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N-Desethyl Bimatoprost

N-Desethyl Bimatoprost

产品编号 T37939   CAS 155205-89-3
别名: 17-phenyl trinor Prostaglandin F2α amide

N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.

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N-Desethyl Bimatoprost Chemical Structure
N-Desethyl Bimatoprost, CAS 155205-89-3
规格 价格/CNY 货期 数量
1 mg ¥ 1,120 35日内发货
5 mg ¥ 4,900 35日内发货
10 mg ¥ 8,690 35日内发货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: N-Desethyl Bimatoprost (T37939)
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产品描述 N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
别名 17-phenyl trinor Prostaglandin F2α amide
分子量 387.51
分子式 C23H33NO4
CAS No. 155205-89-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 20 mg/mL

DMF: 30 mg/mL

Ethanol: 20 mg/mL

PBS (pH 7.2): 2 mg/mL

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母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

N-Desethyl Bimatoprost 155205-89-3 17-phenyl trinor Prostaglandin F2a Amide 17-phenyl trinor Prostaglandin F-2α amide 17phenyl trinor Prostaglandin F2α amide 17-phenyl trinor Prostaglandin F2α amide 17-phenyl trinor Prostaglandin F2α Amide 17-phenyl trinor Prostaglandin F2alpha Amide 17 phenyl trinor Prostaglandin F2α amide Inhibitor inhibitor inhibit

 

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