88
40
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1106L |
α-Factor Mating Pheromone, yeast acetate
Mating Factor α acetate,α-Factor Mating Pheromone, yeast acetate(59401-28-4 free base) |
Others | Others |
α-Factor Mating Pheromone, yeast acetate (Mating Factor α acetate)(59401-28-4 free base) 是由酿酒酵母α细胞分泌的13个氨基酸的肽。 | |||
TP1105 |
α-Factor Mating Pheromone, yeast (TFA)
α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA) |
||
The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle. Alpha Factor Mating Pheromone induces the expression of mating genes, changes in nuclear architecture, and polarzes growth toward the mating partner. | |||
TP1106 |
α-Factor Mating Pheromone, yeast
Mating Factor α |
||
Alpha factor mating pheromone is a peptide of 13 amino acids secreted by Saccharomyces cerevisiae α cells. | |||
T9423 |
Alkyne tyramide
|
Others | Others |
Alkyne tyramide 是抗坏血酸过氧化物酶 2 探针。它有助于鉴定 APEX 标记位点,明确线粒体蛋白的膜拓扑的分配。它显著提高了完整酵母细胞的 APEX 标记效率,比 APEX2 底物生物素苯酚具有更大的细胞壁渗透性。 | |||
T19833 |
5-Fluoroorotic acid
|
DNA/RNA Synthesis; Antifungal | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
5-Fluoroorotic 是一种胸苷酸合成酶的抑制剂,是酵母分子遗传学中的一种选择性试剂。它具有与 5-fluorocytosine 相近的良好表达的抗念珠菌作用,以及适度的抗皮肤真菌作用。 | |||
T8536 |
Filastatin
|
Antifungal | Microbiology/Virology |
Filastatin 是一种长效的白色念珠菌丝状体抑制剂,具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附,从酵母到菌丝的形态转变,抑制菌丝特异性 HWP1 启动子。 | |||
T27617 |
Inz-1
|
P450 | Metabolism |
Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂,对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。 | |||
T40661 |
ML-60218
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
ML-60218 是广谱 RNA pol III 抑制剂,对酿酒酵母和人类的 IC50 分别为 32 和 27 μM。 ML-60218 会破坏已组装的病毒质并阻碍新病毒质的形成。 | |||
T2352 |
AMI-1
|
Histone Methyltransferase | Chromatin/Epigenetic |
AMI1 是一种有效的、可逆的、细胞渗透性的蛋白精氨酸 N-甲基转移酶 (PRMTs) 抑制剂,对人 PRMT1 和酵母 Hmt1p 作用的 IC50值分别为 8.8 和 3.0 μM。它通过阻断肽-底物结合对 PRMTs 发挥抑制作用。 | |||
T10797 |
Chlormidazole hydrochloride
Clomidazole hydrochloride |
Antifungal | Microbiology/Virology |
Chlormidazole hydrochloride (Clomidazole hydrochloride) 是一种抗真菌剂,抑制多种真菌和部分革兰氏阳性球菌,可治疗指甲和皮肤的真菌和细菌感染。 | |||
T8703 |
yGsy2p-IN-1
|
Others | Others |
yGsy2p-IN-1 是酵母糖原合酶 2 抑制剂。它是竞争性人类糖原合酶 1 抑制剂(IC50:2.75 µM),对野生型 hGYS1 的Ki=为 1.31 µM。它是吡唑抑制剂,可用于糖原储存疾病的研究。 | |||
T2028 |
NG 52
NG52,NG-52,Compound 52 |
CDK | Cell Cycle/Checkpoint |
NG 52 (NG-52) 是可逆和 ATP 相容性且具有口服活性的Cdc28p 和Pho85p 激酶抑制剂,IC50分别为 7 μM 和 2 μM。它还抑制磷酸甘油酸激酶 1 的活性,IC50值为 2.5 μM。 | |||
T75163 |
GW297361
|
VEGFR; CDK; Src | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
GW297361 是一种有效的依赖细胞周期蛋白的激酶 Cdk1 抑制剂,对 Pho85 信号通路也具有抑制作用。GW297361对酵母 Cdk1 和 Pho85 的 IC50 分别为 20 nM 和 400 nM。 | |||
T1820 |
CK-636
CK-0944636,CK 636 |
Microtubule Associated | Cytoskeletal Signaling |
CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的IC50值分别为4、24 和 32 μM。 | |||
T3349 |
Tavaborole
Kerydin,AN-2690,他伐硼罗 |
Antibiotic; Antifungal | Microbiology/Virology |
Tavaborole (Kerydin) 是一种抗真菌剂,能抵抗毛癣菌属,起抗甲真菌病作用。 | |||
T25982 |
Pramiconazole
R-126638,R126638,R 126638,Azoline |
Antifungal | Microbiology/Virology |
Pramiconazole (R126638) 是一种可口服的抗真菌化合物。Pramiconazole 是治疗皮肤癣菌和皮肤酵母菌感染的候选化合物,可用于治疗脂溢性皮炎。 | |||
T9602 | Monocaprin | Anti-infection; Antibacterial | Microbiology/Virology |
Monocaprin 是癸酸的 1-单甘油酯,对包膜病毒、某些细菌和酵母白色念珠菌具有抗菌活性。 | |||
T37683 |
3-Hydroxykynurenine
3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine |
Others | Others |
3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) 是色氨酸的活性代谢物,可抑制酵母和大鼠肝脏醛脱氢酶 97% 和 69%。 | |||
T19825 |
X-alpha-Gal
|
Others | Others |
X-alpha-Gal 是 α-半乳糖苷酶的底物。它用于区分酵母的α-半乳糖苷酶阳性菌株。 | |||
T21872 |
CCT018159
|
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
CCT018159 是一种 3,4-二芳基吡唑间苯二酚,是一种 ATP 竞争性HSP90ATPase 抑制剂,对人 Hsp90β 和酵母 Hsp90 具有抑制作用,IC50分别为 3.2 和 6.6 μM。CCT018159 抑制与侵袭和血管生成有关的关键内皮细胞和肿瘤细胞功能。CCT018159 引起与 G1 期阻滞相关的细胞抑制并诱导细胞凋亡。 | |||
T6110 |
YM-201636
|
Influenza Virus; PI3K; Autophagy | Autophagy; Microbiology/Virology; PI3K/Akt/mTOR signaling |
YM201636 是是一种特异性 PIKfyve 抑制剂,IC50值为 33 nM,对 p110α的IC50为 3.3 μM。它还可抑制逆转录病毒复制。 | |||
T38140 |
Phosphatidylethanolamine from bovine
|
||
Phosphatidylethanolamines (bovine) 是从牛脑中分离出来的一种磷脂酰乙醇胺混合物,在 sn-1 和 sn-2 位置上带有不同的脂肪酰基。Phosphatidylethanolamines (bovine) 是在原核生物、哺乳动物、植物和酵母细胞膜中含量均很高的磷脂,约占哺乳动物磷脂总量的 25%。 | |||
T4478 |
CID 16020046
C390-0219 |
Cannabinoid Receptor | GPCR/G Protein |
CID 16020046 (C390-0219) 是一种选择性 GPR55 拮抗剂,在酵母中抑制 GPR55 组成型活性,IC50 为 0.15 μM。它抑制 GPR55 介导的 Ca2+信号传导和 GPR55 介导的 ERK1/2 磷酸化,可降低内皮细胞的伤口愈合,参与血小板功能的调节。 | |||
T68166 |
Traxanox
|
Others | Others |
Traxanox 是一种可口服的利尿剂。Traxanox 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox 对抑制BALB/c小鼠抗体产生的恢复作用。 | |||
T38376 |
2-O-(α-D-Glucopyranosyl)glycerol
2-alphaGG |
Others | Others |
2-O-(α-D-Glucopyranosyl)glycerol (2-alphaGG) 存在于少数细菌和生长在恶劣环境中的植物中,可通过增加渗透压反应来延长出芽酵母的寿命和红孢子虫的寿命。 | |||
T77245 |
Mannan
|
Endogenous Metabolite | Metabolism |
Mannan 是从藻类、蘑菇、酵母和高等植物中分离出的,可作为免疫调节剂。Mannan 抑制肝脏巨噬细胞(M1谱系)的促炎活性对许多肝脏病变(例如坏死或脂肪变性)具有保护作用。 | |||
T9897 |
7-Methoxy-1-naphthaleneacetic acid
|
Others | Others |
7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。 | |||
T68166L |
Traxanox TFA
Traxanox TFA(58712-69-9 Free base) |
Others | Others |
Traxanox TFA 是一种可口服的利尿剂。Traxanox TFA 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox TFA 对抑制BALB/c小鼠抗体产生的恢复作用。 | |||
T37185 |
D-(-)-3-Phosphoglyceric acid disodium
3-Phospho-D-glyceric acid disodium |
Others | Others |
D-(-)-3-Phosphoglyceric acid disodium (3-Phospho-D-glyceric acid disodium) 是糖酵解、糖原合成以及丝氨酸、甘氨酸、苏氨酸生物合成等过程中的重要中间体,竞争性抑制酵母烯醇化酶 (enolase)。作为中间体它还在植物、真核细胞以及原核细胞许多的生物合成信号通路中发挥许多作用。 | |||
T38272 |
Thiacloprid
|
AChR; Parasite | Microbiology/Virology; Neuroscience |
Thiacloprid 属于氯烟碱类杀虫剂,主要用于防治蔬菜和果园中的蚜虫。它会破坏 DNA 的稳定性,通过疏水或氢相互作用,结合到小沟槽中,改变 DNA 的结构和稳定性。 | |||
T10007 |
1,4-Chrysenequinone
Chrysene-1,4-dione,1,4-屈醌 |
AhR | Immunology/Inflammation; Metabolism |
1,4-Chrysenequinone (Chrysene-1,4-dione) 是多环芳香烃类,是芳烃受体 (AhR) 的激活剂 | |||
T26385 |
41F5
41F 5,41F-5 |
||
41F5 is anti-fugal agent. 41F5 is highly active against Histoplasma yeast (MIC50 0.4-0.8 μM). 41F5 has fungistatic activity against Histoplasma yeast with a 50% inhibitory concentration (IC50) of 0.87 μM, and has the greatest selectivity for yeast (at lea | |||
T33454 |
ML407
ML-407,ML 407 |
||
ML407 is a cryptococcus yeast cell apoptosis inducer. | |||
T16912 |
Sortin1
|
Others | Others |
Sortin1, a chemical genetic-hit compound, specifically induces mislocalization of both soluble and membrane-associated vacuolar markers in plants and yeast. | |||
T12258 |
NSC 601980 (analog)
|
Others | Others |
NSC 601980 analog is the analog of the NSC601980 which shows antitumor activity in the yeast screening experiment. | |||
T71437 |
M&B 39279
|
||
M&B 39279 is a potent inhibitor of plant, yeast and mouse protoporphyrinogen oxidase. | |||
T20693 |
Oxiconazole
Oxiconazolum,Ro13-8996,Ro 13-8996,Ro-13-8996 |
||
Oxiconazole, an antifungal medicine, is used to treat certain kinds of yeast or fungal infections of the skin. | |||
T31552 |
DMNP-EDTA
DMNPEDTA,DM-Nitrophen,DM Nitrophen,DMNP EDTA |
||
DMNP-EDTA is a caged Ca2+ chelator which photouncages Cu2+ ions for light-controlled gene expression in yeast. | |||
T26314 | Valyl-ochratoxin A | ||
Valyl-ochratoxin A is a phenylalanyl moiety of ochratoxin A replaced by valine. It is a yeast valyl-tRNA synthetase inhibitor. | |||
T40432 |
Mezerein
|
||
Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC 50 = 141 nM). However, it does not inhibit the growth of yeast expressing PKC. | |||
T39323 |
Temporin L
|
||
Temporin L, a potent antimicrobial peptide, exhibits activity against Gram-negative bacteria and yeast strains, as well as demonstrating antiendotoxin properties. | |||
T34194 | Puntarenine | ||
Puntarenine is an alkaloid of the isohomoprotoberberine family that has shown marginal activity against the dermatophytic fungus Trichophyton mentagrophytes and the yeast Saccharomyces cerevisiae. | |||
T72014 | BZL-HIS-OME 2HCL | ||
BZL-HIS-OME 2HCL is the dihydrochloride salt of BZL-HIS-OME, a sweet almond and yeast β-glucosidase inhibitor. | |||
T29465 |
5-Oxodecanoic acid
5-Ketocapric acid,5-Oxocapric acid |
||
5-Oxodecanoic acid is a biochemical. 5-Oxodecanoic acid can be reducced to 5-hydroxydecanoic acid by intact cells of baker's yeast. | |||
T31711 |
Ethyl L-leucinate HCl
Ethyl L-leucinate hydrochloride,AI3-28816 |
||
Ethyl L-leucinate HCl has been used as a hypertrophic agent to monitor its effects on myotubes and has also been used as a component of PMG media for culturing yeast. | |||
T28790 |
SKF1
|
||
SKF1 is a suppressor of the ability of FK506. SKF1 inhibits cell growth in the presence of high levels of NaCl, induces cell death in low salt conditions, interacts directly with yeast mitochodria. | |||
T76105 | Alcohol oxidase | ||
Alcohol oxidase 是甲醇利用途径的功能酶,能够从酵母的过氧化物酶体中分离得到。 | |||
T32655 |
l-Ergothionine hydrochloride
l-Ergothionine HCl |
||
l-Ergothionine hydrochloride is a sulfur-containing amino acid, which is only produced by Actinomycetales bacteria and non-yeast-like fungi belonging to the division Basidiomycota and Ascomycota. It was originally isolated from Claviceps purpurea or rye e | |||
T70274 | FR171456 | ||
FR171456 is a natural specific inhibitor of mammalian nsdhl and yeast erg26p, inhibiting an artificial hepatitis c viral replicon, and showung broad antifungal activity | |||
T34324 |
Ribulose, L-
L-Adonose,L-Ribulose,L-Erythro-pentulose,L-erythro-2-Pentulose |
||
Ribulose is an important metabolite in pentose interconversions. Ribulose is useful for analyzing L-ribose isomerase, engineering yeast for xylose metabolism, interesting chiral pool compound. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78500 |
α-Factor Mating Pheromone, yeast TFA
Mating Factor α TFA |
||
α-Factor Mating Pheromone, yeast (TFA)为一来自S. cerevisiae的α细胞分泌的十三肽,通过Ste2p受体发挥作用。 | |||
T7846 |
Aegeline
|
Others; Antifungal | Microbiology/Virology; Others |
Aegeline 是从 Aegle marmelos 的叶子中分离出来的一种生物碱酰胺,有抗高血糖和抗血脂异常的活性。 | |||
T4S1820 |
Parishin
巴利森苷A,派立辛,Parishin A |
Others | Others |
Parishin (Parishin A) A 是一种酚类葡萄糖苷,从天麻中分离得到。Parishin 通过调节 Sir2/Uth1/TOR 信号通路而具有抗衰老作用,并延长酵母寿命。 | |||
TN3748 |
D-Asparagine
D-天冬酰胺,H-D-Asn-OH |
Others; Endogenous Metabolite | Metabolism; Others |
D-Asparagine (H-D-Asn-OH) 是酵母菌株的氮源。 D-Asparagine 是 L-Asparagine 水解的竞争性抑制剂 (Ki = 0.24 mM)。 | |||
T0146 |
Tioconazole
UK-20349,Vagistat,噻康唑 |
Antibiotic; Antifection; Antifungal | Microbiology/Virology |
Tioconazole (Vagistat) 是一种广谱性的抗真菌咪唑衍生物。它抑制几种皮肤真菌和几种酵母菌的 MIC50分别小于 3.12 mg/L 和 9 mg/L。 | |||
T19808 |
5-Bromo-5-nitro-1,3-dioxane
Bronidox,5-溴-5-硝基-1,3-二噁烷,5-溴-5-硝基-1,3-二恶烷 |
Others; Antibacterial; Antifungal | Microbiology/Virology; Others |
5-Bromo-5-nitro-1,3-dioxane (Bronidox) 是一种抗菌化合物,可通过必需蛋白硫醇的氧化抑制酶活性并随后抑制微生物的生长。它有抗革兰氏阳性和革兰氏阴性细菌,以及抗真菌活性。 | |||
TN6826 |
D-Xylose
(2S,3R,4S,5R)-oxane-2,3,4,5-tetrol |
||
D-Xylose ((2S,3R,4S,5R)-oxane-2,3,4,5-tetrol)是一种广泛存在于酵母菌中的单糖,参与生物体的代谢。 | |||
TN6736 |
Dihydrolanosterol
24,25-Dihydrolanosterol,Lanostenol,二氢羊毛甾醇 |
Others | Others |
Dihydrolanosterol (24,25-Dihydrolanosterol) 是一种 CYP51 的底物,能够阻碍胆固醇的合成。 | |||
T8260 |
4',5-Dihydroxyflavone
|
Lipoxygenase; Glucosidase | Metabolism |
4',5-Dihydroxyflavone 是大豆 LOX-1,Ki=102.6 μM。它也是一种酵母 α-葡萄糖苷酶抑制剂,IC50=66 μM。 | |||
T2S0300 |
Dihydrocoumarin
二氢香豆素,Chroman-2-one,Hydrocoumarin,melilotin,2-chromanone,3,4-dihydrocoumarin,二氢香豆素;氢化肉桂酸内酯、1,2-苯并二氢吡喃酮、二氢色满酮、二羟基香豆素;苯并二氢吡喃酮;二氢香豆酯、二氢香兰素 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Dihydrocoumarin (melilotin) 是在草木犀中发现的一种天然产物。它是酵母 Sir2p 抑制剂,还抑制人 SIRT1和SIRT2,IC50分别为 208 和 295 μM。 | |||
T0588 |
D-(-)-Arabinose
D-阿拉伯糖,D(-)-Arabinose,D-arabinose |
Others | Others |
D-(-)-Arabinose 是一种单糖,对秀丽隐杆线虫有较强的生长抑制作用(IC50:7.5 mM)。 | |||
T3S2072 |
3-Butylidenephthalide
Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞;丁烯基酞内酯 |
Parasite; Glucosidase | Metabolism; Microbiology/Virology |
3-Butylidenephthalide (Butylidene phthalide) 是从 Ligusticum chuanxiongHort 鉴定出的一种邻苯二甲酸酐衍生物,有杀虫活性。 | |||
T1678 |
Nystatin
Stamycin,Fungicidin,制霉菌素,Nystavescent |
Apoptosis; Antibiotic; Antifungal | Apoptosis; Microbiology/Virology |
Nystatin (Fungicidin) 是一种口服对酵母和支原体有效的多烯类抗真菌抗生素。它能增加质膜对包括氯离子等小单价离子的通透性。它可部分阻止 Oxaliplatin 诱导的脂筏聚集、DR4 和 DR5 聚集的胆固醇隔离试剂,减少细胞凋亡。 | |||
T4852 |
Trimyristin
Trimyristoylglycerol,Tritetradecanoin,三肉豆蔻酸甘油酯,Glyceryl trimyristate,甘油三肉豆蔻酸酯,1,2,3-Tritetradecanoylglycerol |
Phosphatase; Endogenous Metabolite; AChE | Metabolism; Neuroscience |
Trimyristin (Tritetradecanoin) 是一种 Myristica fragransHoutt 的有效成分,能够显著抑制乙酰胆碱酯酶 (AChE),酸性和碱性磷酸酶 (ACP/ALP) 特性。它对 AChE,ACP 和 ALP 的 IC50分别为 0.11、0.16 和 0.18 mM。 | |||
T5278 |
5-Hydroxymethyl-2-furancarboxylic acid
Sumiki's acid,5-羟甲基-2-呋喃甲酸,5-(Hydroxymethyl)-2-furoic acid |
Others; Endogenous Metabolite | Metabolism; Others |
5-Hydroxymethyl-2-furancarboxylic acid (5-(Hydroxymethyl)-2-furoic acid) 是一种人内源性代谢物,主要由 5-羟甲基-2-糠醛代谢产生,并在肾脏中被消除。 | |||
T4882 |
Arabinose
DL-阿拉伯糖,DL-Arabinose,阿拉伯糖 |
Others; Endogenous Metabolite | Metabolism; Others |
Arabinose (DL-Arabinose),也被称为(+/-)-阿拉伯糖或芦荟糖。Arabinose 主要在粪便中检测到。在细胞内,Arabinose 主要位于细胞质中。Arabinose 存在于从酵母到人类的所有真核生物中。 | |||
T4728 |
4-Acetamidobutanoic acid
N-acetyl GABA,4-ACETAMIDOBUTYRIC ACID,4-乙酰氨基丁酸 |
GABA Receptor; Endogenous Metabolite; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
4-Acetamidobutanoic acid (4-ACETAMIDOBUTYRIC ACID) 可在血液、粪便和尿液以及人体前列腺组织中找到,也存在于从酵母到人类的所有真核生物中。它是GABA 衍生物,具有抗氧化和抗菌活性。 | |||
T4010 |
Juglone
5-羟基对萘醌,5-Hydroxy-1,4-naphthoquinone,胡桃酮,Regianin |
DNA/RNA Synthesis; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Juglone (Regianin) 是一种从黑胡桃Juglans regia 中发现的黄色染料,有抗菌作用。 | |||
T6717 |
Vanillin
Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107 |
Others; Endogenous Metabolite | Metabolism; Others |
Vanillin (Zimco) 是一种天然产物,是从香草豆中提取的单个分子,是香水,食品和药物中广泛使用的气味。 | |||
TN2326 |
(Z)-Butylidenephthalide
(Z)-3-Butylidenephthalide |
Glucosidase | Metabolism |
(Z)-Butylidenephthalide ((Z)-3-Butylidenephthalide) 具有抗肿瘤和降血糖作用,能有效抑制胶质瘤的肿瘤生长,抑制 R-葡萄糖苷酶活性。 | |||
T5075 |
Phytic acid potassium
植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Phytic acid potassium (Inositol polyphosphate dipotassium salt) 是内源性代谢产物的一种。 | |||
T4837 |
Itaconic acid
methylene-butanedioicaci,衣康酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Itaconic acid (methylene-butanedioicaci) 是聚合物,化学物质和燃料的合成前体。Itaconic acid 可由真菌合成。它也是巨噬细胞特异性代谢产物。它介导巨噬细胞代谢和腹膜肿瘤之间的串扰。 | |||
T4880 |
L-Dihydroorotic acid
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Others; Endogenous Metabolite | Metabolism; Others |
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。 | |||
T36914 |
2-Hydroxyanthraquinone
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Others | Others |
2-Hydroxyanthraquinone 是一种天然产物,显示出抗肿瘤和免疫抑制活性。 | |||
T8274 |
3-Methyl-L-histidine
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Endogenous Metabolite | Metabolism |
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。 | |||
T8098 |
γ-Hexalactone
γ-caprolactone,gamma-己内酯,γ-己内酯 |
Others | Others |
γ-Hexalactone (γ-caprolactone) 是一种存在成熟水果中的 gamma 内酯。它会导致 DNA 损伤,可用作对氧磷酶 1 的底物 (PON1)。 | |||
T4707 |
3-Hydroxyanthranilic acid
3-HYDROXY-2-AMINOBENZOIC ACID,3-羟基-2-氨基苯甲酸 |
Others; Endogenous Metabolite | Metabolism; Others |
3-Hydroxyanthranilic acid (3-HYDROXY-2-AMINOBENZOIC ACID) 是犬尿氨酸途径中的色氨酸代谢物。它已在人类表皮和膀胱组织中发现,并且在多种生物体液中也已检测到,例如尿液和血液。在细胞内,它主要位于细胞质中。 它存在于从酵母到人类的所有真核生物中。 | |||
TN5192 |
Tuberosin
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NOS; Glucokinase | Immunology/Inflammation; Metabolism |
Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner. | |||
TN3450 |
Artanin
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Antifection | Microbiology/Virology |
Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml. | |||
TN3431 | Apigenin 5-O-beta-D-glucopyranoside | Others | Others |
Apigenin 5-O-beta-D-glucopyranoside has inhibitory activity against the enzyme yeast a-glucosidase, withthe IC50 value of 287.12 muM. | |||
T40600 | Iturin A | ||
Iturin A is a chemical compound with potent antifungal properties against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell, leading to the formation of ion conducting pores. | |||
TN5072 |
Strictosidine
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Others | Others |
Strictosidine has DNA damaging activity in yeast RS 188N mutant, assessed as drug level required to produce 12 mm zone of inhibition. | |||
TN3921 | Effusanin B | Antifection | Microbiology/Virology |
Effusanin B shows antibacterial activity. It exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains. | |||
T72459 | 3-Oxo-hop-22(29)-ene | ||
3-Oxo-hop-22(29)-ene 是一种yeast α-glucosidase 抑制剂。3-Oxo-hop-22(29)-ene 具有中等的抗克氏锥虫和抗墨西哥利什曼原虫活性。3-Oxo-hop-22(29)-ene 具有微弱的抗炎活性。 | |||
TN3719 |
Cristacarpin
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p38 MAPK; ROS; CDK; Antifection; p53 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s | |||
TN3920 |
Effusanin A
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Raf; Antifection | MAPK; Microbiology/Virology |
Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。 它具有 DNA 损伤和抗菌作用。 | |||
T75967 | Bactenecin TFA | ||
Bactenecin TFA (Bactenecin, bovine TFA) 是一种从牛嗜中性粒细胞中分离出来的有效的含 12 个氨基酸的环状抗菌肽。Bactenecin TFA 抑制细菌和酵母菌 (bacteria 和 yeast) 的生长,并能杀死真菌红毛癣菌 (fungusTrichophyton rubrum)。Bactenecin TFA 增加了膜的通透性,抑制了假苹果芽孢杆菌 (B. pseudomallei) 的生长和生物膜的形成。 | |||
T38104 |
Deoxyfusapyrone
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Deoxyfusapyrone is an α-pyrone fungal metabolite originally isolated from F. semitectum and has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses (MICs = 1.56-6.25 μg/ml). Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium, in a disc assay. | |||
T79931 |
Mutanocyclin
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Mutanocyclin 作为一种效能显著的抗真菌剂,能够抑制白色念珠菌 (C. albicans) 的丝状形成,并下调 HWP1、ECE1、FLO8、TEC1 基因的 mRNA 表达水平。此外,Mutanocyclin 在体外小鼠模型中亦能有效抑制酵母形态的发展。 | |||
T75576 | Solidagonic acid | ||
Solidagonic acid 通过促进异常单极纺锤体向双极纺锤体的转变来抑制 HSET 运动活动。Solidagonic acid 抑制裂殖酵母细胞死亡,并使有丝分裂纺锤体从单极形态逆转为双极形态。Solidagonic acid 对 Lactuca sativaL. 和 Lolium multiflorumLam 的幼苗具有生长抑制活性。 |