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Search Results for " hypotensive "

73

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10900	CUDA	PPAR; Epoxide Hydrolase	DNA Damage/DNA Repair; Metabolism
	CUDA 是一种可溶性环氧水解酶抑制剂，对小鼠 sEH 和人 sEH 作用的 IC50分别为 11.1 和 112 nM。它能选择性地上调过氧化物酶体增殖激活受体 PPARα的活性，有用于心血管疾病的研究潜力。
T21957	Guanabenz hydrochloride NE56490	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanabenz hydrochloride (NE56490) 是一种具有降血压作用的口服活性 α2-肾上腺素受体激动剂。
T26923	Bunazosin Hydrochloride E 1015,盐酸布那唑嗪,E643,E-1015,E-643,E 643	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bunazosin Hydrochloride (E 1015) 是一种 α(1)-adrenoceptor 拮抗剂，用作全身性抗高血压药和降眼压药。
T28360	PF-00489791 PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817	PDE	Metabolism
	PF-00489791 (PF4634817) 是一种长效 PDE5 抑制剂，具有降血压活性，可用于研究糖尿病肾病。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T0028	Gamibetal 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸，对癫痫具有潜在的研究价值。
T24932	Vatanidipine AE-0047,AE 0047,AE0047	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂，具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。
TP1918L	Lys-[Des-Arg9]Bradykinin,TFA Lys-[Des-Arg9]Bradykinin,TFA 71800-36-7(fb-tfa)	Bradykinin Receptor	GPCR/G Protein
	Lys-[Des-Arg9]Bradykinin,TFA (71800-36-7 free base) 是内源性强效和高选择性的缓激肽 B1 受体激动剂（对人 B1 和 B2 受体的 Ki 值分别为 0.12 和 > 30000 nM）。降低体内外周血管阻力的降压药。比 [Des-Arg9]-缓激肽强 16 倍。
T22398	Phenidone 菲尼酮,1-phenyl-3-pyrazolidinone	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Phenidone (1-phenyl-3-pyrazolidinone) 是可口服发环氧化酶和脂氧合酶双重抑制剂，可改善实验性自身免疫性脑脊髓炎大鼠的瘫痪，降低自发性高血压大鼠的血压，可用作照片显像剂。
TP1917L1	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)	Bradykinin Receptor	GPCR/G Protein
	Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base) 是一种有效的选择性缓激肽 B1 受体激动剂（兔主动脉中的 EC50 = 9.02 nM），对氨肽酶、激肽酶 I 和 II (ACE) 以及中性内肽酶切割具有抗性。在体内表现出降血压和血管生成活性。
TP1918L1	Lys-[Des-Arg9]Bradykinin acetate Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base)	Bradykinin Receptor	GPCR/G Protein
	Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base) 是一种内源性强效和高选择性的缓激肽 B1 受体激动剂（对人 B1 和 B2 受体的 Ki 值分别为 0.12 和 > 30000 nM）。降低体内外周血管阻力的降压药。比 [Des-Arg9]-缓激肽强 16 倍。
T1050	Prazosin hydrochloride Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress	Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。它可用于研究高血压和酒精使用障碍。它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。
T0782	Benzthiazide Aquatag,苄噻嗪,Lemazide,Dihydrex	Carbonic Anhydrase	Metabolism
	Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。
T68095	Losulazine	Dopamine Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Losulazine 是一种新型的降压化合物。其确切的作用机制尚未确定，但其降压作用取决于完整的、功能性交感神经系统的存在。
T34414	RS 61565 RS-61565,RS61565
	RS 61565 is a hypotensive agent.
T17113	Tolonidine	Others	Others
	Tolonidine is orally active and has been shown to possess hypotensive. Tolonidine is a derivative of imidazoline.
T34294	Reserpiline Elliptamine
	Reserpiline is a hypotensive extract of Rauwolfia vomitoria.
T26586	AL-37350A
	AL-37350A is a 5-HT2 receptor-selective agonist with ocular hypotensive activity.
T13142	Theodrenaline (±)-Theodrenaline,茶碱那林	Others	Others
	Theodrenaline is a cardiac stimulant, also acts as an agent of anti-hypotensive together with cafedrine.
T21274	Amiquinsin
	Amiquinsin is a drug with hypotensive effect.
T10544	Bimatoprost D5 AGN 192024 D5	Others	Others
	Bimatoprost (AGN 192024) D5 is a deuterium-labeled Bimatoprost. Bimatoprost is a topical hypotensive agent frequently used for treating glaucoma and ocular hypertension.
T26417	A 39355 A39355,A-39355
	A 39355 may specifically overcome multidrug resistance without the serious hypotensive effects associated with calcium antagonists.
T32458	L 653328 L 653,328,L653328,L653,328,L-653,328,L-653328
	L 653328 is an ocular hypotensive agent that has modest beta-receptor blocking activity.
T29725	AGN-191129 AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T
	AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypotensive properties, but the receptors
T26426	A 62198 A62198,A-62198
	A 62198 is a potent and selective renin inhibitor with potential as a hypotensive agent.
T30452	Bimatoprost isopropyl ester 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester
	Bimatoprost isopropyl ester is an F-series prostaglandin analog, which has been approved as a hypotensive drug.
T68707	DJ 7141
	DJ 7141 is a unique alpha-2 agonist which shows high affinity to peripheral alpha-2 adrenoceptors but only a mild hypotensive activity.
T37627	Latanoprost ethyl amide
	Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue con...
T68774	Deterenol Free Base
	Deterenol Free Base is a beta-adrenoceptor agonist. It is an effective nonmydriatic and nonmiotic hypotensive agent, which can be used in antiglaucoma treatment.
T27754	KUL-7211 KUL7211,KUL 7211
	KUL-7211 is an β2 and β3 adrenergic receptor agonist. KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect.
T76453	Substance P (6-11)
	Substance P (6-11)，Substance P 的C末端六肽酰胺，可与NK-1速激肽受体结合，展现出对运动神经元的去极化作用以及降压效应。
T16711	Flesinoxan	5-HT Receptor	GPCR/G Protein; Neuroscience
	Flesinoxan is a hypotensive agent and is an effective, high affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
T39246	Brain Natriuretic Peptide-45, mouse Brain Natriuretic Peptide-45, mouse,BNP-45, mouse
	Mouse Brain Natriuretic Peptide-45 (BNP-45, mouse) is a circulating variant of the mouse brain natriuretic peptide derived from the mouse heart. It exhibits powerful hypotensive and natriuretic properties.
T62476	Trimazosin
	Trimazosin 是一种口服具有活力的 quinazoline 衍生物，结构与 prazosin 有关。Trimazosin 能够选择性阻断α1肾上腺素受体 (α1-adrenoceptors)，具有降压 (hypotensive) 活性。
T81557	PAMP-12(human, porcine) TFA
	PAMP-12(human, porcine) TFA，免疫反应性PAMP(ir-PAMP)的关键成分，源自肾上腺髓质素前体，具有调节心血管功能和显著降压作用的生物活性肽。
T25568	Ketanserinol Reduced ketanserin
	Ketanserinol is the metabolite of ketanserin. Ketanserin is a hypotensive drug with 5-HT2 receptor antagonism, used to reverse pulmonary hypertension caused by protamine.
TP1257	Adrenomedullin (AM) (22-52), human 22-52-Adrenomedullin (human)
	Adrenomedullin (ADM) is a 52-aa hypotensive peptide. Adrenomedullin (ADM) has structural similarity with amylin.
TP1207	Brain Natriuretic Peptide-45, rat BNP-45 (rat),Brain natriuretic peptide-45 rat
	BNP-45 (rat) is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.
T37813	Fluprostenol methyl ester
	Fluprostenol is an F-series prostaglandin analog which has been approved for many years as a luteolytic in veterinary animals. The isopropyl ester of fluprostenol (travoprost) is an effective ocular hypotensive drug. CAY10532 is a methyl ester analog of fluprostenol.
T62744	LpxC-IN-9
	LpxC-IN-9 (compound 19) 是一种 LpxC 的有效抑制剂，表现出抗菌和降血压活性。
T9819	Bunazosin
	Bunazosin 是一种有效的选择性 α1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，可用于降压和降眼压研究。
TP1206	BNP-45 (rat) (TFA) (123337-89-3 free base) BNP-45 (rat) (TFA),Brain natriuretic peptide-45 rat TFA
	BNP-45 (rat) TFA is a circulating form of rat brain natriuretic peptide isolated from rat heart with potent hypotensive and natriuretic potency.
T38017	Nω-Propyl-L-arginine hydrochloride
	Highly selective and potent inhibitor of nNOS (Ki = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo. Kakoki et al (2001) The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am.J.Physiol.Regul.Integr.Comp.Physiol. 281 R91 PMID:11404282 \|Zhang et al (1997) Potent and selective inhibition of neuronal nitric oxide synthase by Nω-propyl-L-arginine. J.Med.Chem. 40 3869 PMID:9397167
T37213	5-trans Latanoprost
	Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of between 2-5% in most commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. Fr...
T75084	Foslevcromakalim
	Foslevcromakalim (QLS-101 ) 是一种ATP 敏感的钾通道开启剂。Foslevcromakalim 是用于降眼压作用的前体。
TP1918	Lys-[Des-Arg9]Bradykinin
	Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9]
TP1885	[(pF)Phe4]Nociceptin(1-13)NH2
	Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotrop
T61075	Piperilate
	Piperilate, also known as Pipethanate, is a hetrazepine derivative PAF antagonist and anticholinergic mixture, commonly utilized in bronchial asthma research. This compound exhibits hypotensive properties and has been found to effectively counteract the toxic effects of organophosphates in mice [1] [2] [3].
TP1917	Sar-[D-Phe8]-des-Arg9-Bradykinin
	Potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. Exhibits hypotensive and angiogenic activity in vivo.
T37939	N-Desethyl Bimatoprost 17-phenyl trinor Prostaglandin F2α amide
	N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids ...

化合物

Cat.No: T10900

Target: PPAR, Epoxide Hydrolase

Guanabenz hydrochloride

Cat.No: T21957

Synonym: NE56490

Target: Adrenergic Receptor

Bunazosin Hydrochloride

Cat.No: T26923

Synonym: E 1015,盐酸布那唑嗪,E643,E-1015,E-643,E 643

Target: Adrenergic Receptor

Cat.No: T28360

Synonym: PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817

Target: PDE

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Cat.No: T0028

Synonym: 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid

Target: HIV Protease

Cat.No: T24932

Synonym: AE-0047,AE 0047,AE0047

Target: Calcium Channel

Lys-[Des-Arg9]Bradykinin,TFA

Cat.No: TP1918L

Synonym: Lys-[Des-Arg9]Bradykinin,TFA 71800-36-7(fb-tfa)

Target: Bradykinin Receptor

Cat.No: T22398

Synonym: 菲尼酮,1-phenyl-3-pyrazolidinone

Target: Lipoxygenase, COX

Sar-[D-Phe8]-des-Arg9-Bradykinin acetate

Cat.No: TP1917L1

Synonym: Sar-[D-Phe8]-des-Arg9-Bradykinin acetate(126959-88-4 free base)

Target: Bradykinin Receptor

Lys-[Des-Arg9]Bradykinin acetate

Cat.No: TP1918L1

Synonym: Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base)

Target: Bradykinin Receptor

Prazosin hydrochloride

Cat.No: T1050

Synonym: Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress

Target: Potassium Channel, MRP, Adrenergic Receptor, ABC, Autophagy

Cat.No: T0782

Synonym: Aquatag,苄噻嗪,Lemazide,Dihydrex

Target: Carbonic Anhydrase

Cat.No: T68095

Target: Dopamine Receptor, Norepinephrine

Cat.No: T34414

Synonym: RS-61565,RS61565

Cat.No: T17113

Target: Others

Cat.No: T34294

Synonym: Elliptamine

Cat.No: T26586

Cat.No: T13142

Synonym: (±)-Theodrenaline,茶碱那林

Target: Others

Cat.No: T21274

Cat.No: T10544

Synonym: AGN 192024 D5

Target: Others

Cat.No: T26417

Synonym: A39355,A-39355

Cat.No: T32458

Synonym: L 653,328,L653328,L653,328,L-653,328,L-653328

Cat.No: T29725

Synonym: AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T

Cat.No: T26426

Synonym: A62198,A-62198

Bimatoprost isopropyl ester

Cat.No: T30452

Synonym: 17-phenyl trinor PGF2α-iPr,17-phenyl trinor PGF2α isopropyl ester

Cat.No: T68707

Latanoprost ethyl amide

Cat.No: T37627

Deterenol Free Base

Cat.No: T68774

Cat.No: T27754

Synonym: KUL7211,KUL 7211

Substance P (6-11)

Cat.No: T76453

Cat.No: T16711

Target: 5-HT Receptor

Brain Natriuretic Peptide-45, mouse

Cat.No: T39246

Synonym: Brain Natriuretic Peptide-45, mouse,BNP-45, mouse

Cat.No: T62476

PAMP-12(human, porcine) TFA

Cat.No: T81557

Cat.No: T25568

Synonym: Reduced ketanserin

Adrenomedullin (AM) (22-52), human

Cat.No: TP1257

Synonym: 22-52-Adrenomedullin (human)

Brain Natriuretic Peptide-45, rat

Cat.No: TP1207

Synonym: BNP-45 (rat),Brain natriuretic peptide-45 rat

Fluprostenol methyl ester

Cat.No: T37813

Cat.No: T62744

Cat.No: T9819

BNP-45 (rat) (TFA) (123337-89-3 free base)

Cat.No: TP1206

Synonym: BNP-45 (rat) (TFA),Brain natriuretic peptide-45 rat TFA

Nω-Propyl-L-arginine hydrochloride

Cat.No: T38017

5-trans Latanoprost

Cat.No: T37213

Foslevcromakalim

Cat.No: T75084

Lys-[Des-Arg9]Bradykinin

Cat.No: TP1918

[(pF)Phe4]Nociceptin(1-13)NH2

Cat.No: TP1885

Cat.No: T61075

Sar-[D-Phe8]-des-Arg9-Bradykinin

Cat.No: TP1917

N-Desethyl Bimatoprost

Cat.No: T37939

Synonym: 17-phenyl trinor Prostaglandin F2α amide

Cat. No.	Product Name	Target	Signaling Pathways
T13482	2'-O-Methyladenosine	Endogenous Metabolite	Metabolism
	2'-O-Methyladenosine 是甲基化腺嘌呤的残基，在正常人群和腺苷脱氨基酶缺乏病人的尿液中均可被检测到。它显示出独特的降血压活性。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T5721	Dehydroevodiamine hydrochloride	AChE	Neuroscience
	Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中，能够抑制 AChE。它能够调节一氧化氮的产生，具有降压和神经保护作用。
TQ0185	14-Deoxy-11,12-didehydroandrographolide AP10,14-脱氧-11,12-二去氢穿心莲内酯,14-dehydro Andrographolide	NF-κB	NF-κB
	14-Deoxy-11,12-didehydroandrographolide (AP10) 是一种 Andrographolide 的类似物，能够抑制 NF-κB 活性。
T3013	Catharanthine tartrate Catharanthine hemitartrate,酒石酸长春质碱	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱，可抑制电压门控 L 型钙离子通道，具有抗肿瘤和降血压活性。
T3S0629	Delsoline Belsoline,硬飞燕草碱	Others	Others
	Delsoline (Belsoline) 是一种还亮草的主要生物碱，具有类似箭毒的效果和神经节阻滞作用，可用于肌肉紧张或运动过度的缓解。其中还亮草具有祛风除湿，止痛，活络的功效，可用于风湿，偏瘫，消化不良和咳嗽的研究。
T2S2335	Dehydroevodiamine DHED,去氢吴茱萸碱	Others; NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB; Others
	Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。
TN2322	Yangambin	Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
T8198	Visnagin	Others	Others
	Visnagin 是一种抗氧化剂呋喃香豆素衍生物。它具有预防Cerulein 诱导的急性胰腺炎的潜力。它在血管平滑肌中具有良好的血管扩张作用。它具有抗炎作用，可用于缓解疼痛的研究。
T3S1729	Dihydrolycorine	Others	Others
	Dihydrolycorine 是分离自Lycoris radiate 草药中，是一种真核细胞中蛋白质合成的抑制剂。
T15824	Lysergol	Antibacterial	Microbiology/Virology
	Lysergol 已被用作一种降血压、精神镇痛药以及刺激子宫和肠道的药物。 Lysergol 是从 Ipomoea muricata 的种子中分离出来的一种棒状生物碱，是药物和营养物质的生物增强剂，具有抗菌活性。
T25900	Oosponol Lenzitin
	Oosponol is a dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.
TN2271	Thalrugosaminine	Antifection	Microbiology/Virology
	Thalrugosaminine shows promising antibacterial activity with MIC values of 64-128ug/ml and Staphylococcus species is the most sensitive strains. Thalrugosaminine possesses hypotensive activity in rabbits and is active against Mycobacterium smegmatis.
TN2990	3alpha-dihydrocadambine	Others	Others
	3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats.
T4110	Perivine Perivin,派利文碱	Others	Others
	Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，能够解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于研究阿尔茨海默病。
TN2918	3-Acetoxy-8(17),13E-labdadien-15-oic acid	cAMP; Potassium Channel; Calcium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	ent-3-Acetoxy-labda-8(17),13-dien-15-oic acid have vasorelaxant and hypotensive actions, the mechanisms underlying the cardiovascular actions of the labdane involve the activation of the endothelial NO-cGMP pathway, the opening of K+ channels and the alteration on Ca2+ mobilization.
TN4652	Niazimicin	NF-κB; PI3K; AChR; Antifection	Microbiology/Virology; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as ini
TN1681	Gentianine	Others; TNF; transporter; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism; Others
	Gentianine 是一种有效的 Swertiamarin 衍生物，具有抗糖尿病、抗精神病、抗炎、降血压、利尿等作用，具有被开发成一种安全的降压药物的潜力。

天然产物

2'-O-Methyladenosine

Cat.No: T13482

Target: Endogenous Metabolite

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

Dehydroevodiamine hydrochloride

Cat.No: T5721

Target: AChE

14-Deoxy-11,12-didehydroandrographolide

Cat.No: TQ0185

Synonym: AP10,14-脱氧-11,12-二去氢穿心莲内酯,14-dehydro Andrographolide

Target: NF-κB

Catharanthine tartrate

Cat.No: T3013

Synonym: Catharanthine hemitartrate,酒石酸长春质碱

Target: Others, Calcium Channel

Cat.No: T3S0629

Synonym: Belsoline,硬飞燕草碱

Target: Others

Dehydroevodiamine

Cat.No: T2S2335

Synonym: DHED,去氢吴茱萸碱

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Cat.No: TN2322

Target: Calcium Channel, PAFR

Cat.No: T8198

Target: Others

Dihydrolycorine

Cat.No: T3S1729

Target: Others

Cat.No: T15824

Target: Antibacterial

Cat.No: T25900

Synonym: Lenzitin

Thalrugosaminine

Cat.No: TN2271

Target: Antifection

3alpha-dihydrocadambine

Cat.No: TN2990

Target: Others

Cat.No: T4110

Synonym: Perivin,派利文碱

Target: Others

3-Acetoxy-8(17),13E-labdadien-15-oic acid

Cat.No: TN2918

Target: cAMP, Potassium Channel, Calcium Channel

Cat.No: TN4652

Target: NF-κB, PI3K, AChR, Antifection

Cat.No: TN1681

Target: Others, TNF, transporter, PPAR

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