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Search Results for " h2o2 "

46

抑制剂 & 化合物

34

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19038	NIR-H2O2	Others	Others
	NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. It responds to H2O2 with a large turn-on NIR fluorescence signal upon excitation in the NIR region.
T8132	Iron sucrose Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂，也是一种促氧化剂，可用于研究缺铁性贫血。
T13396	Zinc Protoporphyrin Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX	Apoptosis; Reactive Oxygen Species; Endogenous Metabolite	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的，竞争性血红素加氧酶-1 抑制剂，显著减弱间苯三酚对 H2O2 的保护作用，具有抗癌活性。它用于评估人群铁状态与血红蛋白浓度的组合，也可用作个体孕妇和儿童缺铁的筛查标志物。
T18924	Benzenepentacarboxylic Acid 苯五甲酸,Pentacarboxybenzene	Others	Others
	Benzenepentacarboxylic Acid (Pentacarboxybenzene) 是具有发现和清除HO 自由基作用的荧光染料。
T9560	MAO-B-IN-2
	MAO-B-IN-2 是一种选择性和竞争性的MAO-B 和 BChE 抑制剂，其IC50值分别为 0.51 和 7.00 μM。MAO-B-IN-2 通过良好的 ROS 清除特性减轻 H2O2 诱导的细胞损伤。
T18972	DHBS DCHBS	Others	Others
	DHBS (DCHBS) 与 4-氨基安替比林和过氧化氢联合使用，能够用于偶联酶促反应中过氧化物酶的显色定量。它是 Trinder 试剂的组分，能够与过氧化物酶一起测量过氧化氢的产生。
T24160	IM-54 IM 54,IM54	MLK	MAPK
	IM-54 是一种选择性的氧化应激诱导的坏死 (necrosis) 抑制剂。IM-54 对 H2O2 诱导的坏死有强烈的抑制作用。IM-54 是一种潜在的心脏保护剂和研究细胞死亡分子机制的生物工具。
T1282	Carteolol hydrochloride Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Carteolol hydrochloride (Abbott-43326) 是一种非选择性的β肾上腺素受体阻断剂。
T38165	FBBBE
	FBBBE is a derivatized fluorescein compound that is used to detect the production hydrogen peroxide (H2O2) by cells. Intracellular H2O2, but not extracellular H2O2, initiates the conversion of FBBBE to fluorescein, resulting in an increase in intracellular fluorescence (excitation/emission maxima: 480/512 nm).
T38256	Pentafluorobenzenesulfonyl fluorescein	Others	Others
	Pentafluorobenzenesulfonyl fluorescein 本身无荧光，但在磺酰基键被 H2O2 过水解时会发荧光。Pentafluorobenzenesulfonyl fluorescein 常被当作选择性 H2O2 传感器，可用于检测细胞中的 H2O2 含量。
T23135	Peroxy Orange 1	Others	Others
	fluorescent probe for imaging hydrogen peroxide (H2O2)
T22982	MitoPY1	Others	Others
	a fluorescent probe for imaging hydrogen peroxide (H2O2) in mitochondria of living cells
T34472	S1QEL S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL
	S1QEL is a suppressor of mitochondrial respiratory complex I site IQ electron leak which suppresses superoxide and/or H2O2 production without altering oxidative phosphorylation.
T37658	MitoP
	MitoP is a phenol product produced by the reaction of H2O2 with the ratiometric mass spectrometry probe MitoB . MitoB contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where its arylboronic moiety selectively reacts with H2O2 to produce MitoP. Quantifying the MitoP/MitoB ratio by LC-MS/MS reflects the mitochondrial matrix H2O2 concentration.
T81799	MHLWAAK TFA
	MHLWAAK TFA是从C-藻蓝蛋白胰酶水解产物中分离的抗氧化活性肽。它展现出了较强的DPPH和ABTS自由基清除效应，并且能保护斑马鱼幼虫免遭H2O2引发的氧化伤害。
T81864	MAQAAEYYR
	MAQAAEYYR 是从C-藻蓝蛋白的胰酶水解产物中分离得到的一种具备显著抗氧化活性的肽。它在DPPH和ABTS自由基清除实验中显示出较高的效率，并能有效保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T13727	Huangjiangsu A	Others	Others
	Huangjiangsu A has hepatoprotective potential against H2O2-induced cytotoxicity and ROS generation and could be promising as potential therapeutic agents for liver diseases. Huangjiangsu A is isolated from D. villosa.
T69033	Magnesium Oxaloacetate
	Magnesium Oxaloacetate is an inhibitor of the amebicidal activity of activated murine macrophages, helping the parasite to survive within the mouse large intestine and increasing the survival of C. elegans exposed to H2O2.
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T81863	MAQAAEYYR TFA
	MAQAAEYYR TFA 是从 C-藻蓝蛋白胰酶水解产物中分离得到的一种具有高抗氧化活性的肽。它展现了显著的 DPPH 及 ABTS 自由基清除作用，并能有效保护斑马鱼幼虫不受 H2O2 诱导的氧化损伤。
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T81800	MHLWAAK
	MHLWAAK，抗氧化活性肽，源自C-藻蓝蛋白胰酶水解产物。该肽展现出显著DPPH及ABTS自由基清除效能，并能保护斑马鱼幼虫不受H2O2诱导的氧化损害。
T63364	Nrf2 activator-5
	Nrf2 activator-5 是 Nrf2 的有效激活剂，能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症，表现出抗氧化和抗炎活作用。
T76131	Sarcosine oxidase
	Sarcosine oxidase(SAO)，即肌氨酸氧化酶，可以催化肌氨酸的氧化去甲基化生成甘氨酸，H2O2, 5,10-CH2-四氢叶酸，常用于生化反应。
T38071	HPF
	The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.[1] There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). [2] HPF is a cell-permeable aroma...
T61312	Antioxidant agent-3
	Antioxidant agent-3 (Compound 14q) 是一种抗氧化剂，具有有效的DPPH 自由基清除活性和ABTS+清除活性，IC50分别为 26.58 和 30.31 μM。Antioxidant agent-3 作用于 H2O2处理的 HepG2 细胞，可增加活性氧 (ROS)、超氧化物歧化酶 (SOD) 和谷胱甘肽 (GSH)，并减少乳酸脱氢酶(LDH)。
T81827	MDYYFEER TFA
	MDYYFEER TFA为从C-藻蓝蛋白胰酶水解产物中提取的抗氧化活性肽，展现了显著的DPPH与ABTS自由基清除效果，并能保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T37357	MXS
	MXS is a mitochondria-targeted fluorescent probe for hypochlorous acid (HOCl).1It selectively fluoresces in the presence of OCl-over O2, H2O2, NO, NO2-, NO3-, O2-, ONOO-, and OH when used at a concentration of 10 μM. MXS has been used to monitor real-time mitochondrial HOCl levels in living cells. It displays excitation/emission maxima of 530/654 nm, respectively.
T38370	CAY10731
	CAY10731 is a fluorescent probe for hydrogen sulfide (H2S).[1] Upon reaction with H2S, fluorescein (FITC) is released and its fluorescence can be used to detect H2S. FITC displays excitation/emission maxima of 485/535 nm, respectively. CAY10731 is selective for H2S over glutathione (GSH), cysteine, H2O3-, SO3-, and H2O2 as well as tBuO and OH radicals. It has been used to detect H2S in rat hippocampal slices and nematodes.
T82052	IR-990
	IR-990是NIR-II型可激活荧光探针，拥有受体-π-受体(A-π-A)骨架，能实时体内检测H2O2。该化合物还可用于诊断由活性分子导致的药物性肝损伤(DILI)。
T37720	Difluorinated H2S Fluorescent Probe 1
	Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) when used at a concentration of 1 μM. Difluorinated H2S probe 1 displays excitation/emission maxima of 365/450 nm, respectively. 1.Zhang, J., Gao, Y., Kang, X., et al.o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and...
T81828	MDYYFEER
	MDYYFEER 是源自 C-藻蓝蛋白胰酶水解产物的抗氧化活性肽，能有效清除 DPPH 及 ABTS 自由基，并能保护斑马鱼幼虫免受 H2O2 诱导的氧化损害。
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T79636	PKM2-IN-4
	PKM2-IN-4 (compound 5C)为PKM2的选择性抑制剂，具有0.35 μM的半抑制浓度(IC50)，能够调控丙酮酸依赖的呼吸作用，并诱导线粒体H202的产生和电子传递系统的偶联效应。
T63873	Anti-Aβ agent 1A
	Anti-Aβ agent 1A 是有效的抗淀粉样蛋白-β (amyloid-β) 剂。Anti-Aβ agent 1A 可明显抑制 LPS 诱导的 IL-1β、IL-6 和 TNF-α 水平，并能够利用线粒体途径减少 H2O2诱导的 SH-SY5Y 细胞凋亡，表现出抗氧化、抗炎、抗 Aβ 毒性和神经保护活性。Anti-Aβ agent 1A 能够用于研究阿尔兹海默症。
T38099	APF
	APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxim...
T35976	6-Formylpterin
	Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in hetero-substrate" inhibition at nanomolar concentrations. However
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T62262	Neuroinflammatory-IN-2
	Neuroinflammatory-IN-2 (compound 7i) 是一种有效的抗神经炎症剂，能够作用于 MAO-B (IC50: 10.30 μM)。Neuroinflammatory-IN-2 具有抗神经炎症活性、抗氧化活性、生物金属螯合能力和适当的血脑屏障通透性 (BBB)。Neuroinflammatory-IN-2 在 25 μM 的浓度下可以抑制 96.33% 的 Aβ1-42 聚集。Neuroinflammatory-IN-2 在 H2O2 诱导的 PC-12 细胞损伤中表现出神经保护活性。Neuroinflammatory-IN-2 能够用于研究阿尔兹海默症。
T35965	MitoTEMPOL
	MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-hydroxy-TEMPO) with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria. MitoTEMPOL has been used to elucidate the role of mitochondria-derived superoxide in mitochondrial, cellular, and whole animal signaling.
T60348	N1,N11-Diethylnorspermine
	N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放，导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。
T36459	CAY10730
	CAY10730 is a turn-on fluorescent probe for the detection of nitroreductase activity, a marker of hypoxia. In the presence of nitroreductase, CAY10730 is transformed into a highly fluorescent molecule that displays excitation/emission maxima of 454/520 nm, respectively. It is selective for nitroreductase over a variety of bioanalytes, including glutathione, ascorbic acid, and reactive oxygen species such as H2O2. CAY10730 (1 μM) has been used to detect hypoxia in A549 human lung carcinoma cells.
T36830	9-Nitrooleate
	Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide. 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in a...
T79251	AChE-IN-30
	AChE-IN-30，一种AChE抑制剂，其IC50为4.4 μM。该化合物显示出神经保护活性，能抑制H2O2诱导的细胞凋亡（apoptosis），其机制是通过阻止细胞内ROS的积累。AChE-IN-30适用于阿尔茨海默病的相关研究。
T36502	DCP-Rho1 DCP-Rho1
	DCP-Rho1 is a fluorescent probe for the detection of sulfenic acid-containing proteins.1,2 It displays excitation/emission maxima of 560/581 nm, respectively, and has been used to visualize protein oxidation sites in situ. \|1. Klomsiri, C., Rogers, L.C., Soito, L., et al. Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling. Free Rad. Biol. Med. 71, 49-60 (2014).\|2. Holmila, R.J., Vance, S.A., Chen, X., et ...

化合物

Cat.No: T19038

Target: Others

Cat.No: T8132

Synonym: Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

Zinc Protoporphyrin

Cat.No: T13396

Synonym: Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX

Target: Apoptosis, Reactive Oxygen Species, Endogenous Metabolite

Benzenepentacarboxylic Acid

Cat.No: T18924

Synonym: 苯五甲酸,Pentacarboxybenzene

Target: Others

Cat.No: T9560

Cat.No: T18972

Synonym: DCHBS

Target: Others

Cat.No: T24160

Synonym: IM 54,IM54

Target: MLK

Carteolol hydrochloride

Cat.No: T1282

Synonym: Arteoptic,Abbott-43326,OPC-1085 hydrochloride,盐酸卡替洛尔,Carteolol HCl,Mikelan

Target: Adrenergic Receptor

Cat.No: T38165

Pentafluorobenzenesulfonyl fluorescein

Cat.No: T38256

Target: Others

Peroxy Orange 1

Cat.No: T23135

Target: Others

Cat.No: T22982

Target: Others

Cat.No: T34472

Synonym: S-1QEL,S1 QEL,S 1QEL,S1QEL1.1,S1-QEL

Cat.No: T37658

Cat.No: T81799

Cat.No: T81864

Cat.No: T13727

Target: Others

Magnesium Oxaloacetate

Cat.No: T69033

Cat.No: T71479

Cat.No: T81863

Kahweol palmitate

Cat.No: T68642

Cat.No: T81800

Nrf2 activator-5

Cat.No: T63364

Sarcosine oxidase

Cat.No: T76131

Cat.No: T38071

Antioxidant agent-3

Cat.No: T61312

Cat.No: T81827

Cat.No: T37357

Cat.No: T38370

Cat.No: T82052

Difluorinated H2S Fluorescent Probe 1

Cat.No: T37720

Cat.No: T81828

Kahweol linoleate

Cat.No: T71480

Cat.No: T79636

Anti-Aβ agent 1A

Cat.No: T63873

Cat.No: T38099

Cat.No: T35976

Kahweol stearate

Cat.No: T71478

Kahweol Acetate

Cat.No: T68641

Neuroinflammatory-IN-2

Cat.No: T62262

Cat.No: T35965

N1,N11-Diethylnorspermine

Cat.No: T60348

Cat.No: T36459

Cat.No: T36830

Cat.No: T79251

Cat.No: T36502

Synonym: DCP-Rho1

Cat. No.	Product Name	Target	Signaling Pathways
T4893	Spermidine N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane	Endogenous Metabolite	Metabolism
	Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) 能够维持细胞膜稳定性，提高抗氧化酶活性，改善光系统 II 以及相关基因表达。它结合并激活 NMDA，并已显示以浓度依赖性方式增强 NMDA 诱导的电流。
T5080	Spermidine trihydrochloride Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐	NMDAR; Autophagy	Autophagy; Neuroscience
	Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride) 能够维持细胞膜稳定性，提高抗氧化酶特性，改善光系统 II (PSII) 以及相关基因表达，也能够显著抑制 H2O2和 O2.-含量。
T3982	Vulpinic Acid 狐衣酸,Vulpic acid,Pulvinic acid methyl ester	Others	Others
	Vulpinic Acid (Pulvinic acid methyl ester) 是地衣代谢物，可降低人脐静脉内皮细胞 (HUVEC) 中 H2O2诱导的ROS，氧化应激和氧化应激相关损伤，可作用于厌氧菌、葡萄球菌及肠球菌。它对脉粥样硬化的研究具有潜在的价值。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
TQ0226	Jionoside B1 焦地黄苯乙醇甙B1,吉奥诺苷 B1	Others	Others
	Jionoside B1 has immunosuppressive activity and shows the hepato-protective activity in the H2O2 induced liver injury experiments.
TN4530	Methyl 3-hydroxy-4,5-dimethoxybenzoate 3,4-Dimethoxy-5-hydroxybenzoic acid methyl ester	Antioxidant; Antibiotic	Microbiology/Virology; oxidation-reduction
	Methyl 3-hydroxy-4,5-dimethoxybenzoate (3,4-Dimethoxy-5-hydroxybenzoic acid methyl ester) 是从松花杨梅中提取出来的没食子酸衍生物，具有抗菌活性。在 H2O2 存在下，Methyl 3-hydroxy-4,5-dimethoxybenzoate 展现出抗氧化性作用。
TN2304	Vitexin 2''-O-p-coumarate Vitexin2''-O-p-coumarate,Vitexin 2''-O-p-coumarate	Others	Others
	Vitexin 2''-O-p-coumarate (Vitexin2''-O-p-coumarate) 存在于葫芦巴种子中，可促进 H2O2 诱导的 2BS 细胞增殖。
T3S0208	Hederagenin 28-O-beta-D-glucopyranosyl ester Hederagenin-28-beta-D-glucopyranoside,常春苷元-28-BETA-D-吡喃葡萄糖苷,常春藤皂苷元28-O-beta-D-吡喃葡萄糖酯	Others	Others
	Hederagenin-28-beta-D-glucopyranoside 是一种分离自 Ilex cornuta 中的三萜皂苷，能够保护H2O2诱导的心肌细胞免于损伤。
TN7087	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone	Others	Others
	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio (Thermophillin) 是一种天然产物。它的氧化还原循环是木材褐腐真菌腐烂中Fe2+和H2O2再生的还原当量来源。
T7090	Jionoside A1 焦地黄苯乙醇甙A1,焦地黄苯乙醇苷A1	Others	Others
	Jionoside A1 分离自Radix Rehmanniae Praeparata 中，具有剂量依赖性免疫增强作用，并对 H2O2处理的 SH-SY5Y 细胞具有中等保护活性。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
TN1461	(-)-Butin Butin,漆黄素 ( 紫铆素)	Akt; PI3K; Nrf2	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。
T19229	Catalase	Others	Others
	Catalase 是重要的抗氧化酶,在清除 ROS 及维持氧化还原状态的平衡方面发挥着重要作用。Catalase 与肿瘤的发生,发展关系密切。有潜力用于肿瘤的预防研究。
T5S2283	Sesamolin	p38 MAPK; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物，抑制脂质过氧化，具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化，抑制MAPK 的级联反应。
T3785	11-oxo-mogroside V 11-oxo Mogroside V,11-氧罗汉果苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	11-oxo-mogroside V (11-oxo Mogroside V) 是一种天然甜味剂，具有显著的抗氧化作用。它对活性氧物质具有显著的抑制作用，作用于O2-，H2O2和*OH，EC50分别为 4.79，16.52 和 146.17 μg/mL。
T2854	Phillyrin Forsythin,连翘苷	P450; Influenza Virus; AMPK	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物，具有抗甲型流感病毒的活性，以及抗菌和消炎作用。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
T3671	Vitexin-2"-O-rhamnoside 牡荆素鼠李糖苷,牡荆素-2-O-鼠李糖苷,2''-O-Rhamnosylvitexin,Vitexin-2-O-rhaMnoside,Vitexin-2''-O-rhamnoside,Apigenin-8-C-glucoside	Others	Others
	Vitexin-2"-O-rhamnoside (Apigenin-8-C-glucoside) 是一种黄酮苷类化合物，存在于Cratagus pinnatifidaBge 中，对 H2O2介导的氧化应激损伤具有保护作用，可用于研究心血管系统疾病。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T6S0525	Farrerol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Farrerol 是一种杜鹃花的生物活性成分，具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。
TN2037	Paeonilactone C (3S,3AR,6S,7AR)-3-[(苯甲酰基氧基)甲基]四氢-6-羟基-6-甲基-2,5(3H,4H)-苯并呋喃二酮,芍药内苷 C	Others	Others
	Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity.
TN4892	Randialic acid B	Others	Others
	Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury.
TN2249	(+)-Syringaresinol	Sirtuin; Antifection	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T82058	Inubritannolide A
	Inubritannolide A展示了对由多种诱导剂引起的神经细胞损伤具有微弱的保护作用，这些诱导剂包括H2O2、6-羟基多巴胺(6-OHDA)和脂多糖(LPS)。
TN2015	Ophiopogonanone E	Others	Others
	Ophiopogonanone E has oxygen free radicals(OFRs) scavenging effects, it can scavenge hydroxyl radical(·OH) and hydrogen peroxide(H2O2) in vitro.
TN2036	Paeonilactone B (+)-Paeonilactone B	NADPH-oxidase	Immunology/Inflammation
	Paeonilactone B ((+)-Paeonilactone B) 是一种来自白芍的单萜类化合物，具有神经保护活性，抑制氧化应激，在大鼠皮质细胞在抑制 H2O2 诱导的神经毒性。
TN2013	Ophiopogonanone A	Others	Others
	Ophiopogonanone A has oxygen free radicals(OFRs) scavenging effects, it can scavenge hydroxyl radical(·OH) and hydrogen peroxide(H2O2) in vitro.
TN1578	Dihydroconiferyl alcohol	Others	Others
	Dihydroconiferyl alcohol exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
TN5471	5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one
	5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one has oxygen free radicals(OFRs) scavenging effects, it can scavenge hydroxyl radical(Â·OH) and hydrogen peroxide(H2O2) in vitro.It shows a strong cytotoxic activity on HeLa-S3 cell.
T80861	Vitexin2''-O-p-trans-coumarate
	Vitexin2''-O-p-trans-coumarate，一种类黄酮，从葫芦巴（Trigonella foenum-graecum）种子乙醇提取物中乙酸乙酯可溶性部分分离得到，显著促进 H2O2 诱导的 2BS 细胞增殖。
TN3753	Dalbergioidin	Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ...
TN2191	Scutebarbatine A	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.
T27711	Kahweol Eicosanate J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast
TN6924	Anhydrosafflor yellow B (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB	Others	Others
	Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1) 是从红花中分离出来的，可抑制 ADP 诱导的血小板聚集，在体外表现出显着的抗氧化作用，并对 H2O2 诱导的细胞毒性具有一定的活性。

天然产物

Cat.No: T4893

Synonym: N-(3-Aminopropyl)-1,4-diaminobutane,亚精胺,N-(4-Aminobutyl)-1,3-diaminopropane

Target: Endogenous Metabolite

Spermidine trihydrochloride

Cat.No: T5080

Synonym: Spermidine hydrochloride,4-Azaoctamethylenediamine trihydrochloride,三盐酸亚精胺,亚精胺盐酸盐

Target: NMDAR, Autophagy

Cat.No: T3982

Synonym: 狐衣酸,Vulpic acid,Pulvinic acid methyl ester

Target: Others

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Cat.No: TQ0226

Synonym: 焦地黄苯乙醇甙B1,吉奥诺苷 B1

Target: Others

Methyl 3-hydroxy-4,5-dimethoxybenzoate

Cat.No: TN4530

Synonym: 3,4-Dimethoxy-5-hydroxybenzoic acid methyl ester

Target: Antioxidant, Antibiotic

Vitexin 2''-O-p-coumarate

Cat.No: TN2304

Synonym: Vitexin2''-O-p-coumarate,Vitexin 2''-O-p-coumarate

Target: Others

Hederagenin 28-O-beta-D-glucopyranosyl ester

Cat.No: T3S0208

Synonym: Hederagenin-28-beta-D-glucopyranoside,常春苷元-28-BETA-D-吡喃葡萄糖苷,常春藤皂苷元28-O-beta-D-吡喃葡萄糖酯

Target: Others

2,5-dimethoxycyclohexa-2,5-diene-1,4-dio

Cat.No: TN7087

Synonym: 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone

Target: Others

Cat.No: T7090

Synonym: 焦地黄苯乙醇甙A1,焦地黄苯乙醇苷A1

Target: Others

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Cat.No: TN1461

Synonym: Butin,漆黄素 ( 紫铆素)

Target: Akt, PI3K, Nrf2

Cat.No: T19229

Target: Others

Cat.No: T5S2283

Target: p38 MAPK, Caspase, JNK

11-oxo-mogroside V

Cat.No: T3785

Synonym: 11-oxo Mogroside V,11-氧罗汉果苷

Target: Reactive Oxygen Species

Cat.No: T2854

Synonym: Forsythin,连翘苷

Target: P450, Influenza Virus, AMPK

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Vitexin-2"-O-rhamnoside

Cat.No: T3671

Synonym: 牡荆素鼠李糖苷,牡荆素-2-O-鼠李糖苷,2''-O-Rhamnosylvitexin,Vitexin-2-O-rhaMnoside,Vitexin-2''-O-rhamnoside,Apigenin-8-C-glucoside

Target: Others

Cat.No: T6S2099

Target: Antioxidant, TNF

Cat.No: T6S0525

Target: ERK, p38 MAPK, Akt

Paeonilactone C

Cat.No: TN2037

Synonym: (3S,3AR,6S,7AR)-3-[(苯甲酰基氧基)甲基]四氢-6-羟基-6-甲基-2,5(3H,4H)-苯并呋喃二酮,芍药内苷 C

Target: Others

Randialic acid B

Cat.No: TN4892

Target: Others

(+)-Syringaresinol

Cat.No: TN2249

Target: Sirtuin, Antifection

Inubritannolide A

Cat.No: T82058

Ophiopogonanone E

Cat.No: TN2015

Target: Others

Paeonilactone B

Cat.No: TN2036

Synonym: (+)-Paeonilactone B

Target: NADPH-oxidase

Ophiopogonanone A

Cat.No: TN2013

Target: Others

Dihydroconiferyl alcohol

Cat.No: TN1578

Target: Others

5,7-Dihydroxy-3-(4-hydroxy-3,5-dimethoxybenzyl)-6,8-dimethylchroman-4-one

Cat.No: TN5471

Vitexin2''-O-p-trans-coumarate

Cat.No: T80861

Cat.No: TN3753

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

Scutebarbatine A

Cat.No: TN2191

Target: BCL, Caspase

Kahweol Eicosanate

Cat.No: T27711

Synonym: J002075,J 002075,J-002075

Anhydrosafflor yellow B

Cat.No: TN6924

Synonym: (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB

Target: Others

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