DR 抗原表达，其 IC50 值约为 35 μM，显示出在免疫调节中的潜在应用价值。
T76742	Emapalumab NI-0501	COX	Immunology/Inflammation; Neuroscience
	Emapalumab (NI-0501) 是一种人源化针对干扰素 γ 的人单克隆抗体的 IgG1 单克隆抗体，可阻断其与细胞表面受体的结合并激活炎症信号。Emapalumab 与游离的 IFN-γ 以及与其受体结合的 IFN-γ 具有高结合力 (Kd=1.4 pM)。Emapalumab 可用于噬血细胞性淋巴组织细胞增多症 (HLH) 的研究。
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride	Others; Proteasome; COX	Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome; Ubiquitination
	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。
T83628	TNF/IFNγ-IN-1	Antioxidant; TNF; COX	Apoptosis; Immunology/Inflammation; Neuroscience; oxidation-reduction
	TNF/IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFNγ-IN-1 具有潜在的抗氧化和抗炎活性，可用于类似阿尔茨海默等的神经退行性疾病。
T4403	AX-024 hydrochloride AX-024 HCl	IL Receptor; TNF; COX; IFNAR; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience
	AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂，可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导，具有低毒、高效和高选择性的特点。
T76691	Monalizumab	IFNAR; Chk	Cell Cycle/Checkpoint; Immunology/Inflammation
	Monalizumab 是一种新型靶向自然杀伤细胞群 2A (NKG2A) 的免疫检查点抑制剂。Monalizumab 是一种人源化抗 NKG2A 的单克隆抗体，可促使 IFN-γ 产生，从而激活自然杀伤细胞功能。Monalizumab 具有抗肿瘤活性，可用于研究颈部鳞状细胞癌 (HNSCC)。
T2168	2-(1,8-naphthyridin-2-yl)phenol	STAT	JAK/STAT signaling; Stem Cells
	2-NP 是选择性的STAT1转录增强剂。它能够增强 IFN-γ 的功能，提高对人乳腺癌和纤维肉瘤细胞增殖的抑制能力。
T13063	T6167923	MyD88	Immunology/Inflammation
	T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。
T64280	ODN 2216
	ODN 2216 是一种 TLR9 (toll-like receptor 9) 配体或激动剂，能够诱导产生大量的 IFN-α 和 IFN-β。ODN 2216 可以利用 pDC (浆细胞样 DC) 诱导 IFN-α，以及利用 DC (树突状细胞) 产生IL-12 (p40)。ODN 2216 能够间接的、在 IFN-α/β 介导下刺激外周血单核细胞 (PBMC) 产生 IFN-γ。ODN 2216 可以激活 NK 细胞，诱导 IFN-γ 产生 TCR 触发的 CD4+T 细胞。
T36169	15-LOX-1 inhibitor 1
	9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and IFN-γ-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 μM.
T79189	1-Isopropyltryptophan 1-IsoPT	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	1-Isopropyltryptophan (1-IsoPT)为IDO1抑制剂，能够抑制IFN-γ刺激下IDO-1与IDO-2 mRNA的表达水平。
T16570	Pralnacasan VX-740,HMR 3480	Others	Others
	Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a
T81840	MBP (83-99)
	MBP (83-99)为MBP特异性的T细胞认可的主要免疫表位，能够诱导T细胞增殖并促使IFN-γ释放。
T71839	ATV399
	ATV399 is an inhibitor of iNOS dimerization which protects against Cytokine-Induced rat β-cell dysfunction, thereby inhibiting cleaved caspase-9 activation and subsequent β-cell apoptosis induced by a combination of IL-1β, IFN-γ, and high glucose.
T82743	CFP10 (71–85)
	CFP10 (71–85) 是具生物活性的肽类，能激活表达不同MHC II类与I类分子的人类CD4+和CD8+ T细胞，诱导IFN-γ产生及CTL活性。(CFP10 71–85).
T26895	BRD0476 BRD-0476,ML 187,ML187,ML-187,BRD 0476
	BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT
T62726	Phenylpyropene C
	Phenylpyropene C (S14-95) 是一种 JAK/STAT 通路抑制剂，对 IFN-γ 介导的报告基因表达表现出抑制作用 (IC50:5.4~10.8 μM)。Phenylpyropene C 也是一种酰基辅酶 A 的抑制剂 (IC50: 16.0 μM)。
T78755	PD-1/PD-L1-IN-31	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-31为具高效PD-1/PD-L1抑制能力的化合物（IC50=2.2 nM），能激进IFN-γ分泌及激活外周血单核细胞（PBMC），进而抑制肿瘤细胞生长。
T22506	3,4-DAA	NOS	Immunology/Inflammation
	3,4-DAA 具有抗炎活性，可改善急性肝同种异体移植损伤，通过抑制肠道屏障功能障碍和 NF-κB 活化来缓解严重的急性胰腺炎。3,4-DAA 抑制由 IFN-γ 和脂多糖诱导的 EOC20 细胞诱导型一氧化氮合酶 (iNOS) 发挥作用。
T60266	(Rac)-Indoximod
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta...
T78508	Delmitide acetate RDP-58 acetate	IFNAR	Immunology/Inflammation
	Delmitide acetate (RDP58) 是一种 d-异构体十肽，具有抗炎活性和口服活性。该化合物能够抑制 TNF-α、IFN-γ 以及白细胞介素 (IL)-12 的生成，同时提高血红素加氧酶 1 的活性，可用于针对溃疡性结肠炎的研究。
T64277	ODN 1585
	ODN 1585 是一种有效的 IFN 和 TNFα 产生诱导剂，也是一种 NK (natural killer) 的有效刺激剂，可用做疫苗佐剂。ODN 1585 能够增强 CD8+ T 细胞的功能，包括 CD8+ T 细胞介导的 IFN-γ 的产生。ODN 1585 可以诱导小鼠已建立的黑色素瘤消退，对小鼠的疟疾也表现出完全的保护作用。ODN 1585 能够用于研究急性骨髓性白血病 (AML) 和疟疾。
T38008	KBC-007
	KBC-007 is a synthetic branched chain-containing analog of α-galactosylceramide (α-GalCer). It induces IL-4 and IFN-γ secretion by mouse splenocytes when used at a concentration of 0.5 ng/ml and IL-2 secretion by DN32.D3 NKT hybridoma cells co-cultured with CD1d-transfected RBL cells pre-loaded with KBC-007 at a concentration of 8 ng/ml. KBC-007 (1 μg per animal) increases levels of IL-4, but not IFN-γ, to a similar degree as α-GalCer in mouse serum. KBC-007 (0.5 μg per animal) increases the sur...
T70291	PCC0208018
	PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro.
T68182	3-Hydroxykynurenamine
	3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ...
T75535	5-epi-Arvestonate A
	5-epi-Arvestonate A是一种从(Seriphidium transiliense)绢毛菊中提取的倍半萜化合物，能够通过激活(MITF)小眼相关转录因子和酪氨酸酶家族基因来促进黑色素的产生。此外，5-epi-Arvestonate A还能通过JAK/STAT信号通路，抑制永生化人角化细胞(HaCaT)中IFN-γ趋化因子的表达。
TP1978	11R-VIVIT NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse
T83846	HOXB7 (8-25) TFA Homeobox B7 (8-25)
	HOXB7 (8-25) 是 homeobox B7 (HOXB7) 的肽段，是细胞增殖的主要调控因子和肿瘤基因途径的激活剂。通过 HOXB7 (8-25) 肽脉冲的树突状细胞展示抗原，这些树突状细胞来源于分离的人类外周血单核细胞（PBMCs），刺激CD4+辅助T细胞的激活和IFN-γ的产生，从而引发特异性和多向性肿瘤反应性的抗肿瘤反应。
T26936	C188 Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188
	C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect agai
T76945	Cetrelimab
	Cetrelimab (JNJ 63723283; JNJ 3283) 为人源化IgG4κ单克隆抗体，专门针对PD-1。其与PD-1的结合Kd值为1.72 nM（在HEK293细胞中测得）。Cetrelimab有效阻断PD-1与其配体PD-L1和PD-L2的结合，其IC50值分别为111.7 ng/mL与138.6 ng/mL。此外，Cetrelimab能激活外周T细胞，提升细胞因子（IFN-γ, IL-2, TNF-α）的表达水平，进而抑制肿瘤在体内的生长。
T65390	Fluvoxketone
	Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime.In vitro，the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM.In vivo，fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase i...
T61071	AX-024
	AX-024 is a novel chemical compound that acts as an orally available inhibitor of the TCR-Nck interaction. Its primary mechanism of action is the selective inhibition of T cell activation triggered by TCR stimulation. With an IC50 value of approximately 1 nM, AX-024 effectively modulates cell signaling by specifically targeting SH3 domains. Additionally, AX-024 demonstrates desirable characteristics such as low acute toxicity, high potency, and excellent selectivity. Notably, it exhibits strong ...
T79487	MAO A/HSP90-IN-2	Monoamine Oxidase	Neuroscience
	MAO A/HSP90-IN-2（compound 4-C）是一种针对HSP90和MAO A的双重抑制剂，显示出分别对这两种酶有0.016 μM和4.58 μM的IC50值。该化合物能够上调HSP70，降低HER2和磷酸化AKT的表达，同时能减少GL26细胞中由IFN-γ诱导的PD-L1表达增加。此外，MAO A/HSP90-IN-2能够抑制对Temozolomide敏感或耐药的胶质母细胞瘤(GBM)、结肠癌、白血病和非小细胞肺癌细胞的生长，并可能有助于阻止肿瘤逃避免疫监控。
T83724	TPP-1 hydrochloride Targeting PD-L1 Peptide
	TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时，以4 mg/kg的剂量给药，可减少小鼠异种移植模型中的肿瘤体积。
T82071	Influenza NP (311-325)
	Influenza NP (311-325) 是具有生物活性的肽段，对应于流感病毒核蛋白(NP)的311至325氨基酸。作为MHC II类限制性表位，它用于研究宿主在感染期间的免疫响应。该肽能在细胞内细胞因子检测中诱导强烈的γ干扰素(IFN-γ)产生，但不激活小鼠CD8 T细胞。谷氨酰胺(Q)或谷氨酸(E)位于N端时，焦谷氨酰(pGlu)肽可自发形成。Q或E向pGlu的自然转化及其疏水性γ-内酰胺环在肽的胃肠道蛋白酶稳定性中可能起作用。焦谷氨酰肽作为常见肽的一部分，在HPLC分析中评估肽的纯度。
T83700	IRBP (651-670) (human) TFA IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)
	IRBP651-670（Interphotoreceptor retinoid-binding protein (651-670)）是IRBP（亦称为retinoid-binding protein 3）的肽段，参与色素再生，通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中，利用IRBP651-670诱导自身免疫性葡萄膜炎，这些小鼠携带H-2b单体型。用IRBP651-670（300 µg/动物）免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平，免疫细胞浸润及光感受器损伤。
T35708	N-acetyl-5-Aminosalicylic Acid
	N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ...
T83681	IRBP (1-20) (human, rat) TFA IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	IRBP1-20（1-20）是IRBP的一个十二肽片段，亦称视黄醇结合蛋白3，负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮，参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中，IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20（3 µM）能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战，可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤，以及视网膜脱落。
T83852	EGFRvIII Peptide TFA PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide
	EGFRvIII peptide是一种合成肽，对应于特异性肿瘤、具有持续激活性的EGFR变体EGFRvIII的融合接头，该变体缺少野生型EGFR的第6至273个氨基酸。在25 µg/ml的浓度下，它能与MHC I类亚型HLA-A0201阳性的T2细胞结合。在用于分离的人外周血单个核细胞（PBMCs）衍生的树突状细胞中，EGFRvIII peptide可诱导抗原呈递，进而刺激CD8+细胞毒性T淋巴细胞的激活和IFN*-γ产生。与toll样受体5（TLR5）激动剂鞭毛蛋白B共同免疫EGFRvIII peptide（15 µg/动物），在正交GL261胶质母细胞瘤小鼠异种移植模型中，增加了CD8+ T细胞数量，减少了调节性T细胞（Tregs）数量，减少了肿瘤体积，并提高了生存率。
T37295	Ganglioside GM1 Asialo Mixture
	Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na...
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...

化合物

Cat.No: T9043

Target: P450, STAT

(R)-Lisofylline

Cat.No: T21694

Synonym: (R)-Lisophylline

Target: STAT

(Rac)-Benpyrine

Cat.No: T8692

Target: TNF

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

Cat.No: T1781

Synonym: GW 9508

Target: GPR, Potassium Channel

IFN-γ Antagonist 1

Cat.No: T76637

IFN-γ Antagonist 1 acetate

Cat.No: T76638

Cat.No: T76742

Synonym: NI-0501

Target: COX

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

Cat.No: T16169

Synonym: N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride

Target: Others, Proteasome, COX

TNF/IFNγ-IN-1

Cat.No: T83628

Target: Antioxidant, TNF, COX

AX-024 hydrochloride

Cat.No: T4403

Synonym: AX-024 HCl

Target: IL Receptor, TNF, COX, IFNAR, Interleukin

Cat.No: T76691

Target: IFNAR, Chk

2-(1,8-naphthyridin-2-yl)phenol

Cat.No: T2168

Target: STAT

Cat.No: T13063

Target: MyD88

Cat.No: T64280

15-LOX-1 inhibitor 1

Cat.No: T36169

1-Isopropyltryptophan

Cat.No: T79189

Synonym: 1-IsoPT

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T16570

Synonym: VX-740,HMR 3480

Target: Others

Cat.No: T81840

Cat.No: T71839

CFP10 (71–85)

Cat.No: T82743

Cat.No: T26895

Synonym: BRD-0476,ML 187,ML187,ML-187,BRD 0476

Phenylpyropene C

Cat.No: T62726

PD-1/PD-L1-IN-31

Cat.No: T78755

Target: PD-1/PD-L1

Cat.No: T22506

Target: NOS

(Rac)-Indoximod

Cat.No: T60266

6(5H)-Phenanthridinone

Cat.No: T72017

Delmitide acetate

Cat.No: T78508

Synonym: RDP-58 acetate

Target: IFNAR

Cat.No: T64277

Cat.No: T38008

Cat.No: T70291

3-Hydroxykynurenamine

Cat.No: T68182

5-epi-Arvestonate A

Cat.No: T75535

Cat.No: TP1978

Synonym: NFAT inhibitor, Cell Permeable

HOXB7 (8-25) TFA

Cat.No: T83846

Synonym: Homeobox B7 (8-25)

Cat.No: T26936

Synonym: Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188

Cat.No: T76945

Cat.No: T65390

Cat.No: T61071

MAO A/HSP90-IN-2

Cat.No: T79487

Target: Monoamine Oxidase

TPP-1 hydrochloride

Cat.No: T83724

Synonym: Targeting PD-L1 Peptide

Influenza NP (311-325)

Cat.No: T82071

IRBP (651-670) (human) TFA

Cat.No: T83700

Synonym: IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)

N-acetyl-5-Aminosalicylic Acid

Cat.No: T35708

IRBP (1-20) (human, rat) TFA

Cat.No: T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

EGFRvIII Peptide TFA

Cat.No: T83852

Synonym: PEGFRvIII (9-mer),Epidermal Growth Factor Receptor Variant III Peptide

Ganglioside GM1 Asialo Mixture

Cat.No: T37295

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Cat.No: T36486

Cat. No.	Product Name	Target	Signaling Pathways
TN2539	1beta-Hydroxyalantolactone	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物，可抑制细胞中TNF-α、IL-17、IFN-γ的表达，促进TNF-α、IFN-γ、IL-17的分泌，可防治类风湿性关节炎。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。
T37280	PE(18:1(9Z)/0:0)	Endogenous Metabolite	Metabolism
	PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂，是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生，但不增加 IFN-γ 的产生。在小鼠血清中，PE(18:1(9Z)/0:0)（1 μg/动物）诱导 T 辅助细胞 2 反应。在寒冷暴露三天后，小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。
T14854	Caerulomycin A 浅蓝霉素,Cerulomycin,Caerulomycin	Antifungal	Microbiology/Virology
	Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物，能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路，从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
TN5233	Villosin	Others	Others
	Villosin exhibits potent cytotoxic activity , it may be used as a potential lead molecule for antitumor therapeutic development. Villosin shows inhibitory effects against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with I
TN4959	Schizandriside	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysaccharide-stimulated RAW 264.7 cells. It shows significant cytotoxicity against A549, SK-OV-3, SK
T35895	Ingenol 3,20-dibenzoate
	Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2].

天然产物

1beta-Hydroxyalantolactone

Cat.No: TN2539

Target: IL Receptor, TNF

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

PE(18:1(9Z)/0:0)

Cat.No: T37280

Target: Endogenous Metabolite

Cat.No: T14854

Synonym: 浅蓝霉素,Cerulomycin,Caerulomycin

Target: Antifungal

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: TN5233

Target: Others

Cat.No: TN4959

Target: Prostaglandin Receptor

Ingenol 3,20-dibenzoate

Cat.No: T35895

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