220
21
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0957 |
Isradipine
PN 200-110,伊拉地平 |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂,具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂,也是一种潜在可行的帕金森病神经保护剂。 | |||
T12315 |
OR-1896
|
PDE | Metabolism |
OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator. | |||
T67933 |
BAY-4931
|
PPAR | DNA Damage/DNA Repair; Metabolism |
BAY-4931 是一种有效的、共价的、选择性的 PPARγ反向激动剂,IC50为 0.17 nM。 | |||
T61214 |
EWP 815
|
Phosphatase; Hydroxylase | Metabolism |
EWP 815 is a disulfiram analogue that functions as a powerful inhibitor of Ins(1,4) P 2 phosphatase, Ins(1,4,5) P 3 5-phosphatase, and dopamine β-hydroxylase activity [1] [2]. | |||
T19774 |
Methylisothiazolinone
KB-838,MI,N-Methylisothiazolin-3-one,甲基异噻唑啉酮,Methylisothiazolinone free base |
Antibacterial | Microbiology/Virology |
Methylisothiazolinone (MI) 是合成的杀菌剂和防腐剂,可广泛用于工业和消费产品。它作为化妆品和盥洗用品中的防腐剂。 | |||
T9879 |
Hydroxystilbamidine
Oxistilbamidinum,羟芪巴脒,(E)-hydroxystilbamidine,2-Hydroxy-4,4'-diguanylstilbene,Bis(8-hydroxyquinolinium) sulphate |
Others | Others |
Hydroxystilbamidine ((E)-hydroxystilbamidine) 是一种能够结合 DNA 和 RNA 的染料, 也被发现是细胞核糖核酸酶的强效抑制剂。 | |||
T9111 |
8-Azaadenosine
|
Adenosine deaminase | Metabolism |
8-Azaadenosine 是 ADAR1抑制剂和是 A-to-I 编辑抑制剂。它可阻断 RNA 编辑并抑制甲状腺癌细胞的增殖、3D 生长、侵袭和迁移。 | |||
T24214 |
Phenamacril
JS39919,苯那普利,JS399 19 |
Myosin; Antifungal | Cytoskeletal Signaling; Microbiology/Virology |
Phenamacril (JS39919) 是一种氰基丙烯酸酯类杀菌剂,对镰刀菌,特别是禾谷镰刀菌有很强的抑制作用。它是一种特异性镰刀菌肌球蛋白 I 抑制剂。 | |||
T64347 |
ALDH1A3-IN-3
|
Dehydrogenase | Metabolism |
ALDH1A3-IN-3 (化合物 16) 是一种有效的 ALDH1A3 抑制剂,IC50 值为 0.26 μM。ALDH1A3-IN-3 也是 ALDH3A1 的底物。ALDH1A3-IN-3 可用于前列腺癌的研究。 | |||
T63166L |
(S, R)-LSN 3318839
(S, R)-LSN 3318839(Isomer-2764704-18-7) |
Glucagon Receptor | GPCR/G Protein |
T19637 |
Aluminum phthalocyanine chloride
Phthalocyanine Chloroaluminum,铝酞菁,Chloroaluminum Phthalocyanine |
Others | Others |
Aluminum phthalocyanine chloride (Phthalocyanine Chloroaluminum) 是一种强烈的蓝绿色芳香大环化合物,广泛用于染色。 | |||
T10213 |
A-437203
ABT-925,A37203,Lu201640 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
A-437203 (Lu201640) 是一种基于1H-pyrimidin-2-one scaffold 的、具有选择性的、新型强效的d3受体拮抗剂,对 D2, D3, 和 D4 受体,的Ki 值分别为 71, 1.6 和 6220 nM。 | |||
T35528L |
TD52 dihydrochloride
TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl |
Others | Others |
TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti... | |||
T14513 |
BBIQ
|
TLR | Immunology/Inflammation |
BBIQ 是一种有效且选择性的 toll 样受体 7 (TLR7) 激动剂,对人 TLR7 的 EC50 为 59.1 nM。BBIQ 还是一种功能强大的疫苗佐剂,可增强机体的先天免疫应答。 | |||
T40465 |
SAG dihydrochloride
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG dihydrochloride 是一种强效的 Smoothened(Smo)受体激动剂(EC 50 =3 nM;K d =59 nM)。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。 | |||
T67835 |
LKM38
|
||
LKM38是一种新型的重氮烷基胆固醇探针,是一种有前途的胆固醇模拟物。LKM38既能维持抗胆固醇细胞的生长,又能适当地调节关键的胆固醇平衡途径。LKM38可以作为研究胆固醇蛋白相互作用和贩运的有力工具。 | |||
T22574L |
Angiotensin 1/2 (5-7) acetate
|
RAAS | Endocrinology/Hormones |
Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽,是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原,一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。 | |||
T21610 |
Bradykinin (acetate)
|
Bradykinin Receptor | GPCR/G Protein |
Bradykinin (acetate) 是一种由激肽释放酶-激肽系统产生的活性肽。它是一种炎症介质,也被认为是多种血管和肾功能的神经介质和调节剂。它由血液中的 kallidin 酶促产生,是一种强大的血管扩张剂,可引起平滑肌收缩,并可能介导炎症。它具有作为人血清代谢物和血管扩张剂的作用。它是缓激肽 (2+) 的互变异构体。 | |||
T28029 |
Methylisothiazolinone hydrochloride
N-Methylisothiazolin-3-one,MI,2-甲基-4-异噻唑啉-3-酮盐酸盐,KB-838,Methylisothiazolinone HCl |
||
Methylisothiazolinone is a powerful synthetic biocide and preservative. | |||
T32436 |
L 1935
Compound l1935,L-1935,Histamine-liberator L 1935,L1935 |
||
L 1935 is a type of powerful histamine-liberator. | |||
T25960 |
Piperic acid
NSC 129538,NSC129538,NSC-129538 |
||
Piperic acid is a powerful antioxidant and has potent antibacterial properties | |||
T34124 |
Pranolium
UM-272,SC-27761,UM 272,SC 27761,SC27761 |
||
Pranolium is a quaternary dimethyl derivative of Propranolol, a well-known powerful betareceptor-blocking agent. | |||
T71443 | Amphidinolide D | ||
Amphidinolide D is a powerful activator of actomyosin ATPase enhances skeletal muscle contraction. | |||
T71140 |
MDL-27048
|
||
MDL-27048 is a powerful and reversible microtubule inhibitor. | |||
T33590 |
Nantradol HCl
MCV-4161,MCV4161,UM-1159,UM 1159,MCV 4161,UM1159 |
||
Nantradol HCl is a powerful analgesic widely used to investigate the potential therapeutic applications of cannabinoids. | |||
T39753 |
Etavopivat
FT-4202 |
||
Etavopivat is a powerful, specific, orally bioavailable activator of pyruvate kinase (PKR) in red blood cells (RBCs). It exhibits potent properties against sickling. | |||
T38822 |
D-threo-PPMP
|
||
D-threo-PPMP, a powerful glucosylceramide (GlcCer) synthase inhibitor, effectively impedes karyokinesis and decreases cyst formation. | |||
T25299 |
Degranol
NSC 9698,NSC-9698,NSC9698 |
||
Degranol is a nitrogen mustard derivative alkylating agent utilized as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant. | |||
T30945 |
Cinolazepam
Gerodorm,OX-373 |
||
Cinolazepam is a benzodiazepine derivative drug.It has a powerful sedative effect, so it is mainly used as a hypnotic. | |||
T11107 |
DSP-1053
|
Others | Others |
Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity. | |||
T35661 |
QTX125
|
||
QTX125, a powerful and highly specific HDAC6 inhibitor, demonstrates exceptional selectivity in comparison to other HDACs, resulting in robust antitumor activity[1]. | |||
T68260 | Calmidazolium (cation) | ||
Calmidazolium (cation) is a powerful inhibitor of or red blood cell Ca -ATPase & Ca transport into inside-out red blood cell vesicles; an antagonist of calmodulin. | |||
T28464 |
p-SCN-Bn-TCMC HCl
p-SCN-Bn-TCMC |
||
p-SCN-Bn-TCMC is a bifunctional chelator, it contains a powerful chelator TCMC and reactive tioisocyante linker. TCMC is a powerful chelator with capability to strongly bind radio-isotopic heavy metal ion, which are widely used for radio-diagnostic/imagin | |||
TP2459 |
Lysipressin Acetate
Lysine pitressin,Lysine vasopressin,Lypressin,Lysopressin,Lysipressin Acetate. L-Lysine vasopressin,Lysine-ADH |
||
Lysipressin Acetate is an analog of vasopressin, a powerful vasopressin used to regulate blood pressure. Endogenous vasopressin in most mammalian species. | |||
T40943 |
EMD527040
|
||
EMD527040 is a powerful and highly specific αvβ6 antagonist, exhibiting notable antifibrotic properties. It is suitable for conducting research on carcinoma and liver fibrosis. | |||
T35082 |
VU6010608
VU-6010608,VU 6010608 |
||
VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
T38914 |
MPO-IN-3
|
||
MPO-IN-3, a powerful inhibitor of myeloperoxidase (MPO), is described as such in example 191 of WO2013068875A1. MPO, a heme-containing enzyme, is classified under the peroxidase superfamily. | |||
T40841 |
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide
|
||
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a powerful inhibitor of L-phenylalanine ammonia-lyase, an enzyme responsible for catalyzing the conversion of L-phenylalanine to trans-cinnamic acid. | |||
T20778 |
Epoprostenol
U 53217,U 53,217,U-53,217 |
||
Epoprostenol, a prostaglandin, is a powerful vasodilator. It inhibits platelet aggregation. | |||
T61314 | DC-CPin7 | ||
DC-CPin7, a powerful inhibitor of the bromodomain of CREB-binding protein (CBP), exhibits an IC50 value of 2.5 μM [1]. | |||
T11721L | JDTic dihydrochloride | JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. | |||
T61310 | HIV-1 inhibitor-37 | ||
HIV-1 inhibitor-37 (Compound 83) is a highly powerful HIV-1 inhibitor. It exhibits significant potential for use as an innovative latent HIV-1 reactivating agent [1]. | |||
T40642 |
Chlorpyrifos-oxon
|
||
Chlorpyrifos-oxon, an active metabolite of Chlorpyrifos, is a powerful phosphorylating agent with potent inhibition of AChE activity. It induces cross-linking between tubulin subunits and disrupts microtubule function[4]. | |||
T40568 |
Fmoc-MMAE
|
||
Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC). | |||
T36901 |
Pelcitoclax
|
||
Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1]. | |||
T69443 |
Aminobutane bisphosphonate
|
||
Aminobutane bisphosphonate is a powerful inhibitor of bone resorption. It can potentially be a useful measure for controlling hypercalcemia in patients with carcinoma. | |||
T38779 | NS-102 | ||
NS-102 is a powerful and selective antagonist of the kainate receptor (GluK2), as well as a potent antagonist of the GluR6/7 receptor. | |||
T61712 | Trk-IN-8 | ||
Trk-IN-8, a powerful TRK inhibitor, demonstrates excellent potency against TRKAa, TRKA(G595R), and TRKC(G623R) with IC50 values of 0.42 nM, 0.89 nM, and 1.5 nM, respectively (WO2021115401A1, compound 3) [1]. | |||
T25316 |
Dexecadotril
Retorphan |
||
Dexecadotril is a powerful and selective neprilysin inhibitor. It behaves as a prodrug of the enantiomer of thiorphan. | |||
T75748 |
Indolicidin TFA
|
||
Indolicidin TFA 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1180 |
Dolastatin 10
尾海兔素10,NSC 376128,DLS 10 |
Microtubule Associated | Cytoskeletal Signaling |
Dolastatin 10 (DLS 10) 是一种多肽,可以抑制微管蛋白聚合,显示除抗有丝分裂的活性。 | |||
T5297 |
3-Indolepropionic acid
Indolepropionic acid,IPA,indole-3-propionic acid,吲哚-3-丙酸 |
Antioxidant; Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
3-Indolepropionic acid (Indolepropionic acid) 是强效的抗氧化剂,具有研究阿尔兹海默症的潜能。 | |||
T3749 |
Pyrogallol
连苯三酚,Piral,焦榈酚,1,2,3-trihydroxybenzene |
Apoptosis; Others; Endogenous Metabolite; Antifungal | Apoptosis; Metabolism; Microbiology/Virology; Others |
Pyrogallol (Piral) 是一种通过加热没食子酸制备的强还原剂,能产生自由基。它是一种具有抗真菌和抗牛皮癣活性的多酚。 | |||
T0965 |
Histamine
Ergamine,组胺 |
5-HT Receptor; Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。 | |||
S00015 |
Tea polyphenol
|
Apoptosis; Others; Autophagy | Apoptosis; Autophagy; Others |
Tea polyphenol 也称为绿茶提取物,是茶中天然存在的酚类化合物,具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。 | |||
T6534 |
Histamine dihydrochloride
组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物,是一种强效的胃分泌兴奋剂,支气管平滑肌收缩剂,血管舒张剂,也是一种中枢作用的神经递质。 | |||
T2S1464 |
Thiocolchicoside
硫秋水仙苷;噻可撒可,Thiocolchicine 2-glucoside analog,硫秋水仙苷,Coltramyl |
Others; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; Others |
Thiocolchicoside (Thiocolchicine 2-glucoside analog) 是秋水仙碱的半合成硫衍生物,是竞争性 GABAA 受体拮抗剂和甘氨酸受体拮抗剂。它是肌肉松弛剂,具有抗炎作用,可用于缓解疼痛的研究。 | |||
TC0019 |
Pregnenolone acetate
孕烯醇酮醋酸酯,3β-Hydroxy-5-pregnen-20-one acetate |
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Pregnenolone acetate 是一种强大的神经类固醇,是各种类固醇激素(包括类固醇酮)的主要前体。它作为大麻素 CB1 受体的信号特异性抑制剂,抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。它可以保护大脑免受大麻中毒。 | |||
T10933 |
D-Cysteine
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
D-Cysteine 是一种大肠杆菌生长的有力抑制剂,是半胱氨酸的 D 型异构体。它由 D-氨基酸氧化酶介导产生 H2S,是一种对抗小脑共济失调的神经保护剂。 D-半胱氨酸可以抑制由变形链球菌和链球菌血红蛋白形成的两种生物膜的生长和致龋性。 | |||
T6S0221 |
Eriocitrin
eriodictyol 7-rutinoside,圣草次甙,Eriodictyol-7-O-Rutinoside,Eriodictioside,圣草次甙;圣草次苷,Eriodictyol glycoside |
Apoptosis; Carbonic Anhydrase | Apoptosis; Metabolism |
Eriocitrin (Eriodictyol-7-O-Rutinoside) 是从柠檬中分离出来的一种黄酮类天然产物,是强效的抗氧化剂。它通过激活线粒体涉及的内在信号传导途径来触发细胞凋亡。它通过上调 p53、cyclin A、cyclin D3 和 CDK6 使 S 期细胞周期停滞,从而抑制肝癌细胞的增殖。 | |||
T40803 |
Isoanthricin
(Rac)-Deoxypodophyllotoxin |
||
Isoanthricin, also known as (Rac)-Deoxypodophyllotoxin, is the racemate form of Deoxypodophyllotoxin, a powerful compound with noteworthy antitumor and anti-inflammatory properties. | |||
T7980 |
Hesperidin methylchalcone
|
NF-κB | NF-κB |
Hesperidin methylchalcone 抑制氧化应激,细胞因子产生和NF-κB 活化。它能够抑制炎症和疼痛,具有血管保护作用。 | |||
TN2726 |
Jatrophane 5
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). | |||
T38838 |
QS-21
Stimulon,QS-21 |
||
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
T72731 | Acremoxanthone C | ||
Acremoxantone C 是一种有效的钙调素(CaM)抑制剂,存在于 Purpureocillium lilacinum 中。Acremoxantone C 与人钙调素 (hCaM) 生物传感器 hCaM M124C mBBr 结合,Kd 为 18.25 nM。 | |||
T37687 | Cyclic ADP-ribose ammonium | ||
Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3]. | |||
T79931 |
Mutanocyclin
|
||
Mutanocyclin 作为一种效能显著的抗真菌剂,能够抑制白色念珠菌 (C. albicans) 的丝状形成,并下调 HWP1、ECE1、FLO8、TEC1 基因的 mRNA 表达水平。此外,Mutanocyclin 在体外小鼠模型中亦能有效抑制酵母形态的发展。 | |||
T35895 |
Ingenol 3,20-dibenzoate
|
||
Ingenol 3,20-dibenzoate is a powerful activator of protein kinase C (PKC) isoforms. It effectively induces the translocation of nPKC-delta, -epsilon, and -theta as well as PKC-mu from the cytosolic fraction to the particulate fraction. Through de novo synthesis of macromolecules, it triggers apoptosis with characteristic morphology. Moreover, Ingenol 3,20-dibenzoate enhances IFN-γ production and degranulation in NK cells, particularly when stimulated by NSCLC cells[1][2]. | |||
T71750 | Quinolactacin A1 | ||
Quinolactacin A1 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,可从Penicillium citrinum 中得到。Quinolactacin A1 可用于阿尔茨海默病的研究。 | |||
T16574 |
Pregnenolone monosulfate sodium salt
3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt |
Others | Others |
Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodi | |||
TN2727 |
Jatrophane 2
|
P-gp; Antifection | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera). Jatrophane 2 also demonstrates the mo |