Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 289 | 现货 | ||
100 mg | ¥ 413 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | L-Dihydroorotic acid, also known as (S)-4,5-dihydroorotate or dihydro-L-orotate, belongs to the class of organic compounds known as alpha amino acids and derivatives. Within the cell, L-dihydroorotic acid is primarily located in the cytoplasm and mitochondria. L-Dihydroorotic acid exists in all eukaryotes, ranging from yeast to humans. L-Dihydroorotic acid participates in a number of enzymatic reactions. In particular, L-Dihydroorotic acid can be biosynthesized from ureidosuccinic acid; which is catalyzed by the enzyme cad protein. In addition, L-Dihydroorotic acid and quinone can be converted into orotic acid; which is mediated by the enzyme dihydroorotate dehydrogenase (quinone), mitochondrial. In humans, L-dihydroorotic acid is involved in the pyrimidine metabolism pathway. L-Dihydroorotic acid is also involved in several metabolic disorders, some of which include UMP synthase deficiency (orotic aciduria), the mngie (mitochondrial neurogastrointestinal encephalopathy) pathway, Beta ureidopropionase deficiency, and dihydropyrimidinase deficiency. |
分子量 | 158.11 |
分子式 | C5H6N2O4 |
CAS No. | 5988-19-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 196.1 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 6.3247 mL | 31.6236 mL | 63.2471 mL | 158.1178 mL |
5 mM | 1.2649 mL | 6.3247 mL | 12.6494 mL | 31.6236 mL | |
10 mM | 0.6325 mL | 3.1624 mL | 6.3247 mL | 15.8118 mL | |
20 mM | 0.3162 mL | 1.5812 mL | 3.1624 mL | 7.9059 mL | |
50 mM | 0.1265 mL | 0.6325 mL | 1.2649 mL | 3.1624 mL | |
100 mM | 0.0632 mL | 0.3162 mL | 0.6325 mL | 1.5812 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-Dihydroorotic acid 5988-19-2 Metabolism Others Endogenous Metabolite LDihydroorotic acid dihydrowhey L Dihydroorotic acid L-ureidosuccinic enzyme hydrolyze Inhibitor inhibit acid Reversibly inhibitor