64
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21302 |
UNC569
UNC 569 |
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂,其IC50=2.9 nM,Ki=4.3 nM。它还抑制Axl 和Tyro3,IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。 | |||
T4230 |
PF-3758309 hydrochloride
PF-03758309 hydrochloride |
Apoptosis; PAK | Apoptosis; Cytoskeletal Signaling |
PF-3758309 hydrochloride (PF-03758309 hydrochloride) 是一种口服的、可逆的 ATP 竞争性PAK4抑制剂,Kd 为 2.7 nM,Ki 为 18.7 nM。它抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖,具有 PAK4 抑制剂的预期细胞功能。 | |||
T6626 |
PF-3758309
PF-309,PF-03758309,PF 3758309 |
Apoptosis; PAK | Apoptosis; Cytoskeletal Signaling |
PF-3758309 (PF-03758309) 是一种可口服的、可逆的 ATP 竞争性 PAK4抑制剂。它是一种 PAK4 抑制剂,可抑制锚定独立生长、诱导凋亡、细胞骨架重塑和抑制增殖。 | |||
T7326 |
6H05 (TFA)
6H05 TFA,6H05 trifluoroacetate |
Ras | GPCR/G Protein; MAPK |
6H05 TFA (6H05 trifluoroacetate) 是一种选择性变构致癌突变体 K-Ras(G12C) 抑制剂。 | |||
T37422L |
Ras Inhibitory Peptide acetate
Ras Inhibitory Peptide acetate(159088-48-9 Free base) |
Ras | GPCR/G Protein; MAPK |
Ras Inhibitory Peptide acetate 是一种参与 Ras 依赖性信号通路的肽,Ras 在致癌受体引发的人类癌症中起重要作用。 | |||
T6556 |
K-Ras(G12C) inhibitor 9
|
Raf | MAPK |
K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。 | |||
T6555 |
K-Ras(G12C) inhibitor 12
|
Apoptosis; Raf; Ras | Apoptosis; GPCR/G Protein; MAPK |
K-Ras(G12C) inhibitor 12是一种K-Ras(G12C)抑制剂,作用于H1792细胞,EC50为0.32 μM。 | |||
T9589 |
SI-113
|
SGK | Metabolism |
SI-113 是一种有效的选择性 SGK1 抑制剂,SGK1 是一种丝氨酸/苏氨酸蛋白激酶,可调节多种致癌信号级联反应。 | |||
T2275 |
YK-4-279
4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂,能抑制ESFT 细胞增长,诱导凋亡。 | |||
T1744 |
BIX02188
|
Apoptosis; MEK | Apoptosis; MAPK |
BIX02188 是一种具有选择性和有效性的 MEK5 抑制剂,抑制 MEK5 诱导表达致癌突变体FLT3-ITD的细胞凋亡。 | |||
T69980 |
XMU-MP-2
|
BTK; Protease | Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
XMU-MP-2 是一种有效和选择性的蛋白酶抑制剂,具有抗癌活性,在小鼠异种移植模型中 抑制致癌 BRK 驱动的肿瘤的生长。 | |||
T60031 |
NRX-1933
|
||
NRX-1933 是一种分子胶,可增强致癌转录因子 β-Catenin 与其同源 E3 连接酶 SCFβ-TrCP 之间的相互作用。 | |||
T6284 |
Onalespib
AT13387,Onalespib (AT13387) |
HSP | Cytoskeletal Signaling; Metabolism |
Onalespib (AT13387) 是一种合成的、口服生物可利用的热休克蛋白 90 (Hsp90) 小分子抑制剂,Kd 值为 0.71 nM。具有潜在的抗肿瘤活性。它选择性地与 Hsp90 结合,从而抑制其伴侣功能并促进参与肿瘤细胞增殖和存活的致癌信号蛋白的降解。 | |||
T8402 |
Regorafenib Hydrochloride
瑞戈非尼盐酸盐,BAY73-4506 hydrochloride |
Raf; VEGFR; c-RET; PDGFR; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) 是一种新型口服多激酶抑制剂,可抑制血管生成、基质和致癌受体酪氨酸激酶,具有强大的临床前抗肿瘤活性。它靶向作用于 VEGFR1/2/3、PDGFRβ、Kit、RET 和 Raf-1,IC50值分别为 13/4.2/46、22、7、1.5 和 2.5 nM。 | |||
T3646 |
RSL3
RSL3 1S,1S,3R-RSL3 |
Ferroptosis; GPX; Glutathione Peroxidase | Apoptosis; Metabolism; oxidation-reduction |
RSL3 (RSL3 1S) 是一种 GPX4 的抑制剂,抑制阻断 GSH 合成的 system xc- (IC50=100 nM)。RSL3 是一种不依赖 VDAC 的铁死亡激活剂,对携带致癌 RAS 的肿瘤细胞具有选择性。 | |||
T9072 |
Tuxobertinib
BDTX-189 |
EGFR; HER; BTK; RIP kinase | Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors |
Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂,具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。 | |||
T21981 |
Phthalazinone pyrazole
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。 | |||
TQ0048 |
BI-882370
|
Raf | MAPK |
BI-882370 是高选择性的RAF 激酶抑制剂,其结合位于 BRAF 激酶的 DFG-out 无活性构象处 (ATP 结合位点)。 它抑制 SRC 家族激酶,也抑制 BRAFV600E-mutant、WT BRAF 和 CRAF 激酶,IC50值分别为 0.4、0.8 和 0.6 nM。 | |||
T20168 |
Aurothiomalate sodium
金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂,可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂,也是一种抗风湿剂。 | |||
T6017 |
Linsitinib
OSI-906,林西替尼 |
IGF-1R | Tyrosine Kinase/Adaptors |
Linsitinib (OSI-906) 是选择性的、有效的、具有口服活性的IGF-1和胰岛素受体(IR)的双重抑制剂,IC50分别为 35 和 75 nM。 | |||
T8488 |
GMB-475
|
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
GMB-475 是一种基于PROTAC 的BCR-ABL1酪氨酸激酶降解剂,克服了BCR-ABL1依赖的耐药性。 GMB-475 靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)。导致泛素化和随后的致癌融合蛋白降解 | |||
T63049 |
CHD1Li 6.11
|
Others | Others |
CHD1Li 6.11 是一种致癌 CHD1L 的有效抑制剂,能够作用于 cat-CHD1L 重组蛋白 (IC50: 3.3 μM)。CHD1Li 6.11 是一种口服具有活力的抗肿瘤剂,明显减少由分离的准间充质细胞 (M 表型) 产生的 CRC 异种移植物的肿瘤体积,这些细胞具有增强的致瘤特性。 | |||
T70476 | SML-10-70-1 | ||
SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C. | |||
T34670 |
SNIPER(ABL)-38
|
||
SNIPER(ABL)-38 is a specific and nongenetic IAP-dependent protein eraser (SNIPER) which acts as a protein degradation inducer of oncogenic BCR-ABL protein. | |||
T10846 |
CMLD010509
SDS-1-021 |
Others | Others |
CMLD010509 (SDS-1-021) is a highly selective inhibitor of the oncogenic translation program supporting multiple myeloma (MM)-including key oncoproteins such as MDM2, CCND1, MYC, MAF, and MCL-1. | |||
T33219 |
MB725
MB 725,MB-725 |
||
MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation. | |||
T1931 |
6H05
K-Ras inhibitor |
Raf; Ras | GPCR/G Protein; MAPK |
6H05 (K-Ras inhibitor) 是致癌突变体 K-Ras(G12C) 的选择性变构抑制剂。 | |||
T71635 | Murayaquinone | ||
Murayaquinone is a hepatitis C virus proteinase inhibitor and small molecule antagonist of the oncogenic Tcf/β-catenin protein complex. | |||
T29159 |
WJD008
WJD-008,WJD 008 |
||
WJD008 is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin. WJD008 prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. WJD008 has antiproliferative and anticlonogeni | |||
T32419 |
KRAS4b-PDEδ stabilizer C19
|
||
KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling. | |||
T71717 | KRAS4b-IN-D14 | ||
KRAS4b-IN-D14 is a specific inhibitor of oncogenic KRAS4b signaling which stabilizes the KRAS4b-PDEδ complex and remarkably decreases tumor size and triggered apoptosis of tumor cells. | |||
T69264 |
Aristeromycin diphosphate
|
||
Aristeromycin diphosphate is an inhibitor of S-adenosylhomocysteine hydrolase (AHCY), inducing miR-26a and regulating oncogenic EZH2 expression, showing high inhibitory activity against AHCY, and causing growth inhibition of prostate cancer. | |||
TP1979 |
NLS-StAx-h
|
||
Wnt inhibitor (IC50 = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable. | |||
T68383 |
BIIB028
|
||
BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o... | |||
T39688 |
Zeteletinib
BOS-172738,DS-5010,Zeteletinib |
||
Zeteletinib (BOS-172738; DS-5010) is a highly potent and selective orally active inhibitor of the RET kinase. It demonstrates nanomolar potency against RET while exhibiting over 300-fold selectivity against VEGFR2. Zeteletinib exhibits remarkable efficacy against the wild-type RET, RET V804M/L gatekeeper mutants, as well as the frequently occurring oncogenic RET mutation M918T. Its antitumor activity is potent. | |||
T82381 |
Fmoc-Thr(GalNAc(Ac)3-β-D)-OH
|
||
Fmoc-Thr(GalNAc(Ac)3-β-D)-OH 通过抑制癌细胞生长及增强免疫反应的方式,针对特定癌症途径发挥作用。 | |||
T71837 |
HBX
|
||
HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species. | |||
T75140 | CPD-1224 | ||
CPD-1224 是口服有效的 ALK 抑制剂,是耦连cereblon 配体的ALK 抑制剂衍生物。CPD-1224 靶向 EML4-ALK 致癌融合蛋白,并降解 ALK 和突变体 L1196M/G1202R。 | |||
T39927 |
Zeteletinib hemiadipate
BOS-172738 hemiadipate,DS-5010hemiadipate,Zeteletinib hemiadipate |
||
Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notably, Zeteletinib hemiadipate demonstrates exceptional effectiveness against various forms of RET, including the wild type, RET V804M/L gatekeeper mutants, and the oncogenic RET mutation M918T. Additionally, Zeteletinib hemiadipate exerts potent antitumor effects. | |||
T74278 | HSP70-IN-3 | ||
HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性,并降低致癌转录因子 GLI1 的表达。 | |||
T64059 |
G12Si-5
|
||
G12Si-5 是一种共价的 K-RasG12S 突变体抑制剂,其 Ki 值为 26 μM。G12Si-5 能够结合 S-IIP 结构域,抑制致癌信号。G12Si-5 能够减少 KRAS G12S 突变细胞中的 ERK 磷酸化水平。 | |||
T70424 | EBI-907 | ||
EBI-907 is a highly potent and orally efficacious B-RafV600E inhibitor. EBI-907 displays a low single-digit nanomolar activity (IC50 = 4.9 nM), which is >10-fold more potent than Vemurafenib (IC50 = 59 nM). EBI-907 also exhibits high potency in selectively inhibiting the proliferation of BRAF (V600E)-dependent cell lines (A375 and Colo205) and cellular Erk phosporylation, with superior activity to Vemurafenib. EBI-907, displaying potent activity against a number of important oncogenic kinases i... | |||
T63970 | EZH2-IN-11 | ||
EZH2-IN-11 是 E2HZ 的有效抑制剂。其中 EZH2 的致癌活性已被各种不同癌症类型中的大量研究中证实。EZH2-IN-11 对癌症疾病表现出研究潜力。 | |||
T69055 |
PD153035 nitrate
|
||
PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also... | |||
T68760 | Luminespib mesylate | ||
Luminespib, also known as AUY-922, NVP-AUY922, VER52296, is a derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines. | |||
T78694 | SHP2-IN-13 | ||
SHP2-IN-13是一种针对SHP2“tunnel site” 的变构抑制剂,具备高选择性及口服活性,IC50值为83.0 nM。该化合物可作为研究潜力药物,用于治疗携带RTK致癌驱动因素的癌症以及SHP2相关疾病。 | |||
T9661 | MB710 | ||
MB710 是一种氨基苯并噻唑衍生物,是致癌 p53 突变体 Y220C 的稳定剂。MB710 与 Y220C 口袋紧密结合并稳定p53-Y220C,Kd 值为 4 μM。 MB710 在 p53-Y220C 细胞系中显示抗癌活性。 | |||
T63436 |
Aurora A inhibitor 1
|
||
Aurora A inhibitor 1 是有效的、选择性的 Aurora A 抑制剂。 Aurora A 与多种组织学起源的癌症有关,而且在过度表达时可能表现出致癌活性。Aurora A inhibitor 1 表现出潜力进行 Aurora A 介导的癌症疾病的研究。 | |||
T78651 |
Glecirasib
JAB-21822,KRAS G12C inhibitor 36 |
Ras | GPCR/G Protein; MAPK |
Glecirasib (KRAS G12C inhibitor 36) 作为潜在的KRAS G12C抑制剂,在Ras蛋白家族中发挥作用,对细胞内信号传递具重要影响,并在生长发育中扮演关键角色。本化合物显示出研究KRAS G12C介导的癌症潜力。 | |||
T26456 |
A 83586C
A83586C,A-83586C |
||
A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating o |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1683 |
Demethoxycurcumin
Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin |
Apoptosis; Antioxidant; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction |
Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分,有抗炎和抗癌作用。 | |||
T3763 |
Fumaric acid
Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸 |
Endogenous Metabolite | Metabolism |
Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关,是癌症相关的内源性代谢物。 | |||
T40667 | L-Azatyrosine | ||
L-Azatyrosine, an antitumor antibiotic derived from Streptomyces chibaensis, exhibits the ability to restore the normal phenotypic behavior of transformed cells that carry oncogenic Ras genes. | |||
TN4028 |
Euchrestaflavanone B
|
PARP; Antifection | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of | |||
T82326 | Genkwadaphnin | ||
Genkwadaphnin是一种瑞香烷二萜,能够靶向内输蛋白importin-β1,减少CRPC核心驱动因子在细胞核内的积累,并关闭其下游致癌信号通路。此外,Genkwadaphnin在小鼠体内显现出能显著抑制去势抵抗性前列腺癌(CRPC)发展的抗癌活性。 |