65
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38612 |
Linaprazan glurate
|
Others | Others |
Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。 | |||
T0802 |
Procaine hydrochloride
Novocaine HCl,Procaine HCl,盐酸普鲁卡因 |
Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂,是一种苯甲酸衍生物,具有局部麻醉和抗心律失常特性。 | |||
T7806 |
Licarbazepine
10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平 |
Others | Others |
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂,具有抗惊厥和稳定情绪的功效。 | |||
T0029 |
Procaine
Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因 |
Histone Demethylase; DNA/RNA Synthesis; Sodium Channel | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel |
Procaine (Vitamin H3) 是DNA 脱甲基剂,是一种酯类局部麻醉剂。它起效缓慢,作用持续时间短,主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。 | |||
T80855 |
Vonsetamig
|
||
Vonsetamig为一种人源化IgG4-kappa类、针对TNFRSF17与CD3E的双特异性单克隆抗体,作为抗肿瘤药物使用。 | |||
T13673 |
EGTA-AM
EGTA Acetoxymethyl ester |
Others | Others |
EGTA-AM (EGTA Acetoxymethyl ester) 是一种钙离子螯合剂, 是一种膜渗透形式的 EGTA,是早发型子痫前期和晚发性子痫前期的代谢生物学标志物。 | |||
T31716L |
Etidocaine
|
Others | Others |
Etidocaine 是一种氨基酸酰胺,用作局部麻醉剂,具有快速起效和长效特性。 | |||
T3285L |
Eslicarbazepine
艾司利卡西平,Pazzul,EC 810-248-9,BIA 2-194,Stedesa,Erelib |
Beta-Secretase; Sodium Channel | Membrane transporter/Ion channel; Neuroscience |
Eslicarbazepine (Stedesa) 是口服有效抗惊厥试剂,在局部癫痫的辅助研究中具有价值。 | |||
T24932 |
Vatanidipine
AE-0047,AE 0047,AE0047 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂,具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。 | |||
T7942 |
Tranylcypromine hemisulfate
Tranylcypromine Sulfate,Tranylcypromine (hemisulfate),反苯环丙胺半硫酸盐 |
Histone Demethylase; MAO; Monoamine Oxidase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) 是单胺氧化酶(MAO) 和赖氨酸特异性去甲基化酶 1 (LSD1) 的抑制剂,可用于研究抑郁症和子宫内膜异位症。 | |||
T31860 |
Fosdevirine
GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂 ,具有抗 HIV 活性,可用于研究迟发性癫痫等神经系统相关疾病。 | |||
T9284 |
Dexketoprofen trometamol
|
COX | Immunology/Inflammation; Neuroscience |
Dexketoprofen trometamol 是一种改良的非选择性 COX 抑制剂,起效迅速,可作为口服和非肠道制剂使用。 | |||
T1148 |
Menbutone
孟布酮,Naftobil,Genabilic acid,Genabilin |
Others | Others |
Menbutone (Genabilin) 是一种利胆剂,是氧代丁酸衍生物。 | |||
T4250 |
Bilastine
比拉斯汀,Bilaxten |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bilastine (Bilaxten) 是新型抗组胺药,对H1组胺受体具有高度选择性,起效快,作用时间长的特性,可用于变应性鼻结膜炎和荨麻疹。 | |||
T3285 |
Eslicarbazepine Acetate
Zebinix,Aptiom,BIA 2-093,Exalief,艾司利卡西平醋酸酯,Stedesa |
Beta-Secretase; Sodium Channel | Membrane transporter/Ion channel; Neuroscience |
Eslicarbazepine Acetate (Zebinix) 是一种抗癫痫药物。Eslicarbazepine acetate 也是 β-内分泌酶(β-Secretase)和电压门控钠离子通道的双抑制剂。 | |||
TP1127L1 |
Nemifitide acetate(173240-15-8 free base)
INN 00835 acetate |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) 是一种合成的五肽抗抑郁药,具有快速起效的潜力。它是黑色素细胞抑制因子 (MIF) 的肽类似物。 | |||
T31860L |
(Iso)-Fosdevirine
(Iso)-Fosdevirine(Iso-1018450-26-4),(Iso)-GSK2248761 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
(Iso)-Fosdevirine ( (Iso)-GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂 ,具有抗 HIV 活性,可用于研究迟发性癫痫等神经系统相关疾病。 | |||
T7502L |
PF 05089771
PF-05089771,PF05089771 |
Sodium Channel | Membrane transporter/Ion channel |
PF 05089771是具有口服有效的、选择性的 Nav1.7丙烯酰胺抑制剂。PF-05089771在疼痛和糖尿病神经性疾病的研究中具有价值。 | |||
T1439 |
Lacidipine
SN-305,拉西地平,GX-1048,GR-43659X |
Apoptosis; Calcium Channel; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。 | |||
T64317 |
ZZL-7
|
Serotonin Transporter | Neuroscience |
ZZL-7是一种起效快的抗抑郁药。ZZL-7破坏中缝背核(DRN)神经元一氧化氮合酶(nNOS)和血清素转运蛋白(SERT)之间的相互作用。ZZL-7可以很容易地穿过血脑屏障。ZZL-7在重度抑郁症(MDD)中具有研究价值。 | |||
T22037 |
AS 1892802
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
AS 1892802是一种强效和选择性的ROCK 抑制剂。AS 1892802 用于人ROCK2、大鼠ROCK2和人ROCK1的 IC50值分别为52nM、57nM 和122nM。AS 1892802的镇痛作用起效速度与曲马多和双氯芬酸的起效速度一样快。 | |||
T0192 |
Levetiracetam
左乙拉西坦,UCB L059,SIB-S1 |
DNA Methyltransferase; Others; Calcium Channel | Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others |
Levetiracetam (SIB-S1) 是一种化学增敏剂,增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平,最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药,可结合突触小泡蛋白 SV2A。 | |||
T14884 |
CBR-5884
|
Others; Dehydrogenase | Metabolism; Others |
CBR-5884 是一种磷酸甘油酸脱氢酶抑制剂,IC50为 33 μM。 它抑制癌细胞中的丝氨酸合成,选择性地抑制黑素瘤和乳腺癌细胞系的增殖,对具有高丝氨酸生物合成活性的癌细胞系有选择性毒性。 | |||
T67956 |
Litoxetine
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Litoxetine 是一种选择性的5-HT 摄取抑制剂,是具有5-HT3受体拮抗剂。Litoxetine 可作为一种抗抑郁剂,在雪貂身上显示出止吐特性。Litoxetine (1和10毫克/公斤静脉注射)剂量依赖性地减少了反胃和呕吐的次数,延迟了呕吐的发生。Litoxetine 对大脑5HT3受体有亲和力(Ki = 85 nM)。 | |||
T15257 |
Etripamil
MSP-2017,(-)-MSP-2017 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂,可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入,显示房室结传导并延长房室结不应期 | |||
T21327 |
Uridine triacetate
RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate |
Others | Others |
Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收,在循环中迅速脱乙酰,生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性,或早发性心脏或中枢神经系统 (CNS) 毒性。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
T4996 |
Atosiban
阿托西班,RWJ22164,RW22164 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T0267 |
Zonisamide
AD 810,唑尼沙胺,CI 912 |
Calcium Channel; Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
T4615 |
Balsalazide sodium hydrate
巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT; Interleukin | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。 | |||
T5148 |
Atosiban acetate
RW22164,Atosiban acetate (90779-69-4 free base),RWJ22164,醋酸阿托西班 |
Oxytocin Receptor; Vasopressin Receptor | Endocrinology/Hormones; GPCR/G Protein |
Atosiban acetate (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。 | |||
T6707 |
Tiotropium Bromide hydrate
BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物 |
AChR | Neuroscience |
Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂,可用于治疗慢性阻塞性气道疾病 (COPD)。 | |||
T31732 |
Evogliptin HCl
Evogliptin hydrochloride,DA 1229,DA1229,Evogliptin,DA-1229 |
||
Evogliptin(DA-1229) is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor) that can improve insulin resistance and delays the onset of diabetes. Evogliptin delays the onset of diabetes in young db/db mice and improves insulin sensitiv | |||
T71836 |
2-FPBA
|
||
2-FPBA is a potent, reversible and slow-onset inhibitor of mandelate racemase (MR). | |||
T30250 |
AZD0865
AZD-0865,AZD 0865 |
||
AZD0865 is an effective drug that inhibits gastric H(+), K(+) -ATPase activity and acid formation in vitro, with rapid onset. | |||
T23710 | Watanidipine dihydrochloride | ||
Watanidipine dihydrochloride is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions. | |||
T69472 |
Edrophonium
|
||
Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | |||
T26683 |
AUTEN-67
Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67 |
||
AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease. | |||
T71541 | ASP9133 | ||
ASP9133 is a long-acting muscarinic antagonist (LAMA) which shows more selective inhibition of bronchoconstriction against salivation and more rapid onset of action than tiotropium bromide. | |||
T32054 |
Heme arginate
Hemearginat,Heme arginate complex,Normosang |
||
Heme arginine (or heme arginine) is a compound of heme and arginine used to treat acute porphyria by reducing the excessive production of δ-aminolevulinic acid, which causes acute symptoms during the onset of acute porphyria. | |||
T14682 |
BMS-962212
|
Others | Others |
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1]. | |||
T25698 |
Levoprotiline
Levoprotilinum |
||
Levoprotiline 一种抗抑郁的化合物,它是 Oxaprotiline 的 R-(-)对映体,作用与 Oxaprotiline 相当,并且作用起效潜伏期较短。它是第二代抗抑郁药马普替林的继任者。 | |||
T26920 |
Bucindolol hydrochloride
MJ 131051,Bucindolol HCl,MJ131051,MJ-13105-1,MJ-131051 |
||
Bucindolol is a beta-adrenergic receptor antagonist. Bucindolol is a fourth-generation β-blocker. Bucindolol prevented new-onset AF; β₁ and α(2c) polymorphisms predicted therapeutic response; and the 47% of patients who were β₁389 Arg homozygotes had an e | |||
T36858 |
C12 Galactosylceramide (d18:1/12:0)
|
||
C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus. | |||
T76938 | Camoteskimab | ||
Camoteskimab (AVTX-007)为全人源、高亲和力抗IL-18单克隆抗体,展现于自身炎症性疾病研究潜力,包括成人斯蒂尔病(AOSD)。 | |||
T61091 | p38-α MAPK-IN-4 | ||
p38-α MAPK-IN-4 (Compound 69) 是一种选择性的p38α MAPK 抑制剂,IC50为 1.5 μM。p38-α MAPK-IN-4 在体内可快速、强烈地抑制机械性触诱发痛 (mechanical allodynia) 的发生。 | |||
T37319 |
5β-Dihydroprogesterone
|
||
5β-Dihydroprogesterone (5β-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5β-reductase.25β-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 μg/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAAreceptor antagonist picrotoxin .1It is a negative modulator of homooligomeric Ρ1 subunit-containing GABAAreceptors, inhibiting GABA-induced currents in... | |||
T82470 |
Endokinin C
|
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Endokinin C作为内皮激肽系列中的肽类成分,在疼痛途径中扮演神经递质或调节剂的角色。该化合物的预处理能有效抑制endokinin A/B引发的小鼠划痕行为以及对热的过敏反应。 | |||
T37367 |
Amyloid-β (1-42) Peptide (trifluoroacetate salt)
|
||
Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2,3Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers.1Aβ42 accumulates in the brain of many transgenic mouse models of Alzheimer's disease and, in many models, the onset of amyloid deposition positively correlates with deficits in spatial learning and memory.4 1.Wolfe, M.S.Therapeutic strategi... | |||
T70773 | Noberastine citrate | ||
Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack centra... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19564 |
Stearoylcarnitine
Stearoyl-L-carnitine |
Endogenous Metabolite | Metabolism |
Stearoylcarnitine (Stearoyl-L-carnitine) 是一种脂肪酯脂质分子,是一种人内源代谢产物,可作为早发型子痫前期和晚发性子痫前期的生物标志物。 | |||
T9299 |
D-Leucine
D-亮氨酸,(R)-Leucine |
Endogenous Metabolite | Metabolism |
D-Leucine ((R)-Leucine) 具有抗癫痫特性,活性比L-leucine,能够有效终止癫痫发作。在体外,它能够抑制长期点位,但基底突触传递无影响。 |