117
14
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19840 |
GSK-F1
PI4KA inhibitor-F1 |
PI4K | PI3K/Akt/mTOR signaling |
GSK-F1 (PI4KA inhibitor-F1) 是一种新型强效 PI4KA 抑制剂。 | |||
T67837 |
(3S)-GSK-F1
PI4KA inhibitor-F1 |
PI4K | PI3K/Akt/mTOR signaling |
(3S)-GSK-F1是一种选择性PI4KIIIα抑制剂,pIC50=8.3。 | |||
T83670 |
F1 TFA
Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide |
||
F1是一种抗炎肽,由HIV-1 Tat蛋白质转导域与对应于抑制因子NF-κB激酶-相互作用肽(IKIP)46-60残基的15氨基酸肽链接而成。在5 µM浓度下,F1抑制了小鼠腹腔巨噬细胞中LPS诱导的IκB激酶α(IKKα)和IKKβ的磷酸化以及NF-κB(p65)的核内转移。在体内,F1(5 mg/kg)降低了LPS诱导的脓毒症小鼠模型中IL-6、TNF-α和IL-1β的血清水平,并增加了生存率。 | |||
T126048 |
Coreanoside F1
|
||
Coreanoside F1 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126048,CAS号为 132282-69-0。 | |||
T125155 | Schidigerasaponin F1 | ||
Schidigerasaponin F1 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125155,CAS号为 266998-42-9。 | |||
TP2476 |
Tnrnflrfamide
Thr-asn-arg-asn-phe-leu-arg-phe-NH2,Peptide F(1), lobster,F1 Peptide, lobster,Lobster peptide F1 |
||
Tnrnflrfamide is a SCP (small cardioactive peptide)-like peptide found in lobster neurons; exhibits FMRFamide-like immunoreactivity. | |||
T11254 |
F-1
|
ROS; ALK; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
F-1 是 ALK 和 ROS1 的双重抑制剂,抑制 ALK 的磷酸化及下游通路,可作用于对 ALKWT (IC50:2.1 nM),ROS1WT (IC50:2.3 nM),ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。 | |||
T37919 |
Prostaglandin F1α
PGF1α,Prostaglandin F1α |
||
Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M. [1] PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. [2] It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. [3] | |||
T36162 |
8-iso Prostaglandin F1α
8-iso Prostaglandin F1α |
||
8-iso PGF1α is an isoprostane that was first identified in human semen. It is a member of the isoprostane family, which are eicosanoids of non-cyclooxygenase origin. 8-iso PGF1α is present along with its 19-hydroxy congener at 5-10 μg/ml of seminal plasma. | |||
T36163 |
8-iso Prostaglandin F1β
8-iso Prostaglandin F1β |
||
8-iso PGF1β is a potential autoxidation product of DGLA. There are no published reports on its isolation from any biological source or on its biological activity. | |||
T36772 |
11-deoxy Prostaglandin F1β
11-deoxy Prostaglandin F1β |
||
11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μg/kg. | |||
T37990 |
15-keto Prostaglandin F1α
15-keto Prostaglandin F1α |
||
15-keto PGF1α is the initial metabolite of PGF1α via 15-hydroxy PGDH. In mammals, oxidation of C-15 markedly attenuates receptor binding and activity. In fish, the 15-keto compounds serve as post-ovulatory pheromones and are more active than the parent prostaglandins. | |||
T36771 |
11-deoxy Prostaglandin F1α
11-deoxy Prostaglandin F1α |
||
11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and bronchoconstrictor activities at about half the potency of PGF2α in guinea pigs. | |||
T36148 |
13,14-dihydro-15-keto Prostaglandin F1α
13,14-dihydro-15-keto Prostaglandin F1α |
||
13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach. The measurement of 13,14-dihydro-15-keto PGF1α can be used as a marker of the in vivo production of PGF1α. | |||
T36724 |
6,15-diketo-13,14-dihydro Prostaglandin F1α
6,15-diketo-13,14-dihydro Prostaglandin F1α |
||
6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells. | |||
T83662 |
2,3-dinor-8-iso Prostaglandin F1α
2,3-dinor-8-iso PGF1α,2,3-dinor-iPF1α-III,2,3-dinor-5,6-dihydro-15-F2t-Isoprostane,2,3-dinor-5,6-dihydro-15-F2t-IsoP |
||
2,3-dinor-8-iso Prostaglandin F1α(2,3-dinor-8-iso PGF1α)是一种异前列腺素和花生四烯酸的活性代谢物,也是血小板聚集抑制剂8-iso PGF2α的产物。它通过花生四烯酸的非酶促自由基过氧化作用形成。2,3-dinor-8-iso PGF1α在孤立的猪视网膜和大脑微血管中引起血管收缩(EC50s分别为12.8和18.5 nM),但在31 µM的浓度下使用时不会引起孤立的大鼠主动脉环的收缩。在1 µM的浓度下使用时,它能增加孤立的猪大脑切片中的血栓素B2(TXB2)水平,这一效应可以通过血栓素A合成酶抑制剂CGS 12970、电压门控钙通道抑制剂SKF 96365或烟碱型乙酰胆碱受体(nAChR)拮抗剂α-conotoxin来逆转。 | |||
T13194 |
CSF1R-IN-2
|
c-Fms; c-Met/HGFR; Src | Angiogenesis; Tyrosine Kinase/Adaptors |
CSF1R-IN-2 是一种口服具有活力的、有效的 SRC,MET 和 c-FMS 抑制剂,它们的 IC50 值分别为 0.12 nM,0.14 nM 和 0.76 nM。 | |||
T77745 |
N6F11
|
GPX | oxidation-reduction |
N6F11是一种新型且具有选择性和有效性的铁死亡诱导剂,具有抗癌抗肿瘤活性,通过与癌细胞中的TRIM25结合从而促进GPX4降解。N6F11 可用于研究胰腺癌。 | |||
T10894 |
CSF1R-IN-1
|
c-Fms | Tyrosine Kinase/Adaptors |
CSF1R-IN-1 是一种 CSF1R 抑制剂 (IC50:0.5 nM)。 | |||
T64066 |
CSF1R-IN-3
|
c-Fms; CSF-1R | Tyrosine Kinase/Adaptors |
CSF1R-IN-3是一种口服有效的 CSF-1R 抑制剂,IC50值为2.1nM。CSF1R-IN-3对结直肠癌细胞具有抗增殖活性。CSF1R-IN-3 通过抑制巨噬细胞的迁移,诱导 M2 型巨噬细胞重新编程为 M1 型巨噬细胞,从而表现出抗肿瘤作用和提高免疫力的作用,展现对结直肠癌细胞的活性。 | |||
T13324 |
VUF11207 fumarate
|
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体,pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化,pEC50分别为 8.8 和 7.9。 | |||
T77767L1 |
GLF16 HCl
|
Others | Others |
GLF16 HCl 是一种荧光团偶联的苏丹黑 B 类似物,可通过通过荧光显微镜和流式细胞术快速检测、分离和实时跟踪衰老细胞。 | |||
T61112 |
SLF1081851
|
LPL Receptor | GPCR/G Protein |
SLF1081851 是一种 Spns2 抑制剂,抑制 S1P 释放 (IC50=1.93 μM)。SLF1081851 在发育和免疫系统中起关键作用。 | |||
T6667 |
SF1670
PTP CD45 Inhibitor,PTPase CD45 Inhibitor |
Phosphatase; PTEN; Autophagy | Autophagy; Metabolism; PI3K/Akt/mTOR signaling |
SF1670 (PTPase CD45 Inhibitor) 是一种特异性 PTEN 抑制剂,IC50 为 2 μM。 | |||
T15266 |
F16
(E)-4-(3-indolylvinyl)-N-methylpyridinium iodide |
Others | Others |
F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide)抑制neu-overeigning 细胞的生长和乳腺上皮的增殖。 | |||
T60026 |
KIF18A-IN-2
|
Microtubule Associated | Cytoskeletal Signaling |
KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂,IC50 为 28 nM,可用于染色体不稳定性相关漏洞的研究。 | |||
T4308 |
F1063-0967
|
Phosphatase | Metabolism |
F1063-0967 是双特异性磷酸酶 26 抑制剂,其IC50=11.62 μM。 | |||
T16904 |
Smurf1-IN-A01
A01 |
Others | Others |
Smurf1-IN-A01 (A01) 是泛素连接酶 Smad 泛素化调节因子-1(Smurf1)抑制剂,其kd=3.664 nM。它能够抑制 Smurf1 介导的 Smad1/5 降解,并提高 BMP-2 的反应性。 | |||
T22774L |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA)
|
Others | Others |
eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物,负责将氨酰 tRNA 酶促递送至核糖体。这种亚型(α 1)在脑、胎盘、肺、肝、肾和胰腺中表达,另一种亚型(α 2)在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝,其中一些(如果不是全部)代表不同的假基因。 | |||
T12125 |
MuRF1-IN-1
|
Others | Others |
MuRF1-IN-1 是MuRF1抑制剂,能减少心脏恶病质中的骨骼肌萎缩和功能障碍。 | |||
T15409 |
GNF179
|
Parasite | Microbiology/Virology |
GNF179 是8,8-二甲基 IP 类似物。 它表现出对多药耐药菌株 W2 的效力,具有良好的体外代谢稳定性和体内口服生物相容性。 | |||
T9890 |
HIF1-IN-3
Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- |
HIF | Angiogenesis; Chromatin/Epigenetic |
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) 是HIF-1的有效抑制剂(EC50 = 0.9 μM),可用于抗癌的研究。 | |||
T4125 |
HSF1A
|
HSP | Cytoskeletal Signaling; Metabolism |
HSF1A 是一种可渗透细胞的 HSF1 激活剂,可保护哺乳动物细胞免受应激诱导的细胞凋亡。它还是 TRiC/CCT 的特异性抑制剂。 | |||
T3963 |
VUF10460
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
VUF10460 是一种非咪唑组胺 H4 受体激动剂,与大鼠H4受体结合的pKi 值为7.46。 | |||
T24949 |
VUF10132
VUF-10132,VUF 10132 |
||
VUF10132 is a full inverse CXCR3 N3.35A agonist. | |||
T40232 |
KIF18A-IN-1
KIF18A-IN-1 |
||
KIF18A-IN-1 is a potent inhibitor of the mitotic kinesin KIF18A. This compound demonstrates significant anti-tumor properties. | |||
T26785 |
BFF122
BFF 122,BF5,BFF-122 |
||
BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II). | |||
T70872 | Smurf1 inhibitor 1 | ||
Smurf1 inhibitor 1 is a inhibitor that promotes bone formation. | |||
T62318 | CSF1R-IN-9 | ||
CSF1R-IN-9 (Compound 46) 是一种 CSF-1R 抑制剂 (IC50: 0.028 μM)。 | |||
T74271 | TRIM24/BRPF1-IN-2 | ||
TRIM24/BRPF1-IN-2 (compound 20l) 是一种有效的 TRIM24/BRPF1双重抑制剂,IC50值分别为 0.98 和 1.16 μM。 TRIM24/BRPF1-IN-2 显示出 TRIM24/BRPF1 溴结构域结合亲和力。 TRIM24/BRPF1-IN-2 可用于前列腺癌研究。 | |||
TP1268 |
CEF19, Epstein-Barr Virus latent NA-3A (458-466)
CEF19,Epstein-Barr Virus latent NA-3A 458-466 |
||
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). | |||
T15661 |
Kif15-IN-1
|
Others | Others |
Kif15-IN-1, a mitotic Kinesin family member 15 (Kif15) inhibitor, is utilized in the study of cellular proliferative diseases. | |||
TP2402 |
Peptide VF13N
Epitope VF13N |
||
Peptide VF13N is a synthetic rabies virus glycoprotein T helper cell epitope. | |||
T77932 |
PF15 TFA
|
PROTACs | PROTAC |
PF15 TFA是一种连接FLT3 kinase配体和CRBN配体的PROTAC,作为FLT3-ITD的高选择性降解剂,DC50值为76.7 nM。该化合物可显著抑制FLT3-ITD阳性细胞增殖,并降低FLT3和STAT5磷酸化水平。PF15 TFA亦能抑制小鼠模型的肿瘤生长,并可用于白血病研究。 | |||
T70403 |
VUF14480
|
||
VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH₄ receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction. | |||
T62364 |
CSF1R-IN-5
|
||
CSF1R-IN-5 是一种 CSF1R 的有效抑制剂。其中 CSF-1R 表达于巨噬细胞中,巨噬细胞的存活和分化依赖于 CSF-1/CSF-1R 信号通路。CSF1R-IN-5 可以影响 TAM 和胶质瘤细胞之间炎症因子的交换。CSF1R-IN-5 具有潜力进行癌症疾病的研究。 | |||
T74336 |
YF135
|
||
YF135为一种效能高的KRASG12CPROTAC,能可逆地促使共价结合。该化合物采用KRAS G12C inhibitor 48(compound 6d)作为配体,并以MRTX849搭配VHL配体作为框架进行设计与合成。通过E3连接酶VHL介导的蛋白酶体途径,YF135显著诱导KRASG12C的降解并可逆地降低ERK磷酸化水平。 | |||
T28790 |
SKF1
|
||
SKF1 is a suppressor of the ability of FK506. SKF1 inhibits cell growth in the presence of high levels of NaCl, induces cell death in low salt conditions, interacts directly with yeast mitochodria. | |||
T76245L |
CKLF1-C27 TFA
|
||
CKLF1-C27 是 CKLF1 的 C 末端肽,与 CCR4受体结合并激活 ERK1/2通路。CKLF1-C27 可以通过竞争 CCR4受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进 HUVECs 增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。 | |||
T61554 | CSF1R-IN-13 | ||
CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3401 |
Ginsenoside F1
人参皂苷 F1,20(S)-Ginsenoside F1 |
P450; Endogenous Metabolite | Metabolism |
Ginsenoside F1 (20(S)-Ginsenoside F1) 是一种 Ginsenoside Rg1 的酶促修饰衍生物,它竞争性抑制CYP3A4,对 CYP2D6 具有较弱的抑制作用。 | |||
TN1942 |
Momordicoside F1
苦瓜皂苷 F1 |
Others | Others |
Momordicoside F1 may have antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines. | |||
TN1989 |
Niga-ichigoside F1
苦莓苷F1 |
Others; Nrf2 | Immunology/Inflammation; Others |
Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects. | |||
TN4161 |
Goshonoside F1
|
||
Goshonoside F1是半糯米品种水稻的脂质代谢产物,可被当作培育优良水稻的一个指标。 | |||
TN1080 |
Kaji-ichigoside F1
蔷薇苷 |
||
Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite | |||
TN6448 |
3-Acetyl-ginsenoside F1
|
||
3-Acetyl-ginsenoside F1 可用于生命科学领域的相关研究,其产品编号为 TN6448。 | |||
T81853 |
Marstenacisside F1
|
||
Marstenacisside F1(化合物1)为从通关藤(Marsdenia tenacissima)分离的抗炎聚氧孕烷苷,能抑制脂多糖激活的RAW 264.7细胞产生一氧化氮(NO),属Tenacigenin B衍生物。 | |||
TN2242 |
Suavissimoside R1
甜叶苷R1,Suavissimoside F1 |
Others | Others |
Suavissimoside F1 is a natural product | |||
T3920 |
Pseudoginsenoside F11
Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11 |
Others; Endogenous Metabolite | Metabolism; Others |
Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。 | |||
TN4049 |
F1839-I
|
Others | Others |
F1839-I is a natural product from Stachybotrys sp. | |||
T19328 |
Fructo-oligosaccharide DP11/GF10
|
Others | Others |
Fructo-oligosaccharide DP11/GF10 is a fructooligosaccharide (FOS) compound with a degree of polymerization (DP) equal to 11. FOS consists of 10 fructose units connected by (2→1)-β-glycosidic bonds, with a single D-glucosyl unit present at the non-reducing end. | |||
T19329 |
Fructo-oligosaccharide DP12/GF11
蔗果十二糖 |
Others | Others |
Fructo-oligosaccharide DP12/GF11 is a member of fructooligosaccharides (FOS) characterized by a degree of polymerization (DP) of 12. FOS compounds consist of 11 fructose units connected by (2→1)-β-glycosidic bonds, with a lone D-glucosyl unit located at the non-reducing end. | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T13123 |
Tentoxin
|
Endogenous Metabolite | Metabolism |
Tentoxin 是一种由植物致病真菌产生的环状肽,在敏感植物中,当其浓度在纳摩尔到微摩尔之间时,会使 F1马达失活,而更高的浓度会超过该酶的天然活性 |