Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂,也是一种促氧化剂,可用于研究缺铁性贫血。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 229 | 现货 | ||
100 mg | ¥ 413 | 现货 | ||
200 mg | ¥ 588 | 现货 | ||
500 mg | ¥ 980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 150 | 现货 |
产品描述 | Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia. |
体外活性 | In vitro conditions iron induces a dose-dependent inhibition of viability of the mesothelial cells as reflected by inhibition of the cells growth by 34% at Fe 0.1 mg mL-1 vs. control (P 0.05) increased release of lactate dehydrogenase (LDH) from the cytosol: 67.1 +/- 30.3 mU mL-1 at Fe 1 mg mL-1 vs. 7.9 +/- 6.4 in control group (P 0.001), and reduced synthesis of IL-6: 209 +/- 378 pg mg-1 cell protein at Fe 1 mg mL-1 vs. 38674 +/- 4146 pg mg-1 cell protein in controls (P 0.001).?Cytotoxicity of iron towards mesothelial cells was enhanced in vitro when it was tested in presence of the dialysis fluid.?Iron used in vitro at concentration 0.0001 mg mL-1 and greater induces generation of oxygen-derived free radicals in mesothelial cells.?Furthermore, iron is taken by these cells and stored in their cytosol, resulting in stimulation of the intracellular generation of free radicals[1]. |
细胞实验 | in vitro experiments on human peritoneal, the mesothelial effect of elemental iron (in conc. 0.0001-1 mg mL-1) present in Venofer on their viability, growth and synthesis of IL-6 was studied. Additionally we evaluated with a fluorescent probe (2',7'-dichlorodihydro-fluorescein diacatate) generation of reactive oxygen species in cells exposed to iron sucrose. We also measured accumulation of iron in the cytoplasm of mesothelial cells after their in vitro exposure to Venofer[1]. |
别名 | Iron saccharate, 蔗糖铁, Sucroferric oxyhydroxide |
分子量 | 736.1 |
分子式 | C18H24Fe2O24 |
CAS No. | 8047-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (135.85 mM)
H2O: 100 mg/mL (135.85 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.3585 mL | 6.7926 mL | 13.5851 mL | 33.9628 mL |
5 mM | 0.2717 mL | 1.3585 mL | 2.717 mL | 6.7926 mL | |
10 mM | 0.1359 mL | 0.6793 mL | 1.3585 mL | 3.3963 mL | |
20 mM | 0.0679 mL | 0.3396 mL | 0.6793 mL | 1.6981 mL | |
50 mM | 0.0272 mL | 0.1359 mL | 0.2717 mL | 0.6793 mL | |
100 mM | 0.0136 mL | 0.0679 mL | 0.1359 mL | 0.3396 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Iron sucrose 8047-67-4 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species H2O2 pregnancy ascorbate IDA Intravenous ICAM-1 inhibit NADPH NF-κB Inhibitor VCAM-1 hemoglobin anemia Iron saccharate iron 蔗糖铁 Sucroferric oxyhydroxide safe inhibitor